| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emma Thornton, Robert Vin. Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease. PloS one. vol 7. issue 4. 2012-07-27. PMID:22485158. |
the present study used an in vivo 6-ohda lesion model to determine if dopaminergic degeneration was associated with increased sp in the substantia nigra and whether this degeneration could be prevented by using a sp, nk1 receptor antagonist. |
2012-07-27 |
2023-08-12 |
Not clear |
| Hyo Jin Son, Ji Ae Lee, Nari Shin, Ji Hyun Choi, Jai Woong Seo, Dae Yoon Chi, Cheol Soon Lee, Eun-Mee Kim, Han Choe, Onyou Hwan. A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP. British journal of pharmacology. vol 165. issue 7. 2012-07-23. PMID:21951056. |
in parkinson's disease, the dopaminergic neurones in the substantia nigra undergo degeneration. |
2012-07-23 |
2023-08-12 |
Not clear |
| Alexander Kurz, Caroline May, Oliver Schmidt, Thorsten Müller, Christian Stephan, Helmut E Meyer, Suzana Gispert, Georg Auburger, Katrin Marcu. A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21960009. |
we previously generated mice with transgenic overexpression of human a53t-alpha-synuclein (a53t-snca) in dopaminergic substantia nigra neurons as a model of early pd. |
2012-07-23 |
2023-08-12 |
mouse |
| Laure Chagniel, Christine Robitaille, Manon Lebel, Michel Cy. Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:22037042. |
another fascinating observation was that l-dopa therapy, in combination with intrastriatal infusion of mdl28170, augmented tyrosine hydroxylase levels in the striatum of lesioned rats without affecting the number of dopaminergic cells in the substantia nigra. |
2012-07-23 |
2023-08-12 |
rat |
| P Panther, S Nullmeier, H Dobrowolny, H Schwegler, R Wol. CPB-K mice a mouse model of schizophrenia? Differences in dopaminergic, serotonergic and behavioral markers compared to BALB/cJ mice. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22454846. |
our results can be summarized as follows: compared to balb/cj, cpb-k mice showed:(1) significantly reduced traveling distance and number of contacts in social interaction test, (2) differences in the number of serotonin transporter-immunoreactive neurons and volume of raphe nuclei and a lower serotonergic fiber density in the ventral and dorsal hippocampal subfields ca1 and ca3, (3) no alterations of dopaminergic markers like neuron number, neuron density and volume in subregions of substantia nigra and ventral tegmental area, but a significantly higher dopaminergic fiber density in the dorsal hippocampus, the ventral hippocampus of ca1 and gyrus dentatus, (4) no significant differences in serotonergic and dopaminergic fiber densities in the amygdala.based on our results and previous studies, cpb-k mice compared to balb/cj may serve as an important model to understand the interaction of the serotonergic and dopaminergic system and their impact on sensorimotor gating and cognitive function as related to neuropsychiatric disorders like schizophrenia. |
2012-07-23 |
2023-08-12 |
mouse |
| Hany E S Marei, Asma Althani, Nahla Afifi, Fabrizio Michetti, Mario Pescatori, Roberto Pallini, Patricia Casalbore, Carlo Cenciarelli, Philip Schwartz, Abd-Elmaksoud Ahme. Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra. PloS one. vol 6. issue 12. 2012-07-20. PMID:22163301. |
gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra. |
2012-07-20 |
2023-08-12 |
human |
| Hany E S Marei, Asma Althani, Nahla Afifi, Fabrizio Michetti, Mario Pescatori, Roberto Pallini, Patricia Casalbore, Carlo Cenciarelli, Philip Schwartz, Abd-Elmaksoud Ahme. Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra. PloS one. vol 6. issue 12. 2012-07-20. PMID:22163301. |
we used agilent's and illumina whole human genome oligonucleotide microarray to compare the genomic profiles of human embryonic nsc at a single time point in culture, and a multicellular tissue from postmortem adult substantia nigra (sn) which are rich in dopaminergic (da) neurons. |
2012-07-20 |
2023-08-12 |
human |
| Charalambos Karakasis, Kallirhoe Kalinderi, Zoe Katsarou, Liana Fidani, Sevasti Bostantjopoulo. Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with Parkinson's disease in a Greek population. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 18. issue 12. 2012-07-19. PMID:22001244. |
brain-derived neurotrophic factor (bdnf) enhances survival of dopaminergic neurons in the substantia nigra, whereas in patients with parkinson's disease (pd), the expression of bdnf mrna is decreased, thus making bdnf a candidate gene for pd susceptibility. |
2012-07-19 |
2023-08-12 |
human |
| Senthil Selvaraj, Yuyang Sun, John A Watt, Shouping Wang, Saobo Lei, Lutz Birnbaumer, Brij B Sing. Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. The Journal of clinical investigation. vol 122. issue 4. 2012-07-06. PMID:22446186. |
individuals with parkinson's disease (pd) experience a progressive decline in motor function as a result of selective loss of dopaminergic (da) neurons in the substantia nigra. |
2012-07-06 |
2023-08-12 |
mouse |
