| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuzhen Zhang, Jun Wang, Ning Song, Junxia Xie, Hong Jian. Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18191877. |
our previous study showed increased iron levels in the substantia nigra as well as loss of dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced pd mouse models. |
2009-10-09 |
2023-08-12 |
mouse |
| Wing-Sai Chan, Siva Sundara Kumar Durairajan, Jia-Hong Lu, Yan Wang, Li-Xia Xie, Wan-Fung Kum, Irene Koo, Ken Kin Lam Yung, Min L. Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture. Neurochemistry international. vol 55. issue 6. 2009-10-09. PMID:19409437. |
parkinson's disease (pd) is caused by a progressive degeneration of dopaminergic neurons in the substantia nigra. |
2009-10-09 |
2023-08-12 |
Not clear |
| Jörn Schweitzer, Wolfgang Drieve. Development of the dopamine systems in zebrafish. Advances in experimental medicine and biology. vol 651. 2009-10-09. PMID:19731546. |
the molecular control of dopaminergic differentiation and the evolution of the various dopaminergic systems are not well understood, as research has mostly focused on ascending mammalian dopaminergic systems of the substantia nigra and ventral tegmental area. |
2009-10-09 |
2023-08-12 |
zebrafish |
| Paula M Keeney, Caitlin K Quigley, Lisa D Dunham, Christina M Papageorge, Shilpa Iyer, Ravindar R Thomas, Kathleen M Schwarz, Patricia A Trimmer, Shaharyar M Khan, Francisco R Portell, Kristen E Bergquist, James P Bennet. Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model. Human gene therapy. vol 20. issue 8. 2009-10-07. PMID:19374590. |
neurodegeneration in parkinson's disease (pd) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose detectable respiratory activity associated with depletion of intact mitochondrial dna (mtdna). |
2009-10-07 |
2023-08-12 |
human |
| Shalaka A Mulherkar, Jaiprakash Sharma, Nihar Ranjan Jan. The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein. Journal of neurochemistry. vol 110. issue 6. 2009-09-29. PMID:19645749. |
parkinson's disease (pd) is a common neurodegenerative disorder caused mainly because of the loss of dopaminergic neurons in the substantia nigra. |
2009-09-29 |
2023-08-12 |
Not clear |
| G E Meredith, S Totterdell, M Beales, C K Meshu. Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease. Experimental neurology. vol 219. issue 1. 2009-09-25. PMID:19523952. |
the goal of this study was to determine whether changes in glutamate signaling and uptake contribute to the demise of dopaminergic neurons in the substantia nigra. |
2009-09-25 |
2023-08-12 |
mouse |
| Anna L Bartels, Klaus L Leender. Parkinson's disease: the syndrome, the pathogenesis and pathophysiology. Cortex; a journal devoted to the study of the nervous system and behavior. vol 45. issue 8. 2009-09-22. PMID:19095226. |
an important pathophysiological feature in pd is the loss of part of the dopaminergic neurons in the substantia nigra (sn) resulting in a specific dysorganisation of the complicated basal ganglia (bg) circuits. |
2009-09-22 |
2023-08-12 |
Not clear |
| J Trecki, E M Unterwal. Modulation of cocaine-induced activity by intracerebral administration of CXCL12. Neuroscience. vol 161. issue 1. 2009-09-21. PMID:19303923. |
cxcr4, a receptor activated by cxcl12, is expressed by dopaminergic neurons in the substantia nigra. |
2009-09-21 |
2023-08-12 |
rat |
| Ricarda A Menke, Jan Scholz, Karla L Miller, Sean Deoni, Saad Jbabdi, Paul M Matthews, Mojtaba Zare. MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. NeuroImage. vol 47. issue 2. 2009-09-03. PMID:19447183. |
the substantia nigra contains dopaminergic cells that project to the striatum and are affected by the neurodegenerative process that appears in parkinson's disease (pd). |
2009-09-03 |
2023-08-12 |
human |
| Ruwani Wijeyekoon, Roger A Barke. Cell replacement therapy for Parkinson's disease. Biochimica et biophysica acta. vol 1792. issue 7. 2009-08-25. PMID:19007882. |
parkinson's disease (pd) is a progressive neurodegenerative disorder in which the degeneration of dopaminergic neurons projecting from the substantia nigra to the striatum is a key pathological feature of the disease. |
2009-08-25 |
2023-08-12 |
