| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pepijn van den Munckhof, François Gilbert, Michel Chamberland, Daniel Lévesque, Jacques Droui. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16269007. |
preferential neurodegeneration of dopaminergic neurons in the ventral substantia nigra of the midbrain is a hallmark of parkinson's disease. |
2006-02-14 |
2023-08-12 |
mouse |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |
| V I Mel'nikova, A V Lavrent'eva, V S Kudrin, K S Raevskii, M V Ugryumo. Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus of rat fetuses. Neuroscience and behavioral physiology. vol 35. issue 8. 2006-02-06. PMID:16132261. |
controls were obtained from the fetal substantia nigra, which is enriched with dopaminergic neurons. |
2006-02-06 |
2023-08-12 |
rat |
| Yaping Chu, Weidong Le, Katie Kompoliti, Joseph Jankovic, Elliott J Mufson, Jeffrey H Kordowe. Nurr1 in Parkinson's disease and related disorders. The Journal of comparative neurology. vol 494. issue 3. 2006-02-06. PMID:16320253. |
the present study examined the role of nurr1 in the maintenance of the dopaminergic phenotype within neurons in substantia nigra in pd compared with patients with diagnoses of progressive supranuclear palsy (psp) or alzheimer's disease (ad) or age-matched-matched controls. |
2006-02-06 |
2023-08-12 |
Not clear |
| Jeffrey M Zigman, Juli E Jones, Charlotte E Lee, Clifford B Saper, Joel K Elmquis. Expression of ghrelin receptor mRNA in the rat and the mouse brain. The Journal of comparative neurology. vol 494. issue 3. 2006-02-06. PMID:16320257. |
finally, we examined the coexpression of ghsr with tyrosine hydroxylase and cholecystokinin and demonstrate a high degree of ghsr mrna expression within dopaminergic, cholecystokinin-containing neurons of the substantia nigra and ventral tegmental area. |
2006-02-06 |
2023-08-12 |
mouse |
| Manuchair Ebadi, Sushil K Sharma, Pedram Ghafourifar, Holly Brown-Borg, H El Refae. Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins. Methods in enzymology. vol 396. 2006-01-24. PMID:16291239. |
parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra zona compacta and in other subcortical nuclei associated with a widespread occurrence of lewy bodies. |
2006-01-24 |
2023-08-12 |
Not clear |
| Birgit Liss, Olga Haeckel, Johannes Wildmann, Takashi Miki, Susumu Seino, Jochen Roepe. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16299504. |
the selective degeneration of dopaminergic (da) midbrain neurons in the substantia nigra (sn) is a hallmark of parkinson disease. |
2006-01-24 |
2023-08-12 |
mouse |
| Sang H Choi, Da Y Lee, Eun S Chung, Young B Hong, Seung U Kim, Byung K Ji. Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16219027. |
inhibition of thrombin-induced microglial activation and nadph oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. |
2006-01-20 |
2023-08-12 |
rat |
| Sang H Choi, Da Y Lee, Eun S Chung, Young B Hong, Seung U Kim, Byung K Ji. Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16219027. |
seven days after thrombin injection in the rat substantia nigra (sn), tyrosine hydroxylase immunocytochemistry showed a significant loss of nigral dopaminergic neurons. |
2006-01-20 |
2023-08-12 |
rat |
| Jordi Bové, Delphine Prou, Céline Perier, Serge Przedborsk. Toxin-induced models of Parkinson's disease. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 2. issue 3. 2006-01-20. PMID:16389312. |
it results mainly from the death of dopaminergic neurons in the substantia nigra. |
2006-01-20 |
2023-08-12 |
Not clear |
| A Lessard, V M Picke. Subcellular distribution and plasticity of neurokinin-1 receptors in the rat substantia nigra and ventral tegmental area. Neuroscience. vol 135. issue 4. 2006-01-11. PMID:16165296. |
neurokinin-1 receptors show activity-dependent changes in their surface distributions that are critical in spinal pain mechanisms, and also may play an important role in the motor and affective behaviors influenced by dopaminergic projections from the substantia nigra and ventral tegmental area. |
