| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Judit Soós, József I Engelhardt, László Siklós, László Havas, Katalin Majtény. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257133. |
immunohistochemical techniques revealed a significant increase of poly(adp-ribose) polymerase (parp)-containing nuclei in the dopaminergic neurons of the substantia nigra (sn) in parkinson disease and in diffuse lewy body disease as compared with a group of patients with other neurodegenerative diseases and normal controls. |
2004-10-21 |
2023-08-12 |
Not clear |
| Anna Krygowska-Wajs, Zbigniew Wszole. [Advances in the genetic studies in Parkinson's disease]. Neurologia i neurochirurgia polska. vol 38. issue 2. 2004-10-19. PMID:15307606. |
the discovery of alpha-synuclein, ubiquitin c-terminal hydrolase, parkin, tau and dj-1 mutations and analysis of the biochemical and molecular properties of these gene products point to the critical role of protein aggregation in dopaminergic neurons of the substantia nigra as the basic mechanism leading to neurodegeneration also in sporadic form of the disease. |
2004-10-19 |
2023-08-12 |
Not clear |
| Lidia I Serova, Shreekrishna Maharjan, An Huang, Dong Sun, Gabor Kaley, Esther L Sabba. Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. Brain research. vol 1015. issue 1-2. 2004-10-15. PMID:15223360. |
short-term administration of estradiol benzoate (eb) by five injections of 15 or 40 microg/kg 12 h apart led to increase in th and gtpch mrna levels in dopaminergic and noradrenergic cell bodies of the ventral tegmental area (vta), substantia nigra (sn), locus coeruleus (lc) and the nucleus of solitary tract (nts) depending on dose of administration. |
2004-10-15 |
2023-08-12 |
rat |
| Elizabeth A Mazzio, Karam F A Solima. Glioma cell antioxidant capacity relative to reactive oxygen species produced by dopamine. Journal of applied toxicology : JAT. vol 24. issue 2. 2004-10-14. PMID:15052604. |
the pathology of parkinson's disease involves oxidative damage to dopaminergic neurons of the substantia nigra. |
2004-10-14 |
2023-08-12 |
rat |
| Zhaoliang Hu, Margaret Cooper, David P Crockett, Renping Zho. Differentiation of the midbrain dopaminergic pathways during mouse development. The Journal of comparative neurology. vol 476. issue 3. 2004-10-07. PMID:15269972. |
dopaminergic (da) neurons in the substantia nigra (sn) and ventral tegmental area (vta) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus accumbens, respectively, establishing the mesostriatal and the mesolimbic pathways. |
2004-10-07 |
2023-08-12 |
mouse |
| A S Glass, D P Huynh, Th Franck, D Woitalla, Th Müller, S M Pulst, D Berg, R Krüger, O Ries. Screening for mutations in synaptotagmin XI in Parkinson's disease. Journal of neural transmission. Supplementum. issue 68. 2004-10-05. PMID:15354386. |
parkinson's disease (pd) is characterized by selective degeneration of neurons in the substantia nigra and subsequent dysfunction of dopaminergic neurotransmission. |
2004-10-05 |
2023-08-12 |
Not clear |
| Sarah A Baker, K Adam Baker, Theo Hag. Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. The European journal of neuroscience. vol 20. issue 2. 2004-09-30. PMID:15233767. |
here, we show in adult mice that destruction of the dopaminergic neurons in the substantia nigra and ventral tegmental area in a 6-hydroxydopamine model of parkinson's disease reduced the number of proliferating neural precursors in the subventricular zone of the anterior lateral ventricle by approximately 40%. |
2004-09-30 |
2023-08-12 |
mouse |
| Li-Ping Liang, Manisha Pate. Iron-sulfur enzyme mediated mitochondrial superoxide toxicity in experimental Parkinson's disease. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312163. |
however, the precise mechanism by which mitochondrial oxidative stress mediates the death of dopaminergic neurons of the substantia nigra remains unclear. |
2004-09-30 |
2023-08-12 |
mouse |
| Min-Yau Teo, Michiel van Wyk, John Lin, Janusz Lipsk. Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro. Acta neurobiologiae experimentalis. vol 64. issue 2. 2004-09-30. PMID:15366245. |
differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro. |
2004-09-30 |
2023-08-12 |
rat |
| Björn H Schott, Daniela B Sellner, Corinna-J Lauer, Reza Habib, Julietta U Frey, Sebastian Guderian, Hans-Jochen Heinze, Emrah Düze. Activation of midbrain structures by associative novelty and the formation of explicit memory in humans. Learning & memory (Cold Spring Harbor, N.Y.). vol 11. issue 4. 2004-09-23. PMID:15254215. |
