| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Liu, Shu S Hsu, Suneil K Kalia, Andres M Lozan. Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP. Brain research. vol 994. issue 2. 2004-01-29. PMID:14642650. |
injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or mptp. |
2004-01-29 |
2023-08-12 |
mouse |
| Pierre Champy, Günter U Höglinger, Jean Féger, Christophe Gleye, Reynald Hocquemiller, Alain Laurens, Vincent Guérineau, Olivier Laprévote, Fadia Medja, Anne Lombès, Patrick P Michel, Annie Lannuzel, Etienne C Hirsch, Merle Ruber. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. Journal of neurochemistry. vol 88. issue 1. 2004-01-29. PMID:14675150. |
stereological cell counts showed significant loss of dopaminergic neurones in the substantia nigra (-31.7%), and cholinergic (-37.9%) and dopamine and cyclic amp-regulated phosphoprotein (darpp-32)-immunoreactive gabaergic neurones (-39.3%) in the striatum, accompanied by a significant increase in the number of astrocytes (35.4%) and microglial cells (73.4%). |
2004-01-29 |
2023-08-12 |
rat |
| Ryosuke Takahashi, Yuzuru Ima. Pael receptor, endoplasmic reticulum stress, and Parkinson's disease. Journal of neurology. vol 250 Suppl 3. 2004-01-28. PMID:14579121. |
it is highly expressed by the dopaminergic neurons of the substantia nigra, strongly suggesting that accumulation of unfolded pael-r may lead to selective death of dopaminergic neurons in ar-jp.recently, we identified hsp70 and its co-chaperone chip as novel parkin-binding partners. |
2004-01-28 |
2023-08-12 |
Not clear |
| Richard Grondin, Zhiming Zhang, Yi Ai, Don M Gash, Greg A Gerhard. Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 61. 2004-01-28. PMID:14674610. |
using this approach, we have demonstrated that chronic infusions of nominally 7.5 or 22.5 microg/day gdnf into the lateral ventricle, the putamen or the substantia nigra, using programmable pumps, promotes restoration of the nigrostriatal dopaminergic system and significantly improves motor functions in mptp-lesioned rhesus monkeys with neural deficits modeling the terminal stages of pd and in aged rhesus monkeys modeling the early stages of pd. |
2004-01-28 |
2023-08-12 |
monkey |
| Marta Barrachina, Isabel Domínguez, Santiago Ambrosio, Julio Secades, Rafael Lozano, Isidro Ferre. Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells. Journal of the neurological sciences. vol 215. issue 1-2. 2004-01-20. PMID:14568136. |
finally, citicoline significantly attenuates substantia nigra (sn) dopaminergic cell dropout and tyrosine hydroxylase immunoreactivity in the ipsilateral striatum in rats injected intrastriatally with 6-hydroxydopamine (6-ohda). |
2004-01-20 |
2023-08-12 |
human |
| Sang-H Choi, Da Y Lee, Jae K Ryu, Jean Kim, Eun H Joe, Byung K Ji. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572441. |
one week after intranigral injection of thrombin resulted in a dose-dependent loss of dopaminergic neurons (20-78%) in the rat substantia nigra (sn), as evidenced by tyrosine hydroxylase (th) immunohistochemistry. |
2004-01-06 |
2023-08-12 |
rat |
| John Y Lin, Michiel van Wyk, Tharushini K Bowala, Min-Yau Teo, Janusz Lipsk. Dendritic projections and dye-coupling in dopaminergic neurons of the substantia nigra examined in horizontal brain slices from young rats. Journal of neurophysiology. vol 90. issue 4. 2004-01-05. PMID:12815027. |
dendritic projections and dye-coupling in dopaminergic neurons of the substantia nigra examined in horizontal brain slices from young rats. |
2004-01-05 |
2023-08-12 |
rat |
| Zhehui Feng, Dongdong Li, Peter C W Fung, Zhong Pei, David B Ramsden, Shu-Leong H. COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice. Neuroreport. vol 14. issue 15. 2004-01-05. PMID:14561922. |
the primary lesion in parkinson's disease is the death of dopaminergic neurons in the substantia nigra. |
2004-01-05 |
2023-08-12 |
mouse |
| Matthew S Goldberg, Sheila M Fleming, James J Palacino, Carlos Cepeda, Hoa A Lam, Anushree Bhatnagar, Edward G Meloni, Nanping Wu, Larry C Ackerson, Gloria J Klapstein, Mahadevan Gajendiran, Bryan L Roth, Marie-Francoise Chesselet, Nigel T Maidment, Michael S Levine, Jie She. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. The Journal of biological chemistry. vol 278. issue 44. 2003-12-24. PMID:12930822. |
the number of dopaminergic neurons in the substantia nigra of parkin-/- mice, however, is normal up to the age of 24 months, in contrast to the substantial loss of nigral neurons characteristic of parkinson's disease. |
2003-12-24 |
2023-08-12 |
mouse |
| Gregor J Macdonald, Clive L Branch, Michael S Hadley, Christopher N Johnson, David J Nash, Alexander B Smith, Geoffrey Stemp, Kevin M Thewlis, Antonio K K Vong, Nigel E Austin, Phillip Jeffrey, Kim Y Winborn, Izzy Boyfield, Jim J Hagan, Derek N Middlemiss, Charlie Reavill, Graham J Riley, Jeannette M Watson, Martyn Wood, Steve G Parker, Charles R Ashb. Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist. Journal of medicinal chemistry. vol 46. issue 23. 2003-12-19. PMID:14584946. |
