| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benoît Melchior, Véronique Nerrière-Daguin, David A Laplaud, Séverine Rémy, Sandrine Wiertlewski, Isabelle Neveu, Philippe Naveilhan, Susan O Meakin, Philippe Brache. Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. Experimental neurology. vol 183. issue 2. 2003-10-31. PMID:14552878. |
unilateral injection of this raav into the substantia nigra (sn) resulted in a protracted expression of trka (or c-myc) immunoreactivity in numerous cell bodies, including tyrosine-hydroxylase (th)-positive dopaminergic neurons. |
2003-10-31 |
2023-08-12 |
human |
| P P Michel, E C Hirsch, Y Agi. [Parkinson disease: mechanisms of cell death]. Revue neurologique. vol 158 Spec no 1. 2003-10-30. PMID:12690661. |
parkinson disease is a neurodegenerative disorder of aging characterized by a selective and progressive loss of dopaminergic neurons within the substantia nigra. |
2003-10-30 |
2023-08-12 |
Not clear |
| P P Michel, E C Hirsch, Y Agi. [Parkinson disease: mechanisms of cell death]. Revue neurologique. vol 158 Spec no 1. 2003-10-30. PMID:12690661. |
three populations of dopaminergic neurons seem to coexist in the substantia nigra of parkinsonian patients; (1) senescent neurons that are still spared by the pathological process; (2) sick neurons exhibiting generally a preserved morphology but showing evidence of biochemical and metabolic abnormalities; (3) neurons which have entered into a final state of agony and exhibit the hallmarks of apoptosis, a controlled form of cell death that requires the activation of a particular type of proteases, caspases. |
2003-10-30 |
2023-08-12 |
Not clear |
| F Viallet, T Witja. [Neuroplasticity and Parkinson disease]. Revue neurologique. vol 158 Spec no 1. 2003-10-30. PMID:12690663. |
after a brief survey of some general aspects of plasticity in the cns, the present tutorial review illustrates with recent data from the literature the modes of plastic changes during the course of ipd, either resulting from dopaminergic denervation (hyperactivity of remaining dopaminergic neurons with increase of their excitatory cholinergic innervation in the substantia nigra, enhancement of the corticostriatal glutamatergic synaptic activity at the striatal level) or due to dopaminergic treatment (change in phosphorylation state of the striatal glutamate receptors, internalization of d1 dopamine receptors). |
2003-10-30 |
2023-08-12 |
Not clear |
| Ph Brachet, Ph Damie. [Repair]. Revue neurologique. vol 158 Spec no 1. 2003-10-30. PMID:12690664. |
this is the case with parkinson's disease, which results from a selective loss of dopaminergic neurons of the substantia nigra. |
2003-10-30 |
2023-08-12 |
human |
| Débora Foguel, Marisa C Suarez, Astria D Ferrão-Gonzales, Thais C R Porto, Leonardo Palmieri, Carla M Einsiedler, Leonardo R Andrade, Hilal A Lashuel, Peter T Lansbury, Jeffery W Kelly, Jerson L Silv. Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 17. 2003-10-29. PMID:12900507. |
similarly, amyloid fibril formation by alpha-synuclein (alpha-syn) has been linked to neurodegeneration in parkinson's disease, a movement disorder characterized by selective degeneration of dopaminergic neurons in the substantia nigra. |
2003-10-29 |
2023-08-12 |
human |
| J L W Bosboom, D Stoffers, E Ch Wolter. The role of acetylcholine and dopamine in dementia and psychosis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 65. 2003-10-20. PMID:12946056. |
parkinson's disease (pd) is a progressive neurological disorder in which there is abnormal degeneration of dopaminergic neurons in the substantia nigra and the ventral tegmental area combined with a varying degree of deterioration of the cholinergic, serotonergic and noradrenergic system, leading to a variety of motor and non-motor abnormalities. |
2003-10-20 |
2023-08-12 |
Not clear |
| H Niazi Shahabi, F Bergquist, H Nissbrand. An investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled L-DOPA and high performance liquid chromatography: a new approach in the search for transmitter metabolites. Neuroscience. vol 120. issue 2. 2003-10-14. PMID:12890512. |
an investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled l-dopa and high performance liquid chromatography: a new approach in the search for transmitter metabolites. |
2003-10-14 |
2023-08-12 |
rat |
| F Galeffi, L Bianchi, J P Bolam, L Della Cort. The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis. The European journal of neuroscience. vol 18. issue 4. 2003-10-14. PMID:12925011. |
the loss of dopaminergic neurons of the substantia nigra in parkinson's disease and in animal models of parkinson's disease is associated with an imbalance in the activity of the so-called 'direct' and 'indirect' pathways of information flow through the basal ganglia. |
