| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae-Sun Choi, Mi Suk Lee, Joo-Won Jeon. Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model. Biochemical and biophysical research communications. vol 394. issue 3. 2010-05-04. PMID:20307492. |
the selective death of dopaminergic neurons in substantia nigra was prevented by ep in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse models. |
2010-05-04 |
2023-08-12 |
mouse |
| A V Droblenkov, N P Karelina, P D Shabano. [Diagnostics of alcoholic intoxication from micromorphological changes in neurons and neuroglia of the mesoaccumbocingular dopaminergic system in experiment]. Sudebno-meditsinskaia ekspertiza. vol 52. issue 6. 2010-05-03. PMID:20088135. |
alcohol affects the mesoaccumbocingular system (ventral tegumental region, substantia nigra--nucleus accumbence--anterior cingular cortex) and other parts of the mesocorticolimbic dopaminergic system by altering patterns of dopamine release. |
2010-05-03 |
2023-08-12 |
Not clear |
| Chong Shi, Yu-xin Zhang, Zuo-feng Zhan. [Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 1. 2010-04-29. PMID:19218114. |
to investigate the effect of phosphorylated-erk1/2 (p-erk1/2) on inducible nitric oxide synthase (inos) expression in the substantia nigra (sn) of a mouse model of parkinson's disease (pd), and explore the possible mechanism of dopaminergic (da) neuron loss in the sn of the midbrain in pd. |
2010-04-29 |
2023-08-12 |
mouse |
| Su Ling Leong, Roberto Cappai, Kevin Jeffrey Barnham, Chi Le Lan Pha. Modulation of alpha-synuclein aggregation by dopamine: a review. Neurochemical research. vol 34. issue 10. 2010-04-23. PMID:19444607. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that is characterized by (1) the selective loss of dopaminergic neurons in the substantia nigra and (2) the deposition of misfolded alpha-synuclein (alpha-syn) as amyloid fibrils in the intracellular lewy bodies in various region of the brain. |
2010-04-23 |
2023-08-12 |
Not clear |
| Jesús M López, Laura Domínguez, Nerea Moreno, Ruth Morona, Alberto Joven, Agustín Gonzále. Distribution of orexin/hypocretin immunoreactivity in the brain of the lungfishes Protopterus dolloi and Neoceratodus forsteri. Brain, behavior and evolution. vol 74. issue 4. 2010-04-22. PMID:20090314. |
orexinergic innervation was found in close contact with dopaminergic, noradrenergic and serotoninergic cell groups, homologous to the substantia nigra in the midbrain tegmentum, the locus coeruleus, the nucleus of the solitary tract and the raphe nuclei. |
2010-04-22 |
2023-08-12 |
Not clear |
| Shorafidinkhuja Dadakhujaev, Hae Sook Noh, Eun Joo Jung, Joon Yung Cha, Seon Mi Baek, Ji Hye Ha, Deok Ryong Ki. Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells. Neuroscience letters. vol 472. issue 1. 2010-04-22. PMID:20117172. |
loss of dopaminergic cells induced by alpha-synuclein accumulation in substantia nigra causes the development of parkinson's disease (pd). |
2010-04-22 |
2023-08-12 |
Not clear |
| Maryka Quik, Carla Campos, Neeraja Parameswaran, J William Langston, J Michael McIntosh, Michael Yeluashvil. Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19685015. |
the present experiments were done to determine whether nicotine treatment also led to changes in the substantia nigra, the region containing dopaminergic cell bodies. |
2010-04-21 |
2023-08-12 |
monkey |
| George H Sac. Mitochondrial matters in Parkinson disease: introduction. Journal of bioenergetics and biomembranes. vol 41. issue 6. 2010-04-21. PMID:20039109. |
the central nervous system changes involve dopaminergic neurons in the basal ganglia and substantia nigra. |
2010-04-21 |
2023-08-12 |
Not clear |
| B Han, H Zha. Effects of hydroxysafflor yellow A in the attenuation of MPTP neurotoxicity in mice. Neurochemical research. vol 35. issue 1. 2010-04-19. PMID:19680807. |
the mptp-treated mice exhibited the loss of tyrosine hydroxylase-containing dopaminergic neurons in substantia nigra. |
2010-04-19 |
2023-08-12 |
mouse |
| Shilpa Vashist, Mimi Cushman, James Shorte. Applying Hsp104 to protein-misfolding disorders. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 88. issue 1. 2010-04-16. PMID:20130674. |
