| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Blandini, M T Armentero, R Fancellu, E Blaugrund, G Napp. Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144871. |
both doses of rasagiline markedly increased the survival of dopaminergic neurons in the lesioned substantia nigra, compared to controls (+97% and +119%, respectively). |
2004-06-30 |
2023-08-12 |
rat |
| Hideto Miwa, Tomomi Kubo, Shuhei Morita, Ichiro Nakanishi, Tomoyoshi Kond. Oxidative stress and microglial activation in substantia nigra following striatal MPP+. Neuroreport. vol 15. issue 6. 2004-06-29. PMID:15076730. |
the present study aims to study sequential alterations occurring in both dopaminergic neurons and microglia in substantia nigra (sn) following intrastriatal injection of 1-methyl-4-phenylpridium ion (mpp+) in rats. |
2004-06-29 |
2023-08-12 |
rat |
| Susan Totterdell, Diane Hanger, Gloria E Meredit. The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain. Brain research. vol 1004. issue 1-2. 2004-06-24. PMID:15033420. |
furthermore, the protein is present in the terminals of neurons such as the dopaminergic neurons of the substantia nigra and the glutamatergic neurons of the hippocampus, cell types which accumulate alpha-synuclein in disease. |
2004-06-24 |
2023-08-12 |
mouse |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Brain research. vol 1005. issue 1-2. 2004-06-22. PMID:15044058. |
the local and endogenous nicotinic neuronal transmissions of dopaminergic neurons in the substantia nigra were confirmed electrophysiologically using a slice-patch technique. |
2004-06-22 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Brain research. vol 1005. issue 1-2. 2004-06-22. PMID:15044058. |
these results suggest that dopaminergic neurons in the substantia nigra receive excitatory cholinergic inputs that are mediated via at least two types of postsynaptic nicotinic receptors, namely alpha7 and alpha4beta2 subtypes. |
2004-06-22 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578581. |
electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. |
2004-06-18 |
2023-08-12 |
rat |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578581. |
the electrophysiological characteristics of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra was investigated using the whole-cell patch clamp technique under the voltage-clamp mode. |
2004-06-18 |
2023-08-12 |
rat |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578581. |
nicotine directly acts on postsynaptic alpha4beta2 type nicotinic receptors and induces inward currents, resulting in excitation of dopaminergic neurons in the substantia nigra and subsequent enhancement of dopamine release in the corpus striatum. |
2004-06-18 |
2023-08-12 |
rat |
| D Makarovsky, Y Kalechman, T Sonino, I Freidkin, S Teitz, M Albeck, M Weil, R Geffen-Aricha, G Yadid, B Sredn. Tellurium compound AS101 induces PC12 differentiation and rescues the neurons from apoptotic death. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033807. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2004-06-15 |
2023-08-12 |
Not clear |
| Enza Maria Valente, Patrick M Abou-Sleiman, Viviana Caputo, Miratul M K Muqit, Kirsten Harvey, Suzana Gispert, Zeeshan Ali, Domenico Del Turco, Anna Rita Bentivoglio, Daniel G Healy, Alberto Albanese, Robert Nussbaum, Rafael González-Maldonado, Thomas Deller, Sergio Salvi, Pietro Cortelli, William P Gilks, David S Latchman, Robert J Harvey, Bruno Dallapiccola, Georg Auburger, Nicholas W Woo. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (New York, N.Y.). vol 304. issue 5674. 2004-06-14. PMID:15087508. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. |
2004-06-14 |
2023-08-12 |
Not clear |
| Ryuichi Kohno, Hideyuki Sawada, Yasuhiro Kawamoto, Kengo Uemura, Hiroshi Shibasaki, Shun Shimoham. BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochemical and biophysical research communications. vol 318. issue 1. 2004-06-08. PMID:15110760. |
in pd, alpha-sn-positive glial inclusions are distributed mainly in the dorso-medial region of the substantia nigra, which contains most of the surviving dopaminergic neurons, suggesting that alpha-sn expression might have a neuroprotective function in glial cells. |
