| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tanuja Bordia, Sharon R Grady, J Michael McIntosh, Maryka Qui. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Molecular pharmacology. vol 72. issue 1. 2007-07-30. PMID:17409284. |
parkinson's disease is a neurodegenerative movement disorder characterized by a loss of substantia nigra dopamine neurons, and corresponding declines in molecular components present on striatal dopaminergic nerve terminals. |
2007-07-30 |
2023-08-12 |
mouse |
| Hiroo Yamaguchi, Jie She. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular neurodegeneration. vol 2. 2007-07-30. PMID:17535435. |
we found that dj-1-/- mice at the age of 24-27 months have normal numbers of dopaminergic neurons in the substantia nigra and normal levels of dopamine and its major metabolites in the striatum. |
2007-07-30 |
2023-08-12 |
mouse |
| Gan-Lan Bian, Li-Chun Wei, Mei Shi, Yan-Qin Wang, Rong Cao, Liang-Wei Che. Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine-treated C57BL/6 mice. Brain research. vol 1150. 2007-07-24. PMID:17397812. |
however, most of fluoro-jade c-positive degenerative neurons (98%) lost their immunoreactivity to dopaminergic marker tyrosine hydroxylase in the substantia nigra of mptp-treated mice. |
2007-07-24 |
2023-08-12 |
mouse |
| Marko Schirmer, Alina Lessenich, Sven Lindemann, Wolfgang Lösche. Marked differences in response to dopamine receptor antagonism in two rat mutants, ci2 and ci3, with lateralized rotational behavior. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17442411. |
both mutants show abnormal lateralities in striatal dopamine and in the density of dopaminergic neurons in substantia nigra or ventral tegmental area, which may be involved in the behavioral phenotype of these rats. |
2007-07-24 |
2023-08-12 |
rat |
| Inna Kan, Tali Ben-Zur, Yael Barhum, Yossef S Levy, Alex Burstein, Tirza Charlow, Shlomo Bulvik, Eldad Melamed, Daniel Offe. Dopaminergic differentiation of human mesenchymal stem cells--utilization of bioassay for tyrosine hydroxylase expression. Neuroscience letters. vol 419. issue 1. 2007-07-24. PMID:17475405. |
parkinson's disease (pd) is a neurodegenerative disorder, caused by a selective loss of dopaminergic neurons in the substantia nigra. |
2007-07-24 |
2023-08-12 |
human |
| Samuel A Scott, Naomi M Diaz, Syed O Ahma. Stereologic analysis of cell number and size during postnatal development in the rat substantia nigra. Neuroscience letters. vol 419. issue 1. 2007-07-24. PMID:17481811. |
parkinson's disease is characterized by age-related atrophy and loss of dopaminergic neurons within the compact portion of the substantia nigra (snpc) projecting to neostriatum. |
2007-07-24 |
2023-08-12 |
rat |
| Tom N Grammatopoulos, Susan M Jones, Ferogh A Ahmadi, Brian R Hoover, Lawrence D Snell, Jesse Skoch, Vimal V Jhaveri, Andy M Poczobutt, James A Weyhenmeyer, W Michael Zawad. Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra. Molecular neurodegeneration. vol 2. 2007-07-23. PMID:17224059. |
angiotensin type 1 receptor antagonist losartan, reduces mptp-induced degeneration of dopaminergic neurons in substantia nigra. |
2007-07-23 |
2023-08-12 |
mouse |
| Vittorio Calabrese, Cesare Mancuso, Agrippino Ravagna, Marzia Perluigi, Chiara Cini, Carlo De Marco, D Allan Butterfield, Anna Maria Giuffrida Stell. In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. Journal of neurochemistry. vol 101. issue 3. 2007-07-18. PMID:17241115. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a severe depletion in number of dopaminergic cells of the substantia nigra (sn). |
2007-07-18 |
2023-08-12 |
rat |
| David Sulze. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends in neurosciences. vol 30. issue 5. 2007-07-12. PMID:17418429. |
parkinson's disease arises from genetic and possibly neurotoxic causes that produce massive cell death of the neuromelanin-containing dopaminergic neurons of the substantia nigra. |
2007-07-12 |
2023-08-12 |
Not clear |
| Hsin-Yi Huang, Shinn-Zong Lin, Jon-Son Kuo, Wu-Fu Chen, Mei-Jen Wan. G-CSF protects dopaminergic neurons from 6-OHDA-induced toxicity via the ERK pathway. Neurobiology of aging. vol 28. issue 8. 2007-07-10. PMID:16839644. |
in the present study, we first demonstrated that both g-csf and g-csf receptor were expressed in dopaminergic neurons in the adult substantia nigra and mesencephalic cultures, suggesting that g-csf might exert its neuroprotective effects in dopaminergic neurons. |
2007-07-10 |
2023-08-12 |
rat |
