| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Douglas J Lansk. Chapter 33: the history of movement disorders. Handbook of clinical neurology. vol 95. 2010-12-16. PMID:19892136. |
parkinsonism: pathologic changes in parkinson's disease were recognized in the substantia nigra by blocq and marinescu in the late 19th century, and around 1920 trértiakoff established lewy bodies in the substantia nigra as a pathologic hallmark while the vogts instead emphasized pathologic changes in the striatum; it was only in the mid-1960s that a nigrostriatal dopaminergic pathway was demonstrated and found to be critical to pathogenesis. |
2010-12-16 |
2023-08-12 |
monkey |
| Jaya Sanyal, D P Chakraborty, Biswanath Sarkar, Tapas Kumar Banerjee, Subhash Chandra Mukherjee, Bidhan Chandra Ray, V R Ra. Environmental and familial risk factors of Parkinsons disease: case-control study. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 37. issue 5. 2010-12-10. PMID:21059511. |
while the cause of parkinson's disease (pd) remains unknown, evidence suggests certain environmental factors, such as well water drinking, herbicides, pesticides exposure and neurotoxins, may trigger the chain of oxidative reactions culminating in the death of dopaminergic neurons in substantia nigra to cause parkinsonism. |
2010-12-10 |
2023-08-12 |
Not clear |
| Daniel P Eisenberg, Philip D Kohn, Erica B Baller, Joel A Bronstein, Joseph C Masdeu, Karen F Berma. Seasonal effects on human striatal presynaptic dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 44. 2010-12-08. PMID:21048126. |
analyses comparing voxelwise k(i) values confirmed this finding and evidenced intrastriatal localization of seasonal effects to the caudal putamen (p < 0.05, false-discovery rate corrected), a region that receives dopaminergic input predominantly from the substantia nigra. |
2010-12-08 |
2023-08-12 |
human |
| Fabrizio Stocchi, Stefano Marcon. Factors associated with motor fluctuations and dyskinesia in Parkinson Disease: potential role of a new melevodopa plus carbidopa formulation (Sirio). Clinical neuropharmacology. vol 33. issue 4. 2010-12-02. PMID:20414107. |
parkinson disease is a progressive movement disorder caused by loss of dopaminergic neurons in the substantia nigra. |
2010-12-02 |
2023-08-12 |
Not clear |
| Li Qian, Patrick M Flood, Jau-Shyong Hon. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20571837. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2010-11-30 |
2023-08-12 |
Not clear |
| Momo Tani, Hideki Hayakawa, Toru Yasuda, Tomoko Nihira, Nobutaka Hattori, Yoshikuni Mizuno, Hideki Mochizuk. Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone. Journal of neurochemistry. vol 115. issue 4. 2010-11-23. PMID:20374434. |
α-synuclein (α-syn) is a key protein in parkinson's disease (pd), and its abnormal accumulation is implicated only not in the loss of dopaminergic neurons in the substantia nigra but also in impairment of olfactory bulb (ob) in pd. |
2010-11-23 |
2023-08-12 |
mouse |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Ayse Ulusoy, Fabia Febbraro, Poul H Jensen, Deniz Kirik, Marina Romero-Ramo. Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. The European journal of neuroscience. vol 32. issue 3. 2010-11-22. PMID:20704592. |
when these two forms of alphasyn were co-expressed at these pre-determined levels, it resulted in a more aggressive pathology in fiber terminals as well as dopaminergic cell loss in the substantia nigra. |
2010-11-22 |
2023-08-12 |
rat |
| L Gao, F J Díaz-Corrales, F Carrillo, J Díaz-Martín, M T Caceres-Redondo, M Carballo, A Palomino, J López-Barneo, P Mi. Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson's disease. Acta neurologica Scandinavica. vol 122. issue 1. 2010-11-16. PMID:20085561. |
parkinson's disease (pd) is characterized by the dopaminergic neuronal death in substantia nigra, and genetic factors appear to be involved in the pathophysiology of this disease. |
2010-11-16 |
2023-08-12 |
Not clear |
| L Gao, F J Díaz-Corrales, F Carrillo, J Díaz-Martín, M T Caceres-Redondo, M Carballo, A Palomino, J López-Barneo, P Mi. Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson's disease. Acta neurologica Scandinavica. vol 122. issue 1. 2010-11-16. PMID:20085561. |
brain-derived neurotrophic factor (bdnf) is widely expressed in the central nervous system and is necessary for the survival of dopaminergic neurons in substantia nigra. |
2010-11-16 |
2023-08-12 |
Not clear |
| Rita Valenzuela, Pedro Barroso-Chinea, Begoña Villar-Cheda, Belen Joglar, Ana Muñoz, Jose L Lanciego, Jose L Labandeira-Garci. Location of prorenin receptors in primate substantia nigra: effects on dopaminergic cell death. Journal of neuropathology and experimental neurology. vol 69. issue 11. 2010-11-12. PMID:20940627. |