| Yeom Pyo Lee, Dae Won Kim, Hye Won Kang, Jae Hyeok Hwang, Hoon Jae Jeong, Eun Jeong Sohn, Mi Jin Kim, Eun Hee Ahn, Min Jea Shin, Duk-Soo Kim, Tae-Cheon Kang, Oh-Shin Kwon, Sung-Woo Cho, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-heat shock protein 27 protects from neuronal damage in cells and in a Parkinson's disease mouse model. The FEBS journal. vol 279. issue 11. 2012-07-05. PMID:22429328. |
furthermore, transduced pep-1-hsp27 prevented dopaminergic neuronal cell death in the substantia nigra of mptp-induced pd mouse models. |
2012-07-05 |
2023-08-12 |
mouse |
| Lixiang Ma, Baoyang Hu, Yan Liu, Scott Christopher Vermilyea, Huisheng Liu, Lu Gao, Yan Sun, Xiaoqing Zhang, Su-Chun Zhan. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell stem cell. vol 10. issue 4. 2012-07-03. PMID:22424902. |
transplantation of these human forebrain gaba neurons and their progenitors, but not spinal gaba cells, into the striatum of quinolinic acid-lesioned mice results in generation of large populations of darpp32(+) gaba neurons, which project to the substantia nigra as well as receiving glutamatergic and dopaminergic inputs, corresponding to correction of motor deficits. |
2012-07-03 |
2023-08-12 |
mouse |
| Eun Jung Shin, Eun-Mee Kim, Ji Ae Lee, Hyangshuk Rhim, Onyou Hwan. Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22265821. |
dopaminergic neurons in the substantia nigra are particularly vulnerable, and their degeneration leads to parkinson's disease. |
2012-06-25 |
2023-08-12 |
Not clear |
| T N Sergeyeva, V G Sergeye. Administration of LPS-stimulated autologous macrophages induces α-synuclein aggregation in dopaminergic neurons of rat brain. Bulletin of experimental biology and medicine. vol 150. issue 4. 2012-06-25. PMID:22268028. |
brain immunohistochemistry showed that additional administration of lps (250 μg/kg) to animals during week 4 after injection of lps-stimulated macrophages led to α-synuclein accumulation in 9.4±3.2% dopaminergic neurons of the substantia nigra. |
2012-06-25 |
2023-08-12 |
rat |
| Markus Bingmer, Julia Schiemann, Jochen Roeper, Gaby Schneide. Measuring burstiness and regularity in oscillatory spike trains. Journal of neuroscience methods. vol 201. issue 2. 2012-06-22. PMID:21871494. |
we apply the model to a data set obtained from single dopaminergic substantia nigra neurons recorded extracellularly in vivo. |
2012-06-22 |
2023-08-12 |
Not clear |
| Yu Geng, Marong Fang, Jing Wang, Haiyan Yu, Zhiying Hu, David T Yew, Wei Che. Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells. Phytotherapy research : PTR. vol 26. issue 3. 2012-06-20. PMID:21717513. |
recently, it has been shown that tp prevented the loss of dopaminergic neurons in the substantia nigra of rats in a model of parkinson's disease, but little is known about the precise neuroprotective mechanism of tp. |
2012-06-20 |
2023-08-12 |
rat |
| L MacGillivray, K B Reynolds, M Sickand, P I Rosebush, M F Mazure. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584867. |
inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. |
2012-06-18 |
2023-08-12 |
rat |
| L MacGillivray, K B Reynolds, M Sickand, P I Rosebush, M F Mazure. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584867. |
we studied the time course of changes in dopaminergic neurons in the substantia nigra (sn) after initiation of two different sert inhibitors, citalopram and fluoxetine. |
2012-06-18 |
2023-08-12 |
rat |
| David Ramonet, Agata Podhajska, Klodjan Stafa, Sarah Sonnay, Alzbeta Trancikova, Elpida Tsika, Olga Pletnikova, Juan C Troncoso, Liliane Glauser, Darren J Moor. PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Human molecular genetics. vol 21. issue 8. 2012-06-18. PMID:22186024. |
in the human brain, atp13a2 is localized to pyramidal neurons within the cerebral cortex and dopaminergic neurons of the substantia nigra. |
2012-06-18 |
2023-08-12 |
human |
| Ricardo Pardal, José López-Barne. Neural stem cells and transplantation studies in Parkinson's disease. Advances in experimental medicine and biology. vol 741. 2012-06-15. PMID:22457112. |
parkinson's disease (pd), one of the most frequent neurodegenerative disorders, is primarily caused by the selective degeneration of specific neuronal populations, particularly dopaminergic neurons within the substantia nigra projecting to the striatum (nigrostriatal neurons). |
2012-06-15 |
2023-08-12 |
Not clear |
| David Fan, Mark A Rossi, Henry H Yi. Mechanisms of action selection and timing in substantia nigra neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 16. 2012-06-12. PMID:22514315. |
in short, these results suggest that (1) nigral activity is highly plastic and modified by the learning of the instrumental contingency; (2) gabaergic output from the substantia nigra can simultaneously inhibit and disinhibit downstream structures, while the dopaminergic output also provide bidirectional modulation of the corticostriatal circuits; (3) dopaminergic and gabaergic neurons show similar task-related activity, although da neurons are more responsive to the trial start signal. |
2012-06-12 |
2023-08-12 |
mouse |