| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonio J Herrera, Rocío M de Pablos, Eloisa Carreño-Müller, Ruth F Villarán, José L Venero, Mayka Tomás-Camardiel, Josefina Cano, Alberto Machad. The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18179476. |
when we studied the effects on substantia nigra, we found the disappearance of dopaminergic neurons, shown by loss of th immunoreactivity, loss of expression of th and dopamine transporter mrnas, and disappearance of fluorogold-labelled nigral neurons. |
2008-05-22 |
2023-08-12 |
rat |
| Florian Nagel, Björn H Falkenburger, Lars Tönges, Sebastian Kowsky, Charlotte Pöppelmeyer, Jörg B Schulz, Mathias Bähr, Gunnar P H Diet. Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18182047. |
tat-hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of parkinson's disease. |
2008-05-22 |
2023-08-12 |
Not clear |
| Florian Nagel, Björn H Falkenburger, Lars Tönges, Sebastian Kowsky, Charlotte Pöppelmeyer, Jörg B Schulz, Mathias Bähr, Gunnar P H Diet. Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18182047. |
parkinson's disease is characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2008-05-22 |
2023-08-12 |
Not clear |
| Tomoyo Hashimoto, Katsunori Nishi, Jun Nagasao, Sadatoshi Tsuji, Kiyomitsu Oyanag. Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons. Brain research. vol 1197. 2008-05-20. PMID:18242592. |
a study was conducted to clarify the effects of magnesium (mg) administration in a rat parkinson disease (pd) model involving culture of ventral mesencephalic-striatal cells with 1-methyl-4-phenylpyridinium (mpp+), based on recent evidence for significant loss of dopaminergic neurons exclusively in the substantia nigra of 1-year-old rats after exposure to low mg intake over generations [oyanagi, k., kawakami, e., kikuchi-horie, k., ohara, k., ogata, k., takahama, s., wada, m., kihira, t., yasui, m., 2006. |
2008-05-20 |
2023-08-12 |
rat |
| Tomoyo Hashimoto, Katsunori Nishi, Jun Nagasao, Sadatoshi Tsuji, Kiyomitsu Oyanag. Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons. Brain research. vol 1197. 2008-05-20. PMID:18242592. |
the results indicated that mg might protect dopaminergic neurons in the substantia nigra from degeneration. |
2008-05-20 |
2023-08-12 |
rat |
| Jan Gründemann, Falk Schlaudraff, Olga Haeckel, Birgit Lis. Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic acids research. vol 36. issue 7. 2008-05-19. PMID:18332041. |
elevated alpha-synuclein mrna levels in individual uv-laser-microdissected dopaminergic substantia nigra neurons in idiopathic parkinson's disease. |
2008-05-19 |
2023-08-12 |
human |
| Göran Bertilsson, Cesare Patrone, Olof Zachrisson, Annica Andersson, Karin Dannaeus, Jessica Heidrich, Jarkko Kortesmaa, Alex Mercer, Elisabet Nielsen, Harriet Rönnholm, Lilian Wikströ. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17803225. |
in conclusion, our results show that exendin-4 is able to promote adult neurogenesis in vitro and in vivo, normalize dopamine imbalance, and increase the number of cells positive for markers of dopaminergic neurons in the substantia nigra in a model of parkinson's disease. |
2008-05-13 |
2023-08-12 |
rat |
| Daniel Alvarez-Fischer, Carmen Henze, Corinna Strenzke, Jan Westrich, Boris Ferger, Günter U Höglinger, Wolfgang H Oertel, Andreas Hartman. Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053987. |
the aim of the present study was to characterize the time course of intra-striatal 6-ohda lesions in mice with regard to i) dopaminergic cell loss, ii) dopamine concentrations in the substantia nigra and the striatum, iii) hydroxylation products in substantia nigra and striatum and iv) behavioural impairment. |
2008-05-02 |
2023-08-12 |
mouse |
| Joaquim Vives, Piriya Sasajala, Kuo Hsuan Chang, Suling Zhao, Meng L. A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis (New York, N.Y. : 2000). vol 46. issue 3. 2008-05-01. PMID:18327786. |
the midbrain dopaminergic system, which consists of neurons of the substantia nigra and the ventral tegmental area, is a subject of intense interest, since the loss of neurons from the substantia nigra results in motor disorders characteristic of parkinson's disease. |
2008-05-01 |
2023-08-12 |
mouse |
| Joaquim Vives, Piriya Sasajala, Kuo Hsuan Chang, Suling Zhao, Meng L. A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis (New York, N.Y. : 2000). vol 46. issue 3. 2008-05-01. PMID:18327786. |
