| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Zhao, X-W Zheng, G-W Qin, Y Gai, Z-H Jiang, L-H Gu. In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.). Cellular and molecular life sciences : CMLS. vol 66. issue 9. 2009-07-15. PMID:19322517. |
pharmacologically, bu significantly protected sk-n-sh cells from 1-methyl-4-phenylpyridinium (mpp(+)) insult, produced striking inhibitory actions on dopamine/norepinephrine uptake and win35,428 binding in synaptosomes on in vivo administration, and significantly preventing poor performance on rotarod and dopaminergic loss in substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mice. |
2009-07-15 |
2023-08-12 |
mouse |
| Hülya Bayir, Alexandr A Kapralov, Janfei Jiang, Zhentai Huang, Yulia Y Tyurina, Vladimir A Tyurin, Qing Zhao, Natalia A Belikova, Irina I Vlasova, Akihiro Maeda, Jianhui Zhu, Hye-Mee Na, Pier-Giorgio Mastroberardino, Louis J Sparvero, Andrew A Amoscato, Charleen T Chu, John T Greenamyre, Valerian E Kaga. Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. The Journal of biological chemistry. vol 284. issue 23. 2009-07-13. PMID:19351880. |
co-localization of syn with cytochrome c was detected in aggregates formed upon proapoptotic stimulation of sh-sy5y and hela cells and in dopaminergic substantia nigra neurons of rotenone-treated rats. |
2009-07-13 |
2023-08-12 |
mouse |
| Eniko Vamos, Anett Csati, Laszlo Vecsei, Peter Kliveny. Effects of valproate on the dopaminergic system in mice. Neurological research. vol 31. issue 3. 2009-07-07. PMID:18768113. |
in this study, we tested the behavioral changes induced by valproate and its effect on the dopaminergic cells in the substantia nigra of mice. |
2009-07-07 |
2023-08-12 |
mouse |
| Eniko Vamos, Anett Csati, Laszlo Vecsei, Peter Kliveny. Effects of valproate on the dopaminergic system in mice. Neurological research. vol 31. issue 3. 2009-07-07. PMID:18768113. |
the number of dopaminergic cells in the substantia nigra was reduced after valproate treatment. |
2009-07-07 |
2023-08-12 |
mouse |
| H Jourdi, L Hamo, T Oka, A Seegan, M Baudr. BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices. Neuropharmacology. vol 56. issue 5. 2009-07-02. PMID:19371576. |
neurotoxicity is involved in various neurodegenerative diseases including parkinson's disease (pd), which affects mesencephalic dopaminergic neurons of the substantia nigra (sn). |
2009-07-02 |
2023-08-12 |
Not clear |
| Laura Flinn, Heather Mortiboys, Katrin Volkmann, Reinhard W Köster, Phillip W Ingham, Oliver Bandman. Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain : a journal of neurology. vol 132. issue Pt 6. 2009-06-30. PMID:19439422. |
abrogation of parkin activity leads to a significant decrease in the number of ascending dopaminergic neurons in the posterior tuberculum (homologous to the substantia nigra in humans), an effect enhanced by exposure to mpp+. |
2009-06-30 |
2023-08-12 |
human |
| D E Vaillancourt, M B Spraker, J Prodoehl, I Abraham, D M Corcos, X J Zhou, C L Comella, D M Littl. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology. vol 72. issue 16. 2009-06-22. PMID:19129507. |
in the midbrain of patients with parkinson disease (pd), there is a selective loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (sn). |
2009-06-22 |
2023-08-12 |
mouse |
| Jun Wang, Xi-Xun Du, Hong Jiang, Jun-Xia Xi. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochemical pharmacology. vol 78. issue 2. 2009-06-17. PMID:19464433. |
oxidative stress has been implicated in the degeneration of dopaminergic neurons in the substantia nigra of parkinson's disease patients, and several anti-oxidants have been shown to be effective on the treatment of parkinson's disease. |
2009-06-17 |
2023-08-12 |
Not clear |
| Ji Won Um, Christine Stichel-Gunkel, Hermann Lübbert, Gwang Lee, Kwang Chul Chun. Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Molecular and cellular neurosciences. vol 40. issue 4. 2009-06-16. PMID:19167501. |
parkinson's disease (pd) is characterized by the deterioration of dopaminergic neurons in the pars compacta of substantia nigra and the formation of intraneuronal protein inclusions. |
2009-06-16 |
2023-08-12 |
Not clear |
| Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, Yumi Suzuki, Satoshi Maesawa, Yasukazu Kajita, Masaaki Hirayama, Ikuroh Ohsawa, Shigeo Ohta, Kinji Ohn. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356598. |
