| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Bahn, S Siegert, T Pfander, M L Kramer, W J Schulz-Schaeffer, J W Hewett, X O Breakefield, J C Hedreen, K M Rostás. TorsinB expression in the developing human brain. Brain research. vol 1116. issue 1. 2006-12-12. PMID:16938275. |
expression of torsinb protein was detectable beginning at four to 8 weeks of age in the cerebellum (purkinje cells), substantia nigra (dopaminergic neurons), hippocampus and basal ganglia and was predominantly restricted to neuronal cells. |
2006-12-12 |
2023-08-12 |
human |
| Shankar J Chinta, Julie K Anderse. Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. Free radical biology & medicine. vol 41. issue 9. 2006-12-05. PMID:17023271. |
depletion in levels of the thiol reducing agent glutathione (gsh + gssg) is the earliest reported biochemical event to occur in the parkinsonian substantia nigra prior to selective loss of complex i (ci) activity associated with the disease believed to contribute to subsequent dopaminergic cell death. |
2006-12-05 |
2023-08-12 |
Not clear |
| L M Epp, B Mrave. Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease. Bratislavske lekarske listy. vol 107. issue 6-7. 2006-12-05. PMID:17051898. |
chronically elevated levels of acetaldehyde in patients with cpc might participate in the formation of salsolinol and its metabolites in the brain contributing to the destruction of dopaminergic cells in substantia nigra. |
2006-12-05 |
2023-08-12 |
Not clear |
| Paola Sgadò, Lavinia Albéri, Daniel Gherbassi, Sherri L Galasso, Geert M J Ramakers, Kambiz N Alavian, Marten P Smidt, Richard H Dyck, Horst H Simo. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 41. 2006-11-28. PMID:17015829. |
specifically, postnatal mutant mice exhibit a progressive degeneration of dopaminergic neurons in the substantia nigra during the first 3 mo of their lives, leading to diminished storage and release of dopamine in the caudate putamen, motor deficits similar to akinesia and bradykinesia, and a lower body weight. |
2006-11-28 |
2023-08-12 |
mouse |
| Qian Jiang, Zhen Yan, Jian Fen. Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16887804. |
parkinson disease is characterized by the selective degeneration of dopaminergic (da) neurons in substantia nigra. |
2006-11-27 |
2023-08-12 |
rat |
| Zhiming Zhang, Anders H Andersen, Yi Ai, Aaron Loveland, Peter A Hardy, Greg A Gerhardt, Don M Gas. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. NeuroImage. vol 33. issue 2. 2006-11-21. PMID:16949305. |
the primary findings were (1) the putamen and substantia nigra (sn) but not the caudate nucleus displayed significant bold responses to these dopaminergic drugs; (2) a significant relationship was found between amphetamine-evoked activation and the number of surviving dopamine neurons in the sn, which was also correlated with bradykinesia; and (3) inverse relationships were seen in response to apomorphine and amphetamine stimulation between the mptp-lesioned and unlesioned putamen and sn. |
2006-11-21 |
2023-08-12 |
monkey |
| Heather L Melrose, Sarah J Lincoln, Glenn M Tyndall, Matthew J Farre. Parkinson's disease: a rethink of rodent models. Experimental brain research. vol 173. issue 2. 2006-11-07. PMID:16639500. |
rodent models of parkinsonism aim to reproduce key pathogenic features of the syndrome including movement disorder induced by the progressive loss of dopaminergic neurons in the substantia nigra, accompanied by the formation of alpha-synuclein containing lewy body inclusions. |
2006-11-07 |
2023-08-12 |
Not clear |
| Yong-Ri Ren, Yoichiro Nishida, Kenji Yoshimi, Toru Yasuda, Kou-Ichi Jishage, Toshiki Uchihara, Takanori Yokota, Yoshikuni Mizuno, Hideki Mochizuk. Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain. Journal of neurochemistry. vol 98. issue 6. 2006-11-07. PMID:16787402. |
furthermore, the extent of loss of dopaminergic cell bodies in the substantia nigra did not differ among the groups. |
2006-11-07 |
2023-08-12 |
mouse |
| Maryka Quik, Neeraja Parameswaran, Sarah E McCallum, Tanuja Bordia, Shanshan Bao, Alison McCormack, Amy Kim, Rachel F Tyndale, J William Langston, Donato A Di Mont. Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates. Journal of neurochemistry. vol 98. issue 6. 2006-11-07. PMID:16882311. |
mptp-induced cell loss in the substantia nigra was unaffected by nicotine treatment, indicating that nicotine acts at the striatal level to restore/maintain dopaminergic function. |
2006-11-07 |
2023-08-12 |
monkey |
| Ana Saavedra, Graça Baltazar, Paulo Santos, Caetana M Carvalho, Emília P Duart. Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk. Neurobiology of disease. vol 23. issue 3. 2006-11-01. PMID:16766196. |
