| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael A Hauser, Yi-Ju Li, Hong Xu, Maher A Noureddine, Yujun S Shao, Steven R Gullans, Clemens R Scherzer, Roderick V Jensen, Adam C McLaurin, Jason R Gibson, Burton L Scott, Rita M Jewett, Judith E Stenger, Donald E Schmechel, Christine M Hulette, Jeffery M Vanc. Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. Archives of neurology. vol 62. issue 6. 2005-06-30. PMID:15956162. |
parkinson disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra. |
2005-06-30 |
2023-08-12 |
Not clear |
| Wenya Wang, Chi Ma, Zixu Mao, Mingtao L. JNK inhibition as a potential strategy in treating Parkinson's disease. Drug news & perspectives. vol 17. issue 10. 2005-06-14. PMID:15696229. |
parkinson's disease is characterized by the pathological loss of dopaminergic neurons in the substantia nigra. |
2005-06-14 |
2023-08-12 |
Not clear |
| Manuchair Ebadi, Holly Brown-Borg, Hesham El Refaey, Brij B Singh, Scott Garrett, Shaik Shavali, Sushil K Sharm. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790531. |
parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra zona compacta, and in other sub-cortical nuclei associated with a widespread occurrence of lewy bodies. |
2005-06-13 |
2023-08-12 |
mouse |
| Mika Shimoji, Li Zhang, Allen S Mandir, Valina L Dawson, Ted M Dawso. Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790534. |
the dopaminergic neurotoxin, mptp, replicates many of the pathological signs and motoric features of pd in primates and rodents by selective destruction of dopamine (da) neurons of the substantia nigra. |
2005-06-13 |
2023-08-12 |
mouse |
| Giia-Sheun Peng, Guorong Li, Nian-Sheng Tzeng, Po-See Chen, De-Maw Chuang, Yaw-Don Hsu, Sufen Yang, Jau-Shyong Hon. Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790540. |
parkinson's disease is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic (da) neurons in the substantia nigra. |
2005-06-13 |
2023-08-12 |
rat |
| A J Herrera, M Tomás-Camardiel, J L Venero, J Cano, A Machad. Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599609. |
the specific degeneration of dopaminergic neurons in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd). |
2005-06-07 |
2023-08-12 |
Not clear |
| A Kalenka, J Hinkelbei. [Anaesthesia in patients with Parkinson's disease]. Der Anaesthesist. vol 54. issue 4. 2005-05-24. PMID:15778805. |
the neurodegenerative death of dopaminergic neurons of the pars compacta of the substantia nigra leads to the classical triad of resting tremor, muscle rigidity, and bradykinesia of parkinson's disease. |
2005-05-24 |
2023-08-12 |
Not clear |
| Bruno Conti, Shuei Sugama, Jacinta Lucero, Raphaelle Winsky-Sommerer, Sebastian A Wirz, Pamela Maher, Zane Andrews, Alasdair M Barr, Maria C Morale, Covadonga Paneda, Janell Pemberton, Svetlana Gaidarova, M Margarita Behrens, Flint Beal, Pietro Paolo Sanna, Tamas Horvath, Tamas Bartfa. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816872. |
in these mice, dopaminergic neurons of the substantia nigra showed a twofold elevation in ucp2 expression, elevated uncoupling of their mitochondria, and a marked reduction in indicators of oxidative stress, an effect also observed in the striatum. |
2005-05-20 |
2023-08-12 |
mouse |
| Yoshio Bando, Taiichi Katayama, Manabu Taniguchi, Tomohiko Ishibashi, Noriyuki Matsuo, Satoshi Ogawa, Masaya Tohyam. RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells. Neurobiology of disease. vol 18. issue 1. 2005-05-16. PMID:15649705. |
parkinson's disease is characterized by selective loss of dopaminergic neurons in the substantia nigra. |
2005-05-16 |
2023-08-12 |
Not clear |
| Lei Xu, Jiansong Sheng, Zhongshu Tang, Xuefei Wu, Yi Yu, Hong Guo, Yan Shen, Changfu Zhou, Luminita Paraoan, Jiawei Zho. Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studies. Neurobiology of disease. vol 18. issue 1. 2005-05-16. PMID:15649706. |
destruction of nigrostriatal dopaminergic (da) pathway triggers various persistent responses, such as inflammation and increased synthesis of neural growth factors, both in striatum and in substantia nigra. |
2005-05-16 |
2023-08-12 |
rat |
| Hyun Jin Choi, So Yeon Lee, Yuri Cho, Onyou Hwan. Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. Neurochemistry international. vol 46. issue 4. 2005-05-11. PMID:15707697. |
parkinson's disease is a neurodegenerative disorder associated with progressive loss of dopaminergic cells in the substantia nigra. |
