| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Günter U Höglinger, Joshua J Breunig, Candan Depboylu, Caroline Rouaux, Patrick P Michel, Daniel Alvarez-Fischer, Anne-Laurence Boutillier, James Degregori, Wolfgang H Oertel, Pasko Rakic, Etienne C Hirsch, Stéphane Huno. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 9. 2007-06-13. PMID:17360686. |
the mechanisms leading to degeneration of dopaminergic neurons (dns) in the substantia nigra of patients with parkinson's disease (pd) are not completely understood. |
2007-06-13 |
2023-08-12 |
mouse |
| Beata Jabłońska, Józefa Dabek, Tomasz Lepic. [Surgical treatment of Parkinson's disease as a supplement to pharmacological therapy]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 59. issue 11-12. 2007-06-12. PMID:17427499. |
parkinson's disease is the neurodegenerative disorder characterized by dopaminergic cell loss in the compact part of substantia nigra. |
2007-06-12 |
2023-08-12 |
Not clear |
| Hamid Mirzaei, Jeremy L Schieler, Jean-Christophe Rochet, Fred Regnie. Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry. Analytical chemistry. vol 78. issue 7. 2007-06-07. PMID:16579629. |
parkinson's disease is a movement disorder that results from a loss of dopaminergic neurons in the substantia nigra. |
2007-06-07 |
2023-08-12 |
human |
| Dae-Sung Kim, Ji Young Kim, Minkyung Kang, Myung Soo Cho, Dong-Wook Ki. Derivation of functional dopamine neurons from embryonic stem cells. Cell transplantation. vol 16. issue 2. 2007-05-30. PMID:17474293. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (da) neurons in the substantia nigra of the midbrain. |
2007-05-30 |
2023-08-12 |
human |
| P S Whitto. Inflammation as a causative factor in the aetiology of Parkinson's disease. British journal of pharmacology. vol 150. issue 8. 2007-05-24. PMID:17339843. |
given that dopaminergic neurons in the substantia nigra are relatively vulnerable to 'stress' and the region has a large population of microglia in comparison to other cns structures, these events may easily trigger neurodegeneration. |
2007-05-24 |
2023-08-12 |
human |
| H Koike, A Ishida, M Shimamura, S Mizuno, T Nakamura, T Ogihara, Y Kaneda, R Morishit. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease. Gene therapy. vol 13. issue 23. 2007-05-21. PMID:16791285. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sni). |
2007-05-21 |
2023-08-12 |
human |
| M Schirmer, J N Nobrega, S J Harrison, W Lösche. Alterations in dopamine D3 receptors in the circling (ci3) rat mutant. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17187934. |
consistent with this finding, immunohistological examination of dopaminergic neurons in substantia nigra and ventral tegmental area yielded a significant laterality in the medial part of substantia nigra pars compacta with a lower density of tyrosine hydroxylase-positive neurons in the contralateral hemisphere of mutant circling rats, while no laterality was seen in unaffected rats of the background strain. |
2007-05-21 |
2023-08-12 |
rat |
| G Morfini, G Pigino, K Opalach, Y Serulle, J E Moreira, M Sugimori, R R Llinás, S T Brad. 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 7. 2007-05-17. PMID:17287338. |
1-methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase c. parkinson's disease (pd), a late-onset condition characterized by dysfunction and loss of dopaminergic neurons in the substantia nigra, has both sporadic and neurotoxic forms. |
2007-05-17 |
2023-08-12 |
human |
| E Ch Wolter. PD-related psychosis: pathophysiology with therapeutical strategies. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447413. |
parkinson's disease (pd) is a chronic, neurodegenerative disease with degeneration of the central dopaminergic neurons in the substantia nigra, leading to a depletion of dopamine (da) in the striatum. |
2007-05-17 |
2023-08-12 |
Not clear |
| Daniela Ber. Marker for a preclinical diagnosis of Parkinson's disease as a basis for neuroprotection. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447423. |
however, more than 60% of the dopaminergic neurons of the substantia nigra have already degenerated, when the diagnosis may be established. |
2007-05-17 |
2023-08-12 |
human |
