| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilse Sanet Pienaar, David Trevor Dexter, Pierre Roland Burkhar. Mitochondrial proteomics as a selective tool for unraveling Parkinson's disease pathogenesis. Expert review of proteomics. vol 7. issue 2. 2010-06-28. PMID:20377388. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the large-scale loss of dopaminergic neurons in the substantia nigra and the formation of protein aggregates that accumulate in the cytoplasm of the remaining dopaminergic neurons. |
2010-06-28 |
2023-08-12 |
human |
| Stephanie K Seidlits, Zin Z Khaing, Rebecca R Petersen, Jonathan D Nickels, Jennifer E Vanscoy, Jason B Shear, Christine E Schmid. The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation. Biomaterials. vol 31. issue 14. 2010-06-21. PMID:20171731. |
results demonstrate that the mechanical properties of these scaffolds can assert a defining influence on the differentiation of ventral midbrain-derived npcs, which have strong clinical relevance because of their ability to mature into dopaminergic neurons of the substantia nigra, cells that idiopathically degenerate in individuals suffering from parkinson's disease. |
2010-06-21 |
2023-08-12 |
Not clear |
| Farhad Mashayekhi, Ebrahim Mirzajani, Mohammad Naji, Majid Azar. Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 5. 2010-06-14. PMID:20189394. |
parkinson's disease (pd) is characterized by progressive loss of dopaminergic neurons in the substantia nigra. |
2010-06-14 |
2023-08-12 |
human |
| María Clara Pott Godoy, Carina Cintia Ferrari, Fernando Juan Pitoss. Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. Journal of neuroimmunology. vol 222. issue 1-2. 2010-06-14. PMID:20350768. |
by injecting an adenovirus expressing il-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. |
2010-06-14 |
2023-08-12 |
Not clear |
| L Hunter Randy, Bing Guoyin. Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease. Current neuropharmacology. vol 5. issue 1. 2010-06-11. PMID:18615152. |
evidence suggests inflammation, mitochondria dysfunction, and oxidative stress play major roles in parkinson's disease (pd), where the primary pathology is the significant loss of dopaminergic neurons in the substantia nigra (sn). |
2010-06-11 |
2023-08-12 |
Not clear |
| P Bonsi, D Cuomo, G Martella, G Sciamanna, M Tolu, P Calabresi, G Bernardi, A Pisan. Mitochondrial toxins in Basal Ganglia disorders: from animal models to therapeutic strategies. Current neuropharmacology. vol 4. issue 1. 2010-06-10. PMID:18615133. |
accordingly, in human pd, a specific dysfunction of complex i activity was found in vulnerable dopaminergic neurons of the substantia nigra. |
2010-06-10 |
2023-08-12 |
human |
| Li-Fang Hu, Ming Lu, Chi Xin Tiong, Gavin S Dawe, Gang Hu, Jin-Song Bia. Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging cell. vol 9. issue 2. 2010-06-10. PMID:20041858. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2010-06-10 |
2023-08-12 |
rat |
| Yong-Sheng Wang, Jian-Ping Zhou, Zi-Feng Wei, Qing-You Tian, Hong-Xia Zhou, Yu-Xin Zhan. [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 8. 2010-06-09. PMID:17715026. |
to investigate the effect of phophorylated c-jun (p-c-jun) expression on the expression of cox-2 in the substantia nigra (sn) of the mptp mouse model of subacute parkinson disease (pd) and explore the possible mechanism of the dopaminergic (da) neuron death in pd. |
2010-06-09 |
2023-08-12 |
mouse |
| Malú G Tansey, Matthew S Goldber. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:19913097. |
major unanswered questions include whether protein aggregates cause the selective loss of dopaminergic neurons in the substantia nigra that underlies the clinical symptoms and whether neuroinflammation is a consequence or a cause of nigral cell loss. |
2010-06-08 |
2023-08-12 |
Not clear |
| Elena Puerta, Isabel Hervias, Beatriz Goñi-Allo, Steven F Zhang, Joaquín Jordán, Anatoly A Starkov, Norberto Aguirr. Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity. British journal of pharmacology. vol 160. issue 2. 2010-06-02. PMID:20423338. |
3,4-methylenedioxymethamphetamine (mdma) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. |
2010-06-02 |
2023-08-12 |
mouse |
| Anne N Murph. In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease. EMBO molecular medicine. vol 1. issue 2. 2010-05-26. PMID:20049706. |
