| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Muñoz, Pablo Rey, Maria J Guerra, Estefania Mendez-Alvarez, Ramon Soto-Otero, Jose L Labandeira-Garci. Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology. vol 51. issue 1. 2006-09-11. PMID:16678218. |
pre-treatment with captopril induced a significant reduction in the mptp-induced loss of dopaminergic neurons in the substantia nigra and a significant reduction in the loss of dopaminergic terminals in the striatum. |
2006-09-11 |
2023-08-12 |
mouse |
| Aideen M Sullivan, Gerard W O'Keeff. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment. Journal of anatomy. vol 207. issue 3. 2006-08-21. PMID:16185246. |
gdf5 is under investigation as a potential therapeutic agent for parkinson's disease (pd), which is caused by the progressive degeneration of dopaminergic neurones projecting from the substantia nigra (sn) to the striatum. |
2006-08-21 |
2023-08-12 |
rat |
| Katsura Takano, Yasuko Kitao, Reiko Inagi, Takashi Momoi, Tomohiro Matsuyama, Toshio Miyata, Yukio Yoneda, Hiroyuki Iso, David M Stern, Osamu Hori, Satoshi Ogaw. A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies). Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16782060. |
enhanced er stress was also observed in dopaminergic neurons in the substantia nigra, in parallel with decreased neuronal viability and motor coordination. |
2006-08-21 |
2023-08-12 |
human |
| Hiroshi Yamashita, Takeshi Nakamura, Tetsuya Takahashi, Yoshito Nagano, Masanori Hiji, Takahiro Hirabayashi, Taku Amano, Takeshi Yagi, Norio Sakai, Tatsuo Kohriyama, Masayasu Matsumot. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death. Journal of neurochemistry. vol 98. issue 1. 2006-08-16. PMID:16805795. |
the es cell-derived dopaminergic neurons expressing wild-type or mutant alpha-synuclein exhibited the fundamental characteristics consistent with dopaminergic neurons in the substantia nigra. |
2006-08-16 |
2023-08-12 |
mouse |
| Janelle M Silvers, Michael Y Aksenov, Marina V Aksenova, Jacob Beckley, Petra Olton, Charles F Mactutus, Rosemarie M Booz. Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains. Journal of neurovirology. vol 12. issue 2. 2006-08-11. PMID:16798675. |
dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains. |
2006-08-11 |
2023-08-12 |
human |
| Xuhong Liu, Kelly A Sullivan, James E Madl, Marie Legare, Ronald B Tjalken. Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration. Toxicological sciences : an official journal of the Society of Toxicology. vol 91. issue 2. 2006-08-09. PMID:16551646. |
in contrast, soma and terminals of dopaminergic neurons were morphologically unaltered in either the substantia nigra or striatum, as indicated by immunohistochemical staining for tyrosine hydroxylase. |
2006-08-09 |
2023-08-12 |
mouse |
| S Dey, C F Mactutus, R M Booze, D M Sno. Specificity of prenatal cocaine on inhibition of locus coeruleus neurite outgrowth. Neuroscience. vol 139. issue 3. 2006-08-03. PMID:16483722. |
the present study performed in vitro addressed the specificity of the inhibitory effects of cocaine by comparing locus coeruleus neurite formation and extension to that of dopaminergic substantia nigra neurons following exposure to a physiologically-relevant dose of cocaine (500 ng/ml, two times a day, for four days) during peak neuritogenesis. |
2006-08-03 |
2023-08-12 |
rat |
| H Melrose, S Lincoln, G Tyndall, D Dickson, M Farre. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience. vol 139. issue 3. 2006-08-03. PMID:16504409. |
we find lrrk2 is highly expressed in the striatum, cortex and olfactory tubercle; however, little or no expression is found in the substantia nigra, where dopaminergic neurons preferentially degenerate in parkinson's disease. |
2006-08-03 |
2023-08-12 |
mouse |
| John F Bowyer, Larry C Schmue. Fluoro-Ruby labeling prior to an amphetamine neurotoxic insult shows a definitive massive loss of dopaminergic terminals and axons in the caudate-putamen. Brain research. vol 1075. issue 1. 2006-07-31. PMID:16458862. |
fluoro-ruby (fr) was injected into the substantia nigra (snc) to label dopaminergic axons and terminals in the caudate putamen (cpu) of rats 7 days prior to a neurotoxic d-amphetamine (amph) exposure. |
2006-07-31 |
2023-08-12 |
rat |
| Ira E Clark, Mark W Dodson, Changan Jiang, Joseph H Cao, Jun R Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A Hay, Ming Gu. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. vol 441. issue 7097. 2006-07-31. PMID:16672981. |
parkinson's disease is the second most common neurodegenerative disorder and is characterized by the degeneration of dopaminergic neurons in the substantia nigra. |
2006-07-31 |
2023-08-12 |
human |
| R K Chaturvedi, S Shukla, K Seth, S Chauhan, C Sinha, Y Shukla, A K Agrawa. Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Neurobiology of disease. vol 22. issue 2. 2006-07-25. PMID:16480889. |
bte treatment, either before or after 6-ohda administration protected the dopaminergic neurons, as evident by significantly higher number of surviving tyrosine hydroxylase immunoreactive (th-ir) neurons, increased th protein level and th mrna expression in substantia nigra. |
