| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Moszczynska, Jumana Saleh, Hongyu Zhang, Brian Vukusic, Frank J S Lee, Fang Li. Parkin disrupts the alpha-synuclein/dopamine transporter interaction: consequences toward dopamine-induced toxicity. Journal of molecular neuroscience : MN. vol 32. issue 3. 2007-11-13. PMID:17873367. |
parkinson's disease is characterized by progressive neuronal degeneration of dopaminergic neurons in the substantia nigra. |
2007-11-13 |
2023-08-12 |
Not clear |
| J Eric Ahlsko. Beating a dead horse: dopamine and Parkinson disease. Neurology. vol 69. issue 17. 2007-11-13. PMID:17954785. |
third, the first neurons affected in pd are nondopaminergic; the substantia nigra and other dopaminergic nuclei are affected only later in the course. |
2007-11-13 |
2023-08-12 |
Not clear |
| Risa Sakai, Yoshifumi Irie, Takeshi Murata, Atsushi Ishige, Naoko Anjiki, Kenji Watanab. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Phytotherapy research : PTR. vol 21. issue 9. 2007-10-29. PMID:17486689. |
toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of mptp in mice. |
2007-10-29 |
2023-08-12 |
mouse |
| Risa Sakai, Yoshifumi Irie, Takeshi Murata, Atsushi Ishige, Naoko Anjiki, Kenji Watanab. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Phytotherapy research : PTR. vol 21. issue 9. 2007-10-29. PMID:17486689. |
parkinson's disease (pd) is a neurodegenerative disease of the brain characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-10-29 |
2023-08-12 |
mouse |
| Hong Jiang, Ning Song, Jun Wang, Li-Ying Ren, Jun-Xia Xi. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochemistry international. vol 51. issue 1. 2007-10-17. PMID:17490790. |
peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. |
2007-10-17 |
2023-08-12 |
rat |
| Hong Jiang, Ning Song, Jun Wang, Li-Ying Ren, Jun-Xia Xi. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochemistry international. vol 51. issue 1. 2007-10-17. PMID:17490790. |
to demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (sn), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (th) immunohistochemistry, perls' iron staining, and high performance liquid chromatography-electrochemical detection to study the degeneration of dopaminergic neurons and increased iron content in the sn of iron dextran overloaded animals. |
2007-10-17 |
2023-08-12 |
rat |
| D Skrzydelski, A Guyon, V Daugé, C Rovère, E Apartis, P Kitabgi, J L Nahon, W Rostène, S Mélik Parsadaniant. The chemokine stromal cell-derived factor-1/CXCL12 activates the nigrostriatal dopamine system. Journal of neurochemistry. vol 102. issue 4. 2007-10-04. PMID:17509088. |
we recently demonstrated that dopaminergic (da) neurons of the rat substantia nigra constitutively expressed cxcr4, receptor for the chemokine stromal cell-derived factor-1 (sdf-1)/cxcl12 (sdf-1). |
2007-10-04 |
2023-08-12 |
rat |
| Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, Helen Chapman, Menelas N Pangalos, Neil Upton, David J Virle. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498809. |
in addition, mptp-treated mice were detected to have a marked depletion in striatal dopamine levels and a concomitant reduction in substantia nigra (sn) tyrosine hydroxylase (th) immunoreactivity, at 7 days post-mptp administration, indicative of dopaminergic neuronal loss. |
2007-09-27 |
2023-08-12 |
mouse |
| Emmanuelle Lagrue, Sylvie Chalon, Sylvie Bodard, Elie Saliba, Pierre Gressens, Pierre Castelna. Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice. Pediatric research. vol 62. issue 1. 2007-09-26. PMID:17515828. |
altogether, the data indicate that lamotrigine limits dopaminergic neuronal death in the substantia nigra and promotes striatal dendrites sprouting. |
2007-09-26 |
2023-08-12 |
mouse |
| Alice Guyon, Jean-Louis Naho. Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity. Journal of molecular endocrinology. vol 38. issue 3. 2007-09-18. PMID:17339399. |
in various neuronal populations (ca1 neurons of the hippocampus, granular and purkinje cells of the cerebellum, melanin-concentrating hormone neurons of the lateral hypothalamus, vasopressinergic neurons of the supraoptic and the paraventricular nucleus of the hypothalamus, and dopaminergic neurons of the substantia nigra), sdf-1alpha can modulate the activity of neurons by multiple regulatory pathways including and often combining: (i) modulation of voltage-dependent channels (sodium, potassium, and calcium), (ii) activation of the g-protein-activated inward rectifier potassium current, and (iii) increase in neurotransmitter release (gamma-amino butyric acid (gaba), glutamate, and dopamine), often through ca-dependent mechanisms. |
