| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margaret A Cooper, Kazuto Kobayashi, Renping Zho. Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways. Developmental neurobiology. vol 69. issue 1. 2009-04-15. PMID:19003794. |
dopaminergic neurons from the substantia nigra and the ventral tegmental area of the midbrain project to the caudate/putamen and nucleus accumbens, respectively, establishing the mesostriatal and the mesolimbic pathways. |
2009-04-15 |
2023-08-12 |
mouse |
| Andreas Bender, Rachel-Maria Schwarzkopf, Anja McMillan, Kim J Krishnan, Gabriele Rieder, Manuela Neumann, Matthias Elstner, Douglas M Turnbull, Thomas Klopstoc. Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions. Journal of neurology. vol 255. issue 8. 2009-04-14. PMID:18604467. |
by employing quantitative single cell techniques, we were recently able to show significantly high levels of mtdna deletions in dopaminergic substantia nigra (sn) neurons from pd patients and age-matched controls. |
2009-04-14 |
2023-08-12 |
human |
| Jeannette Henning, Ulf Strauss, Andreas Wree, Jan Gimsa, Arndt Rolfs, Reiner Benecke, Ulrike Gims. Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease. Neuroscience research. vol 62. issue 4. 2009-04-14. PMID:18824050. |
in rat models of parkinson's disease, injections of 6-hydroxydopamine (6-ohda) into different areas of the basal ganglia result in dopaminergic neurodegeneration in the substantia nigra. |
2009-04-14 |
2023-08-12 |
rat |
| Chee Yeun Chung, James B Koprich, Hasan Siddiqi, Ole Isacso. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295143. |
recombinant adeno-associated virus 2-mediated delivery of mutant (a53t) human alpha-synuclein into the substantia nigra (sn) under a neuron-specific synapsin promoter resulted in protracted neurodegeneration with significant dopaminergic (da) neuron loss by 17 weeks. |
2009-04-13 |
2023-08-12 |
human |
| Julie A Przybyla, Juan P Cueva, Benjamin R Chemel, K Joseph Hsu, David J Riese, John D McCorvy, Julia A Chester, David E Nichols, Val J Watt. Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 2. 2009-04-10. PMID:19028082. |
parkinson's disease is a neurodegenerative condition involving the death of dopaminergic neurons in the substantia nigra. |
2009-04-10 |
2023-08-12 |
human |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. |
2009-04-10 |
2023-08-12 |
rat |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) are collectively implicated in motor- and reward-related behaviors. |
2009-04-10 |
2023-08-12 |
rat |
| Ana Saavedra, Graça Baltazar, Emília P Duart. Driving GDNF expression: the green and the red traffic lights. Progress in neurobiology. vol 86. issue 3. 2009-04-09. PMID:18824211. |
in animal models of pd, gdnf delivery to the striatum or the substantia nigra protects dopaminergic neurons against subsequent toxin-induced injury and rescues previously damaged neurons, promoting recovery of the motor function. |
2009-04-09 |
2023-08-12 |
Not clear |
| Gabor G Kovacs, Ivan J Milenkovic, Matthias Preusser, Herbert Budk. Nigral burden of alpha-synuclein correlates with striatal dopamine deficit. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 11. 2009-04-08. PMID:18649394. |
it is unclear whether the accumulation of pathological alpha-synuclein in the substantia nigra in pd correlates with the dopaminergic deficit in the striatal target. |
2009-04-08 |
2023-08-12 |
Not clear |
| Antje Krenz, Björn H Falkenburger, Ellen Gerhardt, Anja Drinkut, Jörg B Schul. Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors. Journal of neurochemistry. vol 108. issue 1. 2009-04-08. PMID:19094062. |
both wt synphilin-1 and r621c synphilin-1 led to the formation of thioflavine-s positive inclusions in c57bl/6 mice and degeneration of dopaminergic neurons in the substantia nigra. |
2009-04-08 |
2023-08-12 |
mouse |
| Wakoto Matsuda, Takahiro Furuta, Kouichi C Nakamura, Hiroyuki Hioki, Fumino Fujiyama, Ryohachi Arai, Takeshi Kanek. Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 2. 2009-04-08. PMID:19144844. |