2004-06-08 |
2023-08-12 |
Not clear |
| Bhisham Chera, Kurt E Schaecher, Anne Rocchini, Syed Z Imam, Eric A Sribnick, Swapan K Ray, Syed F Ali, Naren L Bani. Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Brain research. vol 1006. issue 2. 2004-06-07. PMID:15051518. |
parkinson's disease (pd) is a movement disorder characterized by rigidity, tremor, and bradykinesia, originating from degeneration of dopaminergic neurons in the substantia nigra (sn), retrorubral area, and locus ceoruleus (lc). |
2004-06-07 |
2023-08-12 |
mouse |
| Peter Claus, Stefan Werner, Marco Timmer, Claudia Groth. Expression of the fibroblast growth factor-2 isoforms and the FGF receptor 1-4 transcripts in the rat model system of Parkinson's disease. Neuroscience letters. vol 360. issue 3. 2004-06-07. PMID:15082147. |
we have previously shown that the high molecular weight fgf-2 isoforms (21, 23 kd) stimulated survival- and neurite-promoting activities and protective effects on cultured embryonic dopaminergic (da) neurons of the substantia nigra (neuroscience 100 (2000) 73). |
2004-06-07 |
2023-08-12 |
rat |
| Emilio Fernandez-Espej. Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies. Molecular neurobiology. vol 29. issue 1. 2004-06-04. PMID:15034220. |
parkinson's disease (pd) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. |
2004-06-04 |
2023-08-12 |
rat |
| Wei Zhang, Tongguang Wang, Liya Qin, Hui-Ming Gao, Belinda Wilson, Syed F Ali, Wanqin Zhang, Jau-Shyong Hong, Bin Li. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14734632. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra and depletion of the neurotransmitter dopamine in the striatum. |
2004-06-01 |
2023-08-12 |
mouse |
| Chang-Lin Liang, Omar Nelson, Umar Yazdani, Parichehr Pasbakhsh, Dwight C Germa. Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. The Journal of comparative neurology. vol 473. issue 1. 2004-05-24. PMID:15067721. |
the dopaminergic neurons in the ventral substantia nigra (sn) are significantly more vulnerable to degeneration in parkinson's disease (pd) than the dopaminergic neurons in the ventral tegmental area (vta). |
2004-05-24 |
2023-08-12 |
human |
| G D Bartoszyk, C Van Amsterdam, H E Greiner, W Rautenberg, H Russ, C A Seyfrie. Sarizotan, a serotonin 5-HT1A receptor agonist and dopamine receptor ligand. 1. Neurochemical profile. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 2. 2004-05-19. PMID:14767715. |
however, sarizotan at higher doses decreased da precursor accumulation in reserpinized rats and induced contralateral rotational behavior in unilaterally substantia nigra lesioned rats, indicating some intrinsic dopaminergic activity; at d2 receptors sarizotan may act as a partial agonist, depending on the dopaminergic impulse flow. |
2004-05-19 |
2023-08-12 |
rat |
| Alison L McCormack, Donato A Di Monte, Kioumars Delfani, Ian Irwin, Louis E DeLanney, William J Langston, Ann Marie Janso. Aging of the nigrostriatal system in the squirrel monkey. The Journal of comparative neurology. vol 471. issue 4. 2004-05-19. PMID:15022260. |
first, we examined the possibility that the total number of dopaminergic neurons decline in the substantia nigra as a function of age. |
2004-05-19 |
2023-08-12 |
monkey |
| Shridhar Narayanan, Hoa Lam, F Ivy Carroll, Kabirullah Lutf. Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats. Journal of psychiatry & neuroscience : JPN. vol 29. issue 2. 2004-05-17. PMID:15069465. |
thus, the present study used local administration of ofq/n into the ventral tegmental area (vta), the substantia nigra, the nucleus accumbens and the striatum to determine the contribution of cell-body regions and terminal fields of the dopaminergic neurons to the motor-suppressant effect of ofq/n. |
2004-05-17 |
2023-08-12 |
rat |
| Thomas G Beach, Douglas G Walker, Lucia I Sue, Amanda Newell, Charles C Adler, Jeffrey N Joyc. Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers. Journal of neuropathology and experimental neurology. vol 63. issue 4. 2004-05-12. PMID:15099023. |
substantia nigra marinesco bodies are associated with decreased striatal expression of dopaminergic markers. |
2004-05-12 |
2023-08-12 |
human |