| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vladimir N Uversky, David Elieze. Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein. Current protein & peptide science. vol 10. issue 5. 2010-01-11. PMID:19538146. |
parkinson's disease (pd) is a slowly progressive movement disorder that results from the loss of dopaminergic neurons in the substantia nigra, a small area of cells in the mid-brain. |
2010-01-11 |
2023-08-12 |
Not clear |
| Yin Xia Chao, Bei Ping He, Samuel Sam Wah Ta. Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease. Journal of neuroimmunology. vol 216. issue 1-2. 2010-01-11. PMID:19819031. |
mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against mptp toxicity in the substantia nigra in a model of parkinson's disease. |
2010-01-11 |
2023-08-12 |
mouse |
| Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease. Brain research. vol 1297. 2010-01-08. PMID:19699718. |
while ferritin elevation within dopaminergic (da) neurons of the substantia nigra (sn) is protective against neurodegeneration elicited by two toxin models of parkinson's disease (pd), mptp and paraquat, in young animals, its prolonged elevation results in a selective age-related neurodegeneration. |
2010-01-08 |
2023-08-12 |
mouse |
| Oscar Arias-Carrión, Ti-Fei Yua. Autologous neural stem cell transplantation: a new treatment option for Parkinson's disease? Medical hypotheses. vol 73. issue 5. 2010-01-04. PMID:19467573. |
the clinical motor dysfunction in parkinson s disease (pd) is primarily linked to the depletion of dopamine in the striatum consecutive to the loss of the large dopaminergic neurons in the substantia nigra. |
2010-01-04 |
2023-08-12 |
human |
| James R Connor, Xin-Sheng Wang, Richard P Allen, John L Beard, Jason A Wiesinger, Barbara T Felt, Christopher J Earle. Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain : a journal of neurology. vol 132. issue Pt 9. 2009-12-14. PMID:19467991. |
altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. |
2009-12-14 |
2023-08-12 |
Not clear |
| Henry Lütcke, Holger Gevensleben, Björn Albrecht, Jens Frah. Brain networks involved in early versus late response anticipation and their relation to conflict processing. Journal of cognitive neuroscience. vol 21. issue 11. 2009-12-11. PMID:19016602. |
additionally, late anticipation was associated with increased activity in midbrain dopaminergic nuclei, very likely corresponding to the substantia nigra. |
2009-12-11 |
2023-08-12 |
human |
| Pratibha Mehta Luthra, Amresh Prakash, Sandeep Kumar Barodia, Rita Kumari, Chandra Bhushan Mishra, J B Senthil Kuma. In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A 2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice. Neuroscience letters. vol 463. issue 3. 2009-12-11. PMID:19654038. |
loss of dopaminergic nigrostriatal neurons in the substantia nigra leads to parkinson's disease (pd). |
2009-12-11 |
2023-08-12 |
mouse |
| Andrea Tarozzi, Fabiana Morroni, Adriana Merlicco, Silvana Hrelia, Cristina Angeloni, Giorgio Cantelli-Forti, Patrizia Hreli. Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. Journal of neurochemistry. vol 111. issue 5. 2009-12-11. PMID:19780897. |
the total gsh depletion observed in the substantia nigra (sn) appears to be responsible for subsequent oxidative stress (os), mitochondrial dysfunction, and dopaminergic cell loss in patients with parkinson's disease. |
2009-12-11 |
2023-08-12 |
Not clear |
| Marta Biagioli, Milena Pinto, Daniela Cesselli, Marta Zaninello, Dejan Lazarevic, Paola Roncaglia, Roberto Simone, Christina Vlachouli, Charles Plessy, Nicolas Bertin, Antonio Beltrami, Kazuto Kobayashi, Vittorio Gallo, Claudio Santoro, Isidro Ferrer, Stefano Rivella, Carlo Alberto Beltrami, Piero Carninci, Elio Raviola, Stefano Gustincic. Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 36. 2009-12-07. PMID:19717439. |
the mesencephalic dopaminergic (mda) cell system is composed of two major groups of projecting cells in the substantia nigra (sn) (a9 neurons) and the ventral tegmental area (vta) (a10 cells). |
2009-12-07 |
2023-08-12 |
mouse |
| Afsaneh Gaillard, Mickael Decressac, Isabelle Frappé, Pierre Olivier Fernagut, Laetitia Prestoz, Stephan Besnard, Mohamed Jabe. Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19616502. |
the main transplantation strategy in parkinson's disease has been to place dopaminergic grafts not in their ontogenic site, the substantia nigra, but in their target area, the striatum with contrasting results. |
2009-12-03 |
2023-08-12 |
mouse |