importantly, hsp104 antagonizes the degeneration of dopaminergic neurons induced by alpha-synuclein misfolding in the rat substantia nigra. |
2010-04-16 |
2023-08-12 |
rat |
| Sandro Argüelles, Antonio J Herrera, Eloisa Carreño-Müller, Rocío M de Pablos, Ruth F Villarán, Ana M Espinosa-Oliva, Alberto Machado, Josefina Can. Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme. Neurotoxicology. vol 31. issue 1. 2010-04-13. PMID:19969022. |
degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme. |
2010-04-13 |
2023-08-12 |
rat |
| Wolfgang H Jos. Gastrointestinal dysfunction in Parkinson's Disease. Journal of the neurological sciences. vol 289. issue 1-2. 2010-04-05. PMID:19717168. |
these degenerations are likely to develop prior to the degeneration of dopaminergic neurons of the substantia nigra. |
2010-04-05 |
2023-08-12 |
Not clear |
| Fei Xu, Jian-hong Luo, Jing-hua Ji. [Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 37. issue 5. 2010-04-02. PMID:18925724. |
parkinson's disease (pd) is characterized pathologically by the relatively preferential loss of dopaminergic neurons with resultant depletion of striatal dopamine and presence of lewy bodies mainly composed by alpha-synuclein (alpha-syn) in the remaining neurons in the substantia nigra. |
2010-04-02 |
2023-08-12 |
Not clear |
| Nikhil Adi, Deborah C Mash, Yousuf Ali, Carlos Singer, Lina Shehadeh, Spyridon Papapetropoulo. Melatonin MT1 and MT2 receptor expression in Parkinson's disease. Medical science monitor : international medical journal of experimental and clinical research. vol 16. issue 2. 2010-04-01. PMID:20110911. |
selective, regional dopaminergic neuronal degeneration in the substantia nigra and other cns areas including the amygdala are observed in all patients. |
2010-04-01 |
2023-08-12 |
Not clear |
| Dennis W Dickson, Hiroshige Fujishiro, Carolyn Orr, Anthony DelleDonne, Keith A Josephs, Roberta Frigerio, Melinda Burnett, Joseph E Parisi, Kevin J Klos, J Eric Ahlsko. Neuropathology of non-motor features of Parkinson disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082965. |
extrapyramidal signs in pd are tightly linked to striatonigral dopaminergic denervation associated with neuronal loss and lewy bodies in the residual neurons of the substantia nigra. |
2010-03-31 |
2023-08-12 |
Not clear |
| Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdi. Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082978. |
large-scale transcriptomics analysis of gene expression profile of sporadic parkinson's disease (pd) substantia nigra (sn) has identified a number of differentially expressed genes participating in the neurotoxic cascade of da neurons death, in particular those related to handling of proteins, dopaminergic transmission and iron metabolism. |
2010-03-31 |
2023-08-12 |
human |
| Roger A Barke. Parkinson's disease and growth factors - are they the answer? Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082986. |
the core loss of dopaminergic neurons in the substantia nigra in parkinson's disease (pd) coupled to the therapeutic benefits of dopaminergic therapies in patients, simplifies the treatment strategy for this disease. |
2010-03-31 |
2023-08-12 |
Not clear |
| E C Hirsc. Iron transport in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082992. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd) but the neurodegenerative mechanisms have not been completely elucidated. |
2010-03-31 |
2023-08-12 |
mouse |
| June-Hee Park, Grigori Enikolopo. Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079351. |
the dentate gyrus (dg), a site of continuous production of new neurons in the adult hippocampus, receives dopaminergic inputs from the neurons of the substantia nigra (sn). |
2010-03-26 |
2023-08-12 |
mouse |
| Zhentao Zhang, Xuebing Cao, Nian Xiong, Hongcai Wang, Jinsha Huang, Shenggang Sun, Zhihou Liang, Tao Wan. DNA polymerase-beta is required for 1-methyl-4-phenylpyridinium-induced apoptotic death in neurons. Apoptosis : an international journal on programmed cell death. vol 15. issue 1. 2010-03-23. PMID:19937276. |
the biochemical pathways that mediate the degeneration of dopaminergic neurons in the substantia nigra of patients with parkinson's disease are largely unknown. |
2010-03-23 |
2023-08-12 |
Not clear |