location of prorenin receptors in primate substantia nigra: effects on dopaminergic cell death. |
2010-11-12 |
2023-08-12 |
rat |
| Antonio Romero-Ruiz, Rebeca Mejías, Juan Díaz-Martín, José López-Barneo, Lin Ga. Mesencephalic and striatal protein profiles in mice over-expressing glucose-6-phosphate dehydrogenase in dopaminergic neurons. Journal of proteomics. vol 73. issue 9. 2010-11-10. PMID:20594931. |
oxidative damage in dopaminergic neurons of the substantia nigra plays an important role in the pathogenesis of parkinson's disease. |
2010-11-10 |
2023-08-12 |
mouse |
| Antonio Romero-Ruiz, Rebeca Mejías, Juan Díaz-Martín, José López-Barneo, Lin Ga. Mesencephalic and striatal protein profiles in mice over-expressing glucose-6-phosphate dehydrogenase in dopaminergic neurons. Journal of proteomics. vol 73. issue 9. 2010-11-10. PMID:20594931. |
we have previously shown that over-expression of g6pd in dopaminergic neurons of the substantia nigra results in resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinsonism in mice. |
2010-11-10 |
2023-08-12 |
mouse |
| Amélie C Lanoue, Alexandra Dumitriu, Richard H Myers, Jean-Jacques Soghomonia. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Experimental neurology. vol 226. issue 1. 2010-10-28. PMID:20832408. |
neuropathology of pd primarily involves loss of dopaminergic neurons in the substantia nigra, pars compacta, although more widespread pathology from the brainstem to the cerebral cortex occurs at different stages of the disease. |
2010-10-28 |
2023-08-12 |
Not clear |
| Ruth F Villarán, Ana M Espinosa-Oliva, Manuel Sarmiento, Rocío M De Pablos, Sandro Argüelles, María J Delgado-Cortés, Verónica Sobrino, Nico Van Rooijen, José L Venero, Antonio J Herrera, Josefina Cano, Alberto Machad. Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20584104. |
to ascertain this possibility, a model of dopaminergic neurodegeneration based on the injection of the inflammatory agent lipopolysaccharide (lps) within the substantia nigra was assayed in rats with ulcerative colitis (uc) induced by the ingestion of dextran sulphate sodium. |
2010-10-19 |
2023-08-12 |
rat |
| Ruth F Villarán, Ana M Espinosa-Oliva, Manuel Sarmiento, Rocío M De Pablos, Sandro Argüelles, María J Delgado-Cortés, Verónica Sobrino, Nico Van Rooijen, José L Venero, Antonio J Herrera, Josefina Cano, Alberto Machad. Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20584104. |
we found an increase in the levels of inflammatory markers from serum (tumor necrosis factor-α, il-1β, il-6 and the acute phase protein c-reactive protein) and substantia nigra (tumor necrosis factor-α, il-1β, il-6, inducible nitric oxide synthase, intercellular adhesion molecule-1, microglial and astroglial populations) of rats with uc, as well as an alteration of the blood-brain barrier permeability and the loss of dopaminergic neurons. |
2010-10-19 |
2023-08-12 |
rat |
| Sarika Singh, Sachin Kumar, Madhu Dikshi. Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide. Redox report : communications in free radical research. vol 15. issue 3. 2010-10-08. PMID:20594414. |
the primary pathology in parkinson's disease patients is significant loss of dopaminergic neurons in the substantia nigra through multiple mechanisms. |
2010-10-08 |
2023-08-12 |
rat |
| Adarsh M Kumar, J B Fernandez, Elyse J Singer, Deborah Commins, Drenna Waldrop-Valverde, Raymond L Ownby, Mahendra Kuma. Human immunodeficiency virus type 1 in the central nervous system leads to decreased dopamine in different regions of postmortem human brains. Journal of neurovirology. vol 15. issue 3. 2010-10-06. PMID:19499455. |
it is hypothesized that hiv-1-mediated neuropathogenesis involves degeneration of dopaminergic neurons in the substantia nigra and the loss of dopaminergic terminals in the bg, leading to deficits in the central dopaminergic activity, resulting in progressive impairment of neurocognitive and motor functions. |
2010-10-06 |
2023-08-12 |
human |
| Livia Pasquali, Stefano Ruggieri, Luigi Murri, Antonio Paparelli, Francesco Forna. Does autophagy worsen or improve the survival of dopaminergic neurons? Parkinsonism & related disorders. vol 15 Suppl 4. 2010-09-30. PMID:20123552. |
with respect to dopaminergic neurons, there is evidence that autophagy occurs during damage to substantia nigra neurons such as in parkinson's disease. |
2010-09-30 |
2023-08-12 |
Not clear |
| Xiao-Kun Liu, Gang Wang, Sheng-Di Che. Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease? Neuroscience bulletin. vol 26. issue 3. 2010-09-29. PMID:20502506. |
the present review was mainly focused on the recent findings on the contradictory roles of sk channels in modulating dopaminergic neurons in substantia nigra and in the pathogenesis of parkinson's disease (pd). |
2010-09-29 |
2023-08-12 |
Not clear |