| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monika Vinish, Sudesh Prabhakar, Madhu Khullar, Indu Verma, Akshay Anan. Genetic screening reveals high frequency of PARK2 mutations and reduced Parkin expression conferring risk for Parkinsonism in North West India. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 2. 2010-03-19. PMID:19734163. |
among several aetiological factors, park2 mutations are the most common cause of parkinson disease (pd) that result in degeneration of dopaminergic neurons in the substantia nigra. |
2010-03-19 |
2023-08-12 |
Not clear |
| Thomas Jubault, Simona M Brambati, Clotilde Degroot, Benoît Kullmann, Antonio P Strafella, Anne-Louise Lafontaine, Sylvain Chouinard, Oury Monch. Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI. PloS one. vol 4. issue 12. 2010-03-17. PMID:20011063. |
post-mortem studies tend to show that the destruction of dopaminergic neurons in the substantia nigra constitutes an intermediate step in a broader neurodegenerative process rather than a unique feature of parkinson's disease, as a consistent pattern of progression would exist, originating from the medulla oblongata/pontine tegmentum. |
2010-03-17 |
2023-08-12 |
Not clear |
| Kentaro Yamakawa, Yasuhiko Izumi, Hiroki Takeuchi, Noriyuki Yamamoto, Toshiaki Kume, Akinori Akaike, Ryosuke Takahashi, Shun Shimohama, Hideyuki Sawad. Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. Biochemical and biophysical research communications. vol 391. issue 1. 2010-03-15. PMID:19900407. |
parkinson's disease is characterized by selective loss of dopaminergic neurons in the substantia nigra and by the appearance of lewy bodies. |
2010-03-15 |
2023-08-12 |
human |
| Y-Q Xue, B-F Ma, L-R Zhao, J B Tatom, B Li, L-X Jiang, R L Klein, W-M Dua. AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease. Gene therapy. vol 17. issue 1. 2010-03-08. PMID:19727138. |
we have recently shown that intrastriatal injection of recombinant human erythropoietin (epo) protects dopaminergic (da) neurons in the substantia nigra (sn) from 6-hydroxydopamine (6-ohda) toxicity in a rat model of parkinson's disease. |
2010-03-08 |
2023-08-12 |
human |
| David A Gallagher, Anthony H V Schapir. Etiopathogenesis and treatment of Parkinson's disease. Current topics in medicinal chemistry. vol 9. issue 10. 2010-03-04. PMID:19754402. |
parkinson's disease (pd) is a complex neurodegenerative disorder characterised by dopaminergic cell loss in the substantia nigra. |
2010-03-04 |
2023-08-12 |
Not clear |
| Mario Di Napol. New molecular avenues in Parkinson's disease therapy. Current topics in medicinal chemistry. vol 9. issue 10. 2010-03-04. PMID:19754406. |
idiopathic parkinson's disease (pd) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss within the substantia nigra. |
2010-03-04 |
2023-08-12 |
Not clear |
| Miguel A Ortiz-Ortiz, José M Morán, Luz M Ruiz-Mesa, Mireia Niso-Santano, José M Bravo-SanPedro, Rubén Gómez-Sánchez, Rosa A González-Polo, José M Fuente. Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. Neuroscience letters. vol 468. issue 2. 2010-03-04. PMID:19879924. |
since oxidative stress has been implicated in the degeneration of dopaminergic neurons in the substantia nigra in parkinson's disease (pd), curcumin has been proposed to have potential therapeutic value for the treatment of neurodegenerative diseases such as pd. |
2010-03-04 |
2023-08-12 |
rat |
| Violetta Dziedziejko, Monika Białecka, Anna Machoy-Mokrzyńska, Gabriela Kłodowska-Duda, Dariusz Chlube. [The role of estrogens in Parkinson's disease]. Postepy higieny i medycyny doswiadczalnej (Online). vol 63. 2010-03-04. PMID:20097949. |
the neuropathological basis of parkinson's disease is selective degeneration of dopaminergic neurons in the brain's substantia nigra, which results in an imbalance between neurotransmitters in the central nervous system, mainly between dopamine and acetylcholine. |
2010-03-04 |
2023-08-12 |
Not clear |
| Laura Domínguez, Ruth Morona, Alberto Joven, Agustín González, Jesús M Lópe. Immunohistochemical localization of orexins (hypocretins) in the brain of reptiles and its relation to monoaminergic systems. Journal of chemical neuroanatomy. vol 39. issue 1. 2010-03-03. PMID:19665547. |
however, orexinergic innervation was found in dopaminergic, noradrenergic and serotoninergic cell groups, such as the substantia nigra and ventral tegmental area in the midbrain tegmentum, the locus coeruleus, the nucleus of the solitary tract and the raphe nuclei. |
2010-03-03 |
2023-08-12 |
Not clear |
| Barbara Monti, Valentina Gatta, Francesca Piretti, Simonetta S Raffaelli, Marco Virgili, Antonio Contestabil. Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein. Neurotoxicity research. vol 17. issue 2. 2010-03-02. PMID:19626387. |
