| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung-Wook Chae, Bok Yun Kang, Onyou Hwang, Hyun Jin Cho. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18403118. |
the inducible isoform cox-2 is upregulated in the dopaminergic neurons of the substantia nigra of postmortem parkinson's disease (pd) patients and in neurotoxin-induced parkinsonism models. |
2008-08-13 |
2023-08-12 |
Not clear |
| Kristi L Haik, Deborah A Shear, Chad Hargrove, Jared Patton, Michelle Mazei-Robison, Michael I Sandstrom, Gary L Dunba. 7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Experimental and clinical psychopharmacology. vol 16. issue 2. 2008-08-13. PMID:18489022. |
parkinson's disease (pd) is a neurodegenerative disorder in which loss of dopaminergic (da) neurons (>50%) in the substantia nigra (sn) precedes most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. |
2008-08-13 |
2023-08-12 |
rat |
| Naomi P Visanji, Antonia Orsi, Tom H Johnston, Patrick A Howson, Kimberly Dixon, Noelle Callizot, Jonathan M Brotchie, Daryl D Ree. PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 7. 2008-08-12. PMID:18364399. |
oral administration of pym50028 (10 mg/kg/day for 60 days) to mptp-lesioned mice, commencing after a striatal impairment was evident, resulted in a significant elevation of striatal gdnf (297%) and bdnf (511%), and attenuated the loss of striatal dopaminergic transporter levels and dopaminergic neurons in the substantia nigra. |
2008-08-12 |
2023-08-12 |
mouse |
| Cheng-Fang Huang, Gang Li, Rong Ma, Sheng-Gang Sun, Jian-Guo Che. Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo. Neuroscience bulletin. vol 24. issue 2. 2008-08-11. PMID:18369384. |
to evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2008-08-11 |
2023-08-12 |
rat |
| Eric J Benner, Rebecca Banerjee, Ashley D Reynolds, Simon Sherman, Vladimir M Pisarev, Vladislav Tsiperson, Craig Nemachek, Pawel Ciborowski, Serge Przedborski, R Lee Mosley, Howard E Gendelma. Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one. vol 3. issue 1. 2008-08-08. PMID:18167537. |
the neuropathology of parkinson's disease (pd) includes loss of dopaminergic neurons in the substantia nigra, nitrated alpha-synuclein (n-alpha-syn) enriched intraneuronal inclusions or lewy bodies and neuroinflammation. |
2008-08-08 |
2023-08-12 |
Not clear |
| R G Nair-Roberts, S D Chatelain-Badie, E Benson, H White-Cooper, J P Bolam, M A Ungles. Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18355970. |
stereological estimates of dopaminergic, gabaergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. |
2008-08-07 |
2023-08-12 |
rat |
| Sandro Alves, Etienne Régulier, Isabel Nascimento-Ferreira, Raymonde Hassig, Noelle Dufour, Arnulf Koeppen, Ana Luísa Carvalho, Sérgio Simões, Maria C Pedroso de Lima, Emmanuel Brouillet, Veronica Colomer Gould, Nicole Déglon, Luís Pereira de Almeid. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Human molecular genetics. vol 17. issue 14. 2008-08-07. PMID:18385100. |
in substantia nigra, unilateral overexpression of mutant ataxin-3 led to: apomorphine-induced turning behavior; formation of ubiquitinated ataxin-3 aggregates; alpha-synuclein immunoreactivity; and loss of dopaminergic markers (th and vmat2). |
2008-08-07 |
2023-08-12 |
mouse |
| Margarete Zanardo Gomes, Rita Raisman-Vozari, Elaine A Del Be. A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain research. vol 1203. 2008-08-01. PMID:18313645. |
treatment with the l-noarg significantly reduced 6-ohda-induced dopaminergic damage in the dorsal striatum, ventral substantia nigra and lateral globus pallidus, but had no effects in the dorsal substantia nigra and in the cingulate cortex. |
2008-08-01 |
2023-08-12 |
rat |
| Ikuko Mizuta, Tatsuhiko Tsunoda, Wataru Satake, Yuko Nakabayashi, Masahiko Watanabe, Atsushi Takeda, Kazuko Hasegawa, Kenji Nakashima, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Tatsushi Tod. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. Human genetics. vol 124. issue 1. 2008-07-30. PMID:18568448. |
parkinson's disease (pd), one of the most common human neurodegenerative disorders, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2008-07-30 |
