| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J M Hoozemans, E S van Haastert, P Eikelenboom, R A I de Vos, J M Rozemuller, W Schepe. Activation of the unfolded protein response in Parkinson's disease. Biochemical and biophysical research communications. vol 354. issue 3. 2007-04-19. PMID:17254549. |
immunoreactivity for the upr activation markers phosphorylated pancreatic er kinase (pperk) and phosphorylated eukaryotic initiation factor 2alpha (peif2alpha) is detected in neuromelanin containing dopaminergic neurons in the substantia nigra of pd cases but not in control cases. |
2007-04-19 |
2023-08-12 |
Not clear |
| Hans-Hermann Hoepken, Suzana Gispert, Blas Morales, Oliver Wingerter, Domenico Del Turco, Alexander Mülsch, Robert L Nussbaum, Klaus Müller, Stefan Dröse, Ulrich Brandt, Thomas Deller, Brunhilde Wirth, Alexei P Kudin, Wolfram S Kunz, Georg Auburge. Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiology of disease. vol 25. issue 2. 2007-04-11. PMID:17141510. |
oxidative stress and protein aggregation are biochemical hallmarks of parkinson's disease (pd), a frequent sporadic late-onset degenerative disorder particularly of dopaminergic neurons in the substantia nigra, resulting in impaired spontaneous movement. |
2007-04-11 |
2023-08-12 |
Not clear |
| S J O'Dell, N B Gross, A N Fricks, B D Casiano, T B Nguyen, J F Marshal. Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17157992. |
after killing, dopaminergic damage was assessed by both quantifying 3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester ([(125)i]rti-55) binding to striatal dopamine transporters and counting tyrosine hydroxylase-positive cells in the substantia nigra. |
2007-04-11 |
2023-08-12 |
rat |
| S Urakawa, H Hida, T Masuda, S Misumi, T-S Kim, H Nishin. Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17161913. |
striatal damage was induced at an age of 8 weeks by injection of the neuro-toxins 6-hydroxydopamine (6-ohda) or quinolinic acid (qa) into the striatum, or by injection of 6-ohda into the substantia nigra (sn), which depleted nigrostriatal dopaminergic innervation. |
2007-04-11 |
2023-08-12 |
rat |
| Maya G Purisai, Alison L McCormack, Suzanne Cumine, Jie Li, Martha Z Isla, Donato A Di Mont. Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration. Neurobiology of disease. vol 25. issue 2. 2007-04-11. PMID:17166727. |
dopaminergic cells in the substantia nigra are highly vulnerable to the neurodegenerative process of parkinson's disease. |
2007-04-11 |
2023-08-12 |
mouse |
| T M Korotkova, B P Klyuch, A A Ponomarenko, J S Lin, H L Haas, O A Sergeev. Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors. Neuropharmacology. vol 52. issue 2. 2007-04-10. PMID:17070873. |
we investigated the modafinil action on identified dopaminergic and gabaergic neurons in the ventral tegmental area (vta) and substantia nigra (sn) of rat brain slices. |
2007-04-10 |
2023-08-12 |
rat |
| Alexandre Kreisler, Patrick Gelé, Jean-François Wiart, Michel Lhermitte, Alain Destée, Régis Borde. Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not. Brain research. vol 1135. issue 1. 2007-04-05. PMID:17196944. |
we also demonstrated the presence of ppar-alpha in the dopaminergic neurons of the murine substantia nigra. |
2007-04-05 |
2023-08-12 |
mouse |
| Yasuko Kitao, Yuzuru Imai, Kentaro Ozawa, Ayane Kataoka, Toshio Ikeda, Mariko Soda, Kazuhiko Nakimawa, Hiroshi Kiyama, David M Stern, Osamu Hori, Kazumasa Wakamatsu, Shosuke Ito, Shigeyoshi Itohara, Ryosuke Takahashi, Satoshi Ogaw. Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Human molecular genetics. vol 16. issue 1. 2007-04-03. PMID:17116640. |
pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. |
2007-04-03 |
2023-08-12 |
mouse |
| Randy L Hunter, Natasa Dragicevic, Kristen Seifert, Dong Young Choi, Mei Liu, Hyoung-Chun Kim, Wayne A Cass, Patrick G Sullivan, Guoying Bin. Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17254027. |
evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative stress play significant and perhaps synergistic roles in parkinson's disease (pd), where the primary pathology is significant loss of the dopaminergic neurons in the substantia nigra. |
