| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoqi Zhu, Xuncui Wang, Yuefa Chen, Shu Yang, Hui Cheng, Ning Wang, Qinglin L. Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease. Planta medica. vol 76. issue 16. 2011-05-02. PMID:20509103. |
thus, we examined whether puerarin is capable to protect dopaminergic neurons of the substantia nigra against 6-hydroxydopamine induced neuronal cell death. |
2011-05-02 |
2023-08-12 |
rat |
| V G Khaindrava, E A Kozina, V G Kucherianu, G N Kryzhanovskiĭ, V S Kudrin, P D Klodt, E V Bocharov, K S Raevskiĭ, M V Ugriumo. [Modeling of preclinical and early clinical stages of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 110. issue 7. 2011-05-02. PMID:20639856. |
in the substantia nigra, there were no changes in dopamine content but the number of dopaminergic neurons decreased by 43%. |
2011-05-02 |
2023-08-12 |
mouse |
| Satoshi Fuke, Mie Kubota-Sakashita, Takaoki Kasahara, Yasufumi Shigeyoshi, Tadafumi Kat. Regional variation in mitochondrial DNA copy number in mouse brain. Biochimica et biophysica acta. vol 1807. issue 3. 2011-04-18. PMID:21145305. |
high levels of mtdna copies were found in the ventral tegmental area and substantia nigra, two major nuclei containing dopaminergic neurons. |
2011-04-18 |
2023-08-12 |
mouse |
| Dario Domenico Lofrumento, Concetta Saponaro, Antonia Cianciulli, Francesco De Nuccio, Vincenzo Mitolo, Giuseppe Nicolardi, Maria Antonietta Panar. MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain. Neuroimmunomodulation. vol 18. issue 2. 2011-04-06. PMID:20938211. |
parkinson's disease (pd) is a common neurodegenerative disease characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2011-04-06 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |
| Sonia George, Su San Mok, Milawaty Nurjono, Scott Ayton, David I Finkelstein, Colin L Masters, Qiao-Xin Li, Janetta G Culveno. α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20464527. |
parkinson's disease (pd) is a severe neurodegenerative disorder characterised by loss of dopaminergic neurons of the substantia nigra. |
2011-04-04 |
2023-08-12 |
mouse |
| Qinbo Zhou, Juntao Li, Hanzhi Wang, Yanqing Yin, Jiawei Zho. Identification of nigral dopaminergic neuron-enriched genes in adult rats. Neurobiology of aging. vol 32. issue 2. 2011-03-30. PMID:19303663. |
dopaminergic (da) neurons in the substantia nigra play crucial roles in movement control and other physiological activities. |
2011-03-30 |
2023-08-12 |
rat |
| Hey-Kyeong Jeong, Ilo Jou, Eun-hye Jo. Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Experimental & molecular medicine. vol 42. issue 12. 2011-03-23. PMID:20962566. |
systemic lps administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. |
2011-03-23 |
2023-08-12 |
rat |
| Hey-Kyeong Jeong, Ilo Jou, Eun-hye Jo. Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Experimental & molecular medicine. vol 42. issue 12. 2011-03-23. PMID:20962566. |
interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mrna/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (sn), where dopaminergic neurons are located. |
2011-03-23 |
2023-08-12 |
rat |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
gfrα1 is expressed in the striatum, a target of the dopaminergic projection of the substantia nigra. |
2011-03-22 |
2023-08-12 |
mouse |
| Pernille Bøttger, Zuzanna Tracz, Anders Heuck, Poul Nissen, Marina Romero-Ramos, Karin Lykke-Hartman. Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain. The Journal of comparative neurology. vol 519. issue 2. 2011-03-18. PMID:21165980. |
atp1α(3) expression was not significant in the dopaminergic cells of substantia nigra. |
2011-03-18 |
2023-08-12 |
mouse |
| Shih-Ying Wu, Tzu-Feng Wang, Lung Yu, Chauying J Jen, Jih-Ing Chuang, Fong-Sen Wu, Chih-Wei Wu, Yu-Min Ku. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain, behavior, and immunity. vol 25. issue 1. 2011-03-10. PMID:20851176. |
parkinson's disease (pd) is characterized by a progressive and selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2011-03-10 |
2023-08-12 |
Not clear |
| Gang Wang, Li Zhou, Yingbo Zhang, Miaoxian Dong, Xiaoming Li, Jicheng Liu, Yingcai Ni. Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. Neuroscience letters. vol 487. issue 1. 2011-03-09. PMID:20934486. |
apoptosis is a widely accepted component of the pathogenesis of parkinson's disease (pd), a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. |
2011-03-09 |
2023-08-12 |
rat |
| Maarit Hellman, Johan Peränen, Mart Saarma, Perttu Perm. 1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor. Biomolecular NMR assignments. vol 4. issue 2. 2011-03-04. PMID:20617400. |
parkinson's disease (pd) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. |
2011-03-04 |
2023-08-12 |
human |
| Arianna Tucci, Mike A Nalls, Henry Houlden, Tamas Revesz, Andrew B Singleton, Nicholas W Wood, John Hardy, Coro Paisán-Rui. Genetic variability at the PARK16 locus. European journal of human genetics : EJHG. vol 18. issue 12. 2011-02-28. PMID:20683486. |
parkinson's disease (pd) is a complex neurodegenerative disease which is clinically heterogeneous and pathologically consists of loss of dopaminergic neurons in the substantia nigra and intracytoplasmic neuronal inclusions containing alpha-synuclein aggregations known as lewy bodies. |
2011-02-28 |
2023-08-12 |
Not clear |
| Maria José Diógenes, Tiago Fleming Outeir. Neurotrophic factors as a protective strategy in Parkinson's disease. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942787. |
the loss of dopaminergic neurons in the substantia nigra justified the use of dopaminergic therapies in patients. |
2011-02-28 |
2023-08-12 |
human |
| O-B Tysnes, B Müller, J P Larse. Are dysautonomic and sensory symptoms present in early Parkinson's disease? Acta neurologica Scandinavica. Supplementum. issue 190. 2011-02-25. PMID:20586740. |
the motor symptoms in pd are related to the degeneration of dopaminergic cells in the substantia nigra (sn). |
2011-02-25 |
2023-08-12 |
Not clear |
| V Gunderse. Protein aggregation in Parkinson's disease. Acta neurologica Scandinavica. Supplementum. issue 190. 2011-02-25. PMID:20586742. |
pathologically parkinson's disease is characterized by loss of dopaminergic neurons in the compact part of substantia nigra. |
2011-02-25 |
2023-08-12 |
Not clear |
| Jun Ping Cao, Fu Zhen Li, Yuan Yuan Zhu, Hong Hua Yuan, Zheng Quan Yu, Dian Shuai Ga. Expressions and possible roles of GDNF receptors in the developing dopaminergic neurons. Brain research bulletin. vol 83. issue 6. 2011-02-24. PMID:20884338. |
glial cell line-derived neurotrophic factor (gdnf) has an essential role in the survival and maturation of the dopaminergic (da) neurons in the substantia nigra (sn) of mammalian embryonic brain. |
2011-02-24 |
2023-08-12 |
human |
| Yasuhiko Izumi, Toshiaki Kume, Akinori Akaik. [Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 131. issue 1. 2011-02-24. PMID:21212609. |
parkinson disease is one of the most common neurodegenerative disorders and is characterized by the selective loss of dopaminergic neurons in the substantia nigra. |
2011-02-24 |
2023-08-12 |
Not clear |