| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Timmer, Konstantin Cesnulevicius, Christian Winkler, Julia Kolb, Esther Lipokatic-Takacs, Julia Jungnickel, Claudia Groth. Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 3. 2007-02-06. PMID:17234579. |
fibroblast growth factor (fgf)-2 and fgf receptor 3 are required for the development of the substantia nigra, and fgf-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. |
2007-02-06 |
2023-08-12 |
mouse |
| Javorina Milosevic, Martina Maisel, Florian Wegner, Julia Leuchtenberger, Roland H Wenger, Manfred Gerlach, Alexander Storch, Johannes Schwar. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215402. |
in substantia nigra (sn) of adult hif-1alpha cko mice, protein levels of dopaminergic marker molecules such as tyrosine hydroxylase (th) and aldehyde dehydrogenase were reduced by 41 and 61%, respectively. |
2007-02-02 |
2023-08-12 |
mouse |
| James E Galvi. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16791599. |
major disease symptoms are due to the loss of dopaminergic (da) neurons in substantia nigra (sn). |
2007-02-01 |
2023-08-12 |
mouse |
| Elena Gonzalez-Rey, Alejo Chorny, Amelia Fernandez-Martin, Nieves Varela, Mario Delgad. Vasoactive intestinal peptide family as a therapeutic target for Parkinson's disease. Expert opinion on therapeutic targets. vol 9. issue 5. 2007-01-25. PMID:16185148. |
parkinson's disease (pd) is a common neurodegenerative disorder with no effective protective treatment, characterised by a massive degeneration of dopaminergic neurons in the substantia nigra and the subsequent loss of their projecting nerve fibres in the striatum. |
2007-01-25 |
2023-08-12 |
Not clear |
| Stavros J Baloyannis, Vassiliki Costa, Ioannis S Baloyanni. Morphological alterations of the synapses in the locus coeruleus in Parkinson's disease. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16753180. |
from the morphological point of view it is characterized by the degeneration of a substantial number of dopaminergic neurons of the substantia nigra and a considerable degeneration of neuronal networks in locus coeruleus, putamen, globus pallidus, thalamus and some areas of the cortex of the brain hemispheres. |
2007-01-23 |
2023-08-12 |
Not clear |
| B B Kelly, E Hedlund, C Kim, H Ishiguro, O Isacson, D M Chikaraishi, K-S Kim, G Fen. A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. Neuroscience. vol 142. issue 2. 2007-01-23. PMID:16876957. |
degeneration of the dopaminergic neurons of the substantia nigra is a hallmark of parkinson's disease. |
2007-01-23 |
2023-08-12 |
mouse |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
parkinson's disease (pd) is characterised by the loss of dopaminergic neurones in the substantia nigra (sn) but the pathogenic mechanism remains unknown. |
2007-01-23 |
2023-08-12 |
human |
| Edel T Kavanagh, John P Loughlin, Kate Reed Herbert, Peter Dockery, Afshin Samali, Karen M Doyle, Adrienne M Gorma. Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine. Biochemical and biophysical research communications. vol 351. issue 4. 2007-01-23. PMID:17092485. |
6-hydroxydopamine (6-ohda) is often used in models of parkinson's disease since it can selectively target and kill dopaminergic cells of the substantia nigra. |
2007-01-23 |
2023-08-12 |
Not clear |
| Isabel Lastres-Becker, Javier Fernández-Rui. An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments. Current medicinal chemistry. vol 13. issue 30. 2007-01-23. PMID:17168732. |
pd is characterized by degeneration of the pigmented neuromelanin bearing cells of the pars compacta of the substantia nigra that leads to a severe dopaminergic denervation of the striatum. |
2007-01-23 |
2023-08-12 |
Not clear |
| Xiaoyang Shan, Liying Chi, Michael Bishop, Chun Luo, Lindsey Lien, Zheng Zhang, Rugao Li. Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice. Stem cells (Dayton, Ohio). vol 24. issue 5. 2007-01-18. PMID:16424396. |
enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinson's disease-like mice. |
2007-01-18 |
2023-08-12 |
mouse |
| Xiaoyang Shan, Liying Chi, Michael Bishop, Chun Luo, Lindsey Lien, Zheng Zhang, Rugao Li. Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice. Stem cells (Dayton, Ohio). vol 24. issue 5. 2007-01-18. PMID:16424396. |
research reports on de novo neurogenesis, particularly dopaminergic (da) neurogenesis in the adult mammalian substantia nigra (sn), remain very controversial. |
2007-01-18 |
2023-08-12 |
mouse |
| Zena De March, Carmela Giampà, Stefano Patassini, Giorgio Bernardi, Francesca R Fusc. Cellular localization of TRPC5 in the substantia nigra of rat. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16635549. |
trpc are involved in metabotropic glutamate receptor (mglur)-mediated excitatory post-synaptic currents (epscs) in the dopaminergic neurons of the substantia nigra. |
2007-01-16 |
2023-08-12 |
rat |
| Supriti Samantaray, Swapan K Ray, Syed F Ali, Naren L Bani. Calpain activation in apoptosis of motoneurons in cell culture models of experimental parkinsonism. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105932. |
parkinson's disease (pd) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (sn). |
2007-01-10 |
2023-08-12 |
Not clear |
| Erwin Lauwers, Dirk Bequé, Koen Van Laere, Johan Nuyts, Guy Bormans, Luc Mortelmans, Cindy Casteels, Linda Vercammen, Olivier Bockstael, Bart Nuttin, Zeger Debyser, Veerle Baekeland. Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16423428. |
parkinson's disease is a neurodegenerative disorder affecting the dopaminergic neurons in the substantia nigra. |
2007-01-09 |
2023-08-12 |
rat |
| Erwin Lauwers, Dirk Bequé, Koen Van Laere, Johan Nuyts, Guy Bormans, Luc Mortelmans, Cindy Casteels, Linda Vercammen, Olivier Bockstael, Bart Nuttin, Zeger Debyser, Veerle Baekeland. Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16423428. |
there was a strong correlation between the reduction of dopaminergic neurons in the substantia nigra and the reduction of dopamine transporter binding in the striatum. |
2007-01-09 |
2023-08-12 |
rat |
| Oscar Arias-Carrión, Salvador Hernández-López, Osvaldo Ibañez-Sandoval, José Bargas, Arturo Hernández-Cruz, René Drucker-Colí. Neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant. Journal of neuroscience research. vol 84. issue 7. 2007-01-03. PMID:17006899. |
neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant. |
2007-01-03 |
2023-08-12 |
rat |
| Maria Lindskog, MyungSook Kim, Martin A Wikström, Kim T Blackwell, Jeanette Hellgren Kotalesk. Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation. PLoS computational biology. vol 2. issue 9. 2006-12-22. PMID:16965177. |
reinforcement learning theorizes that strengthening of synaptic connections in medium spiny neurons of the striatum occurs when glutamatergic input (from cortex) and dopaminergic input (from substantia nigra) are received simultaneously. |
2006-12-22 |
2023-08-12 |
Not clear |
| Xu-Qing Cao, Hiroyuki Arai, Yong-Ri Ren, Hideki Oizumi, Ning Zhang, Shiho Seike, Tsuyoshi Furuya, Toru Yasuda, Yoshikuni Mizuno, Hideki Mochizuk. Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:17076657. |
mptp induced dopaminergic cell death in the substantia nigra. |
2006-12-20 |
2023-08-12 |
mouse |
| Hong Jiang, Zhuo Luan, Jun Wang, Junxia Xi. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochemistry international. vol 49. issue 6. 2006-12-12. PMID:16806586. |
neuroprotective effects of iron chelator desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. |
2006-12-12 |
2023-08-12 |
rat |
| Hong Jiang, Zhuo Luan, Jun Wang, Junxia Xi. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochemistry international. vol 49. issue 6. 2006-12-12. PMID:16806586. |
the aim of the present study was to investigate whether the iron chelator desferal prevents the degeneration of dopaminergic neurons in the substantia nigra (sn) induced by iron-overload in rats. |
2006-12-12 |
2023-08-12 |
rat |