| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esther Gramage, Gonzalo Herradó. Connecting Parkinson's disease and drug addiction: common players reveal unexpected disease connections and novel therapeutic approaches. Current pharmaceutical design. vol 17. issue 5. 2011-08-09. PMID:21375485. |
during the last few years, a possible specific cause triggering death of dopaminergic neurons in the substantia nigra, drug of abuse-induced neurotoxicity, is being considered as a potential mechanism to develop pd, especially in the case of abuse of amphetamine and its derivatives. |
2011-08-09 |
2023-08-12 |
Not clear |
| Kozue Kubo, Takefumi Inada, Koh Shing. Possible role of propofol's cyclooxygenase-inhibiting property in alleviating dopaminergic neuronal loss in the substantia nigra in an MPTP-induced murine model of Parkinson's disease. Brain research. vol 1387. 2011-08-03. PMID:21376018. |
possible role of propofol's cyclooxygenase-inhibiting property in alleviating dopaminergic neuronal loss in the substantia nigra in an mptp-induced murine model of parkinson's disease. |
2011-08-03 |
2023-08-12 |
mouse |
| Yuangang Zhu, Chunli Duan, Li Lü, Hua Gao, Chunli Zhao, Shun Yu, Kenji Uéda, Piu Chan, Hui Yan. α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator. The international journal of biochemistry & cell biology. vol 43. issue 5. 2011-08-01. PMID:21310263. |
our findings suggest that overexpression of α-syn may cause mitochondrial defects in dopaminergic neurons of the substantia nigra through an association with adenylate translocator and activation of mitochondria-dependent cell death pathways. |
2011-08-01 |
2023-08-12 |
rat |
| Fernando Cardona, Jose Vicente Sánchez-Mut, Hernán Dopazo, Jordi Pérez-Tu. Phylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1. Human mutation. vol 32. issue 4. 2011-07-22. PMID:21412950. |
parkinson disease (pd) is the second most common neurodegenerative disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2011-07-22 |
2023-08-12 |
Not clear |
| b' Susanna Amadio, Cinzia Montilli, Barbara Picconi, Paolo Calabresi, Cinzia Volont\\xc3\\xa. Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study. Purinergic signalling. vol 3. issue 4. 2011-07-14. PMID:18404452.' |
this generates a rearrangement of p2 proteins: most p2x and p2y receptors are decreased on gabaergic and dopaminergic neurons, in the lesioned striatum and substantia nigra, respectively, as a consequence of dopaminergic denervation and/or neuronal degeneration. |
2011-07-14 |
2023-08-12 |
rat |
| C I Raga. Metal ions in neuroscience. Metal-based drugs. vol 4. issue 3. 2011-07-14. PMID:18475782. |
in parkinson's disease, the selective loss of dopaminergic neurones in the substantia nigra may be caused by radical-mediated damage and there is good evidence to suggest that fe(2+) or (3+) is important in promoting formation of radical species. |
2011-07-14 |
2023-08-12 |
Not clear |
| Torsten Falk, Shiling Zhang, Scott J Sherma. Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease. Molecular neurodegeneration. vol 4. 2011-07-14. PMID:20003314. |
parkinson's disease (pd) results from the degeneration of dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine released in the striatum. |
2011-07-14 |
2023-08-12 |
rat |
| Mong-Lin Yang, Linda Hasadsri, Wendy S Woods, Julia M Georg. Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons. Molecular neurodegeneration. vol 5. issue 1. 2011-07-14. PMID:20181133. |
abnormal accumulation of alpha-synuclein aggregates in dopaminergic neurons of the substantia nigra is diagnostic of sporadic parkinson's disease, and mutations in the protein are linked to early onset forms of the disease. |
2011-07-14 |
2023-08-12 |
Not clear |
| Peter Redgrave, Veronique Coizet, Eliane Comoli, John G McHaffie, Mariana Leriche, Nicolas Vautrelle, Lauren M Hayes, Paul Overto. Interactions between the Midbrain Superior Colliculus and the Basal Ganglia. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:20941324. |
the sc also provides afferent signals to the other principal input nuclei of the basal ganglia, the dopaminergic neurones in substantia nigra and to the subthalamic nucleus. |
2011-07-14 |
2023-08-12 |
Not clear |
| James B Koprich, Tom H Johnston, M Gabriela Reyes, Xuan Sun, Jonathan M Brotchi. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:21029459. |
