| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kimberlee D'Ardenne, Samuel M McClure, Leigh E Nystrom, Jonathan D Cohe. BOLD responses reflecting dopaminergic signals in the human ventral tegmental area. Science (New York, N.Y.). vol 319. issue 5867. 2008-03-13. PMID:18309087. |
although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fmri) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (vstr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (vta) and substantia nigra]. |
2008-03-13 |
2023-08-12 |
human |
| Dae Y Song, Young C Yang, Dong H Shin, Shuei Sugama, Yoon S Kim, Bong H Lee, Tong H Joh, Byung P Ch. Axotomy-induced dopaminergic neurodegeneration is accompanied with c-Jun phosphorylation and activation transcription factor 3 expression. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:18036593. |
to elucidate the significance and functional role of these immediate-early genes during neuronal damage in the central nervous system, we examined temporal and spatial profiles of pc-jun and atf3 in dopaminergic neurons of the substantia nigra (sn) following transection of the medial forebrain bundle (mfb) in adult rats. |
2008-03-05 |
2023-08-12 |
rat |
| Dong-Jae Jun, Jaeyoon Kim, Sang-Yong Jung, Ran Song, Ji-Hyun Noh, Yong-Soo Park, Sung-Ho Ryu, Joung-Hun Kim, Young-Yun Kong, Jun-Mo Chung, Kyong-Tai Ki. Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors. The Journal of biological chemistry. vol 282. issue 52. 2008-03-04. PMID:17962183. |
when sn4741 cells, which are dopaminergic neurons derived from the substantia nigra of transgenic mouse embryos, are exposed to atp, cell death occurs. |
2008-03-04 |
2023-08-12 |
mouse |
| Stéphanie Pain, Laurence Barrier, Julie Deguil, Serge Milin, Alain Piriou, Bernard Fauconneau, Guylène Pag. A cell-permeable peptide inhibitor TAT-JBD reduces the MPP+-induced caspase-9 activation but does not prevent the dopaminergic degeneration in substantia nigra of rats. Toxicology. vol 243. issue 1-2. 2008-02-29. PMID:18037221. |
a cell-permeable peptide inhibitor tat-jbd reduces the mpp+-induced caspase-9 activation but does not prevent the dopaminergic degeneration in substantia nigra of rats. |
2008-02-29 |
2023-08-12 |
rat |
| Kim L Hoke, Michael J Ryan, Walter Wilczynsk. Functional coupling between substantia nigra and basal ganglia homologues in amphibians. Behavioral neuroscience. vol 121. issue 6. 2008-02-29. PMID:18085893. |
as further evidence for a functional coupling between the dopaminergic cells in the posterior tuberculum (the putative substantia nigra homologue) and the basal ganglia, a positive relationship was demonstrated between the size of the dopaminergic cell population and the neural activation levels within the dorsal pallidum. |
2008-02-29 |
2023-08-12 |
Not clear |
| Kevin B Clayton, Aideen M Sulliva. Differential effects of GDF5 on the medial and lateral rat ventral mesencephalon. Neuroscience letters. vol 427. issue 3. 2008-02-25. PMID:17935884. |
growth/differentiation factor 5 (gdf5) is a member of the transforming growth factor-beta (tgf-beta) superfamily that has potent neurotrophic and protective effects on dopaminergic neurones and is expressed in the developing rat substantia nigra (the ventral mesencephalon; vm). |
2008-02-25 |
2023-08-12 |
rat |
| Keiya Ozaw. [Gene therapy using AAV]. Uirusu. vol 57. issue 1. 2008-02-21. PMID:18040154. |
pd is a progressive neurodegenerative disorder that predominantly affects dopaminergic neurons in the substantia nigra. |
2008-02-21 |
2023-08-12 |
Not clear |
| I Rite, S Argüelles, J L Venero, S García-Rodriguez, A Ayala, J Cano, A Machad. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. Journal of neuroscience research. vol 85. issue 16. 2008-02-19. PMID:17705290. |
in this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss of more than 80% dopamine terminals in the striatum, with a similar diminution of dopamine levels in both structures. |
2008-02-19 |
2023-08-12 |
rat |
| Gunnar P H Dietz, Kerstin V Stockhausen, Birgit Dietz, Björn H Falkenburger, Paola Valbuena, Felipe Opazo, Paul Lingor, Katrin Meuer, Jochen H Weishaupt, Jörg B Schulz, Mathias Bäh. Membrane-permeable Bcl-xL prevents MPTP-induced dopaminergic neuronal loss in the substantia nigra. Journal of neurochemistry. vol 104. issue 3. 2008-02-19. PMID:17995935. |