recent evidence suggests a close functional relationship between memory formation in the hippocampus and dopaminergic neuromodulation originating in the ventral tegmental area and medial substantia nigra of the midbrain. |
2004-09-23 |
2023-08-12 |
human |
| Beth-Anne Sieber, Alexander Kuzmin, Josep M Canals, Anne Danielsson, Gustavo Paratcha, Ernest Arenas, Jordi Alberch, Sven Ove Ogren, Carlos F Ibáñe. Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Molecular and cellular neurosciences. vol 26. issue 3. 2004-09-17. PMID:15234346. |
adult transgenic mice showed a 30-40% reduction in the total volume of the substantia nigra (sn) without detectable differences in the number of dopaminergic neurons. |
2004-09-17 |
2023-08-12 |
mouse |
| Yoshihisa Kurachi, Masaru Ishi. Cell signal control of the G protein-gated potassium channel and its subcellular localization. The Journal of physiology. vol 554. issue Pt 2. 2004-09-16. PMID:12923211. |
the neuronal k(g) channel, which contains kir3.2c, is localized in the postsynaptic density (psd) of various neurones including dopaminergic neurones in substantia nigra. |
2004-09-16 |
2023-08-12 |
Not clear |
| Jing Zhang, David R Goodlet. Proteomic approach to studying Parkinson's disease. Molecular neurobiology. vol 29. issue 3. 2004-09-16. PMID:15181239. |
parkinson's disease is a common age-related neurodegenerative disease characterized pathologically by a loss of dopaminergic neurons in the substantia nigra with resultant depletion of striatal dopamine and presence of lewy bodies in the remaining neurons. |
2004-09-16 |
2023-08-12 |
human |
| Charbel E-H Moussa, Christophe Wersinger, York Tomita, Anita Sidh. Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine. Biochemistry. vol 43. issue 18. 2004-09-08. PMID:15122920. |
parkinson's disease (pd) involves loss of dopaminergic neurons in the substantia nigra and is characterized by intracellular inclusions, lewy bodies, consisting primarily of aggregated alpha-synuclein. |
2004-09-08 |
2023-08-12 |
human |
| V Fraix, P Pollak, S Chabardes, C Ardouin, A Koudsie, A Benazzouz, P Krack, A Batir, J-F Le Bas, A-L Benabi. [Deep brain stimulation]. Revue neurologique. vol 160. issue 5 Pt 1. 2004-08-31. PMID:15269668. |
it was demonstrated in animal models of parkinson's disease that the loss of dopaminergic neurons within the substantia nigra, at the origin of the striatal dopaminergic defect, induces an overactivity of the excitatory glutamatergic subthalamo-internal pallidum pathway. |
2004-08-31 |
2023-08-12 |
Not clear |
| C Levecque, A Destée, V Mouroux, P Amouyel, M-C Chartier-Harli. Assessment of Nurr1 nucleotide variations in familial Parkinson's disease. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276233. |
parkinson's disease (pd) is characterised by the death of dopaminergic neurons of the substantia nigra. |
2004-08-25 |
2023-08-12 |
Not clear |
| V Frai. [Gene therapy for Parkinson's disease]. La Revue de medecine interne. vol 25. issue 7. 2004-08-18. PMID:15219371. |
parkinson's disease is a progressive neurodegenerative disorder whose main histopathological feature is the loss of dopaminergic neurons in the pars compacta of the substantia nigra with secondary striatal dopaminergic insufficiency. |
2004-08-18 |
2023-08-12 |
Not clear |
| Mark J Hokenson, Vladimir N Uversky, John Goers, Ghiam Yamin, Larissa A Munishkina, Anthony L Fin. Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein. Biochemistry. vol 43. issue 15. 2004-08-13. PMID:15078109. |
the aggregation of normally soluble alpha-synuclein in the dopaminergic neurons of the substantia nigra is a crucial step in the pathogenesis of parkinson's disease. |
2004-08-13 |
2023-08-12 |
Not clear |
| Min Zhu, Sudha Rajamani, Joanna Kaylor, Shubo Han, Feimeng Zhou, Anthony L Fin. The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. The Journal of biological chemistry. vol 279. issue 26. 2004-08-13. PMID:15096521. |
parkinson's disease is a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons from the substantia nigra; currently, no cure exists. |
2004-08-13 |
2023-08-12 |
Not clear |
| Keiya Ozaw. [AAV vector-mediated gene transfer and its application to the nervous system]. Rinsho shinkeigaku = Clinical neurology. vol 43. issue 11. 2004-08-13. PMID:15152479. |
pd is a progressive neurodegenerative disorder that predominantly affects dopaminergic neurons in the substantia nigra. |
2004-08-13 |
2023-08-12 |
monkey |