this approach permitted the visualisation of midbrain specific dopaminergic axonal tracts from both the substantia nigra and the ventral tegmental area in phenotypically normal heterozygous pitx3-taulacz brain tissues, either in situ or following culture in vitro, by a simple and sensitive beta-galactosidase enzyme reaction. |
2008-05-01 |
2023-08-12 |
mouse |
| Kaya Bork, Christoph Kannicht, Sabine Nöhring, Werner Reutter, Wenke Weidemann, Gerald W Hart, Rüdiger Horstkort. N-propanoylmannosamine interferes with O-GlcNAc modification of the tyrosine 3-monooxygenase and stimulates dopamine secretion. Journal of neuroscience research. vol 86. issue 3. 2008-04-28. PMID:17896794. |
the most consistent neurochemical abnormality in parkinson's disease is degeneration of dopaminergic neurons in the substantia nigra, leading to a reduction of striatal dopamine levels. |
2008-04-28 |
2023-08-12 |
Not clear |
| Balusamy Jagatha, Rajeswara Babu Mythri, Shireen Vali, M M Srinivas Bharat. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free radical biology & medicine. vol 44. issue 5. 2008-04-24. PMID:18166164. |
oxidative stress has been implicated in the degeneration of dopaminergic neurons in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2008-04-24 |
2023-08-12 |
mouse |
| Marcel M Daad. In vitro assays for neural stem cell differentiation: induction of dopaminergic phenotype. Methods in molecular biology (Clifton, N.J.). vol 438. 2008-04-17. PMID:18369760. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. |
2008-04-17 |
2023-08-12 |
Not clear |
| R Laguna Goya, P Tyers, R A Barke. The search for a curative cell therapy in Parkinson's disease. Journal of the neurological sciences. vol 265. issue 1-2. 2008-04-11. PMID:17936303. |
parkinson's disease (pd) is a neurodegenerative disorder, characterised by the progressive loss of dopaminergic neurons in the substantia nigra, and typically treated by dopamine replacement. |
2008-04-11 |
2023-08-12 |
human |
| Stefan Jean-Pierre Haas, Stanislav Petrov, Golo Kronenberg, Oliver Schmitt, Andreas Wre. Orthotopic transplantation of immortalized mesencephalic progenitors (CSM14.1 cells) into the substantia nigra of hemiparkinsonian rats induces neuronal differentiation and motoric improvement. Journal of anatomy. vol 212. issue 1. 2008-04-11. PMID:18036147. |
here we examined whether csm14.1 cells grafted bilaterally orthotopically in the substantia nigra of hemiparkinsonian rats have the potential to differentiate into dopaminergic neurons. |
2008-04-11 |
2023-08-12 |
rat |
| S Crotty, P Fitzgerald, E Tuohy, D M Harris, A Fisher, A Mandel, A E Bolton, A M Sullivan, Y Nola. Neuroprotective effects of novel phosphatidylglycerol-based phospholipids in the 6-hydroxydopamine model of Parkinson's disease. The European journal of neuroscience. vol 27. issue 2. 2008-04-08. PMID:18190522. |
immunocytochemical studies of the ipsilateral substantia nigra showed that vp025 significantly inhibited 6-ohda-induced loss of dopaminergic neurons. |
2008-04-08 |
2023-08-12 |
rat |
| Sohei Yoshida, Tameko Kihira, Yoshiro Yas. [Etiology of Kii ALS/PDC, featuring a mineral hypothesis]. Rinsho shinkeigaku = Clinical neurology. vol 47. issue 11. 2008-04-04. PMID:18210851. |
recently, a significant loss of dopaminergic neurons was identified exclusively in the substantia nigra in 1-year-old rat fed under a low mg intake over two generations. |
2008-04-04 |
2023-08-12 |
rat |
| Hyun-Jin Kim, Xiaotang Fan, Chiara Gabbi, Konstantin Yakimchuk, Paolo Parini, Margaret Warner, Jan-Ake Gustafsso. Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 6. 2008-03-31. PMID:18238900. |
administration of beta-sitosterol (42 mg/kg per day) for 3 weeks to 8-month-old male lxrbeta-/- mice resulted in the death of motor neurons in the lumbar region of the spinal cord and loss of tyrosine hydroxylase-positive dopaminergic neurons in the substantia nigra. |
2008-03-31 |
2023-08-12 |
mouse |
| S Vali, R B Mythri, B Jagatha, J Padiadpu, K S Ramanujan, J K Andersen, F Gorin, M M S Bharat. Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model. Neuroscience. vol 149. issue 4. 2008-03-28. PMID:17936517. |
oxidative/nitrosative stress and mitochondrial dysfunction have been implicated in the degeneration of dopaminergic neurons in the substantia nigra during parkinson's disease (pd). |
2008-03-28 |
2023-08-12 |
mouse |
| H Boecker, J Jankowski, P Ditter, L Schee. A role of the basal ganglia and midbrain nuclei for initiation of motor sequences. NeuroImage. vol 39. issue 3. 2008-03-25. PMID:18024158. |
involvement of the substantia nigra during planning, as shown here, indicates dopaminergic gating of motor sequences. |
2008-03-25 |
2023-08-12 |
human |