subsequent evaluation in the rat has shown that 58 preferentially reduces firing of dopaminergic cells in the ventral tegmental area (a10) compared to the substantia nigra (a9), an observation consistent with a prediction for atypical antipsychotic efficacy. |
2003-12-19 |
2023-08-12 |
rat |
| Peter D Alfinito, Sheng-Ping Wang, Lawrence Manzino, Sonia Rijhsinghani, Gail D Zeevalk, Patricia K Sonsall. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 34. 2003-12-16. PMID:14645494. |
adenosinergic protection of dopaminergic and gabaergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. |
2003-12-16 |
2023-08-12 |
mouse |
| Karine Parain, Céline Hapdey, Estelle Rousselet, Véronique Marchand, Bernard Dumery, Etienne C Hirsc. Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin. Brain research. vol 984. issue 1-2. 2003-12-10. PMID:12932857. |
the loss of dopaminergic neurons induced by mptp in the substantia nigra was significantly less severe in the chronic nicotine treatment groups (at 0.2 and 2 mg/kg) and the low exposure to cigarette smoke group than in the high exposure to cigarette smoke subgroup and the placebo treated subgroup. |
2003-12-10 |
2023-08-12 |
mouse |
| Patrick L McGeer, Claudia Schwab, Andre Parent, Doris Doude. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Annals of neurology. vol 54. issue 5. 2003-12-10. PMID:14595649. |
this report describes the presence of reactive microglia, the accumulation of extracellular melanin, and the extensive loss of dopaminergic neurons in the substantia nigra of monkeys administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) 5 to 14 years before death. |
2003-12-10 |
2023-08-12 |
monkey |
| R Eilam, Y Peter, Y Groner, M Sega. Late degeneration of nigro-striatal neurons in ATM-/- mice. Neuroscience. vol 121. issue 1. 2003-12-05. PMID:12946702. |
the present data indicate that atm-/- mice exhibit a progressive, age-dependent, reduction in dopaminergic cells of the substantia nigra, followed by a reduction in projection neurons of the striatum. |
2003-12-05 |
2023-08-12 |
mouse |
| F Bergquist, H Nissbrand. Influence of R-type (Cav2.3) and t-type (Cav3.1-3.3) antagonists on nigral somatodendritic dopamine release measured by microdialysis. Neuroscience. vol 120. issue 3. 2003-12-04. PMID:12895515. |
the release of dopamine from soma and dendrites of dopaminergic neurons in substantia nigra has been reported to be calcium-dependent, but it remains to be determined which calcium channels mediate this effect. |
2003-12-04 |
2023-08-12 |
rat |
| Zhizhong Dong, Boris Ferger, Jean-Charles Paterna, Denise Vogel, Sven Furler, Maribel Osinde, Joram Feldon, Hansruedi Büele. Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 21. 2003-12-04. PMID:14530399. |
here we show that recombinant adeno-associated virus-mediated cdcrel-1 gene transfer to the substantia nigra of rats results in a rapid onset (6-10 days) of nigral and striatal cdcrel-1 expression that is followed by a progressive loss of nigral dopaminergic neurons and a decline of the striatal dopamine levels. |
2003-12-04 |
2023-08-12 |
rat |
| Manfred Gerlach, Kay L Double, Dorit Ben-Shachar, Luigi Zecca, Moussa B H Youdim, Peter Riedere. Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotoxicity research. vol 5. issue 1-2. 2003-11-21. PMID:12832223. |
neuromelanin (nm) is a granular, dark brown pigment produced in some but not all of the dopaminergic neurons of the human substantia nigra (sn). |
2003-11-21 |
2023-08-12 |
human |
| E Fernández-Espejo, F El Banoua, I Caraballo, B Galán, J A Flore. [Natural "dopaminotrophic" cell transplant: a new concept in antiparkinsonian therapy]. Revista de neurologia. vol 36. issue 6. 2003-11-12. PMID:12652418. |
parkinson s disease is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. |
2003-11-12 |
2023-08-12 |
rat |
| Baptiste A Faucheux, Marie-Elise Martin, Carole Beaumont, Jean-Jacques Hauw, Yves Agid, Etienne C Hirsc. Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911622. |
neuromelanin is a dark pigment produced in the dopaminergic neurones of the human substantia nigra and has the ability to bind a variety of metal ions, especially iron. |
2003-11-12 |
2023-08-12 |
human |
| Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development. Journal of chemical neuroanatomy. vol 26. issue 1. 2003-11-06. PMID:12954528. |
we have used highly sensitive in situ hybridization to determine opioid receptor and peptide expression in embryonic and postnatal rat striatum, to follow the compartmentalization into patch and matrix structures, and have examined their developmental expression in the dopaminergic cell group of the substantia nigra (sn). |
2003-11-06 |
2023-08-12 |
rat |