| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heather A Boger, Lawrence D Middaugh, Vandana Zaman, Barry Hoffer, Ann-Charlotte Granhol. Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene. Brain research. vol 1241. 2009-01-26. PMID:18822276. |
glial cell line-derived neurotrophic factor (gdnf), a member of the transforming growth factor beta (tgfbeta) superfamily, is a potent neurotrophic protein promoting the survival and maintenance of dopaminergic (da) neurons in the substantia nigra during development and adulthood. |
2009-01-26 |
2023-08-12 |
mouse |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
monoamine concentrations and dopaminergic nerve terminals in the striatum and the number of dopaminergic neurons in the substantia nigra (sn) were assessed. |
2009-01-26 |
2023-08-12 |
mouse |
| Xiaomin Su, Kathleen A Maguire-Zeiss, Rita Giuliano, Landa Prifti, Karthik Venkatesh, Howard J Federof. Synuclein activates microglia in a model of Parkinson's disease. Neurobiology of aging. vol 29. issue 11. 2009-01-23. PMID:17537546. |
this age-related progressive disorder is typified by invariant loss of dopaminergic substantia nigra neurons (dan), dystrophic neurites, the presence of alpha-synuclein (syn) positive intracytoplasmic inclusions (lewy bodies) in the remaining dan, and activated microglia. |
2009-01-23 |
2023-08-12 |
mouse |
| Louisa C Johnston, Xiaomin Su, Kathleen Maguire-Zeiss, Karen Horovitz, Irina Ankoudinova, Dmitry Guschin, Piotr Hadaczek, Howard J Federoff, Krystof Bankiewicz, John Forsayet. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 8. 2009-01-22. PMID:18545225. |
in parkinson's disease (pd) chronic inflammation occurs in the substantia nigra (snc) concurrently with dopaminergic neurodegeneration. |
2009-01-22 |
2023-08-12 |
human |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
persistent mdma-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. |
2009-01-15 |
2023-08-12 |
mouse |
| Songhee Jeon, Youn Jung Kim, Seung-Tae Kim, Woongjoon Moon, Younbyoung Chae, Minjeong Kang, Mi-Young Chung, Hyangsook Lee, Mi-Sook Hong, Joo-Ho Chung, Tong H Joh, Hyejung Lee, Hi-Joon Par. Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model. Proteomics. vol 8. issue 22. 2009-01-13. PMID:18942673. |
acupuncture is frequently used as an alternative therapy for parkinson's disease (pd), and it attenuates dopaminergic (da) neurodegeneration in the substantia nigra (sn) in pd animal models. |
2009-01-13 |
2023-08-12 |
mouse |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd), but the neurodegenerative mechanisms have not been completely elucidated. |
2009-01-07 |
2023-08-12 |
mouse |
| Kjell G Fuxe, Alexander O Tarakanov, Larisa B Goncharova, Luigi F Agnat. A new road to neuroinflammation in Parkinson's disease? Brain research reviews. vol 58. issue 2. 2008-12-18. PMID:18457883. |
here, we clarify how chemokines and cytokines can participate in pathogenic processes of parkinson's disease, especially in dopaminergic neurons of substantia nigra. |
2008-12-18 |
2023-08-12 |
Not clear |
| Wayne Murrell, Andrew Wetzig, Michael Donnellan, François Féron, Tom Burne, Adrian Meedeniya, James Kesby, John Bianco, Chris Perry, Peter Silburn, Alan Mackay-Si. Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease. Stem cells (Dayton, Ohio). vol 26. issue 8. 2008-12-16. PMID:18535154. |
parkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. |
2008-12-16 |
2023-08-12 |
rat |
| Daria Drobysheva, Kristen Ameel, Brandon Welch, Esther Ellison, Khan Chaichana, Bryan Hoang, Shilpy Sharma, Wendi Neckameyer, Irina Srinakevitch, Kelley J Murphy, Aloisia Schmi. An optimized method for histological detection of dopaminergic neurons in Drosophila melanogaster. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 56. issue 12. 2008-12-16. PMID:18574253. |
parkinson's disease (pd) affects >1 million americans and is marked by the loss of dopaminergic neurons in the substantia nigra. |
2008-12-16 |
2023-08-12 |
human |
| Daniel Alvarez-Fischer, Serge Guerreiro, Stéphane Hunot, Françoise Saurini, Marc Marien, Pierre Sokoloff, Etienne C Hirsch, Andreas Hartmann, Patrick P Miche. Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid. Journal of neurochemistry. vol 107. issue 3. 2008-12-16. PMID:18761710. |
