| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun Jung Park, Phil Hyu Lee, Oh Young Bang, Gwang Lee, Young Hwan Ah. Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's disease. Journal of neurochemistry. vol 107. issue 1. 2008-11-03. PMID:18665911. |
parkinson's disease is a common progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. |
2008-11-03 |
2023-08-12 |
human |
| Baek-Soo Han, Lorraine Iacovitti, Taku Katano, Nobutaka Hattori, Wongi Seol, Kwang-Soo Ki. Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra. Neuroscience letters. vol 442. issue 3. 2008-10-21. PMID:18634852. |
expression of the lrrk2 gene in the midbrain dopaminergic neurons of the substantia nigra. |
2008-10-21 |
2023-08-12 |
mouse |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2008-10-14 |
2023-08-12 |
human |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
after different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (sn, 1 week) were stained with iba-1 and/or gfap antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (th) to monitor dopaminergic cell survival (sn group only). |
2008-10-14 |
2023-08-12 |
human |
| Shyamal H Mehta, John C Morgan, Kapil D Seth. Neuroimaging and transcranial ultrasonography in Parkinson's disease. Current neurology and neuroscience reports. vol 8. issue 4. 2008-10-09. PMID:18590613. |
parkinson's disease is a progressive, widespread, neurodegenerative disease in which the involvement of the dopaminergic neurons of the substantia nigra results in significant dopamine depletion in the striatum. |
2008-10-09 |
2023-08-12 |
Not clear |
| Shankar J Chinta, Julie K Anderse. Redox imbalance in Parkinson's disease. Biochimica et biophysica acta. vol 1780. issue 11. 2008-10-08. PMID:18358848. |
parkinson's disease (pd) is an adult-onset neurodegenerative disorder characterized by preferential loss of dopaminergic neurons in an area of the midbrain called the substantia nigra (sn) along with occurrence of intraneuronal inclusions called lewy bodies. |
2008-10-08 |
2023-08-12 |
Not clear |
| Ju Hee Lim, Kyeong-Man Kim, Seong Who Kim, Onyou Hwang, Hyun Jin Cho. Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage. Pharmacological research. vol 57. issue 5. 2008-10-07. PMID:18455424. |
parkinson's disease (pd) is a neurodegenerative disorder associated with selective loss of dopaminergic neurons in the substantia nigra. |
2008-10-07 |
2023-08-12 |
Not clear |
| Michael DeCuypere, Vassilios N Kalabokis, Ruyi Hao, Dorothy Schroeder, Duane D Miller, Mark S LeDou. Localization of N-methyl-norsalsolinol within rodent and human brain. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438936. |
in comparison to normal human controls, n-methyl-norsalsolinol levels were significantly lower in the substantia nigra and caudate nuclei from pd patients, a finding possibly related to the death of nigrostriatal dopaminergic neurons. |
2008-09-30 |
2023-08-12 |
mouse |
| Xiaotang Fan, Hyun-Jin Kim, Didier Bouton, Margaret Warner, Jan-Ake Gustafsso. Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 36. 2008-09-30. PMID:18768805. |
liver x receptor (lxr) beta regulates cholesterol levels in the brain and is essential for maintenance of motor neurons in the spinal cord and dopaminergic neurons in the substantia nigra. |
2008-09-30 |
2023-08-12 |
mouse |
| Clemens R Scherzer, Jeffrey A Grass, Zhixiang Liao, Imelda Pepivani, Bin Zheng, Aron C Eklund, Paul A Ney, Juliana Ng, Meghan McGoldrick, Brit Mollenhauer, Emery H Bresnick, Michael G Schlossmache. GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 31. 2008-09-25. PMID:18669654. |
endogenous gata-2 is highly expressed in substantia nigra vulnerable to pd, occupies intron-1, and modulates snca expression in dopaminergic cells. |
2008-09-25 |
2023-08-12 |
human |