in parkinson's disease, mitochondrial dysfunction and the associated oxidative stress are major causes of dopaminergic cell loss in the substantia nigra. |
2009-06-12 |
2023-08-12 |
human |
| Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, Yumi Suzuki, Satoshi Maesawa, Yasukazu Kajita, Masaaki Hirayama, Ikuroh Ohsawa, Shigeo Ohta, Kinji Ohn. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356598. |
tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. |
2009-06-12 |
2023-08-12 |
human |
| Smitha Karunakaran, Uzma Saeed, Mamata Mishra, R Khader Valli, Shanker Datt Joshi, Durga Praveen Meka, Pankaj Seth, Vijayalakshmi Ravindranat. Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 47. 2009-06-09. PMID:19020042. |
selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. |
2009-06-09 |
2023-08-12 |
mouse |
| Na K Kim, Byung H Choi, Xian Huang, Brian J Snyder, Shefqat Bukhari, Tae-Ho Kong, Hyeonseon Park, Hyung C Park, So R Park, Yoon H. Granulocyte-macrophage colony-stimulating factor promotes survival of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced murine Parkinson's disease model. The European journal of neuroscience. vol 29. issue 5. 2009-06-09. PMID:19245369. |
furthermore, administration of gm-csf (50 microg/kg body weight/day) in vivo for 7 days protected dopaminergic neurons in the substantia nigra and improved locomotor behavior in a mouse mptp model of pd. |
2009-06-09 |
2023-08-12 |
mouse |
| b' Agust\\xc3\\xadn Anastas\\xc3\\xada, Luciana Torre, Gabriel A de Erausquin, Daniel H Masc\\xc3\\xb. Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson\'s disease. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19245661.' |
we have investigated the effects of ee on 6-hydroxydopamine (6-ohda)-induced neuronal death after unilateral administration to the medial forebrain bundle, which reaches 85-95% of dopaminergic neurons in the substantia nigra after 3 weeks. |
2009-06-09 |
2023-08-12 |
rat |
| You-Joung Kim, Hyun-Jung Park, Gwang Lee, Oh Young Bang, Young Hwan Ahn, Eunhye Joe, Hyun Ok Kim, Phil Hyu Le. Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action. Glia. vol 57. issue 1. 2009-05-26. PMID:18661552. |
parkinson's disease (pd) is a common, progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2009-05-26 |
2023-08-12 |
human |
| Eugene V Mosharov, Kristin E Larsen, Ellen Kanter, Kester A Phillips, Krystal Wilson, Yvonne Schmitz, David E Krantz, Kazuto Kobayashi, Robert H Edwards, David Sulze. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. vol 62. issue 2. 2009-05-20. PMID:19409267. |
parkinson's disease (pd) is a synucleinopathy characterized by a preferential loss of dopaminergic neurons in the substantia nigra (sn), whereas neurons of the ventral tegmental area (vta) are spared. |
2009-05-20 |
2023-08-12 |
Not clear |
| Ling-Yun Li, Xi-Lin Zhao, Xi-Feng Fei, Zhen-Lun Gu, Zheng-Hong Qin, Zhong-Qin Lian. Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra. Acta pharmacologica Sinica. vol 29. issue 5. 2009-05-07. PMID:18430361. |
bilobalide inhibits 6-ohda-induced activation of nf-kappab and loss of dopaminergic neurons in rat substantia nigra. |
2009-05-07 |
2023-08-12 |
rat |
| Dario Greco, Floriana Volpicelli, Antonio Di Lieto, Damiana Leo, Carla Perrone-Capano, Petri Auvinen, Umberto di Porzi. Comparison of gene expression profile in embryonic mesencephalon and neuronal primary cultures. PloS one. vol 4. issue 3. 2009-04-24. PMID:19305503. |
in the mammalian central nervous system (cns) an important contingent of dopaminergic neurons are localized in the substantia nigra and in the ventral tegmental area of the ventral midbrain. |
2009-04-24 |
2023-08-12 |
Not clear |
| Etienne C Hirsch, Stéphane Huno. Neuroinflammation in Parkinson's disease: a target for neuroprotection? The Lancet. Neurology. vol 8. issue 4. 2009-04-23. PMID:19296921. |
parkinson's disease is characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra. |
2009-04-23 |
2023-08-12 |
Not clear |
| Shin-Ichi Kyuho. Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18952148. |
because they have been reported to possess neuroprotective effects on dopaminergic neurons in the substantia nigra (sn), isoflavones appear particularly promising for post-menopausal women at risk for pd. |
2009-04-16 |
2023-08-12 |
rat |