| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Ma, Yan-chun Wang, Shui-yong Ga. [Effects of electroacupuncture on behaviors and dopaminergic neurons in the rat of Parkinson's disease]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 26. issue 9. 2006-10-26. PMID:17036487. |
to explore the possibility of electroacupuncture (ea) for prevention of the injury of dopaminergic neurons in the substantia nigra of the rat with parkinson's disease. |
2006-10-26 |
2023-08-12 |
rat |
| K L Double, G M Hallida. New face of neuromelanin. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017518. |
the massive, early and relatively circumscribed death of the dopaminergic neurons of the substantia nigra in parkinson's disease has not yet been adequately explained. |
2006-10-24 |
2023-08-12 |
Not clear |
| K L Double, G M Hallida. New face of neuromelanin. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017518. |
the available data suggest that the melaninisation of the dopaminergic neurons of the substantia nigra is a critical factor to explain the vulnerability of this brain region to early and massive degeneration in parkinson's disease. |
2006-10-24 |
2023-08-12 |
Not clear |
| G U Höglinger, W H Oertel, E C Hirsc. The rotenone model of parkinsonism--the five years inspection. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017540. |
the published data suggest that the model does not ideally reproduce the pathophysiology of parkinson's disease, that rotenone treatment does not cause a purely neurodegenerative concondition, that the rotenone model does not ideally recapitulate the motor symptoms of parkinson's disease, that degeneration of the dopaminergic neurons is highly variable, that striatal neurons appear to degenerate more consistently than neurons in the substantia nigra, and that cytoplasmic accumulation of the tau protein is more abundant than alpha-synuclein aggregation in severely lesioned animals. |
2006-10-24 |
2023-08-12 |
rat |
| M J Zigmon. Triggering endogenous neuroprotective mechanisms in Parkinson's disease: studies with a cellular model. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017565. |
we have now shown that gdnf can also protect against the effects of 6-hydroxydopamine (6-ohda) in a dopaminergic cell line and in cultures of primary da neurons prepared from rat substantia nigra (sn). |
2006-10-24 |
2023-08-12 |
rat |
| J B Schul. Anti-apoptotic gene therapy in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017569. |
apoptosis, whether caspase-dependent or caspase-independent, has been implicated as one of the important mechanisms leading to the death of dopaminergic neurons in the substantia nigra of parkinson's disease patients. |
2006-10-24 |
2023-08-12 |
mouse |
| Christian Pifl, Oleh Hornykiewic. Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys. Neurochemistry international. vol 49. issue 5. 2006-10-18. PMID:16698121. |
in parkinson's disease (pd) and experimental parkinsonism, losses of up to 60% and 80%, respectively, of dopaminergic neurons in substantia nigra, and dopamine (da) in striatum remain asymptomatic. |
2006-10-18 |
2023-08-12 |
monkey |
| Przemysław Nowak, Łukasz Labus, Richard M Kostrzewa, Ryszard Bru. DSP-4 prevents dopamine receptor priming by quinpirole. Pharmacology, biochemistry, and behavior. vol 84. issue 1. 2006-10-02. PMID:16675001. |
because 1) dopaminergic neurons originate in midbrain nuclei (substantia nigra and ventral tegmental area), and 2) noradrenergic neurons originate in pontine (locus coeruleus) and medullary areas, it might be presumed that these two monoaminergic systems are independent, not interdependent. |
2006-10-02 |
2023-08-12 |
rat |
| Ulrike Rölleke, Gabriele Flügge, Stephanie Plehm, Christina Schlumbohm, Victor William Armstrong, Ralf Dressel, Barbara Uchanska-Ziegler, Andreas Ziegler, Eberhard Fuchs, Boldizsár Czéh, Lutz Walte. Differential expression of major histocompatibility complex class I molecules in the brain of a New World monkey, the common marmoset (Callithrix jacchus). Journal of neuroimmunology. vol 176. issue 1-2. 2006-09-29. PMID:16750573. |
in-situ hybridization with emulsion autoradiography demonstrated mhc class i mrna in distinct pyramidal neurons of cortex and hippocampus, in granule neurons of the dentate gyrus, in dopaminergic neurons of substantia nigra and in motor neurons of nucleus ruber. |
2006-09-29 |
2023-08-12 |
monkey |
| Satoshi Ohashi, Atsushi Mori, Naoki Kurihara, Yasuhide Mitsumoto, Masami Naka. Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16581184. |
an extensive dopaminergic cell loss was found in both the striatum and substantia nigra of older mice given one and two injections of mptp with marked decrease in striatal dopamine (da) levels, but not young mice. |
2006-09-28 |
2023-08-12 |
mouse |
| Claire E Heise, Zui Chih Teo, Bradley A Wallace, Keyoumars Ashkan, Alim-Louis Benabid, John Mitrofani. Cell survival patterns in the pedunculopontine tegmental nucleus of methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys and 6OHDA-lesioned rats: evidence for differences to idiopathic Parkinson disease patients? Anatomy and embryology. vol 210. issue 4. 2006-09-27. PMID:16237536. |