| Steven R Danielson, Julie K Anderse. Oxidative and nitrative protein modifications in Parkinson's disease. Free radical biology & medicine. vol 44. issue 10. 2008-09-22. PMID:18395015. |
increased oxidative stress appears to be a common causative aspect involved in the preferential loss of dopaminergic neurons in a region of the brain prominently affected by the disorder, the substantia nigra (sn). |
2008-09-22 |
2023-08-12 |
Not clear |
| Rajnish K Chaturvedi, M Flint Bea. PPAR: a therapeutic target in Parkinson's disease. Journal of neurochemistry. vol 106. issue 2. 2008-09-16. PMID:18384649. |
parkinson's disease (pd) is a progressive and chronic neurodegenerative disorder, characterized by progressive loss of dopaminergic neurons in substantia nigra. |
2008-09-16 |
2023-08-12 |
Not clear |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
the current transplantation paradigm for parkinson's disease that places foetal dopaminergic cells in the striatum neither normalizes neuronal activity in basal ganglia structures such as the substantia nigra (sn) and subthalamic nucleus (stn) nor leads to complete functional recovery. |
2008-09-15 |
2023-08-12 |
human |
| Ann K Wright, Clare Miller, Maya Williams, Gordon Arbuthnot. Microglial activation is not prevented by tacrolimus but dopamine neuron damage is reduced in a rat model of Parkinson's disease progression. Brain research. vol 1216. 2008-09-08. PMID:18495090. |
a progressive model of parkinson's disease has been recently developed in the rat where a unilateral excitotoxic injection into the globus pallidus leads to a gradual loss of dopaminergic neurons in the ipsilateral substantia nigra over a period of at least 6 weeks. |
2008-09-08 |
2023-08-12 |
rat |
| András Csillag, Eszter Bálint, Agota Adám, Gergely Zacha. The organisation of the basal ganglia in the domestic chick (Gallus domesticus): anatomical localisation of DARPP-32 in relation to glutamate. Brain research bulletin. vol 76. issue 3. 2008-09-04. PMID:18498930. |
similar to mammals, the avian ac and mst receive glutamatergic input from the pallium and dopaminergic input from the substantia nigra and ventral tegmental area. |
2008-09-04 |
2023-08-12 |
chicken |
| Hong Jiang, Lin-Jing Li, Jun Wang, Jun-Xia Xi. Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Experimental neurology. vol 212. issue 2. 2008-09-02. PMID:18577498. |
ghrelin antagonizes mptp-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. |
2008-09-02 |
2023-08-12 |
mouse |
| Fang Liu, Jagadish Hindupur, Jamie L Nguyen, Katie J Ruf, Junyi Zhu, Jeremy L Schieler, Connie C Bonham, Karl V Wood, V Jo Davisson, Jean-Christophe Roche. Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults. Free radical biology & medicine. vol 45. issue 3. 2008-08-26. PMID:18456002. |
parkinson's disease (pd) is a neurologic disorder characterized by dopaminergic cell death in the substantia nigra. |
2008-08-26 |
2023-08-12 |
Not clear |
| Xi Jun He, Hirofumi Yamauchi, Koji Uetsuka, Hiroyuki Nakayam. Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease. Neurotoxicology. vol 29. issue 3. 2008-08-25. PMID:18387672. |
in recent years, the notion that the neurotoxicity of mptp is restricted to dopaminergic neurons in the substantia nigra (sn) has been challenged. |
2008-08-25 |
2023-08-12 |
mouse |
| Yi Wei Lu, Eng-King Ta. Molecular biology changes associated with LRRK2 mutations in Parkinson's disease. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18338801. |
parkinson's disease (pd) is characterized by progressive dopaminergic neuronal loss in the substantia nigra. |
2008-08-20 |
2023-08-12 |
Not clear |
| Natasha Luquin, John Mitrofani. Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats? Parkinsonism & related disorders. vol 14. issue 3. 2008-08-13. PMID:18029221. |
does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6ohda-lesioned rats? |
2008-08-13 |
2023-08-12 |
rat |