| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V G Khaindrava, P V Ershov, V E Antsiperov, Iu V Obukhov, A K Nanaev, M V Ugriumo. [Optimization of counting process of dopaminergic neurons in substantia nigra of parkinsonian mice]. Tsitologiia. vol 52. issue 6. 2010-09-28. PMID:20737900. |
[optimization of counting process of dopaminergic neurons in substantia nigra of parkinsonian mice]. |
2010-09-28 |
2023-08-12 |
mouse |
| P Wang, L Niu, L Gao, W-X Li, D Jia, X-L Wang, G-D Ga. Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson's disease. The Journal of international medical research. vol 38. issue 3. 2010-09-28. PMID:20819446. |
acute administration of mptp led to decreased glutathione content and reduced superoxide dismutase activity in the substantia nigra of the mice, which resulted in oxidative stress, loss of nigral dopaminergic neurons and motor dysfunction. |
2010-09-28 |
2023-08-12 |
mouse |
| Jia-Yi Li, Elisabet Englund, Håkan Widner, Stig Rehncrona, Anders Björklund, Olle Lindvall, Patrik Brundi. Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 8. 2010-09-20. PMID:20198645. |
our data indicate that lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra. |
2010-09-20 |
2023-08-12 |
human |
| David Vauzour, Giulia Corona, Jeremy P E Spence. Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity. Archives of biochemistry and biophysics. vol 501. issue 1. 2010-09-20. PMID:20361927. |
parkinson's disease is characterized by a progressive and selective loss of dopaminergic neurons in the substantia nigra. |
2010-09-20 |
2023-08-12 |
Not clear |
| Mohamed R Ahmed, Amandine Berthet, Evgeny Bychkov, Gregory Porras, Qin Li, Bernard H Bioulac, Yonatan T Carl, Bertrand Bloch, Seunghyi Kook, Incarnation Aubert, Sandra Dovero, Evelyne Doudnikoff, Vsevolod V Gurevich, Eugenia V Gurevich, Erwan Bezar. Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Science translational medicine. vol 2. issue 28. 2010-09-20. PMID:20410529. |
parkinson's disease is caused primarily by degeneration of brain dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine in the striatum. |
2010-09-20 |
2023-08-12 |
rat |
| Juan Carlos Corona, Alfredo Gimenez-Cassina, Filip Lim, Javier Díaz-Nid. Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20143419. |
a typical feature of parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex i activity may play an important role. |
2010-09-16 |
2023-08-12 |
mouse |
| Shin-ichi Muramats. [Cell therapy for Parkinson disease]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 11. 2010-09-02. PMID:20030240. |
since grafts were transplanted ectopically into the striatum instead of the substantia nigra in most current protocols, surviving dopaminergic neurons would not have to be the same subtype as the nigral cells. |
2010-09-02 |
2023-08-12 |
Not clear |
| [Neurochemical mechanisms of sleep regulation]. Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka. issue 50. 2010-08-26. PMID:20666118. |
the wake-promoting neurons at the midbrain level are glutamatergic neurons of midbrain reticular formation, dopaminergic neurons of substantia nigra and ventral tegmental area. |
2010-08-26 |
2023-08-12 |
rat |
| Shin Miyazaki, Takashi Yanagida, Kana Nunome, Shizuma Ishikawa, Masatoshi Inden, Yoshihisa Kitamura, Shinsuke Nakagawa, Takahiro Taira, Kosaku Hirota, Masami Niwa, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18373560. |
these compounds prevented dopaminergic cell death in the substantia nigra and restored movement abnormality in 6-hydroxyldopamine-injected pd model rats. |
2010-08-13 |
2023-08-12 |
rat |
| Y Aluf, J Vaya, S Khatib, Y Loboda, S Kizhner, John P M Finber. Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydroxydopamine as assessed by a novel multifunctional marker molecule. Free radical research. vol 44. issue 6. 2010-08-13. PMID:20370558. |
partial dopaminergic deafferentation was induced by injection of 6-hydroxydopamine (250 microg) to the left lateral ventricle, which depleted ipsilateral striatal dopamine by 46% and dopaminergic cells in left substantia nigra by 44%, 5 weeks after administration. |
2010-08-13 |
2023-08-12 |
rat |
| Hiroto Uchida, Hironori Yokoyama, Hiroki Kimoto, Hiroyuki Kato, Tsutomu Arak. Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats. International journal of experimental pathology. vol 91. issue 3. 2010-07-30. PMID:20353427. |
