| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Zechel, J Jarosik, I Kiprianova, A Schober, K Unsicker, O von Bohlen und Halbac. FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice. The European journal of neuroscience. vol 23. issue 6. 2006-05-30. PMID:16553632. |
to address the putative physiological relevance of endogenous fgf-2 for midbrain dopaminergic neurons, we have analysed densities of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and th-positive fibers in the striatum and amygdala of adult fgf-2-deficient mice. |
2006-05-30 |
2023-08-12 |
mouse |
| Hyun Jin Choi, So Yeon Lee, Yuri Cho, Haja No, Seong Who Kim, Onyou Hwan. Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. Neurochemistry international. vol 48. issue 4. 2006-05-26. PMID:16343695. |
parkinson's disease (pd) is a neurodegenerative disorder associated with a selective loss of dopaminergic neurons in the substantia nigra. |
2006-05-26 |
2023-08-12 |
Not clear |
| Sung Tae Kim, Ji Hyun Choi, Donghou Kim, Onyou Hwan. Increases in TH immunoreactivity, neuromelanin and degeneration in the substantia nigra of middle aged mice. Neuroscience letters. vol 396. issue 3. 2006-05-25. PMID:16377085. |
the dopaminergic (dargic) neurons in the substantia nigra (sn) are particularly vulnerable to oxidative stress and during aging. |
2006-05-25 |
2023-08-12 |
mouse |
| V Klawitter, P Morales, S Johansson, D Bustamante, M Goiny, J Gross, J Luthman, M Herrera-Marschit. Effects of perinatal asphyxia on cell survival, neuronal phenotype and neurite growth evaluated with organotypic triple cultures. Amino acids. vol 28. issue 2. 2006-05-24. PMID:15723243. |
compared to controls, the total number of nr1-positive neurons in substantia nigra, as well as the number of secondary to higher level branching of th-positive neurites from asphyxiated pups were decreased, illustrating the vulnerability of the dopaminergic systems to perinatal asphyxia. |
2006-05-24 |
2023-08-12 |
rat |
| J G McHaffie, H Jiang, P J May, V Coizet, P G Overton, B E Stein, P Redgrav. A direct projection from superior colliculus to substantia nigra pars compacta in the cat. Neuroscience. vol 138. issue 1. 2006-05-24. PMID:16361067. |
the midbrain superior colliculus also is sensitive to such stimuli, exhibits sensory responses with latencies reliably less than those of dopaminergic neurons, and, in rat, has been shown to send direct projections to regions of the substantia nigra and ventral tegmental area containing dopaminergic neurons (e.g. |
2006-05-24 |
2023-08-12 |
rat |
| Gülin Oz, Melissa Terpstra, Ivan Tkác, Pratibha Aia, Jodi Lowary, Paul J Tuite, Rolf Gruette. Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla: detection of high GABA concentrations. Magnetic resonance in medicine. vol 55. issue 2. 2006-05-11. PMID:16408282. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra (sn), the cause of which is unknown. |
2006-05-11 |
2023-08-12 |
human |
| I G Sil'ki. Possible mechanisms of the involvement of dopaminergic cells and cholinergic interneurons in the striatum in the conditioned-reflex selection of motor activity. Neuroscience and behavioral physiology. vol 36. issue 2. 2006-05-10. PMID:16380830. |
a possible mechanism for the involvement of cholinergic interneurons in the striatum and dopaminergic cells in the substantia nigra in the selection from among several types of motor activity during learning is proposed. |
2006-05-10 |
2023-08-12 |
Not clear |
| Rajnish Kumar Chaturvedi, Shubha Shukla, Kavita Seth, Ashok Kumar Agrawa. Nerve growth factor increases survival of dopaminergic graft, rescue nigral dopaminergic neurons and restores functional deficits in rat model of Parkinson's disease. Neuroscience letters. vol 398. issue 1-2. 2006-05-10. PMID:16423459. |
further, a significant increase was also observed in substantia nigra th-ir neurons count in co-transplanted rats, exhibiting a potential neuroprotective and neurorescue effects of ngf on nigrostriatal dopaminergic neurons. |
2006-05-10 |
2023-08-12 |
rat |
| A Guyon, D Skrzydelsi, C Rovère, W Rostène, S Mélik Parsadaniantz, J L Naho. Stromal cell-derived factor-1alpha modulation of the excitability of rat substantia nigra dopaminergic neurones: presynaptic mechanisms. Journal of neurochemistry. vol 96. issue 6. 2006-05-10. PMID:16476083. |
in rat substantia nigra (sn), chemokine (cxc motif) receptor 4 (cxcr4) for the chemokine stromal cell-derived factor (sdf)-1alpha is expressed on dopaminergic (da) neurones, but also on non-da cells, suggesting presynaptic actions. |
2006-05-10 |
2023-08-12 |
rat |