2006-07-25 |
2023-08-12 |
rat |
| Theo Hatzipetros, Bryan K Yamamot. Dopaminergic and GABAergic modulation of glutamate release from rat subthalamic nucleus efferents to the substantia nigra. Brain research. vol 1076. issue 1. 2006-07-25. PMID:16680828. |
dopaminergic and gabaergic modulation of glutamate release from rat subthalamic nucleus efferents to the substantia nigra. |
2006-07-25 |
2023-08-12 |
rat |
| Sara González, Camila Scorticati, Moisés García-Arencibia, Rosario de Miguel, José A Ramos, Javier Fernández-Rui. Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. Brain research. vol 1073-1074. 2006-07-19. PMID:16412990. |
dose-response studies with 6-hydroxydopamine revealed that the application of 200 microg per animal caused hypokinetic signs (decreased ambulatory activity, increased inactivity, and reduced motor coordination), which paralleled several signs of degeneration of nigrostriatal dopaminergic neurons (dopamine depletion in the caudate-putamen, and decreased mrna levels for tyrosine hydroxylase and superoxide dismutase-1 and -2 in the substantia nigra). |
2006-07-19 |
2023-08-12 |
rat |
| Yongquan Luo, Catherine Schwartz, Soojung Shin, Xianmin Zeng, Nong Chen, Yue Wang, Xiang Yu, Mahendra S Ra. A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells. Stem cells (Dayton, Ohio). vol 24. issue 4. 2006-06-30. PMID:16357341. |
using human adult brain substantia nigra, human embryonic stem cells (escs), and the differentiated progeny of pluripotent cells, we showed that this array was capable of distinguishing dopaminergic neurons, glial cells, and pluripotent cells by their gene expression profiles in a concentration-dependent manner. |
2006-06-30 |
2023-08-12 |
human |
| Patrick P Michel, Merle Ruberg, Etienne Hirsc. Dopaminergic neurons reduced to silence by oxidative stress: an early step in the death cascade in Parkinson's disease? Science's STKE : signal transduction knowledge environment. vol 2006. issue 332. 2006-06-30. PMID:16639033. |
the most important pathological feature of the disease is the death of brainstem dopaminergic neurons in the substantia nigra, which leads to characteristic motor symptoms. |
2006-06-30 |
2023-08-12 |
Not clear |
| Hee Soon Choi, Sun Hwa Lee, So Young Kim, Jae Jin An, Seok Il Hwang, Dae Won Kim, Ki Yeon Yoo, Moo Ho Won, Tae Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung Woo Cho, Oh Shin Kwon, Jin Hi Choi, Jinseu Park, Won Sik Eum, Soo Young Cho. Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo. Journal of biochemistry and molecular biology. vol 39. issue 3. 2006-06-30. PMID:16756753. |
parkinson's disease (pd) is a common neurodegenerative disorder and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2006-06-30 |
2023-08-12 |
mouse |
| Kiyomitsu Oyanagi, Emiko Kawakami, Kae Kikuchi-Horie, Kazuhiko Ohara, Kentaro Ogata, Sachiko Takahama, Manabu Wada, Tameko Kihira, Masayuki Yasu. Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 26. issue 2. 2006-06-23. PMID:16708544. |
significant loss of dopaminergic neurons was identified exclusively in the substantia nigra in 1-year-old rats that had been exposed continuously to low mg intake (one-fifth of the normal level) over generations. |
2006-06-23 |
2023-08-12 |
human |
| Katrin Meuer, Claudia Pitzer, Peter Teismann, Carola Krüger, Bettina Göricke, Rico Laage, Paul Lingor, Kerstin Peters, Johannes C M Schlachetzki, Kazuto Kobayashi, Gunnar P H Dietz, Daniela Weber, Boris Ferger, Wolf-Rüdiger Schäbitz, Alfred Bach, Jörg B Schulz, Mathias Bähr, Armin Schneider, Jochen H Weishaup. Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16573658. |
here, we report that the g-csf receptor is expressed in rodent dopaminergic substantia nigra neurons, suggesting that g-csf might be neuroprotective for dopaminergic neurons and a candidate molecule for the treatment of parkinson's disease. |
2006-06-22 |
2023-08-12 |
mouse |
| Katrin Meuer, Claudia Pitzer, Peter Teismann, Carola Krüger, Bettina Göricke, Rico Laage, Paul Lingor, Kerstin Peters, Johannes C M Schlachetzki, Kazuto Kobayashi, Gunnar P H Dietz, Daniela Weber, Boris Ferger, Wolf-Rüdiger Schäbitz, Alfred Bach, Jörg B Schulz, Mathias Bähr, Armin Schneider, Jochen H Weishaup. Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16573658. |
moreover, subcutaneous application of g-csf at a dose of 40 microg/kg body weight daily over 13 days rescued dopaminergic substantia nigra neurons from mptp-induced death in aged mice, as shown by quantification of tyrosine hydroxylase-positive substantia nigra cells. |
2006-06-22 |
2023-08-12 |
mouse |
| Vanessa A Fitsanakis, Catherine Au, Keith M Erikson, Michael Aschne. The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochemistry international. vol 48. issue 6-7. 2006-06-09. PMID:16513220. |
the initial symptoms of manganism are likely due to the involvement of the globus pallidus, a region rich in gamma-aminobutyric acid (gaba) projections, while those of parkinson's disease are related to the degeneration of the substantia nigra, a dopaminergic nucleus. |
2006-06-09 |
2023-08-12 |
Not clear |