furthermore, our double-labelled immunohistochemical study suggests that bdnf released by gfap-positive astrocytes may play a key role in the survival of dopaminergic neurones in the ipsilateral substantia nigra at the chronic stage after transient focal cerebral ischaemia, although the areas of the ipsilateral substantia nigra are decreased progressively after ischaemia. |
2010-07-30 |
2023-08-12 |
rat |
| E A Kozina, V G Khaindrava, V S Kudrin, V G Kucherianu, P D Klodt, E V Bocharov, K S Raevskiĭ, G N Kryzhanovskiĭ, M V Ugriumo. [Experimental modeling of functional deficiency of the nigrostriatal dopaminergic system in mice]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 96. issue 3. 2010-07-20. PMID:20535997. |
cell bodies of dopaminergic da-ergic neurons are located in the compact zone of the substantia nigra, and their axons are projected along the nigrostriatal tract to the striatum. |
2010-07-20 |
2023-08-12 |
mouse |
| Li Lu, Fengqiao Li, Xiaomin Wan. Novel anti-inflammatory and neuroprotective agents for Parkinson's disease. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20015029. |
parkinson's disease (pd) is a type of motor system disorder that results from the progressive loss of dopaminergic (daergic) neurons in the substantia nigra (sn) of the midbrain. |
2010-07-12 |
2023-08-12 |
Not clear |
| Guillaume Drion, Maxime Bonjean, Olivier Waroux, Jacqueline Scuvée-Moreau, Jean-Françis Liégeois, Terrence J Sejnowski, Rodolphe Sepulchre, Vincent Seuti. M-type channels selectively control bursting in rat dopaminergic neurons. The European journal of neuroscience. vol 31. issue 5. 2010-07-12. PMID:20180842. |
midbrain dopaminergic neurons in the substantia nigra, pars compacta and ventral tegmental area are critically important in many physiological functions. |
2010-07-12 |
2023-08-12 |
rat |
| Bae Dong Jung, Eun-Joo Shin, Xuan-Khanh Thi Nguyen, Chun-Hui Jin, Jae-Hyung Bach, Seok Joo Park, Seung-Yeol Nah, Myung-Bok Wie, Guoying Bing, Hyoung-Chun Ki. Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration. Neurochemistry international. vol 56. issue 2. 2010-07-08. PMID:19850096. |
in addition, it is important that cytoplasmic accumulation of alpha-synuclein was observed in the substantia nigra of mice treated with lps plus ma, and that l-dopa treatment significantly attenuated behavioral changes and dopaminergic deficits induced by lps plus ma. |
2010-07-08 |
2023-08-12 |
mouse |
| Hong-Ning Zhang, Chun-Na An, Hui-Nan Zhang, Xiao-Ping P. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227465. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-07-08 |
2023-08-12 |
mouse |
| David Vauzour, Maria Buonfiglio, Giulia Corona, Joselita Chirafisi, Katerina Vafeiadou, Cristina Angeloni, Silvana Hrelia, Patrizia Hrelia, Jeremy P E Spence. Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. Molecular nutrition & food research. vol 54. issue 4. 2010-07-01. PMID:20166144. |
the degeneration of dopaminergic neurons in the substantia nigra has been linked to the formation of the endogenous neurotoxin 5-s-cysteinyl-dopamine. |
2010-07-01 |
2023-08-12 |
Not clear |
| Abdelmojib Al-Wandi, Natalia Ninkina, Steven Millership, Sally J M Williamson, Paul A Jones, Vladimir L Buchma. Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiology of aging. vol 31. issue 5. 2010-06-28. PMID:19097673. |
in particular, no significant changes in striatal dopamine metabolism and only subtle deficit of dopaminergic neurons in the substantia nigra were found in juvenile or adult mice. |
2010-06-28 |
2023-08-12 |
mouse |
| Abdelmojib Al-Wandi, Natalia Ninkina, Steven Millership, Sally J M Williamson, Paul A Jones, Vladimir L Buchma. Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiology of aging. vol 31. issue 5. 2010-06-28. PMID:19097673. |
to assess whether aging and synuclein deficiency may have additive detrimental effect on the nigrostriatal system, we studied dopaminergic neurons of the substantia nigra and their striatal synapses in 24-26-month-old alpha-synuclein and gamma-synuclein null mutant mice. |
2010-06-28 |
2023-08-12 |
mouse |
| Michael J O'Neill, Eric R Siemer. Pharmacological approaches to disease-modifying therapies in Parkinson's disease. Expert review of neurotherapeutics. vol 2. issue 6. 2010-06-28. PMID:19810916. |
dopaminergic cells located in the substantia nigra and whose terminals extend to the striatum degenerate slowly such that 60% of cells are already lost when clinical motor symptoms first become evident. |
2010-06-28 |
2023-08-12 |
Not clear |