2007-04-02 |
2023-08-12 |
rat |
| Kazuhiko Nakadate, Takahiro Noda, Shin-Ichi Sakakibara, Kenzo Kumamoto, Tadao Matsuura, Jeffery N Joyce, Shuichi Ued. Progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat. Acta neuropathologica. vol 112. issue 1. 2007-03-29. PMID:16609850. |
progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat. |
2007-03-29 |
2023-08-12 |
rat |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
quantification of mptp-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. |
2007-03-27 |
2023-08-12 |
mouse |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
thus, this method provides a quantitative means to measure dopamine neuron toxicity in the substantia nigra and, as such has potential application in evaluating regimens that may be neuroprotective or neurorestorative for dopaminergic neurons. |
2007-03-27 |
2023-08-12 |
mouse |
| Yogeshwar V Kalkonde, William W Morgan, Jose Sigala, Shivani K Maffi, Carlo Condello, William Kuziel, Seema S Ahuja, Sunil K Ahuj. Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17126305. |
astrocytes were the predominant source of ccl2 and ccl3 in the striatum and the substantia nigra, and dopaminergic neurons in the substantia nigra constitutively expressed these two chemokines. |
2007-03-27 |
2023-08-12 |
mouse |
| Rieko Setsuie, Yu-Lai Wang, Hideki Mochizuki, Hitoshi Osaka, Hideki Hayakawa, Nobutsune Ichihara, Hang Li, Akiko Furuta, Yae Sano, Ying-Jie Sun, Jungkee Kwon, Tomohiro Kabuta, Kenji Yoshimi, Shunsuke Aoki, Yoshikuni Mizuno, Mami Noda, Keiji Wad. Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16965839. |
we found a significant reduction in the dopaminergic neurons in the substantia nigra and the dopamine content in the striatum in the high-expressing i93m tg mice as compared with non-tg mice at 20 weeks of age. |
2007-03-20 |
2023-08-12 |
mouse |
| M Saldaña, M Bonastre, E Aguilar, C Mari. Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: role in neurotoxicity and stereotyped behavior. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17069804. |
our results suggest that the increase in bcl-2 expression in the haloperidol-treated animals might be a compensatory mechanism that may reflect cellular damage induced by haloperidol in the dopaminergic neurons in the pars compacta of the substantia nigra. |
2007-03-20 |
2023-08-12 |
rat |
| Andreas Borta, Günter U Höglinge. Dopamine and adult neurogenesis. Journal of neurochemistry. vol 100. issue 3. 2007-03-20. PMID:17101030. |
in addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in parkinson's disease? |
2007-03-20 |
2023-08-12 |
human |
| Laure Sonnier, Gwenaëlle Le Pen, Andreas Hartmann, Jean-Charles Bizot, Fabrice Trovero, Marie-Odile Krebs, Alain Prochiant. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267560. |
en1 and, to a lesser degree, en2 also are expressed in the adult substantia nigra (sn) and ventral tegmental area (vta), two dopaminergic (da) nuclei of the ventral midbrain. |
2007-03-16 |
2023-08-12 |
mouse |
| D Reglödi, A Lubics, P Kiss, I Lengvári, B Gaszner, G Tóth, O Hegyi, A Tamá. Effect of PACAP in 6-OHDA-induced injury of the substantia nigra in intact young and ovariectomized female rats. Neuropeptides. vol 40. issue 4. 2007-03-15. PMID:16904179. |
recently, we have shown that pacap reduces dopaminergic cell loss and ameliorates behavioral outcome following unilateral 6-ohda-induced injury of the substantia nigra in male rats. |
2007-03-15 |
2023-08-12 |
rat |
| Hee Soon Choi, Jae Jin An, So Young Kim, Sun Hwa Lee, Dae Won Kim, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung-Woo Cho, Oh-Shin Kwon, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962931. |
parkinson disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-02-16 |
2023-08-12 |
mouse |
| Amit Saraf, David M Virshup, Stefan Strac. Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17085438. |
whereas b'beta was highly expressed in dopaminergic cell bodies in the substantia nigra, the pp2a regulatory subunit was excluded from th-positive terminal fields in the striatum and failed to colocalize with presynaptic markers in general. |
2007-02-08 |
2023-08-12 |
rat |