| E C Hirsc. Altered regulation of iron transport and storage in Parkinson's disease. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447430. |
parkinson's disease (pd) is characterized by the death of dopaminergic neurons in the substantia nigra. |
2007-05-17 |
2023-08-12 |
Not clear |
| E C Hirsc. Altered regulation of iron transport and storage in Parkinson's disease. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447430. |
the increased iron content may result from an increased iron penetration into the brain parenchyma due to a higher expression of lactoferrin and lactoferrin receptors at the level of the blood vessels and dopaminergic neurons in the substantia nigra in pd. |
2007-05-17 |
2023-08-12 |
Not clear |
| J Salazar, N Mena, M T Núñe. Iron dyshomeostasis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447431. |
the work of youdim and collaborators has been fundamental in describing the accumulation of iron confined to the substantia nigra (sn) in parkinson's disease (pd) and to clarify iron toxicity pathways and oxidative damage in dopaminergic neurons. |
2007-05-17 |
2023-08-12 |
Not clear |
| Wei-Guo Liu, Guo-Qiang Lu, Biao Li, Sheng-Di Che. Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease. Parkinsonism & related disorders. vol 13. issue 2. 2007-05-15. PMID:16963309. |
in addition, inverse transfer of ntn protein into the substantia nigra (sn) was able to protect dopaminergic neurons from 6-ohda toxicity. |
2007-05-15 |
2023-08-12 |
rat |
| Ji Man Han, Yong Jin Lee, So Yeon Lee, Eun Mee Kim, Younghye Moon, Ha Won Kim, Onyou Hwan. Protective effect of sulforaphane against dopaminergic cell death. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17259450. |
parkinson's disease (pd) is a progressive neurodegenerative disorder with a selective loss of dopaminergic neurons in the substantia nigra. |
2007-05-14 |
2023-08-12 |
Not clear |
| Rajeswara Babu Mythri, Balusamy Jagatha, Nityananda Pradhan, Julie Andersen, M M Srinivas Bharat. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxidants & redox signaling. vol 9. issue 3. 2007-05-10. PMID:17184173. |
selective damage of mitochondrial complex i within the dopaminergic neurons of the substantia nigra is the central event during parkinson disease. |
2007-05-10 |
2023-08-12 |
Not clear |
| Renee M Miller, Gretchen L Kiser, Tamma Kaysser-Kranich, Cindy Casaceli, Emanuela Colla, Michael K Lee, Chockalingham Palaniappan, Howard J Federof. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17254569. |
our study reveals gene dosage-dependent dysregulation of several genes important for the dopaminergic phenotype in mice over-expressing wild-type human alpha-synuclein in the substantia nigra at time points preceding neuronal cell death. |
2007-05-10 |
2023-08-12 |
mouse |
| Jessie L St Martin, Jochen Klucken, Tiago F Outeiro, Paul Nguyen, Christine Keller-McGandy, Ippolita Cantuti-Castelvetri, Tom N Grammatopoulos, David G Standaert, Bradley T Hyman, Pamela J McLea. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17241127. |
targeted over-expression of human alpha-synuclein using viral-vector mediated gene delivery into the substantia nigra of rats and non-human primates leads to dopaminergic cell loss and the formation of alpha-synuclein aggregates reminiscent of lewy bodies. |
2007-05-01 |
2023-08-12 |
mouse |
| Jessie L St Martin, Jochen Klucken, Tiago F Outeiro, Paul Nguyen, Christine Keller-McGandy, Ippolita Cantuti-Castelvetri, Tom N Grammatopoulos, David G Standaert, Bradley T Hyman, Pamela J McLea. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17241127. |
recombinant aav expressing alpha-synuclein was stereotaxically injected into the substantia nigra of mice, leading to a 25% reduction of dopaminergic neurons after 24 weeks of transduction. |
2007-05-01 |
2023-08-12 |
mouse |
| Makio Mogi, Tomoyoshi Kondo, Yoshikuni Mizuno, Toshiharu Nagats. p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain. Neuroscience letters. vol 414. issue 1. 2007-04-27. PMID:17196747. |
the interferon-gamma level was significantly higher in the nigrostriatal dopaminergic regions (substantia nigra, caudate nucleus, and putamen) in parkinsonian patients than in the controls (p<0.05), but was not significantly different in the cerebellum or frontal cortex between the two groups. |
2007-04-27 |
2023-08-12 |
human |