| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lokesh Agrawal, Jean-Pierre Louboutin, Elena Marusich, Beverley A S Reyes, Elisabeth J Van Bockstaele, David S Straye. Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates. Brain research. vol 1306. 2010-02-03. PMID:19815008. |
we examined the role of reactive oxygen species (ros) in loss of dopaminergic neurons (dns) from the substantia nigra (sn) in neuroaids. |
2010-02-03 |
2023-08-12 |
rat |
| Zhiyin Xun, Thomas C Kaufman, David E Clemme. Stable isotope labeling and label-free proteomics of Drosophila parkin null mutants. Journal of proteome research. vol 8. issue 10. 2010-02-01. PMID:19705877. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra and formation of intracytoplasmic lewy bodies (lbs). |
2010-02-01 |
2023-08-12 |
drosophila_melanogaster |
| Rachel Hammond, Sandra Blaess, Asa Abeliovic. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PloS one. vol 4. issue 9. 2010-02-01. PMID:19774071. |
midbrain dopaminergic axons project from the substantia nigra (sn) and the ventral tegmental area (vta) to rostral target tissues, including the striatum, pallidum, and hypothalamus. |
2010-02-01 |
2023-08-12 |
mouse |
| Jiangang Long, Hongxiang Gao, Lijuan Sun, Jiankang Liu, Xi Zhao-Wilso. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation research. vol 12. issue 5. 2010-02-01. PMID:19929256. |
this model for parkinson disease recapitulates essential features of the disorder, including loss of dopaminergic neurons in the substantia nigra and a locomotor dysfunction that is displayed by a progressive loss of climbing ability measured using a geotaxis assay. |
2010-02-01 |
2023-08-12 |
human |
| Raphael Béné, Sonja Antić, Mislav Budisić, Marijana Lisak, Zlatko Trkanjec, Vida Demarin, Slava Podobnik-Sarkanj. Parkinson's disease. Acta clinica Croatica. vol 48. issue 3. 2010-01-29. PMID:20055267. |
parkinson's disease is one of the most common neurodegenerative diseases caused by degeneration of dopaminergic neurons in substantia nigra. |
2010-01-29 |
2023-08-12 |
Not clear |
| J Eric Ahlsko. Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 10. 2010-01-27. PMID:19815446. |
the dopaminergic substantia nigra is uniquely vulnerable to mitochondrial challenges, which might at least be partially attributable to large energy demands consequent to thin, unmyelinated axons with enormous terminal fields. |
2010-01-27 |
2023-08-12 |
Not clear |
| Lu Zhang, Li Li, Heather W Leavesley, Xun Zhang, Joseph L Borowitz, Gary E Iso. Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19841471. |
cyanide is a potent neurotoxicant that can produce dopaminergic neuronal death in the substantia nigra and is associated with a parkinson-like syndrome. |
2010-01-26 |
2023-08-12 |
mouse |
| Carles Gaig, Eduardo Tolos. When does Parkinson's disease begin? Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877243. |
pathological and neuroimaging studies have shown that in parkinson's disease (pd) there is a "subclinical" or "premotor" period during which dopaminergic neurons in the substantia nigra (sn) degenerate but typical motor symptoms have not yet developed. |
2010-01-26 |
2023-08-12 |
Not clear |
| Irmgard Paris, Jorge Lozano, Carolina Perez-Pastene, Patricia Muñoz, Juan Segura-Aguila. Molecular and neurochemical mechanisms in PD pathogenesis. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19526278. |
oxidation of dopamine to aminochrome seems to be a normal process leading to aminochrome polymerization to form neuromelanin, since normal individuals have this pigment in their dopaminergic neurons in the substantia nigra. |
2010-01-25 |
2023-08-12 |
Not clear |
| Mika Shimoji, Fernando Pagan, Edward B Healton, Italo Mocchett. CXCR4 and CXCL12 expression is increased in the nigro-striatal system of Parkinson's disease. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19551455. |
in the human substantia nigra (sn), cxcr4 immunoreactivity was high in dopaminergic neurons. |
2010-01-25 |
2023-08-12 |
mouse |
| Uzma Saeed, Smitha Karunakaran, Durga Praveen Meka, Ratnacaram Chandrahaas Koumar, Sujanitha Ramakrishnan, Shanker Datt Joshi, Prakash Nidadavolu, Vijayalakshmi Ravindranat. Redox activated MAP kinase death signaling cascade initiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection. Neurotoxicity research. vol 16. issue 2. 2010-01-22. PMID:19526288. |