2005-05-11 |
2023-08-12 |
Not clear |
| R M Miller, L L Chen, G L Kiser, T L Giesler, T M Kaysser-Kranich, C Palaniappan, H J Federof. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of aging. vol 26. issue 5. 2005-05-09. PMID:15708451. |
the gradual loss of striatal dopamine and dopaminergic neurons residing in the substantia nigra (sn) causes parkinsonism characterized by slow, halting movements, rigidity, and resting tremor when neuronal loss exceeds a threshold of approximately 80%. |
2005-05-09 |
2023-08-12 |
mouse |
| Jennifer T Trevitt, Joseph Morrow, John F Marshal. Dopamine manipulation alters immediate-early gene response of striatal parvalbumin interneurons to cortical stimulation. Brain research. vol 1035. issue 1. 2005-05-09. PMID:15713275. |
the striatum also receives dopaminergic projections from the substantia nigra, but it has been challenging to study the impact of dopamine (da) cell injury on corticostriatal activity in vivo due to limitations in the methods used to induce cortical activity. |
2005-05-09 |
2023-08-12 |
rat |
| Manuela Basso, Sabrina Giraudo, Davide Corpillo, Bruno Bergamasco, Leonardo Lopiano, Mauro Fasan. Proteome analysis of human substantia nigra in Parkinson's disease. Proteomics. vol 4. issue 12. 2005-05-05. PMID:15526345. |
besides the consolidated view of oxidative stress involvement in pd pathogenesis, suggested by overexpression of mitochondrial and reactive oxygen species (ros)-scavenging proteins, these results indicate a possible potentiation mechanism of afferent signals to substantia nigra following degeneration of dopaminergic neurons. |
2005-05-05 |
2023-08-12 |
human |
| Zhizhong Dong, David P Wolfer, Hans-Peter Lipp, Hansruedi Büele. Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease. Molecular therapy : the journal of the American Society of Gene Therapy. vol 11. issue 1. 2005-05-04. PMID:15585408. |
hsp70 reduced mptp-induced apoptosis in the substantia nigra, and unilateral protection of the dopaminergic system by hsp70 was associated with increased amphetamine-induced turning toward the uninjected side. |
2005-05-04 |
2023-08-12 |
mouse |
| Michael Hsu, Bharath Srinivas, Jyothi Kumar, Rajagopalan Subramanian, Julie Anderse. Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715660. |
an early biochemical change in the parkinsonian substantia nigra (sn) is reduction in total glutathione (gsh + gssg) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex i activity, dopamine loss, and cell death. |
2005-04-28 |
2023-08-12 |
Not clear |
| Jie Li, Min Zhu, Sudha Rajamani, Vladimir N Uversky, Anthony L Fin. Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils. Chemistry & biology. vol 11. issue 11. 2005-04-25. PMID:15556002. |
the aggregation of alpha-synuclein in dopaminergic neurons of the substantia nigra is a critical step in the pathogenesis of parkinson's disease. |
2005-04-25 |
2023-08-12 |
Not clear |
| T D Charlier, G F Ball, J Balthazar. Sexual behavior activates the expression of the immediate early genes c-fos and Zenk (egr-1) in catecholaminergic neurons of male Japanese quail. Neuroscience. vol 131. issue 1. 2005-04-25. PMID:15680688. |
increases in c-fos expression were observed in th-immunoreactive cells in the periaqueductal gray and ventral tegmental area, but not in the substantia nigra, of i+f and cx+t+f birds indicating the activation of dopaminergic neurons during sexual behavior. |
2005-04-25 |
2023-08-12 |
Not clear |
| Matthew S Goldberg, Antonio Pisani, Marian Haburcak, Timothy A Vortherms, Tohru Kitada, Cinzia Costa, Youren Tong, Giuseppina Martella, Anne Tscherter, Andrea Martins, Giorgio Bernardi, Bryan L Roth, Emmanuel N Pothos, Paolo Calabresi, Jie She. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. vol 45. issue 4. 2005-04-25. PMID:15721235. |
although dj-1(-/-) mice had normal numbers of dopaminergic neurons in the substantia nigra, evoked dopamine overflow in the striatum was markedly reduced, primarily as a result of increased reuptake. |
2005-04-25 |
2023-08-12 |
mouse |
| D M Jacobowitz, A T Kallaraka. Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. Neurotoxicity research. vol 6. issue 4. 2005-04-22. PMID:15545008. |
at both dilutions dense dopaminergic fibers were observed in the rat caudate-putamen, nigrostriatal tract, and substantia nigra. |
2005-04-22 |
2023-08-12 |
human |