for many years research in parkinson's disease (pd) has linked mitochondrial dysfunction with the characteristic loss of dopaminergic neurons of the substantia nigra, accumulation of cytoplasmic inclusions termed lewy bodies, and motor dysfunction (henchcliffe & beal, 2008). |
2010-05-26 |
2023-08-12 |
Not clear |
| Chin-Yu Lu, Pei-Lu Yi, Chon-Haw Tsai, Chiung-Hsiang Cheng, Han-Han Chang, Yi-Tse Hsiao, Fang-Chia Chan. TNF-NF-kappaB signaling mediates excessive somnolence in hemiparkinsonian rats. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20043954. |
our results indicated that microglial activation caused the loss of dopaminergic neurons in the substantia nigra, and the expression of tnf-alpha, but not il-1beta, increased in the midbrain and hypothalamus in mg-132-induced hemiparkinsonian rats. |
2010-05-25 |
2023-08-12 |
rat |
| Fabio Coppedè, Roberto Ceravolo, Francesca Migheli, Francesca Fanucchi, Daniela Frosini, Gabriele Siciliano, Ubaldo Bonuccelli, Lucia Miglior. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. Neuroscience letters. vol 473. issue 3. 2010-05-17. PMID:20193742. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders characterized by progressive and profound loss of dopaminergic neurons in the substantia nigra (sn) resulting in resting tremor, rigidity, bradykinesia, and postural instability. |
2010-05-17 |
2023-08-12 |
mouse |
| G Di Giovanni, V Di Matteo, E Esposit. Birth, life and death of dopaminergic neurons in the substantia nigra. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411763. |
birth, life and death of dopaminergic neurons in the substantia nigra. |
2010-05-14 |
2023-08-12 |
Not clear |
| H J Waldvogel, K Baer, R L M Faul. The localization of inhibitory neurotransmitter receptors on dopaminergic neurons of the human substantia nigra. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411768. |
the localization of inhibitory neurotransmitter receptors on dopaminergic neurons of the human substantia nigra. |
2010-05-14 |
2023-08-12 |
human |
| Ezia Guatteo, Maria Letizia Cucchiaroni, Nicola B Mercur. Substantia nigra control of basal ganglia nuclei. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411770. |
here we overview the electrophysiological properties of these substantia nigra neurons in the pars compacta and reticulata, together with their synaptic connections, and discuss the functional effects of dopaminergic and gabaergic inputs within the basal ganglia. |
2010-05-14 |
2023-08-12 |
Not clear |
| Oscar Arias-Carrión, Elizabeth Yamada, Nils Freundlieb, Miriam Djufri, Lukas Maurer, Guido Hermanns, Bastian Ipach, Wei-Hua Chiu, Corinna Steiner, Wolfgang H Oertel, Günter U Höglinge. Neurogenesis in substantia nigra of parkinsonian brains? Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411786. |
the clinical motor dysfunction in parkinson's disease is primarily the consequence of a progressive degeneration of dopaminergic neurons in the substantia nigra of the nigrostriatal pathway. |
2010-05-14 |
2023-08-12 |
Not clear |
| Oscar Arias-Carrión, Elizabeth Yamada, Nils Freundlieb, Miriam Djufri, Lukas Maurer, Guido Hermanns, Bastian Ipach, Wei-Hua Chiu, Corinna Steiner, Wolfgang H Oertel, Günter U Höglinge. Neurogenesis in substantia nigra of parkinsonian brains? Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411786. |
here, we review the published evidence of whether adult neurogenesis exists or not within the substantia nigra, where dopaminergic neurons are lost in parkinson's disease. |
2010-05-14 |
2023-08-12 |
Not clear |
| Xinxin Yang, Lu Song, Zhenguo Li. The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease. Neuroreport. vol 21. issue 4. 2010-05-05. PMID:20087233. |
tissue processing showed that rtms alleviated 6-ohda-induced loss of dopaminergic neurons in rat substantia nigra. |
2010-05-05 |
2023-08-12 |
rat |
| Hai-Jie Yang, Lei Wang, Yin-Yan Xia, Piek-Ngoh Chang, Zhi-Wei Fen. NF-kappaB mediates MPP+-induced apoptotic cell death in neuroblastoma cells SH-EP1 through JNK and c-Jun/AP-1. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19778565. |
parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in substantia nigra with unknown etiology. |
2010-05-04 |
2023-08-12 |
human |