selective injury to dopaminergic neurons up-regulates gdnf in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk. |
2006-11-01 |
2023-08-12 |
Not clear |
| Ana Saavedra, Graça Baltazar, Paulo Santos, Caetana M Carvalho, Emília P Duart. Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk. Neurobiology of disease. vol 23. issue 3. 2006-11-01. PMID:16766196. |
the effect of selective injury to dopaminergic neurons on the expression of glial cell line-derived neurotrophic factor (gdnf) was examined in substantia nigra cell cultures. |
2006-11-01 |
2023-08-12 |
Not clear |
| Antti J Väänänen, Pekka Rauhala, Raimo K Tuominen, Päivi Lies. KDI tripeptide of gamma1 laminin protects rat dopaminergic neurons from 6-OHDA induced toxicity. Journal of neuroscience research. vol 84. issue 3. 2006-11-01. PMID:16810683. |
we found that a single unilateral injection of the kdi tripeptide into the substantia nigra before an injection of 6-ohda protected the dopaminergic neurons from the neurotoxicity of 6-ohda. |
2006-11-01 |
2023-08-12 |
rat |
| Antti J Väänänen, Pekka Rauhala, Raimo K Tuominen, Päivi Lies. KDI tripeptide of gamma1 laminin protects rat dopaminergic neurons from 6-OHDA induced toxicity. Journal of neuroscience research. vol 84. issue 3. 2006-11-01. PMID:16810683. |
compared to rats treated with 6-ohda alone, the kdi + 6-ohda-treated substantia nigra was relatively intact with large numbers of dopaminergic neurons present at the injection side. |
2006-11-01 |
2023-08-12 |
rat |
| Antti J Väänänen, Pekka Rauhala, Raimo K Tuominen, Päivi Lies. KDI tripeptide of gamma1 laminin protects rat dopaminergic neurons from 6-OHDA induced toxicity. Journal of neuroscience research. vol 84. issue 3. 2006-11-01. PMID:16810683. |
quantification of the rescue effect of the kdi tripeptide indicated that, in animals receiving kdi before 6-ohda, 33% of tyrosine hydroxylase-positive dopaminergic neurons of the substantia nigra were present as compared to the contralateral non-injected side. |
2006-11-01 |
2023-08-12 |
rat |
| Alessandro Martorana, Carmela Giampà, Zena DeMarch, Maria Teresa Viscomi, Stefano Patassini, Giuseppe Sancesario, Giorgio Bernardi, Francesca R Fusc. Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930403. |
the expression, at mrna level, of several trpcs has been demonstrated recently in dopaminergic neurons of the substantia nigra (sn). |
2006-11-01 |
2023-08-12 |
rat |
| Keith Chiasson, Benoît Daoust, Daniel Levesque, Maria-Grazia Martinol. Dopamine D2 agonists, bromocriptine and quinpirole, increase MPP+ -induced toxicity in PC12 cells. Neurotoxicity research. vol 10. issue 1. 2006-10-31. PMID:17000468. |
dopaminergic cell loss in the mesencephalic substantia nigra is the hallmark of parkinson's disease and may be associated with abnormal oxidative metabolic activity. |
2006-10-31 |
2023-08-12 |
Not clear |
| Ubaldo Bonuccelli, Paolo Del Dott. New pharmacologic horizons in the treatment of Parkinson disease. Neurology. vol 67. issue 7 Suppl 2. 2006-10-30. PMID:17030738. |
many of the motoric features that define parkinson's disease (pd) result primarily from the loss of dopaminergic neurons of the substantia nigra. |
2006-10-30 |
2023-08-12 |
Not clear |
| L Zecca, F A Zucca, A Albertini, E Rizzio, R G Fariell. A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology. vol 67. issue 7 Suppl 2. 2006-10-30. PMID:17030740. |
in many parkinsonian syndromes, neuromelanin (nm)-containing dopaminergic neurons of the substantia nigra (sn) are selectively targeted by the noxius pathogens. |
2006-10-30 |
2023-08-12 |
human |
| D Ruano, E Revilla, M Paz Gavilán, M L Vizuete, C Pintado, J Vitorica, A Castañ. Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection. Neuroscience. vol 140. issue 4. 2006-10-26. PMID:16713109. |
co-injections of lipopolysaccharide with sb203580, a p38 map kinase inhibitor, reduced inducible nitric oxide synthase and caspase-11 mrna expression, and also rescued dopaminergic neurons in substantia nigra. |
2006-10-26 |
2023-08-12 |
Not clear |
| D Ruano, E Revilla, M Paz Gavilán, M L Vizuete, C Pintado, J Vitorica, A Castañ. Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection. Neuroscience. vol 140. issue 4. 2006-10-26. PMID:16713109. |
moreover data strongly support that lipopolysaccharide-induced dopaminergic cellular death in substantia nigra could be mediated, at least in part, by the p38 signal pathway leading to activation of inducible nitric oxide synthase and caspase-11. |
2006-10-26 |
2023-08-12 |
Not clear |