2023-08-12 |
human |
| Greg Sutherland, George Mellick, Jeremy Newman, Kay L Double, Julia Stevens, Linda Lee, Dominic Rowe, Peter Silburn, Glenda M Hallida. Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 4. 2008-07-23. PMID:18085551. |
idiopathic parkinson's disease is a common movement disorder characterized by a loss of dopaminergic neurons in the substantia nigra. |
2008-07-23 |
2023-08-12 |
human |
| Patrick L McGeer, Edith G McGee. Glial reactions in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 4. 2008-07-22. PMID:18044695. |
dopaminergic neurons of the substantia nigra are particularly vulnerable to oxidative and inflammatory attack. |
2008-07-22 |
2023-08-12 |
Not clear |
| Karen E Murphy, Tanya Karaconji, Craig D Hardman, Glenda M Hallida. Excessive dopamine neuron loss in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 4. 2008-07-22. PMID:18163454. |
progressive supranuclear palsy (psp) and parkinson's disease (pd) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. |
2008-07-22 |
2023-08-12 |
Not clear |
| Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Anderse. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286173. |
elevated astrocytic mao-b mimicking age related increase resulted in specific, selective and progressive loss of dopaminergic neurons in the substantia nigra (sn), the same subset of neurons primarily impacted in the human condition. |
2008-07-15 |
2023-08-12 |
mouse |
| Kimberly B Bjugstad, Yang D Teng, D Eugene Redmond, John D Elsworth, Robert H Roth, Shannon K Cornelius, Evan Y Snyder, John R Slade. Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease. Experimental neurology. vol 211. issue 2. 2008-07-07. PMID:18394605. |
hnscs were implanted into the caudate nucleus (bilaterally) and substantia nigra (unilaterally) of 7, adult st. kitts african green monkeys (chlorocebus sabaeus) with previous exposure to systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), a neurotoxin that disrupts the dopaminergic nigrostriatal pathway. |
2008-07-07 |
2023-08-12 |
human |
| Mary B Newman, Roy A E Baka. Therapeutic potentials of human embryonic stem cells in Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 5. issue 2. 2008-06-20. PMID:18394566. |
the loss of dopaminergic neurons of the substantia nigra is the pathological hallmark characteristic of parkinson's disease (pd). |
2008-06-20 |
2023-08-12 |
human |
| L Stude. Culture of substantia nigra neurons. Current protocols in neuroscience. vol Chapter 3. 2008-06-19. PMID:18428467. |
cell cultures have also been used to study the development of substantia nigra, allowing investigators to identify early inductive events important for nigral development and to study dopaminergic differentiation and target innervation. |
2008-06-19 |
2023-08-12 |
chicken |
| Randy L Hunter, Dong-Young Choi, Stuart A Ross, Guoying Bin. Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. Neuroscience letters. vol 432. issue 3. 2008-06-12. PMID:18207323. |
we created an inflammation-induced parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. |
2008-06-12 |
2023-08-12 |
rat |
| Tobias Thomas, Marco Timmer, Konstantin Cesnulevicius, Edward Hitti, Alexey Kotlyarov, Matthias Gaeste. MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18298661. |
in the mptp mouse model for parkinson's disease, mk2-deficient mice show a reduced neuroinflammation and less degeneration of dopaminergic neurons in the substantia nigra after mptp lesion compared with wild-type mice. |
2008-06-12 |
2023-08-12 |
mouse |
| H Niazi Shahabi, D R Andersson, H Nissbrand. Cytochrome P450 2E1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production. Synapse (New York, N.Y.). vol 62. issue 5. 2008-06-03. PMID:18288650. |
cytochrome p450 2e1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production. |
2008-06-03 |
2023-08-12 |
rat |
| Marek Jankowsk. [The role of JNK pathway in familial Parkinson's disease]. Postepy biochemii. vol 53. issue 3. 2008-06-03. PMID:18399358. |
parkinson's disease is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra. |
2008-06-03 |
2023-08-12 |
Not clear |