| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Omar Ahmad, Ji-Hyuk Park, Lisa Stenho-Bittel, Yuen-Sum La. Effects of endurance exercise on ventral tegmental area neurons in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-treated mice. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19084578. |
loss of dopaminergic neurons in the substantia nigra (a9 cells) and ventral tegmental area (vta) (a10 cells) has been reported in parkinson's disease with reference to causing motor and non-motor deficits, although clinical and laboratory animal studies on the degeneration of vta neurons are less emphasized comparative to the degeneration of substantia nigra neurons. |
2009-03-24 |
2023-08-12 |
mouse |
| S N Haber, E Lynd, C Klein, H J Groenewege. Topographic organization of the ventral striatal efferent projections in the rhesus monkey: an anterograde tracing study. The Journal of comparative neurology. vol 293. issue 2. 2009-03-19. PMID:19189717. |
although the densest terminal fields occur in the medial portion, numerous fibers also extend laterally to innervate the dorsal stratum of dopaminergic neurons of the substantia nigra and the retrorubral area. |
2009-03-19 |
2023-08-12 |
monkey |
| Justin J Wright, Peter D Goodnight, Matthew D McEvo. The utility of ketamine for the preoperative management of a patient with Parkinson's disease. Anesthesia and analgesia. vol 108. issue 3. 2009-03-12. PMID:19224812. |
loss of dopaminergic neurons from the substantia nigra characterizes the classical pathology of parkinson's disease, but persistent activation of n-methyl-d-aspartate receptors is also a major component. |
2009-03-12 |
2023-08-12 |
Not clear |
| A Guyon, D Skrzydelski, C Rovère, E Apartis, W Rostène, P Kitabgi, S Mélik Parsadaniantz, J L Naho. Stromal-cell-derived factor 1alpha /CXCL12 modulates high-threshold calcium currents in rat substantia nigra. The European journal of neuroscience. vol 28. issue 5. 2009-03-05. PMID:18671738. |
dopaminergic neurons of the substantia nigra constitutively express the cxcr4 receptor for the chemokine stromal-cell-derived factor 1alpha (cxcl12) but, to date, no direct effect of cxcr4 activation by cxcl12 on membrane conductance of dopaminergic neurons has been demonstrated. |
2009-03-05 |
2023-08-12 |
rat |
| A Guyon, D Skrzydelski, C Rovère, E Apartis, W Rostène, P Kitabgi, S Mélik Parsadaniantz, J L Naho. Stromal-cell-derived factor 1alpha /CXCL12 modulates high-threshold calcium currents in rat substantia nigra. The European journal of neuroscience. vol 28. issue 5. 2009-03-05. PMID:18671738. |
we tested the effects of cxcl12 on whole-cell currents of dopaminergic neurons recorded in patch clamp in substantia nigra slices and showed that cxcl12 (0.01-10 nm) increased the amplitude of total high-voltage-activated (hva) ca currents through cxcr4 activation. |
2009-03-05 |
2023-08-12 |
rat |
| Claire Henchcliffe, M Flint Bea. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature clinical practice. Neurology. vol 4. issue 11. 2009-03-03. PMID:18978800. |
parkinson disease (pd) is associated with progressive loss of dopaminergic neurons in the substantia nigra, as well as with more-widespread neuronal changes that cause complex and variable motor and nonmotor symptoms. |
2009-03-03 |
2023-08-12 |
Not clear |
| Anand S Srivastava, Rakesh Malhotra, Jason Sharp, Travis Berggre. Potentials of ES cell therapy in neurodegenerative diseases. Current pharmaceutical design. vol 14. issue 36. 2009-03-02. PMID:19128238. |
a histological hallmark of these disorders is the occurrence of disease-specific cell death in specific regional subpopulations of neurons, such as the loss of dopaminergic neurons in the substantia nigra in parkinson's disease. |
2009-03-02 |
2023-08-12 |
Not clear |
| Han-Qing Chen, Zheng-Yu Jin, Xi-Jin Wang, Xue-Ming Xu, Li Deng, Jian-Wei Zha. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neuroscience letters. vol 448. issue 2. 2009-02-27. PMID:18952146. |
parkinson's disease is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra. |
2009-02-27 |
2023-08-12 |
Not clear |
| Jing Liu, Yan-Yong Wang, Li Liu, Quan-Dong Wang, Zhen-Yun Yuan, Zhong-Xia Zhang, Ping Gu, Ming-Wei Wan. Damage to the nigrostriatal system in the MPTP-treated SAMP8 mouse. Neuroscience letters. vol 448. issue 2. 2009-02-27. PMID:18977411. |
these results indicated that there were marked decreases in striatal da levels and a loss of dopaminergic neurons in the substantia nigra, with the behavior change following shortly thereafter, in mptp-samp8 mice. |
2009-02-27 |
2023-08-12 |
mouse |