| M Saldaña, J Mullol, E Aguilar, M Bonastre, C Mari. Nuclear factor kappa-B p50 and p65 subunits expression in dementia with Lewy bodies. Neuropathology and applied neurobiology. vol 33. issue 3. 2007-07-06. PMID:17442064. |
parkinsonism in dlb is mainly caused by neuronal loss with lewy bodies (lbs) in the substantia nigra, thereby inducing degeneration of the nigrostriatal dopaminergic pathway similar to that in parkinson's disease (pd). |
2007-07-06 |
2023-08-12 |
human |
| M Saldaña, J Mullol, E Aguilar, M Bonastre, C Mari. Nuclear factor kappa-B p50 and p65 subunits expression in dementia with Lewy bodies. Neuropathology and applied neurobiology. vol 33. issue 3. 2007-07-06. PMID:17442064. |
the decrease in the expression of the p50 subunit in the substantia nigra of dlb cases achieved in the present study may increase the vulnerability of the dopaminergic neurones to a possible neurotoxic effect of p65 subunit. |
2007-07-06 |
2023-08-12 |
human |
| Benjamin Sredni, Revital Geffen-Aricha, Wenzhen Duan, Michael Albeck, Frances Shalit, Harry M Lander, Noa Kinor, Ortal Sagi, Amnon Albeck, Sigal Yosef, Miri Brodsky, Dvora Sredni-Kenigsbuch, Tali Sonino, Dan L Longo, Mark P Mattson, Gal Yadi. Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17314138. |
in parkinson's disease (pd) dopaminergic neurons in the substantia nigra (sn) become dysfunctional and many ultimately die. |
2007-07-03 |
2023-08-12 |
Not clear |
| Heather Klintworth, Kathleen Newhouse, Tingting Li, Won-Seok Choi, Roland Faigle, Zhengui Xi. Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 97. issue 1. 2007-07-03. PMID:17324951. |
parkinson's disease (pd) is characterized by selective loss of dopaminergic neurons in the substantia nigra of the brain. |
2007-07-03 |
2023-08-12 |
rat |
| N A Do Thi, P Saillour, L Ferrero, T Paunio, J Malle. Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease? Gene therapy. vol 14. issue 5. 2007-06-29. PMID:17093508. |
we found that (i) the nse promoter can restrict transgene expression in neurons; (ii) ad-nse-gdnf significantly protected dopaminergic (da) neurons in the substantia nigra (sn) but did not reverse the impairments of amphetamine-induced rotational behavior in lesioned rats. |
2007-06-29 |
2023-08-12 |
rat |
| L J Ramírez-Jirano, J L Ruiz-Sandoval, F J Jiménez-Gil, J Ramírez-Vega, E Vargas-Frutos, M P Gallegos-Arreol. [Frequency of the IVS4+66A-G polymorphism in the alpha-synuclein gene in patients with Parkinson's disease in north-western Mexico]. Revista de neurologia. vol 44. issue 1. 2007-06-29. PMID:17199224. |
histopathologically, is characterized by a severe loss of dopaminergic neurons in the substantia nigra and inclusions consisting of insoluble protein aggregates called lewy bodies, this are comprised in part of alpha-synuclein. |
2007-06-29 |
2023-08-12 |
Not clear |
| Zhong-Qin Liang, Yun-Lin Li, Xi-Lin Zhao, Rong Han, Xiao-Xia Wang, Yumei Wang, Thomas N Chase, M Catherine Bennett, Zheng-Hong Qi. NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain research. vol 1145. 2007-06-26. PMID:17368433. |
apoptotic death of dopaminergic neurons was suggested by the appearance of tunel-positive nuclei in substantia nigra and internucleosomal dna fragmentation as detected by agarose gel electrophoresis. |
2007-06-26 |
2023-08-12 |
rat |
| Dennis W Dickson, Rosa Rademakers, Michael L Hutto. Progressive supranuclear palsy: pathology and genetics. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493041. |
the substantia nigra shows loss of pigment corresponding to nigrostriatal dopaminergic degeneration. |
2007-06-26 |
2023-08-12 |
Not clear |
| Peng Yang, Aygul Dankowski, Theo Hag. Protein tyrosine phosphatase inhibition reduces degeneration of dopaminergic substantia nigra neurons and projections in 6-OHDA treated adult rats. The European journal of neuroscience. vol 25. issue 5. 2007-06-25. PMID:17425559. |
protein tyrosine phosphatase inhibition reduces degeneration of dopaminergic substantia nigra neurons and projections in 6-ohda treated adult rats. |
2007-06-25 |
2023-08-12 |
rat |
| Harold L Newmark, Jonathan Newmar. Vitamin D and Parkinson's disease--a hypothesis. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 4. 2007-06-22. PMID:17230473. |
it results from selective loss (death) of dopaminergic neurons in the substantia nigra region of the brain, largely developed prior to clinical diagnosis, and continuous after diagnosis, despite use of current therapeutic modalities. |
2007-06-22 |
2023-08-12 |
Not clear |