| Raquel Martín-Ibañez, Monica Jenstad, Paul Berghuis, Robert H Edwards, Hiroyuki Hioki, Takeshi Kaneko, Jan Mulder, Josep M Canals, Patrik Ernfors, Farrukh A Chaudhry, Tibor Harkan. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. The European journal of neuroscience. vol 23. issue 4. 2006-05-09. PMID:16519671. |
the excitability of dopaminergic (da) neurons in the substantia nigra is controlled by the convergent activity of multiple glutamatergic afferents. |
2006-05-09 |
2023-08-12 |
rat |
| Juergen Borlak, Stella Marie Reamon-Buettne. N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease. BMC medical genetics. vol 7. 2006-05-09. PMID:16571112. |
parkinson's disease (pd) is a movement disorder caused by the degeneration of dopaminergic neurons in the substantia nigra of the midbrain. |
2006-05-09 |
2023-08-12 |
Not clear |
| Winnie Jeng, Annmarie Ramkissoon, Toufan Parman, Peter G Well. Prostaglandin H synthase-catalyzed bioactivation of amphetamines to free radical intermediates that cause CNS regional DNA oxidation and nerve terminal degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 6. 2006-05-08. PMID:16581972. |
similarly in vivo, mda and meth caused dose- and time-dependent dna oxidation in multiple brain regions, remarkably dependent on the regional phs levels, including the striatum and substantia nigra, wherein neurodegeneration of dopaminergic nerve terminals was evidenced by decreased immunohistochemical staining of tyrosine hydroxylase. |
2006-05-08 |
2023-08-12 |
Not clear |
| H Arai, T Furuya, Y Mizuno, H Mochizuk. Inflammation and infection in Parkinson's disease. Histology and histopathology. vol 21. issue 6. 2006-05-04. PMID:16528677. |
the hallmark of parkinson's disease (pd) is a specific degeneration of dopaminergic neurons in the substantia nigra (sn). |
2006-05-04 |
2023-08-12 |
Not clear |
| George K Tofaris, Pablo Garcia Reitböck, Trevor Humby, Sarah L Lambourne, Mark O'Connell, Bernardino Ghetti, Helen Gossage, Piers C Emson, Lawrence S Wilkinson, Michel Goedert, Maria Grazia Spillantin. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 15. 2006-05-02. PMID:16611810. |
pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for lewy body disorders. |
2006-05-02 |
2023-08-12 |
mouse |
| F Fumagalli, G Racagni, M A Riv. Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease. The pharmacogenomics journal. vol 6. issue 2. 2006-04-28. PMID:16402079. |
brain-derived neurotrophic factor (bdnf) colocalizes with dopamine neurons in the substantia nigra, where dopaminergic cell bodies are located, and it has recently garnered attention as a molecule crucial for cognition, a function that is also compromised in pd patients. |
2006-04-28 |
2023-08-12 |
Not clear |
| Robert L Copeland, Yaminah A Leggett, Yasmine M Kanaan, Robert E Taylor, Yousef Tizab. Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371323. |
parkinson's disease is associated with degeneration of dopaminergic cell bodies in the substantia nigra. |
2006-04-27 |
2023-08-12 |
human |
| Diana Reimers, Antonio S Herranz, Juan José Díaz-Gil, María Val T Lobo, Carlos L Paíno, Raquel Alonso, María José Asensio, Rafael Gonzalo-Gobernado, Eulalia Bazá. Intrastriatal infusion of liver growth factor stimulates dopamine terminal sprouting and partially restores motor function in 6-hydroxydopamine-lesioned rats. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 54. issue 4. 2006-04-25. PMID:16344326. |
there was no evidence of dopaminergic neurogenesis in the striatum or substantia nigra in any experimental group at the times studied. |
2006-04-25 |
2023-08-12 |
rat |
| Hiromi Hayashita-Kinoh, Masanori Yamada, Takanori Yokota, Yoshikuni Mizuno, Hideki Mochizuk. Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model. Biochemical and biophysical research communications. vol 341. issue 4. 2006-04-25. PMID:16460685. |
down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of parkinson's disease rat model. |
2006-04-25 |
2023-08-12 |
human |
| Claire Henchcliffe, H Christian Schumacher, F Tuna Burgu. Recent advances in Parkinson's disease therapy: use of monoamine oxidase inhibitors. Expert review of neurotherapeutics. vol 5. issue 6. 2006-04-18. PMID:16274338. |
monoamine oxidase inhibitors inhibit dopamine metabolism and are therefore effective in treating parkinson's disease, a condition associated with progressive striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra. |
2006-04-18 |
2023-08-12 |
Not clear |
| M A Hellmann, H Panet, Y Barhum, E Melamed, D Offe. Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents. Neuroscience letters. vol 395. issue 2. 2006-04-13. PMID:16359791. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2006-04-13 |
2023-08-12 |
Not clear |