| Masaki Ikeda, Takeshi Kawarabayashi, Yasuo Harigaya, Atsushi Sasaki, Shuichi Yamada, Etsuro Matsubara, Tetsuro Murakami, Yuya Tanaka, Tomoko Kurata, Xu Wuhua, Kenji Ueda, Hisashi Kuribara, Yasushi Ikarashi, Yoichi Nakazato, Koichi Okamoto, Koji Abe, Mikio Shoj. Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology. Brain research. vol 1250. 2009-02-27. PMID:18992718. |
familial and sporadic pd show common pathological features of alphasyn pathologies, e.g., lewy bodies (lbs) and lewy neurites (lns), and a loss of dopaminergic neurons in the substantia nigra that leads to motor disturbances. |
2009-02-27 |
2023-08-12 |
mouse |
| Eriko Aoki, Ryohei Yano, Hironori Yokoyama, Hiroyuki Kato, Tsutomu Arak. Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Experimental and molecular pathology. vol 86. issue 1. 2009-02-25. PMID:19027004. |
these results demonstrate that dopaminergic neuronal loss may be caused by apoptosis due to increased cytokines and apoptosis-related proteins via the activation of nf-kappab in reactive astrocytes of the substantia nigra after mptp treatment in mice. |
2009-02-25 |
2023-08-12 |
mouse |
| Rebecca L Miller, Marilyn James-Kracke, Grace Y Sun, Albert Y Su. Oxidative and inflammatory pathways in Parkinson's disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18363100. |
parkinson's disease (pd) is the second most prevalent age-related neurodegenerative disease with physiological manifestations including tremors, bradykinesia, abnormal postural reflexes, rigidity and akinesia and pathological landmarks showing losses of dopaminergic neurons in the substantia nigra. |
2009-02-23 |
2023-08-12 |
Not clear |
| Koen Bossers, Gideon Meerhoff, Rawien Balesar, Jeroen W van Dongen, Chris G Kruse, Dick F Swaab, Joost Verhaage. Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18462474. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2009-02-19 |
2023-08-12 |
Not clear |
| Koen Bossers, Gideon Meerhoff, Rawien Balesar, Jeroen W van Dongen, Chris G Kruse, Dick F Swaab, Joost Verhaage. Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18462474. |
to gain insight into changes in gene expression during early stages of dopaminergic neurodegeneration, we selectively investigated the relatively spared parts of the pd substantia nigra, and correlated gene expression changes with alterations in neuronal density. |
2009-02-19 |
2023-08-12 |
Not clear |
| Koen Bossers, Gideon Meerhoff, Rawien Balesar, Jeroen W van Dongen, Chris G Kruse, Dick F Swaab, Joost Verhaage. Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18462474. |
as the changes occur in relatively spared parts of the pd substantia nigra, they suggest novel disease mechanisms involving neurotrophic support and axon guidance in early stages of cellular stress events, ultimately leading to dopaminergic cell death in pd. |
2009-02-19 |
2023-08-12 |
Not clear |
| Vardan T Karamyan, Robert C Spet. Distribution of the non-AT1, non-AT2 angiotensin-binding site in the rat brain: preliminary characterization. Neuroendocrinology. vol 88. issue 4. 2009-02-19. PMID:18562784. |
very high binding occurs in brain regions associated with dopaminergic reward (nucleus accumbens, ventral tegmental area) and motor (substantia nigra, caudate/putamen) systems. |
2009-02-19 |
2023-08-12 |
rat |
| Jiro Fukae, Shigeto Sato, Kahori Shiba, Ken-ichi Sato, Hideo Mori, Philip A Sharp, Yoshikuni Mizuno, Nobutaka Hattor. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. FEBS letters. vol 583. issue 3. 2009-02-16. PMID:19146857. |
accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (sn) of arpd. |
2009-02-16 |
2023-08-12 |
Not clear |
| Anthony H V Schapir. The clinical relevance of levodopa toxicity in the treatment of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 23 Suppl 3. 2009-02-13. PMID:18781678. |
for many years there has been concern regarding its potential to be toxic to the dopaminergic cells of the substantia nigra. |
2009-02-13 |
2023-08-12 |
Not clear |
| Yoland Smith, Rosa Villalb. Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brains. Movement disorders : official journal of the Movement Disorder Society. vol 23 Suppl 3. 2009-02-13. PMID:18781680. |
although the striatum remains the main functional target of dopamine, it is now appreciated that there is dopaminergic innervation of the pallidum, subthalamic nucleus, and substantia nigra. |
2009-02-13 |
2023-08-12 |
Not clear |
| Xuefei Wu, Po See Chen, Shannon Dallas, Belinda Wilson, Michelle L Block, Chao-Chuan Wang, Harriet Kinyamu, Nick Lu, Xi Gao, Yan Leng, De-Maw Chuang, Wanqin Zhang, Ru Band Lu, Jau-Shyong Hon. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18611290. |
parkinson's disease (pd) is characterized by the selective and progressive loss of dopaminergic (da) neurons in the midbrain substantia nigra. |
2009-01-26 |
2023-08-12 |
Not clear |