2006-01-11 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
we report pitx3 expression in almost all dopaminergic substantia nigra (sn) and ventral tegmental area (vta) neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Renee M Miller, Howard J Federof. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 11. issue 6. 2006-01-05. PMID:16282595. |
parkinson disease (pd) targets dopaminergic neurons in the substantia nigra, resulting in motor disturbances such as resting tremor, bradykinesia, and rigidity. |
2006-01-05 |
2023-08-12 |
human |
| S K Ray, G G Wilford, S F Ali, N L Bani. Calpain upregulation in spinal cords of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease. Annals of the New York Academy of Sciences. vol 914. 2006-01-04. PMID:11085327. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), a heroin analogue, is a neurotoxin that undergoes in vivo oxidation by monoamine oxidase-b (mao-b) to 1-methyl-4-phenylpyridinium ion (mpp+) which preferentially exerts its toxic effects on the dopaminergic neurons of the substantia nigra in brain. |
2006-01-04 |
2023-08-12 |
mouse |
| S Jourdain, M Morissette, N Morin, T Di Paol. Oestrogens prevent loss of dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Journal of neuroendocrinology. vol 17. issue 8. 2005-12-23. PMID:16011487. |
oestriol treatment had no effect on dopaminergic markers in mptp mice whereas oestrone prevented striatal dat loss and the decrease of vmat2 mrna in the substantia nigra. |
2005-12-23 |
2023-08-12 |
mouse |
| Ronald L Klein, Robert D Dayton, Wen-Lang Lin, Dennis W Dickso. Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiology of disease. vol 20. issue 1. 2005-12-19. PMID:16137567. |
using a viral vector for mutant (p301l) tau, we studied the effects of gene transfer to the rat substantia nigra in terms of structural and functional properties of dopaminergic neurons. |
2005-12-19 |
2023-08-12 |
human |
| Dominique Caparros-Lefebvre, Andrew J Lee. Atypical unclassifiable parkinsonism on Guadeloupe: an environmental toxic hypothesis. Movement disorders : official journal of the Movement Disorder Society. vol 20 Suppl 12. 2005-12-13. PMID:16092100. |
neuronal death involves cholinergic and dopaminergic cells of the substantia nigra and gabaergic neurons of the striatum, associated with microglial proliferation. |
2005-12-13 |
2023-08-12 |
human |
| Yong Ren, Wenhua Liu, Houbo Jiang, Qian Jiang, Jian Fen. Selective vulnerability of dopaminergic neurons to microtubule depolymerization. The Journal of biological chemistry. vol 280. issue 40. 2005-12-02. PMID:16091364. |
parkinson disease (pd) is characterized by the specific degeneration of dopaminergic (da) neurons in substantia nigra and has been linked to a variety of environmental and genetic factors. |
2005-12-02 |
2023-08-12 |
Not clear |
| Jordi Bové, Jordi Serrats, Guadalupe Mengod, Roser Cortés, Eduardo Tolosa, Concepció Mari. Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways. Experimental brain research. vol 165. issue 3. 2005-12-01. PMID:15968457. |
in parkinson's disease (pd), the striatal dopamine depletion and the following overactivation of the indirect pathway of the basal ganglia leads to very early disinhibition of the subthalamic nucleus (stn) that may contribute to the progression of pd by glutamatergic overstimulation of the dopaminergic neurons in the substantia nigra. |
2005-12-01 |
2023-08-12 |
rat |
| A Lopez-Real, P Rey, R Soto-Otero, E Mendez-Alvarez, J L Labandeira-Garci. Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism. Journal of neuroscience research. vol 81. issue 6. 2005-11-30. PMID:16015598. |
rats treated with captopril and 6-hydroxydopamine showed significantly less reduction in the number of dopaminergic neurons (i.e., immunoreactive to tyrosine hydroxylase) in the substantia nigra and in the density of striatal dopaminergic terminals than 6-hydroxydopamine-lesioned rats not treated with captopril. |
2005-11-30 |
2023-08-12 |
rat |