although there have been many studies documenting the loss of dopaminergic cells from the substantia nigra in these animal models, there has been little, if any, documentation of a loss of cells in the ppt. |
2006-09-27 |
2023-08-12 |
rat |
| Shigeki Arawaka, Manabu Wada, Saori Goto, Hiroki Karube, Masahiro Sakamoto, Chang-Hong Ren, Shingo Koyama, Hikaru Nagasawa, Hideki Kimura, Toru Kawanami, Keiji Kurita, Katsushi Tajima, Makoto Daimon, Masanori Baba, Takashi Kido, Sachiko Saino, Kaoru Goto, Hironobu Asao, Chihumi Kitanaka, Emi Takashita, Seiji Hongo, Takao Nakamura, Takamasa Kayama, Yoshihiro Suzuki, Kazuo Kobayashi, Tadashi Katagiri, Katsuro Kurokawa, Masayuki Kurimura, Itaru Toyoshima, Kazuhiro Niizato, Kuniaki Tsuchiya, Takeshi Iwatsubo, Masaaki Muramatsu, Hiroto Matsumine, Takeo Kat. The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 36. 2006-09-26. PMID:16957079. |
sporadic parkinson's disease (spd) is a common neurodegenerative disorder, characterized by selective degeneration of dopaminergic neurons in the substantia nigra. |
2006-09-26 |
2023-08-12 |
Not clear |
| b' S O Talanov, V F Sahach, M M Oleshko, V O Ma\\xc4\\xads\'ky\\xc4\\xa. [Inhibitors of mitochondrial permeability transition pore prevent apoptosis of dopaminergic neurons in the mesencephalon]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 52. issue 4. 2006-09-26. PMID:16958211.' |
in the study the role of apoptosis in development of dopaminergic neuronal cell death within substantia nigra (parts compacta) and ventral tegmental area induced by 6-ohda was investigated. |
2006-09-26 |
2023-08-12 |
Not clear |
| D Reglódi, A Tamás, I Lengvári, G Toth, L Szalontay, A Lubic. Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease. Annals of the New York Academy of Sciences. vol 1070. 2006-09-25. PMID:16888218. |
we have previously shown that pacap ameliorates the neurological symptoms and reduces the dopaminergic cell loss in young male rats, in a 6-hydroxydopamine (6-ohda)-induced lesion of the substantia nigra, a model of parkinson's disease. |
2006-09-25 |
2023-08-12 |
rat |
| Evelyn Braungart, Manfred Gerlach, Peter Riederer, Ralf Baumeister, Marius C Hoene. Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings. Neuro-degenerative diseases. vol 1. issue 4-5. 2006-09-20. PMID:16908987. |
the neurotoxin mptp and its active metabolite mpp+ cause parkinson's disease (pd)-like symptoms in vertebrates by selectively destroying dopaminergic neurons in the substantia nigra. |
2006-09-20 |
2023-08-12 |
caenorhabditis_elegans |
| Ikuko Mizuta, Wataru Satake, Yuko Nakabayashi, Chiyomi Ito, Satoko Suzuki, Yoshio Momose, Yoshitaka Nagai, Akira Oka, Hidetoshi Inoko, Jiro Fukae, Yuko Saito, Motoji Sawabe, Shigeo Murayama, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Tatsushi Tod. Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Human molecular genetics. vol 15. issue 7. 2006-09-19. PMID:16500997. |
parkinson's disease (pd), one of the most common human neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2006-09-19 |
2023-08-12 |
human |
| B Scholtissen, F R J Verhey, H W M Steinbusch, A F G Leentjen. Serotonergic mechanisms in Parkinson's disease: opposing results from preclinical and clinical data. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 1. 2006-09-15. PMID:16252066. |
the classical triad of symptoms, tremor, rigidity, and bradykinesia is mainly caused by degeneration of dopaminergic neurons from the substantia nigra. |
2006-09-15 |
2023-08-12 |
human |
| Luciana Mosca, Eugenio Lendaro, Maria d'Erme, Sonia Marcellini, Sonia Moretti, Maria Anna Rose. 5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y. Neurochemistry international. vol 49. issue 3. 2006-09-15. PMID:16549224. |
in recent years a catechol-thioether metabolite of dopamine, 5-s-cysteinyl-dopamine, has been identified in certain dopaminergic regions of the brain, notably the substantia nigra. |
2006-09-15 |
2023-08-12 |
human |
| Bai-Yun Zeng, Salma Bukhatwa, Atsuko Hikima, Sarah Rose, Peter Jenne. Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats. Annals of neurology. vol 60. issue 2. 2006-09-15. PMID:16862581. |
dopaminergic cell death was accompanied by the appearance of ubiquitin and alpha-synuclein-positive inclusions in the substantia nigra in these rats. |
2006-09-15 |
2023-08-12 |
rat |
| Cristina M Bäckman, Lufei Shan, Ya Jun Zhang, Barry J Hoffer, Sherry Leonard, Juan C Troncoso, Paul Vonsatel, Andreas C Toma. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Molecular and cellular endocrinology. vol 252. issue 1-2. 2006-09-12. PMID:16644101. |
these data suggest that the extensive loss of dopaminergic neurons in the substantia nigra, and concomitant loss of striatal dopamine, may induce compensatory changes in the expression of target derived gdnf, but not its receptor system. |
2006-09-12 |
2023-08-12 |
human |