the decrease of the dopaminergic marker tyrosine hydroxylase in substantia nigra and striatum caused by 7 days toxin administration was prevented in vpa-fed rats. |
2010-03-02 |
2023-08-12 |
rat |
| Hideaki Matsui, Yoshihito Taniguchi, Haruhisa Inoue, Yoshito Kobayashi, Yoshiyuki Sakaki, Atsushi Toyoda, Kengo Uemura, Daisuke Kobayashi, Shunichi Takeda, Ryosuke Takahash. Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement. Neuroscience research. vol 66. issue 2. 2010-03-02. PMID:19895857. |
parkinson's disease is a neurodegenerative disease associated with the degeneration of dopaminergic neurons in the substantia nigra. |
2010-03-02 |
2023-08-12 |
mouse |
| Joanne Clark, David K Simo. Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease. Antioxidants & redox signaling. vol 11. issue 3. 2010-03-01. PMID:18717631. |
parkinson's disease (pd) is a progressive, primarily motor disorder that is characterized by loss of dopaminergic (da) neurons within the substantia nigra (sn). |
2010-03-01 |
2023-08-12 |
mouse |
| Ana Clara Cristóvão, Dong-Hee Choi, Graça Baltazar, M Flint Beal, Yoon-Seong Ki. The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death. Antioxidants & redox signaling. vol 11. issue 9. 2010-03-01. PMID:19450058. |
male c57bl/6 mice received intraperitoneal (ip) injections of paraquat (10 mg/kg) once every 3 days and showed increased nox1 levels in the substantia nigra as well as a 35% reduction in tyrosine hydroxylase-positive dopaminergic neurons 5 days after the last injection. |
2010-03-01 |
2023-08-12 |
mouse |
| Randy L Hunter, Mei Liu, Dong Young Choi, Wayne A Cass, Guoying Bin. Inflammation and age-related iron accumulation in F344 rats. Current aging science. vol 1. issue 2. 2010-03-01. PMID:20021380. |
intracranial injection of the bacterial endotoxin, lipopolysaccharide (lps), has been shown to induce microglia activation, oxidative stress, mitochondrial impairment, iron accumulation, and dopaminergic neurodegeneration within the substantia nigra. |
2010-03-01 |
2023-08-12 |
rat |
| Fabio S L da Conceição, Stacie Ngo-Abdalla, Jean-Christophe Houzel, Stevens K Rehe. Murine model for Parkinson's disease: from 6-OH dopamine lesion to behavioral test. Journal of visualized experiments : JoVE. issue 35. 2010-03-01. PMID:20081770. |
key symptoms, such as tremor, rigidity and bradikinesia, develop when about 3/4 of dopaminergic cells are lost in the substantia nigra, and fail to provide for the smooth, coordinated regulation of striatal motor circuits. |
2010-03-01 |
2023-08-12 |
mouse |
| Yu Luo, Sara Arezou Sarabi, Cristina Backman, Lufei Shan, Barry Hoffer, Howard Federof. Expression pattern of NuIP gene in adult mouse brain. Brain research. vol 1302. 2010-02-23. PMID:19765553. |
interestingly, nuip is expressed in high levels in midbrain dopaminergic neurons including ventral tegmental area (vta) and substantia nigra (sn) dopaminergic neurons but is not expressed or expressed in low levels in other dopaminergic neurons such as olfactory bulb and hypothalamus. |
2010-02-23 |
2023-08-12 |
mouse |
| Hong-Ning Zhang, Chun-Na An, Man Xu, De-An Guo, Min Li, Xiao-Ping P. Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin. Biological & pharmaceutical bulletin. vol 32. issue 11. 2010-02-17. PMID:19881299. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-02-17 |
2023-08-12 |
rat |
| Chee Yeun Chung, James B Koprich, Penelope J Hallett, Ole Isacso. Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 52. 2010-02-17. PMID:20007772. |
in parkinson's disease (pd), dopaminergic (da) neurons in the substantia nigra (sn, a9) are particularly vulnerable, compared to adjacent da neurons within the ventral tegmental area (vta, a10). |
2010-02-17 |
2023-08-12 |
human |
| Daniel R Andersson, Evelina Björnsson, Filip Bergquist, Hans Nissbrand. Motor activity-induced dopamine release in the substantia nigra is regulated by muscarinic receptors. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19944096. |
the results indicate that muscarinic activity in the substantia nigra is of functional importance in an animal parkinson's disease model, and strengthen the notion that nigral dopaminergic regulation of motor activity/performance is independent of striatal dopamine release. |
2010-02-16 |
2023-08-12 |
Not clear |
| Yi-Fang Cui, Gunnar Hargus, Jin-Chong Xu, Janinne Sylvie Schmid, Yan-Qin Shen, Markus Glatzel, Melitta Schachner, Christian Bernreuthe. Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice. Brain : a journal of neurology. vol 133. issue Pt 1. 2010-02-12. PMID:19995872. |
drug treatment and deep brain stimulation can ameliorate symptoms, but the progressive degeneration of dopaminergic neurons in the substantia nigra eventually leads to severe motor dysfunction. |
2010-02-12 |
2023-08-12 |
mouse |