| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Hawlitschka, Stefan J P Haas, Oliver Schmitt, Dieter G Weiss, Andreas Wre. Effects of systemic PSI administration on catecholaminergic cells in the brain, adrenal medulla and carotid body in Wistar rats. Brain research. vol 1173. 2008-01-09. PMID:17850771. |
inhibiting the proteasomal protein degradation in vivo where they observed in sprague-dawley rats distinct symptoms of parkinson's disease, a typical slow progredient loss of dopaminergic neurons in the substantia nigra and a lack of dopaminergic afferences in the striatum. |
2008-01-09 |
2023-08-12 |
rat |
| Gilmor I Keshet, Ravi J Tolwani, Angelica Trejo, Peggy Kraft, Regis Doyonnas, Carol Clayberger, James M Weimann, Helen M Bla. Increased host neuronal survival and motor function in BMT Parkinsonian mice: involvement of immunosuppression. The Journal of comparative neurology. vol 504. issue 6. 2008-01-04. PMID:17722033. |
a bmt from mice transgenic for green fluorescent protein (gfp(+)) given either before or after administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) led to the accumulation of transplanted adult gfp(+) bone-marrow-derived cells (bmdc) in the substantia nigra, where dopaminergic neurodegeneration occurs in pd. |
2008-01-04 |
2023-08-12 |
mouse |
| Gang Li, Rong Ma, Ying X. [Protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 8. 2008-01-03. PMID:16970095. |
[protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra]. |
2008-01-03 |
2023-08-12 |
Not clear |
| Gang Li, Rong Ma, Ying X. [Protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 8. 2008-01-03. PMID:16970095. |
to study the protective effects of triptolide (tri) on the lipopolysaccharide (lps)-mediated degeneration of dopaminergic neurons in substantia nigra. |
2008-01-03 |
2023-08-12 |
Not clear |
| Donald R Staine. Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides? Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17562359. |
parkinson's disease (pd) is a motor disease including disorders of mobility, fine tremor, rigidity and posture caused by a relentless deterioration of dopaminergic cells in the substantia nigra (sn). |
2008-01-03 |
2023-08-12 |
Not clear |
| Christine Klein, Katja Lohmann-Hedric. Impact of recent genetic findings in Parkinson's disease. Current opinion in neurology. vol 20. issue 4. 2007-12-27. PMID:17620882. |
parkinson's disease is the second most common age-related neurodegenerative disorder and is characterized clinically by classical parkinsonism and pathologically by selective loss of dopaminergic neurons in the substantia nigra and lewy bodies. |
2007-12-27 |
2023-08-12 |
Not clear |
| Ben Ampe, Ann Massie, Jean D'Haens, Guy Ebinger, Yvette Michotte, Sophie Sarr. NMDA-mediated release of glutamate and GABA in the subthalamic nucleus is mediated by dopamine: an in vivo microdialysis study in rats. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17727638. |
the observed effects in intact animals depend on the nigral dopaminergic innervation, as dopamine denervation, by means of 6-hydroxydopamine lesioning of the substantia nigra, clearly abolished the effects of nmda on neurotransmitter release at the level of the stn. |
2007-12-21 |
2023-08-12 |
rat |
| Ramez Wassef, Ronny Haenold, Alfred Hansel, Nathan Brot, Stefan H Heinemann, Toshinori Hosh. Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032652. |
parkinson's disease (pd), a common neurodegenerative disease, is caused by loss of dopaminergic neurons in the substantia nigra. |
2007-12-18 |
2023-08-12 |
human |
| Rebecca L Miller, Grace Y Sun, Albert Y Su. Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. Brain research. vol 1167. 2007-12-14. PMID:17662968. |
excess production of reactive oxygen species (ros) is an important mechanism underlying the pathogenesis of a number of neurodegenerative diseases including parkinson's disease (pd) which is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. |
2007-12-14 |
2023-08-12 |
Not clear |
| Stéphanie Mounayar, Sabrina Boulet, Dominique Tandé, Caroline Jan, Mathias Pessiglione, Etienne C Hirsch, Jean Féger, Marc Savasta, Chantal François, Léon Trembla. A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery. Brain : a journal of neurology. vol 130. issue Pt 11. 2007-12-13. PMID:17855373. |
despite this obvious behavioural difference, immunohistological methods revealed that the loss of dopaminergic cell bodies in substantia nigra was substantial and similar in both mptp-treated groups. |
2007-12-13 |
2023-08-12 |
monkey |