the pathological hallmarks of parkinson's disease (pd) include the presence of alpha-synuclein (α-syn) rich lewy bodies and neurites and the loss of dopaminergic (da) neurons of the substantia nigra (sn). |
2011-07-14 |
2023-08-12 |
human |
| Beate Winner, Daniela M Vogt-Weisenhorn, Chichung D Lie, Ingmar Blümcke, Jürgen Winkle. Cellular repair strategies in Parkinson's disease. Therapeutic advances in neurological disorders. vol 2. issue 1. 2011-07-14. PMID:21180641. |
these motor symptoms result largely from the deficiency or dysfunction of dopaminergic neurons in the substantia nigra. |
2011-07-14 |
2023-08-12 |
Not clear |
| Beate Winner, Daniela M Vogt-Weisenhorn, Chichung D Lie, Ingmar Blümcke, Jürgen Winkle. Cellular repair strategies in Parkinson's disease. Therapeutic advances in neurological disorders. vol 2. issue 1. 2011-07-14. PMID:21180641. |
histopathological analysis reveals depletion of dopaminergic neurons as well as eosinophilic intracytoplasmic inclusions (lewy bodies) in surviving neurons of the substantia nigra and other brain regions. |
2011-07-14 |
2023-08-12 |
Not clear |
| Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malle. 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21211034. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), resulting in tremor, rigidity, and bradykinesia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Kemal Ugur Tufekci, Sermin Genc, Kursad Gen. The endotoxin-induced neuroinflammation model of Parkinson's disease. Parkinson's disease. vol 2011. 2011-07-14. PMID:21331154. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2011-07-14 |
2023-08-12 |
Not clear |
| Tahira Farooqui, Akhlaq A Farooqu. Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. Parkinson's disease. vol 2011. 2011-07-14. PMID:21403820. |
pd is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, depletion of dopamine in the striatum, abnormal mitochondrial and proteasomal functions, and accumulation of α-synuclein that may be closely associated with pathological and clinical abnormalities. |
2011-07-14 |
2023-08-12 |
Not clear |
| A Machado, A J Herrera, J L Venero, M Santiago, R M De Pablos, R F Villarán, A M Espinosa-Oliva, S Argüelles, M Sarmiento, M J Delgado-Cortés, R Mauriño, J Can. Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence. Parkinson's disease. vol 2011. 2011-07-14. PMID:21603178. |
in all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as il-1β and tnf-α. |
2011-07-14 |
2023-08-12 |
Not clear |
| Anna R Carta, Augusta Pisanu, Ezio Carbon. Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? Parkinson's disease. vol 2011. 2011-07-14. PMID:21603186. |
moreover, after the discovery of infiltrating activated limphocytes in the substantia nigra (sn) of pd patients, most recent research supports a role of immune-mediated mechanisms in the pathological process leading to chronic neuroinflammation and dopaminergic degeneration. |
2011-07-14 |
2023-08-12 |
Not clear |
| Paul Chorley, Anil K Set. Dopamine-signaled reward predictions generated by competitive excitation and inhibition in a spiking neural network model. Frontiers in computational neuroscience. vol 5. 2011-07-14. PMID:21629770. |
dopaminergic neurons in the mammalian substantia nigra display characteristic phasic responses to stimuli which reliably predict the receipt of primary rewards. |
2011-07-14 |
2023-08-12 |
Not clear |
| Irene Re Taravini, Mariela Chertoff, Eduardo G Cafferata, José Courty, Mario G Murer, Fernando J Pitossi, Oscar S Gershani. Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats. Molecular neurodegeneration. vol 6. 2011-07-14. PMID:21649894. |
pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of parkinson's disease patients. |
2011-07-14 |
2023-08-12 |
rat |
| Irene Re Taravini, Mariela Chertoff, Eduardo G Cafferata, José Courty, Mario G Murer, Fernando J Pitossi, Oscar S Gershani. Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats. Molecular neurodegeneration. vol 6. 2011-07-14. PMID:21649894. |
to establish whether pleiotrophin has a trophic effect on nigrostriatal dopaminergic neurons in vivo, we injected a recombinant adenovirus expressing pleiotrophin in the substantia nigra of 6-hydroxydopamine lesioned rats. |
2011-07-14 |
2023-08-12 |
rat |