| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca R Fusco, Alessandro Martorana, Carmela Giampà, Zena De March, Fabrizio Vacca, Alessandro Tozzi, Patrizia Longone, Silvia Piccirilli, Stefano Paolucci, Giuseppe Sancesario, Nicola B Mercuri, Giorgio Bernard. Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes. Neuroscience letters. vol 365. issue 2. 2004-08-09. PMID:15245795. |
we performed a double labeling study for trpc3 and one of the following cell-specific markers: mouse anti-glial fibrillary acidic protein (gfap) for astrocytes; mouse anti-rip for oligodendrocytes, or mouse anti-ox42 for microglia, or mouse anti-neun for neuronal nuclei or mouse anti-tyrosine hydroxylase (th) for detection of dopaminergic neurons of the substantia nigra. |
2004-08-09 |
2023-08-12 |
mouse |
| J S Lonstein, J D Blaustei. Immunocytochemical investigation of nuclear progestin receptor expression within dopaminergic neurones of the female rat brain. Journal of neuroendocrinology. vol 16. issue 6. 2004-08-06. PMID:15189328. |
additionally, although progesterone alters mesolimbic and nigrostriatal dopamine release, and the numerous behaviours that these pathways influence, these data again suggest that it does not do so via nuclear progestin receptor in dopaminergic cells of the ventral tegmental area and substantia nigra. |
2004-08-06 |
2023-08-12 |
rat |
| Sophie Sarre, Hong Yuan, Nadine Jonkers, An Van Hemelrijck, Guy Ebinger, Yvette Michott. In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198664. |
we investigated the effect of an injection of 6-hydroxydopamine (6-ohda) into the rat medial forebrain bundle (mfb) on the degeneration and the function of the dopaminergic cell bodies in the substantia nigra (sn) 3 and 5 weeks after lesioning. |
2004-08-06 |
2023-08-12 |
rat |
| S Nedergaar. A Ca2+-independent slow afterhyperpolarization in substantia nigra compacta neurons. Neuroscience. vol 125. issue 4. 2004-08-02. PMID:15120845. |
the discharge properties of dopaminergic neurons in substantia nigra are influenced by slow adaptive responses, which have not been fully identified. |
2004-08-02 |
2023-08-12 |
rat |
| Helena Frielingsdorf, Katherine Schwarz, Patrik Brundin, Paul Mohape. No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 27. 2004-07-30. PMID:15210991. |
no evidence for new dopaminergic neurons in the adult mammalian substantia nigra. |
2004-07-30 |
2023-08-12 |
Not clear |
| Helena Frielingsdorf, Katherine Schwarz, Patrik Brundin, Paul Mohape. No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 27. 2004-07-30. PMID:15210991. |
using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-parkinsonian rodents, or even after growth factor treatment. |
2004-07-30 |
2023-08-12 |
Not clear |
| Helena Frielingsdorf, Katherine Schwarz, Patrik Brundin, Paul Mohape. No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 27. 2004-07-30. PMID:15210991. |
we conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra. |
2004-07-30 |
2023-08-12 |
Not clear |
| Daniela Marazziti, Elisabetta Golini, Silvia Mandillo, Armando Magrelli, Walter Witke, Rafaele Matteoni, Glauco P Tocchini-Valentin. Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 27. 2004-07-30. PMID:15218106. |
these functional alterations are not associated with any substantial loss of substantia nigra neurons or degeneration of striatal dopaminergic afferences, the main histological marks of parkinson's disease. |
2004-07-30 |
2023-08-12 |
mouse |
| Myung S Yoo, Hibiki Kawamata, Dae J Kim, Hong S Chun, Jin H So. Experimental strategy to identify genes susceptible to oxidative stress in nigral dopaminergic neurons. Neurochemical research. vol 29. issue 6. 2004-07-26. PMID:15176479. |
neuropathological evidence from both human and experimental models of parkinson's disease (pd) firmly supports a significant role for oxidative stress (os) in the death of dopaminergic (da) neurons in substantia nigra. |
2004-07-26 |
2023-08-12 |
human |
| Xuebing Cao, Shenggang Sun, E'tang Ton. Experimental study on heterograft of glomus cells of carotid body for hemiparkinsonian rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 22. issue 2. 2004-07-22. PMID:12658754. |
to observe the effects of heterograft of glomus cells of carotid body on hemiparkinsonian rat models, rats with unilateral 6-hydroxydopamine (6-ohda)-induced lesions of the right dopaminergic neurons of substantia nigra received intrastriatal glomus cells heterograft. |
2004-07-22 |
2023-08-12 |
rat |
| Yan Xu, Shenggang Sun, Xuebing Cao, Etang Ton. Protective effect of GSH on PD model induced by 6-OHDA in vitro. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 22. issue 4. 2004-07-20. PMID:12674779. |