our findings demonstrate that individual dopaminergic neurons of the substantia nigra can broadcast a dopamine signal and exert strong influence over a large number of striatal neurons. |
2009-04-08 |
2023-08-12 |
rat |
| Qian Wang, Huan Zheng, Zuo-feng Zhang, Yu-xin Zhan. [Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 28. issue 9. 2009-04-06. PMID:18819875. |
to investigate the role of p38 signaling pathway in modulating the expression of cyclooxygenase-2 (cox-2) in the substantia nigra (sn) of mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced parkinson disease (pd), and explore the possible mechanism of the dopaminergic (da) neuron death in pd and the effects of ginsenoside rg1 on the p38 signaling pathway and da neurons. |
2009-04-06 |
2023-08-12 |
mouse |
| Glenda Hallida. Clinicopathological aspects of motor parkinsonism. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267237. |
in all three disorders the main regulators of the caudate nucleus and putamen (dopaminergic substantia nigra and glutaminergic caudal intralaminar nuclei), as well as the cortical projection from the presupplementary motor area, degenerate. |
2009-04-01 |
2023-08-12 |
Not clear |
| Matthew J Chiocco, Brandon K Harvey, Yun Wang, Barry J Hoffe. Neurotrophic factors for the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267258. |
pathologically, there is a loss of the dopaminergic neurons in the substantia nigra that project to the striatum. |
2009-04-01 |
2023-08-12 |
Not clear |
| Lynn Bedford, Simon Paine, Nooshin Rezvani, Maureen Mee, James Lowe, R John Maye. The UPS and autophagy in chronic neurodegenerative disease: six of one and half a dozen of the other--or not? Autophagy. vol 5. issue 2. 2009-03-30. PMID:19077533. |
deletion of the gene in dopaminergic neurons in the substantia nigra generates a new model of parkinson disease. |
2009-03-30 |
2023-08-12 |
Not clear |
| Feng Jin, Qin Wu, Yuan-Fu Lu, Qi-Hai Gong, Jing-Shan Sh. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. European journal of pharmacology. vol 600. issue 1-3. 2009-03-27. PMID:18940189. |
6-ohda-induced parkinson's disease rat model involves chronic inflammation, mitochondrial dysfunction, and oxidative stress, and the loss of the dopaminergic neurons in the substantia nigra is the predominant lesion. |
2009-03-27 |
2023-08-12 |
rat |
| Feng Jin, Qin Wu, Yuan-Fu Lu, Qi-Hai Gong, Jing-Shan Sh. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. European journal of pharmacology. vol 600. issue 1-3. 2009-03-27. PMID:18940189. |
ultrastructural analysis showed that resveratrol alleviated 6-ohda-induced chromatin condensation, mitochondrial tumefaction and vacuolization of dopaminergic neurons in rat substantia nigra. |
2009-03-27 |
2023-08-12 |
rat |
| Hiroki Takeuchi, Takashi Yanagida, Masatoshi Inden, Kazuyuki Takata, Yoshihisa Kitamura, Kentaro Yamakawa, Hideyuki Sawada, Yasuhiko Izumi, Noriyuki Yamamoto, Takeshi Kihara, Kengo Uemura, Haruhisa Inoue, Takashi Taniguchi, Akinori Akaike, Ryosuke Takahashi, Shun Shimoham. Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. Journal of neuroscience research. vol 87. issue 2. 2009-03-25. PMID:18803299. |
parkinson's disease (pd) is the second most common neurodegenerative disease and is characterized by dopaminergic (da) neuronal cell loss in the substantia nigra. |
2009-03-25 |
2023-08-12 |
mouse |
| Haolan Ruan, Yi Yang, Xiaonan Zhu, Xuelan Wang, Ruzhu Che. Neuroprotective effects of (+/-)-catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19070648. |
mptp caused the death of dopaminergic neurons in the substantia nigra and decreased the level of striatal dopamine. |
2009-03-24 |
2023-08-12 |
mouse |
| Haolan Ruan, Yi Yang, Xiaonan Zhu, Xuelan Wang, Ruzhu Che. Neuroprotective effects of (+/-)-catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19070648. |
however, pretreatment with (+/-)-catechin was found to protect dopaminergic neurons in the substantia nigra against mptp toxicity, and restore the depletion of striatal dopamine in mice. |
2009-03-24 |
2023-08-12 |
mouse |