membrane-permeable bcl-xl prevents mptp-induced dopaminergic neuronal loss in the substantia nigra. |
2008-02-19 |
2023-08-12 |
mouse |
| Fang Zhou, Jia-Yong Wu, Xiu-Lan Sun, Hong-Hong Yao, Jian-Hua Ding, Gang H. Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17356569. |
in the present study, we demonstrated that systematic administration with iptakalim (ipt), an adenosine triphosphate (atp)-sensitive potassium channel (k(atp)) opener, could alleviate rotenone-induced degeneration of dopaminergic neurons in rat substantia nigra along with the downregulation of microglial activation and mrna levels of tumor necrosis factor-alpha (tnf-alpha) and cyclooxygenase-2 (cox-2). |
2008-02-14 |
2023-08-12 |
rat |
| Emilce Carrasco, Diana Casper, Peter Werne. PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. Journal of neuroscience research. vol 85. issue 14. 2008-02-14. PMID:17868147. |
oxidative stress and increased cyclooxygenase-2 (cox-2) activity are both implicated in the loss of dopaminergic neurons from the substantia nigra (sn) in idiopathic parkinson's disease (pd). |
2008-02-14 |
2023-08-12 |
rat |
| M L Block, J-S Hon. Chronic microglial activation and progressive dopaminergic neurotoxicity. Biochemical Society transactions. vol 35. issue Pt 5. 2008-02-05. PMID:17956294. |
pd (parkinson's disease) is characterized by the selective and progressive loss of da neurons (dopaminergic neurons) in the substantia nigra. |
2008-02-05 |
2023-08-12 |
Not clear |
| Oronzo Scarciolla, Francesco Brancati, Enza Maria Valente, Alessandro Ferraris, Maria Vittoria De Angelis, Stefano Valbonesi, Barbara Garavaglia, Antonino Uncini, Giandomenico Palka, Liborio Stuppia, Bruno Dallapiccol. Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 15. 2008-01-31. PMID:17914726. |
parkinson's disease (pd) is a common disorder caused by degeneration of dopaminergic neurons in the substantia nigra and other brain areas. |
2008-01-31 |
2023-08-12 |
Not clear |
| Mario Di Napoli, Imtiaz M Shah, David A Stewar. Molecular pathways and genetic aspects of Parkinson's disease: from bench to bedside. Expert review of neurotherapeutics. vol 7. issue 12. 2008-01-31. PMID:18052765. |
idiopathic parkinson's disease (pd) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss within the substantia nigra. |
2008-01-31 |
2023-08-12 |
Not clear |
| D C Duke, L B Moran, R K B Pearce, M B Graebe. The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics. vol 8. issue 2. 2008-01-23. PMID:17211632. |
sporadic parkinson's disease (pd) is characterized by progressive death of dopaminergic neurons within the substantia nigra. |
2008-01-23 |
2023-08-12 |
Not clear |
| Italo Mocchetti, Alessia Bachis, Rachel L Nosheny, Gianluigi Tand. Brain-derived neurotrophic factor expression in the substantia nigra does not change after lesions of dopaminergic neurons. Neurotoxicity research. vol 12. issue 2. 2008-01-17. PMID:17967737. |
brain-derived neurotrophic factor expression in the substantia nigra does not change after lesions of dopaminergic neurons. |
2008-01-17 |
2023-08-12 |
Not clear |
| M D Neely, D E Schmidt, A Y Deutc. Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neuroscience. vol 149. issue 2. 2008-01-16. PMID:17888581. |
dendrites of these neurons receive cortical glutamatergic inputs onto the dendritic spine head and dopaminergic inputs from the substantia nigra onto the spine neck. |
2008-01-16 |
2023-08-12 |
rat |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (sn). |
2008-01-14 |
2023-08-12 |
mouse |
| Vural Ozdemir, M Mazen Jamal, Klara Osapay, Martin R Jadus, Zsuzsanna Sandor, Mehrtash Hashemzadeh, Sandor Szab. Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 55. issue 6. 2008-01-10. PMID:17963681. |
the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,36-tetrahydropyridine (mptp) depletes central dopamine and induces lesions in the substantia nigra, and, if given in high doses, mptp induces a parkinson disease-like syndrome and gastric ulcers. |
2008-01-10 |
2023-08-12 |
Not clear |
| Dekel Segev, Alon Korngree. Kinetics of two voltage-gated K+ conductances in substantia nigra dopaminergic neurons. Brain research. vol 1173. 2008-01-09. PMID:17826751. |
dopaminergic neurons (da) constitute the bulk of substantia nigra neurons and are related to diseases such as parkinson's disease. |
2008-01-09 |
2023-08-12 |
Not clear |