Not clear |
| Robert M Kessler, Neil D Woodward, Patrizia Riccardi, Rui Li, M Sib Ansari, Sharlett Anderson, Benoit Dawant, David Zald, Herbert Y Meltze. Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects. Biological psychiatry. vol 65. issue 12. 2009-08-20. PMID:19251247. |
studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments. |
2009-08-20 |
2023-08-12 |
human |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
intrastriatally injected manf protected nigrostriatal dopaminergic nerves from 6-ohda-induced degeneration as evaluated by counting tyrosine hydroxylase (th)-positive cell bodies in the substantia nigra (sn) and th-positive fibers in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Yingjun Zheng, Akiya Watakabe, Masahiko Takada, Akiyoshi Kakita, Hisaaki Namba, Hitoshi Takahashi, Tetsuo Yamamori, Hiroyuki Naw. Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19336245. |
these observations suggest that erbb4 is expressed in the dopaminergic neurons of primate substantia nigra and erbb4 abnormality might contribute to the dopaminergic pathology associated with schizophrenia or other brain diseases. |
2009-08-10 |
2023-08-12 |
human |
| Lilia Marinova-Mutafchieva, Mona Sadeghian, Lauren Broom, John B Davis, Andrew D Medhurst, David T Dexte. Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease. Journal of neurochemistry. vol 110. issue 3. 2009-08-07. PMID:19549006. |
relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of parkinson's disease. |
2009-08-07 |
2023-08-12 |
Not clear |
| Brandon K Harvey, Jenny Chou, Hui Shen, Barry J Hoffer, Yun Wan. Diadenosine tetraphosphate reduces toxicity caused by high-dose methamphetamine administration. Neurotoxicology. vol 30. issue 3. 2009-08-04. PMID:19442829. |
previous studies have shown that ap(4)a reduced neurodegeneration caused by the dopaminergic neurotoxin 6-hydroxydopamine in rat striatum and substantia nigra. |
2009-08-04 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Emi Kurimoto, Sachiko Takemori, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Yasuhiko Izumi, Toshiaki Kume, Koichi Shudo, Akinori Akaik. Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457078. |
finally, oral administration of am80 prevented dopaminergic cell loss in the substantia nigra induced by local injection of lipopolysaccharide in mice, indicating that rars are a promising target of therapeutics for neurodegenerative disorders. |
2009-07-31 |
2023-08-12 |
mouse |
| Hyman M Schipper, Wei Song, Hillel Zukor, Jacob R Hascalovici, David Zeligma. Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457088. |
in parkinson disease, ho-1 is markedly over-expressed in astrocytes of the substantia nigra and decorates lewy bodies in affected dopaminergic neurons. |
2009-07-31 |
2023-08-12 |
human |
| Randy L Hunter, Baohua Cheng, Dong-Young Choi, Mei Liu, Shuwei Liu, Wayne A Cass, Guoying Bin. Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice. Journal of neuroscience research. vol 87. issue 8. 2009-07-30. PMID:19224579. |
we showed progressive and specific dopaminergic neurodegeneration in the substantia nigra, which is accompanied by striatal dopamine depletion and progressive behavioral impairment, which was alleviated by the use of the pd drug l-dopa. |
2009-07-30 |
2023-08-12 |
mouse |
| Andreas Weihofen, Kelly Jean Thomas, Beth L Ostaszewski, Mark R Cookson, Dennis J Selko. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry. vol 48. issue 9. 2009-07-20. PMID:19152501. |
recessive mutations in pink1 lead to a selective degeneration of dopaminergic neurons in the substantia nigra that is characteristic of parkinson disease. |
2009-07-20 |
2023-08-12 |
Not clear |
| Arthur S Walters, William G Ondo, Wen Zhu, Weidong L. Does the endogenous opiate system play a role in the Restless Legs Syndrome? A pilot post-mortem study. Journal of the neurological sciences. vol 279. issue 1-2. 2009-07-17. PMID:19167016. |
although one of the main hypotheses for pathogenesis has been that there is a dopaminergic hypofunction in rls, this lack of decrease in tyrosine hydroxylase in substantia nigra is consistent with previously published post-mortem data in rls. |
2009-07-17 |
2023-08-12 |
Not clear |