| Masahiko Watabe, Toshio Nakak. Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. The Journal of pharmacology and experimental therapeutics. vol 323. issue 2. 2007-12-06. PMID:17726156. |
parkinson's disease is a chronic neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. |
2007-12-06 |
2023-08-12 |
human |
| Mei-Jen Wang, Shinn-Zong Lin, Jon-Son Kuo, Hsin-Yi Huang, Shih-Fang Tzeng, Chia-Hsin Liao, Der-Cherng Chen, Wu-Fu Che. Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 9. 2007-12-06. PMID:17947696. |
in the present study, we demonstrated that expression of ucn in rat substantia nigra was found to be localized principally to dopaminergic neurons. |
2007-12-06 |
2023-08-12 |
rat |
| Nicole Exner, Bettina Treske, Dominik Paquet, Kira Holmström, Carola Schiesling, Suzana Gispert, Iria Carballo-Carbajal, Daniela Berg, Hans-Hermann Hoepken, Thomas Gasser, Rejko Krüger, Konstanze F Winklhofer, Frank Vogel, Andreas S Reichert, Georg Auburger, Philipp J Kahle, Bettina Schmid, Christian Haas. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 45. 2007-12-06. PMID:17989306. |
degeneration of dopaminergic neurons in the substantia nigra is characteristic for parkinson's disease (pd), the second most common neurodegenerative disorder. |
2007-12-06 |
2023-08-12 |
human |
| Myoung-Chul Yoon, Mal-Soon Shin, Tea-Soo Kim, Bo-Kyun Kim, Il-Gyu Ko, Yun-Hee Sung, Sung-Eun Kim, Hee-Hyuk Lee, Young-Pyo Kim, Chang-Ju Ki. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neuroscience letters. vol 423. issue 1. 2007-12-03. PMID:17644250. |
in parkinson's disease, the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra leads to debilitating motor dysfunction. |
2007-12-03 |
2023-08-12 |
rat |
| Myoung-Chul Yoon, Mal-Soon Shin, Tea-Soo Kim, Bo-Kyun Kim, Il-Gyu Ko, Yun-Hee Sung, Sung-Eun Kim, Hee-Hyuk Lee, Young-Pyo Kim, Chang-Ju Ki. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neuroscience letters. vol 423. issue 1. 2007-12-03. PMID:17644250. |
in the present study, we investigated the effects of treadmill exercise on the dopaminergic neuronal cell death in the substantia nigra and on the dopaminergic fiber loss in the striatum of parkinson's rats. |
2007-12-03 |
2023-08-12 |
rat |
| Myoung-Chul Yoon, Mal-Soon Shin, Tea-Soo Kim, Bo-Kyun Kim, Il-Gyu Ko, Yun-Hee Sung, Sung-Eun Kim, Hee-Hyuk Lee, Young-Pyo Kim, Chang-Ju Ki. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neuroscience letters. vol 423. issue 1. 2007-12-03. PMID:17644250. |
however, treadmill running enhanced the survival of dopaminergic neurons in the substantia nigra and also their fibers projecting into the striatum. |
2007-12-03 |
2023-08-12 |
rat |
| Henrik H Hansen, Jesper Tobias Andreasen, Pia Weikop, Naheed Mirza, Jørgen Scheel-Krüger, Jens D Mikkelse. The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine. European journal of pharmacology. vol 570. issue 1-3. 2007-11-30. PMID:17628530. |
mesencephalic kcnq (also termed k(v)7) potassium channels suppress the basal activity of dopaminergic neurons in the substantia nigra and ventral tegmental area. |
2007-11-30 |
2023-08-12 |
rat |
| D Alvarez-Fischer, G Blessmann, C Trosowski, M Béhé, T Schurrat, A Hartmann, T M Behr, W H Oertel, G U Höglinger, H Höffke. Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease. NeuroImage. vol 38. issue 1. 2007-11-26. PMID:17716921. |
it is unclear, however, if there is a stable relationship between the striatal [(123)i]fp-cit binding and other functionally important parameters of the nigrostriatal system, such as the striatal dopamine levels and the number of dopaminergic neurons in the substantia nigra. |
2007-11-26 |
2023-08-12 |
mouse |
| Bianca C Wittmann, Nico Bunzeck, Raymond J Dolan, Emrah Düze. Anticipation of novelty recruits reward system and hippocampus while promoting recollection. NeuroImage. vol 38. issue 1. 2007-11-26. PMID:17764976. |
the dopaminergic midbrain, which comprises the substantia nigra and ventral tegmental area (sn/vta), plays a central role in reward processing. |
2007-11-26 |
2023-08-12 |
human |
| Abesh Kumar Bhattacharjee, Lindsey M Meister, Lisa Chang, Richard P Bazinet, Laura White, Stanley I Rapopor. In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease. NeuroImage. vol 37. issue 4. 2007-11-20. PMID:17681816. |
parkinson's disease involves loss of dopamine (da)-producing neurons in the substantia nigra, associated with fewer pre-synaptic da transporters (dats) but more post-synaptic dopaminergic d2 receptors in terminal areas of these neurons. |
2007-11-20 |
2023-08-12 |
rat |