| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroaki Matsubayashi, Atsuko Inoue, Taku Amano, Takahiro Seki, Yoshihiro Nakata, Masashi Sasa, Norio Saka. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469877. |
involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell pcr study using acutely dissociated nigral neurons. |
2005-04-19 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Atsuko Inoue, Taku Amano, Takahiro Seki, Yoshihiro Nakata, Masashi Sasa, Norio Saka. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469877. |
the receptor subtypes, which mediate nicotine-induced excitation of dopaminergic neurons in the substantia nigra, were investigated by whole-cell patch clamp studies and single-cell rt-pcr using acutely dissociated nigral neurons. |
2005-04-19 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Atsuko Inoue, Taku Amano, Takahiro Seki, Yoshihiro Nakata, Masashi Sasa, Norio Saka. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469877. |
these results suggest that nicotine directly acts on postsynaptic alpha7- and alpha4beta2-type nicotinic acetylcholine receptors and induces inward current, which result in the excitation of dopaminergic neurons in the substantia nigra. |
2005-04-19 |
2023-08-12 |
Not clear |
| Nelson B Cole, Diane D Murphy, Jacob Lebowitz, Luca Di Noto, Rodney L Levine, Robert L Nussbau. Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments. The Journal of biological chemistry. vol 280. issue 10. 2005-04-19. PMID:15615715. |
oxidative stress is implicated in a number of neuro-degenerative diseases and is associated with the selective loss of dopaminergic neurons of the substantia nigra in parkinson's disease. |
2005-04-19 |
2023-08-12 |
Not clear |
| Andrea Tamás, Andrea Lubics, Luca Szalontay, István Lengvári, Dóra Reglod. Age and gender differences in behavioral and morphological outcome after 6-hydroxydopamine-induced lesion of the substantia nigra in rats. Behavioural brain research. vol 158. issue 2. 2005-04-19. PMID:15698888. |
tyrosine-hydroxylase (th) immunohistochemistry was done in order to assess the dopaminergic cell loss in the substantia nigra. |
2005-04-19 |
2023-08-12 |
rat |
| M J Porritt, P E Batchelor, D W Howell. Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Experimental neurology. vol 192. issue 1. 2005-04-14. PMID:15698637. |
therefore, reduced bdnf mrna expression in parkinson's disease substantia nigra may contribute directly to the death of nigral dopaminergic neurons and the development of parkinson's disease. |
2005-04-14 |
2023-08-12 |
rat |
| Charles B Glaser, Ghiam Yamin, Vladimir N Uversky, Anthony L Fin. Methionine oxidation, alpha-synuclein and Parkinson's disease. Biochimica et biophysica acta. vol 1703. issue 2. 2005-04-12. PMID:15680224. |
the aggregation of normally soluble alpha-synuclein in the dopaminergic neurons of the substantia nigra is a crucial step in the pathogenesis of parkinson's disease. |
2005-04-12 |
2023-08-12 |
Not clear |
| V I Mel'nikov, A V Lavrent'eva, V S Kudrin, K S Raevskiĭ, M V Ugriumo. [Dopamine synthesis by non-dopaminergic neurons of the rat fetus arquate nucleus]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 7. 2005-04-01. PMID:15462205. |
the fetal substantia nigra containing dopaminergic neurons served as control. |
2005-04-01 |
2023-08-12 |
rat |
| Bianca C Wittmann, Björn H Schott, Sebastian Guderian, Julietta U Frey, Hans-Jochen Heinze, Emrah Düze. Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron. vol 45. issue 3. 2005-03-29. PMID:15694331. |
long-term potentiation in the hippocampus can be enhanced and prolonged by dopaminergic inputs from midbrain structures such as the substantia nigra. |
2005-03-29 |
2023-08-12 |
Not clear |
| Heidi Fedorow, Russell Pickford, James M Hook, Kay L Double, Glenda M Halliday, Manfred Gerlach, Peter Riederer, Brett Garne. Dolichol is the major lipid component of human substantia nigra neuromelanin. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686500. |
neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (sn). |
2005-03-21 |
2023-08-12 |
human |