to study the effects of 6-hydroxydopamine (6-ohda) and reduced glutathione (gsh) on the nigral dopaminergic neurons in brain slices in vitro, immolunohistochemical technique was used to observe the changes of th-stained neurons, including cell bodies and the dendrites, in the substantia nigra (sn) of midbrain slices of rats after incubation for 1 h in the presence of gsh 15 min before and during the period of incubation with 6-ohda. |
2004-07-20 |
2023-08-12 |
rat |
| Dóra Reglodi, Andrea Lubics, Andrea Tamás, Luca Szalontay, István Lengvár. Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease. Behavioural brain research. vol 151. issue 1-2. 2004-07-19. PMID:15084446. |
tyrosine-hydroxylase immunohistochemistry revealed that control animals had more than 95% loss of the dopaminergic cells in the ipsilateral substantia nigra, while pacap-treated animals had only approximately 50% loss of dopaminergic cells. |
2004-07-19 |
2023-08-12 |
rat |
| Christina P Lynn-Bullock, Kristy Welshhans, Sarah L Pallas, Paul S Kat. The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats. Journal of chemical neuroanatomy. vol 27. issue 2. 2004-07-16. PMID:15121217. |
however, 5-htp treatment also caused ectopic 5-hydroxytryptophan-immunoreactivity and serotonin-immunoreactivity in normally dopaminergic neurons of the substantia nigra par compacta. |
2004-07-16 |
2023-08-12 |
rat |
| Hyun Jin Choi, So Yeon Lee, Yuri Cho, Onyou Hwan. JNK activation by tetrahydrobiopterin: implication for Parkinson's disease. Journal of neuroscience research. vol 75. issue 5. 2004-07-13. PMID:14991847. |
parkinson's disease (pd) is a progressive neurologic disease associated with selective degeneration of dopaminergic neurons in the substantia nigra. |
2004-07-13 |
2023-08-12 |
Not clear |
| Larissa A Munishkina, Jeremy Henriques, Vladimir N Uversky, Anthony L Fin. Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation. Biochemistry. vol 43. issue 11. 2004-07-13. PMID:15023080. |
filamentous alpha-synuclein is the major component of lewy bodies and lewy neurites, the intracellular inclusions in the dopaminergic neurons of the substantia nigra, which are considered the pathological hallmark of parkinson's disease. |
2004-07-13 |
2023-08-12 |
Not clear |
| E I Mukhin, Yu K Mukhina, T N Nabiev. The role of the substantia nigra in cognitive activity in cats. Neuroscience and behavioral physiology. vol 34. issue 3. 2004-07-13. PMID:15151183. |
neurosurgical or neurochemical exclusion of the substantia nigra in cats led to significant impairment of conditioned reflex activity, generalization and abstraction processes; these recovered with pharmacological treatment directed to the dopaminergic system, with partial recovery after treatment directed to the gabaergic and cholinergic systems. |
2004-07-13 |
2023-08-12 |
Not clear |
| J L W Bosboom, E Ch Wolter. Psychotic symptoms in Parkinson's disease: pathophysiology and management. Expert opinion on drug safety. vol 3. issue 3. 2004-07-13. PMID:15155149. |
parkinson's disease (pd) is a chronic neurodegenerative disease, in which mainly dopaminergic neurons in the substantia nigra in the brain degenerate, leading to a depletion of dopamine (da) in the striatum. |
2004-07-13 |
2023-08-12 |
Not clear |
| Lixia Lu, Frauke Neff, Zhou Dun, Bernhard Hemmer, Wolfgang H Oertel, Jürgen Schlegel, Andreas Hartman. Gene expression profiles derived from single cells in human postmortem brain. Brain research. Brain research protocols. vol 13. issue 1. 2004-07-06. PMID:15063837. |
dopaminergic neurons from different midbrain areas including substantia nigra, central gray substance and ventral tegmental area were identified and isolated by immuno-laser capture microscopy (lcm). |
2004-07-06 |
2023-08-12 |
human |
| Joelle M van der Walt, Maher A Noureddine, Raja Kittappa, Michael A Hauser, William K Scott, Ron McKay, Fengyu Zhang, Jeffrey M Stajich, Kenichiro Fujiwara, Burton L Scott, Margaret A Pericak-Vance, Jeffery M Vance, Eden R Marti. Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. American journal of human genetics. vol 74. issue 6. 2004-07-06. PMID:15122513. |
the pathogenic process responsible for the loss of dopaminergic neurons within the substantia nigra of patients with parkinson disease (pd) is poorly understood. |
2004-07-06 |
2023-08-12 |
human |
| Akinori Iwashita, Syunji Yamazaki, Kayoko Mihara, Kouji Hattori, Hirofumi Yamamoto, Junya Ishida, Nobuya Matsuoka, Seitaro Muto. Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14985416. |
intoxication lead to parp activation and cell damage in the nigrostriatal dopaminergic pathway, which was significantly ameliorated by oral administration of fr255595 (10-32 mg/kg), both in the substantia nigra and in the striatum via marked reduction of parp activation, even with delayed treatment. |
2004-07-01 |
2023-08-12 |
mouse |