our results show, however, that mptp infusion via alzet osmotic minipumps (40 mg/kg/day) produces only a transient depletion in striatal dopamine (da) without causing dopaminergic cell loss in the substantia nigra. |
2008-12-16 |
2023-08-12 |
mouse |
| Shih-Ya Hung, Houng-Chi Liou, Kai-Hsiang Kang, Ruey-Meei Wu, Chun-Chiang Wen, Wen-Mei F. Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity. Molecular pharmacology. vol 74. issue 6. 2008-12-16. PMID:18799798. |
it was found that overexpression of ho-1 significantly increased the survival rate of dopaminergic neurons; reduced the production of tumor necrosis factor alpha (tnf-alpha) and interleukin-1beta (il-1beta) in substantia nigra; antagonized the reduction of striatal dopamine content induced by mpp(+); and also up-regulated brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) expression in substantia nigra. |
2008-12-16 |
2023-08-12 |
human |
| Bernard Schneider, Romain Zufferey, Patrick Aebische. Viral vectors, animal models and new therapies for Parkinson's disease. Parkinsonism & related disorders. vol 14 Suppl 2. 2008-12-12. PMID:18585946. |
both lentiviral and adeno-associated vectors efficiently transduce dopaminergic neurons in the substantia nigra, and transgenic expression of alpha-synuclein leads to the progressive loss of neurons positive for dopaminergic markers, with the formation of intraneuronal alpha-synuclein aggregates. |
2008-12-12 |
2023-08-12 |
Not clear |
| James P O'Callaghan, Krishnan Sriram, Diane B Mille. Defining "neuroinflammation". Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991877. |
we used a single low-dose regimen of mptp or meth, a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without affecting the cell body in the substantia nigra. |
2008-12-09 |
2023-08-12 |
mouse |
| S Q Wales, J M Laing, L Chen, L Aurelia. ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+. Gene therapy. vol 15. issue 20. 2008-12-04. PMID:18496573. |
apoptosis is a widely accepted component of the pathogenesis of parkinson's disease (pd), a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. |
2008-12-04 |
2023-08-12 |
Not clear |
| Princy S Quadros, Lisa J Schlueter, Christine K Wagne. Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats. Developmental neurobiology. vol 68. issue 12. 2008-11-26. PMID:18712784. |
the results demonstrate that pr is transiently expressed within the first 2 weeks of life in specific motor, sensory and reticular core nuclei as well as within midbrain dopaminergic cell groups such as the substantia nigra and the ventral tegmental area. |
2008-11-26 |
2023-08-12 |
mouse |
| Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. The effect of glucocorticoids on bradykinesia induced by immobilization stress. Hormones and behavior. vol 54. issue 1. 2008-11-18. PMID:18342862. |
it was also recently reported that imo damages dopaminergic (da) neurons in the substantia nigra (sn), which is known to cause symptoms similar to parkinson's disease (pd). |
2008-11-18 |
2023-08-12 |
mouse |
| Emilce Carrasco, Peter Werner, Diana Caspe. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597941. |
dopaminergic neurons in the substantia nigra (sn) selectively die in parkinson's disease (pd), but it is unclear how and why this occurs. |
2008-11-05 |
2023-08-12 |
human |
| Supriti Samantaray, Swapan K Ray, Naren L Bani. Calpain as a potential therapeutic target in Parkinson's disease. CNS & neurological disorders drug targets. vol 7. issue 3. 2008-11-05. PMID:18673214. |
pathophysiology of idiopathic parkinson's disease (pd) is associated with degeneration of dopaminergic neurons and inflammatory responses in the mid-brain substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
Not clear |
| Pier G Mastroberardino, Adam L Orr, Xiaoping Hu, Hye Mee Na, J Timothy Greenamyr. A FRET-based method to study protein thiol oxidation in histological preparations. Free radical biology & medicine. vol 45. issue 7. 2008-11-04. PMID:18620047. |
when applied to an animal model of parkinson's disease, our technique demonstrated that thiol oxidation occurs selectively in the dopaminergic neurons of the substantia nigra, the same neurons that are lost selectively in the disease. |
2008-11-04 |
2023-08-12 |
Not clear |