| Gonzalo Bustos, Jorge Abarca, Jorge Campusano, Victor Bustos, Viviana Noriega, Esteban Aliag. Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain. Brain research. Brain research reviews. vol 47. issue 1-3. 2005-03-15. PMID:15572168. |
dopaminergic nigrostriatal neurons may be considered as bipolar functional entities since they are endowed with the ability to synthesize, store and release the transmitter dopamine (da) at the somatodendritic level in the substantia nigra (sn). |
2005-03-15 |
2023-08-12 |
Not clear |
| Miguel A Díaz del Guante, Mauricio Rivas, Roberto A Prado-Alcalá, Gina L Quirart. Amnesia produced by pre-training infusion of serotonin into the substantia nigra. Neuroreport. vol 15. issue 16. 2005-03-14. PMID:15538188. |
interference with dopaminergic, gabaergic or cholinergic activity of the substantia nigra is sufficient to disrupt cognitive functions. |
2005-03-14 |
2023-08-12 |
rat |
| Karen Müller Smith, Lorri Bauer, Mariellen Fischer, Russell Barkley, Bradford A Navi. Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635701. |
nr4a2, or nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (vta) and the substantia nigra (sn). |
2005-03-14 |
2023-08-12 |
human |
| Darryl W Eyles, Steven Smith, Robert Kinobe, Martin Hewison, John J McGrat. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. Journal of chemical neuroanatomy. vol 29. issue 1. 2005-03-10. PMID:15589699. |
the strongest immunohistochemical staining for both the receptor and enzyme was in the hypothalamus and in the large (presumably dopaminergic) neurons within the substantia nigra. |
2005-03-10 |
2023-08-12 |
human |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
to explore further the relationship between the mesencephalic dopaminergic neurons and pfc gabaergic neurons, we investigated the effects of nicotine and passive exposure to cigarette smoke on the regulation of tyrosine hydroxylase (th) in vta and substantia nigra (snc) and dopamine (da) d1 receptor levels in nucleus accumbens (nac) and caudate-putamen (cpu). |
2005-03-07 |
2023-08-12 |
rat |
| Y Shimizu, S Sugama, L A Degiorgio, B P Cho, T H Jo. Cell-type specific signal transduction and gene regulation via mitogen-activated protein kinase pathway in catecholaminergic neurons by restraint stress. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541904. |
the stimuli, such as stress or reserpine administration, significantly increased the th gene in noradrenergic neurons in the locus ceruleus (lc), but not in dopaminergic neurons in the substantia nigra (sn). |
2005-03-07 |
2023-08-12 |
Not clear |
| Jörg B Schulz, Björn H Falkenburge. Neuronal pathology in Parkinson's disease. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15365812. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra leading to the major clinical and pharmacological abnormalities of pd. |
2005-03-04 |
2023-08-12 |
Not clear |
| Andreas Schobe. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15503155. |
pd is characterized by massive degeneration of dopaminergic neurons in the substantia nigra, the loss of striatal dopaminergic fibers and a dramatic reduction of the striatal dopamine levels. |
2005-03-04 |
2023-08-12 |
human |
| Christelle Monaca, Charlotte Laloux, Jean-Marie Jacquesson, Patrick Gelé, Xavier Maréchal, Régis Bordet, Alain Destée, Philippe Derambur. Vigilance states in a parkinsonian model, the MPTP mouse. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525288. |
after recovery, polysomnography was recorded over 48 h. dopaminergic lesions of the substantia nigra and striata were evaluated using immunohistochemical markers. |
2005-03-04 |
2023-08-12 |
mouse |
| Iwona Kurkowska-Jastrzebska, Tomasz Litwin, Ilona Joniec, Agnieszka Ciesielska, Adam Przybyłkowski, Andrzej Członkowski, Anna Członkowsk. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. International immunopharmacology. vol 4. issue 10-11. 2005-02-23. PMID:15313429. |
we observed the same protection in both situations: less dopamine depletion and less decrease in the number of dopaminergic cells in the substantia nigra (sn). |
2005-02-23 |
2023-08-12 |
mouse |