2003-10-14 |
2023-08-12 |
rat |
| William Dauer, Serge Przedborsk. Parkinson's disease: mechanisms and models. Neuron. vol 39. issue 6. 2003-10-14. PMID:12971891. |
parkinson's disease (pd) results primarily from the death of dopaminergic neurons in the substantia nigra. |
2003-10-14 |
2023-08-12 |
Not clear |
| Alexandra Gulácsi, Christian R Lee, Attila Sík, Tero Viitanen, Kai Kaila, James M Tepper, Tamás F Freun. Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 23. 2003-10-08. PMID:12967985. |
previous studies have shown that gaba(a)-mediated inhibition is less effective in dopaminergic than in gabaergic neurons in substantia nigra. |
2003-10-08 |
2023-08-12 |
rat |
| Alexandra Gulácsi, Christian R Lee, Attila Sík, Tero Viitanen, Kai Kaila, James M Tepper, Tamás F Freun. Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 23. 2003-10-08. PMID:12967985. |
light-microscopic immunocytochemistry revealed that the potassium-chloride cotransporter 2 (kcc2) was localized only in the dendrites of nondopaminergic (primarily gabaergic) neurons in the substantia nigra, whereas the voltage-sensitive chloride channel 2 (clc-2) was observed only in the dopaminergic neurons of the pars compacta. |
2003-10-08 |
2023-08-12 |
rat |
| Paul Tuite, Jennifer Ris. Recent developments in the pharmacological treatment of Parkinson's disease. Expert opinion on investigational drugs. vol 12. issue 8. 2003-09-30. PMID:12882620. |
parkinson's disease (pd) is a neurodegenerative disorder associated with the loss of dopaminergic neurons in the substantia nigra. |
2003-09-30 |
2023-08-12 |
Not clear |
| J Srinivasan, W J Schmid. Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. The European journal of neuroscience. vol 17. issue 12. 2003-09-24. PMID:12823465. |
parkinson's disease is characterized not only by a progressive loss of dopaminergic neurons in the substantia nigra but also by a degeneration of locus coeruleus noradrenergic neurons. |
2003-09-24 |
2023-08-12 |
rat |
| J Srinivasan, W J Schmid. Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. The European journal of neuroscience. vol 17. issue 12. 2003-09-24. PMID:12823465. |
decreased dopamine content in the striatum, substantia nigra and pre-frontal cortex was observed after dopaminergic lesion with 6-hydroxydopamine (42.9%). |
2003-09-24 |
2023-08-12 |
rat |
| Anthony H V Schapir. Neuroprotection and dopamine agonists. Neurology. vol 58. issue 4 Suppl 1. 2003-09-15. PMID:11909981. |
several factors are known to be capable of inducing relatively selective dopaminergic cell death in the substantia nigra and inducing the clinical features that characterize parkinson's disease (pd). |
2003-09-15 |
2023-08-12 |
human |
| Kay L Double, Manfred Gerlach, Volker Schünemann, Alfred X Trautwein, Luigi Zecca, Mario Gallorini, Moussa B H Youdim, Peter Riederer, Dorit Ben-Shacha. Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochemical pharmacology. vol 66. issue 3. 2003-09-12. PMID:12907248. |
the vulnerability of the dopaminergic neurons of the substantia nigra (sn) in parkinson's disease has been related to the presence of the pigment neuromelanin (nm) in these neurons. |
2003-09-12 |
2023-08-12 |
human |
| Dong-Youn Hwang, Paul Ardayfio, Un Jung Kang, Elena V Semina, Kwang-Soo Ki. Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain research. Molecular brain research. vol 114. issue 2. 2003-09-05. PMID:12829322. |
selective loss of dopaminergic neurons in the substantia nigra of pitx3-deficient aphakia mice. |
2003-09-05 |
2023-08-12 |
mouse |
| Olga Corti, Alexis Bric. [Parkinson's disease: what have we learned from the genes responsible for familial forms?]. Medecine sciences : M/S. vol 19. issue 5. 2003-09-04. PMID:12836396. |
parkinson's disease is characterized by the progressive and selective loss of the dopaminergic neurons in the substantia nigra and the presence of ubiquitinated protein inclusions termed lewy bodies. |
2003-09-04 |
2023-08-12 |
Not clear |
| Guangyu Gu, Ariel Y Deutch, Jeff Franklin, Shawn Levy, Douglas C Wallace, Jing Zhan. Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochemical and biophysical research communications. vol 308. issue 1. 2003-09-03. PMID:12890501. |
since mitochondrial dysfunction plays an important role in the pathogenesis of dopaminergic neurodegeneration in parkinson's disease, we determined the expression of genes related to mitochondrial function in the substantia nigra of mice treated with n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) using a cdna array. |
2003-09-03 |
2023-08-12 |
mouse |