2007-09-18 |
2023-08-12 |
Not clear |
| D R Deng, S Djalali, M Höltje, G Grosse, T Stroh, I Voigt, H Kusserow, F Theuring, G Ahnert-Hilger, H Hörtnag. Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants. Neuroscience. vol 147. issue 2. 2007-09-18. PMID:17543467. |
the initial differentiation of dopaminergic neurons and fibers in the substantia nigra at e12.5 was transiently delayed in ko and oe mice as compared with wt mice, but no abnormalities in noradrenergic development were apparent in later stages. |
2007-09-18 |
2023-08-12 |
mouse |
| Bing Xue, Jian Jiao, Lei Zhang, Kai-Rong Li, Yun-Tao Gong, Jun-Xia Xie, Xiao-Min Wan. Triptolide upregulates NGF synthesis in rat astrocyte cultures. Neurochemical research. vol 32. issue 7. 2007-09-17. PMID:17401680. |
triptolide (t10), an extract from the traditional chinese herb, tripterygium wilfordii hook f (twhf), has been shown to attenuate the rotational behavior induced by d: -amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of parkinson's disease. |
2007-09-17 |
2023-08-12 |
rat |
| Mehdi Gasmi, Eugene P Brandon, Christopher D Herzog, Alistair Wilson, Kathie M Bishop, Eva K Hofer, Justine J Cunningham, Marie A Printz, Jeffrey H Kordower, Raymond T Bartu. AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. Neurobiology of disease. vol 27. issue 1. 2007-09-06. PMID:17532642. |
neurturin (ntn) is a neurotrophic factor with known potential to protect and restore the function of dopaminergic substantia nigra neurons whose degeneration has been most closely linked to the major motor deficits in parkinson's disease (pd). |
2007-09-06 |
2023-08-12 |
human |
| Ariel A Di Nardo, Stéphane Nedelec, Alain Trembleau, Michel Volovitch, Alain Prochiantz, Maria Luz Montesino. Dendritic localization and activity-dependent translation of Engrailed1 transcription factor. Molecular and cellular neurosciences. vol 35. issue 2. 2007-08-31. PMID:17399993. |
engrailed1 (en1) is a homeoprotein transcription factor expressed throughout adulthood in several midbrain cells, including the dopaminergic neurons of the substantia nigra. |
2007-08-31 |
2023-08-12 |
Not clear |
| Chee Yeun Chung, James B Koprich, Shogo Endo, Ole Isacso. An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 31. 2007-08-28. PMID:17670978. |
in parkinson's disease, dopaminergic (da) neurons in the substantia nigra (sn) (a9) are particularly vulnerable, whereas adjacent da neurons within the ventral tegmental area (a10) are essentially spared. |
2007-08-28 |
2023-08-12 |
human |
| Päivi Lindholm, Merja H Voutilainen, Juha Laurén, Johan Peränen, Veli-Matti Leppänen, Jaan-Olle Andressoo, Maria Lindahl, Sanna Janhunen, Nisse Kalkkinen, Tõnis Timmusk, Raimo K Tuominen, Mart Saarm. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. vol 448. issue 7149. 2007-08-27. PMID:17611540. |
a single injection of cdnf before 6-ohda delivery into the striatum significantly reduced amphetamine-induced ipsilateral turning behaviour and almost completely rescued dopaminergic tyrosine-hydroxylase-positive cells in the substantia nigra. |
2007-08-27 |
2023-08-12 |
mouse |
| Päivi Lindholm, Merja H Voutilainen, Juha Laurén, Johan Peränen, Veli-Matti Leppänen, Jaan-Olle Andressoo, Maria Lindahl, Sanna Janhunen, Nisse Kalkkinen, Tõnis Timmusk, Raimo K Tuominen, Mart Saarm. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. vol 448. issue 7149. 2007-08-27. PMID:17611540. |
when administered four weeks after 6-ohda, intrastriatal injection of cdnf was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in substantia nigra. |
2007-08-27 |
2023-08-12 |
mouse |
| Tie-Shan Tang, Xi Chen, Jing Liu, Ilya Bezprozvann. Dopaminergic signaling and striatal neurodegeneration in Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652581. |
striatal msn neurons receive glutamatergic input from the cortex and dopaminergic input from the substantia nigra. |
2007-08-20 |
2023-08-12 |
mouse |
| Andreas Hald, Johan Van Beek, Julie Lothariu. Inflammation in Parkinson's disease: causative or epiphenomenal? Sub-cellular biochemistry. vol 42. 2007-08-06. PMID:17612055. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra (sn). |
2007-08-06 |
2023-08-12 |
human |
| Audrey Graham, Robert Walker, Pauline Baird, Caroline N Hahn, John K Fazakerle. CNS gene therapy applications of the Semliki Forest virus 1 vector are limited by neurotoxicity. Molecular therapy : the journal of the American Society of Gene Therapy. vol 13. issue 3. 2007-07-31. PMID:16423561. |
this system selectively and extensively mediated gene expression in dopaminergic neurons of the substantia nigra. |
2007-07-31 |
2023-08-12 |
mouse |