| Afsaneh Gaillard, Mickael Decressac, Isabelle Frappé, Pierre Olivier Fernagut, Laetitia Prestoz, Stephan Besnard, Mohamed Jabe. Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19616502. |
most of the dopaminergic cells within the transplant expressed the substantia nigra marker girk2 while a lesser proportion expressed the ventral tegmental area marker calbindin. |
2009-12-03 |
2023-08-12 |
mouse |
| Su Ling Leong, Chi L L Pham, Denise Galatis, Michelle T Fodero-Tavoletti, Keyla Perez, Andrew F Hill, Colin L Masters, Feda E Ali, Kevin J Barnham, Roberto Cappa. Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation. Free radical biology & medicine. vol 46. issue 10. 2009-11-13. PMID:19248830. |
pd involves the loss of dopaminergic neurons in the substantia nigra and the subsequent depletion of dopamine (da) in the striatum. |
2009-11-13 |
2023-08-12 |
Not clear |
| K Mizoguchi, H Shoji, Y Tanaka, W Maruyama, T Tabir. Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19463906. |
in addition, aged rats showed reduced dopaminergic transmission in the prelimbic cortical region of the pfc, concomitant with attenuated tyrosine hydroxylase activity in the pfc, but not in the ventral tegmental area and substantia nigra, which was evaluated immunohistochemically and enzymatically. |
2009-11-10 |
2023-08-12 |
human |
| A Guyon, D Skrzydelski, I De Giry, C Rovère, G Conductier, J M Trocello, V Daugé, P Kitabgi, W Rostène, J L Nahon, S Mélik Parsadaniant. Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19477239. |
using patch-clamp recordings of dopaminergic neurons in slices of the rat substantia nigra, we observed that a prolonged exposure (>8 min) to 10 nm ccl2 significantly increases the membrane resistance of dopaminergic neurons by closure of background channels mainly selective to potassium ions. |
2009-11-10 |
2023-08-12 |
rat |
| Zhihua Xie, Gregory M Mille. Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochemical pharmacology. vol 78. issue 9. 2009-11-10. PMID:19482011. |
taar1 is expressed and widely distributed in brain monoaminergic systems and co-localized with the dopamine transporter in a subset of dopaminergic neurons in rhesus monkey and mouse brain substantia nigra. |
2009-11-10 |
2023-08-12 |
mouse |
| Tohru Kitada, Youren Tong, Clement A Gautier, Jie She. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19694908. |
surprisingly, we found that triple knockout mice lacking parkin, dj-1, and pink1 have normal morphology and numbers of dopaminergic and noradrenergic neurons in the substantia nigra and locus coeruleus, respectively, at the ages of 3, 16, and 24 months. |
2009-11-06 |
2023-08-12 |
mouse |
| Jin Young Shin, Hyun-Jung Park, Young Hwan Ahn, Phil Hyu Le. Neuroprotective effect of L-dopa on dopaminergic neurons is comparable to pramipexol in MPTP-treated animal model of Parkinson's disease: a direct comparison study. Journal of neurochemistry. vol 111. issue 4. 2009-11-06. PMID:19765187. |
parkinson's disease (pd) is a chronic neurodegenerative disease characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra. |
2009-11-06 |
2023-08-12 |
mouse |
| Geou-Yarh Liou, Kathleen A Gall. New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2. The Biochemical journal. vol 424. issue 1. 2009-11-03. PMID:19839940. |
now it is of utmost importance to establish whether lrrk2 is a bona fide kinase in vitro and in vivo and to understand how mutations of lrrk2 lead to the specific loss of dopaminergic neurons in the substantia nigra to cause pd. |
2009-11-03 |
2023-08-12 |
Not clear |
| Baohua Cheng, Xinxin Yang, Liangxiang An, Bo Gao, Xia Liu, Shuwei Li. Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease. Brain research. vol 1286. 2009-10-20. PMID:19559687. |
in our present work, we examined whether kd protected dopaminergic neurons of substantia nigra (sn) against 6-hydroxydopamine (6-ohda) neurotoxicity in a rat model of parkinson's disease (pd) using nissl staining and tyrosine hydroxylase (th) immunohistochemistry. |
2009-10-20 |
2023-08-12 |
rat |
| Nina Rawal, Olga Corti, Paola Sacchetti, Hector Ardilla-Osorio, Bita Sehat, Alexis Brice, Ernest Arena. Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochemical and biophysical research communications. vol 388. issue 3. 2009-10-13. PMID:19591802. |
parkinson's disease (pd) is caused by degeneration of the dopaminergic (da) neurons of the substantia nigra but the molecular mechanisms underlying the degenerative process remain elusive. |
2009-10-13 |
2023-08-12 |
Not clear |