administration of mptp (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) to female mice does not lead to mitochondrial complex i inhibition as seen in males and the progressive dopaminergic cell loss in substantia nigra (snpc) is significantly attenuated. |
2010-01-22 |
2023-08-12 |
mouse |
| Yuri Cho, Hyo Jin Son, Eun-Mee Kim, Ji Hyun Choi, Sung Tae Kim, In Jung Ji, Dong Hee Choi, Tong H Joh, Yoon Seong Kim, Onyou Hwan. Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19582534. |
in parkinson disease (pd), the dopaminergic (daergic) neurons in the substantia nigra undergo degeneration. |
2010-01-22 |
2023-08-12 |
Not clear |
| Hideaki Matsui, Yoshihito Taniguchi, Haruhisa Inoue, Kengo Uemura, Shunichi Takeda, Ryosuke Takahash. A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish. Neuroscience research. vol 65. issue 3. 2010-01-18. PMID:19665499. |
parkinson's disease (pd) is the second most common neurodegenerative disease associated with the degeneration of dopaminergic neurons in the substantia nigra. |
2010-01-18 |
2023-08-12 |
human |
| David Weise, Reinhard Lorenz, Mira Schliesser, Andreas Schirbel, Karlheinz Reiners, Joseph Classe. Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 11. 2010-01-15. PMID:19514075. |
substantia nigra echogenicity: a structural correlate of functional impairment of the dopaminergic striatal projection in parkinson's disease. |
2010-01-15 |
2023-08-12 |
Not clear |
| Yongsheng Wang, Yuxin Zhang, Zifeng Wei, Hui Li, Hongxia Zhou, Zhiyong Zhang, Zuofeng Zhan. JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease. Journal of the neurological sciences. vol 285. issue 1-2. 2010-01-14. PMID:19604516. |
we found that inhibiting jnk with sp600125, a special inhibitor of jnk, reduced the levels of c-jun phosphorylation, blocked p-c-jun translocation from the cytoplasm to the nucleus in dopaminergic neurons of substantia nigra, mitigated the loss of dopaminergic neurons, and improved motor function in mptp-induced pd in c57bl/6n mice. |
2010-01-14 |
2023-08-12 |
mouse |
| Makoto Naoi, Hong Yi, Wakako Maruyama, Keiko Inaba, Masayo Shamoto-Nagai, Yukihiro Akao, Manfred Gerlach, Peter Riedere. Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells. Neuroscience letters. vol 465. issue 2. 2010-01-14. PMID:19737600. |
neuromelanin (nm)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in parkinson's disease (pd), suggesting the involvement of nm in the pathogenesis. |
2010-01-14 |
2023-08-12 |
human |
| H Yao, F Peng, Y Fan, X Zhu, G Hu, S J Buc. TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway. Cell death and differentiation. vol 16. issue 12. 2010-01-13. PMID:19680266. |
administration of pdgf was able to rescue the dopaminergic neurons in the substantia nigra from tat-induced neurotoxicity. |
2010-01-13 |
2023-08-12 |
mouse |
| Jun Jia, ZuoLi Sun, Bo Li, YanLi Pan, HaoMin Wang, Xuan Wang, Fen Yu, LiMin Liu, LiJuan Zhang, XiaoMin Wan. Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19549545. |
tyrosine hydroxylase immunohistochemical staining revealed that ea at 100 hz protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn). |
2010-01-12 |
2023-08-12 |
rat |
| Shoko Shibata, Masahide Maeda, Kyoji Furuta, Masaaki Suzuki, Kentaro Oh-Hashi, Kazutoshi Kiuchi, Yoko Hirat. Neuroprotective effects of (arylthio)cyclopentenone derivatives on manganese-induced apoptosis in PC12 cells. Brain research. vol 1294. 2010-01-12. PMID:19643096. |
parkinson's disease is characterized by degeneration of dopaminergic neurones in the substantia nigra. |
2010-01-12 |
2023-08-12 |
Not clear |
| Agnès Nadjar, Olivier Berton, Shuhong Guo, Patricia Leneuve, Sandra Dovero, Elsa Diguet, François Tison, Baolu Zhao, Martin Holzenberger, Erwan Bezar. IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP. Neurobiology of aging. vol 30. issue 12. 2010-01-11. PMID:18394756. |
interestingly, mptp induced more severe lesions of dopaminergic neurons of the substantia nigra, in igf-1r(+/-) mice than in wild-type animals. |
2010-01-11 |
2023-08-12 |
mouse |