| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suling Zhao, Sarah Maxwell, Antonio Jimenez-Beristain, Joaquim Vives, Eva Kuehner, Jiexin Zhao, Carmel O'Brien, Carmen de Felipe, Elena Semina, Meng L. Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons. The European journal of neuroscience. vol 19. issue 5. 2004-05-05. PMID:15016072. |
in the central nervous system, pitx3-directed gfp was visualized in dopaminergic (da) neurons in the substantia nigra and ventral tegmental area. |
2004-05-05 |
2023-08-12 |
mouse |
| R G Wiley, M B Harrison, A I Levey, D A Lapp. Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514035. |
local intrastriatal injections produced destruction of dopaminergic neurons in the ipsilateral substantia nigra consistent with suicide transport of the immunotoxin. |
2004-04-30 |
2023-08-12 |
rat |
| R G Wiley, M B Harrison, A I Levey, D A Lapp. Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514035. |
produced significant loss of dopaminergic neurons in the substantia nigra and ventral tegmental area bilaterally without evident damage to any other aminergic structures such as the locus coeruleus and raphe nuclei. |
2004-04-30 |
2023-08-12 |
rat |
| Gina L Forster, Charles D Blah. Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat. The European journal of neuroscience. vol 17. issue 4. 2004-04-21. PMID:12603265. |
these results suggest that the pedunculopontine tegmental nucleus utilizes nicotinic and ionotropic glutamate receptors in the substantia nigra to mediate rapid activation, m2-like muscarinic autoreceptors in the pedunculopontine tegmental nucleus to mediate decreased activation, and muscarinic receptors in the substantia nigra (probably of the m5 subtype) to mediate prolonged activation, of the nigrostriatal dopaminergic system. |
2004-04-21 |
2023-08-12 |
rat |
| Henk J Groenewegen, Odile A van den Heuvel, Danielle C Cath, P Voorn, Dick J Veltma. Does an imbalance between the dorsal and ventral striatopallidal systems play a role in Tourette's syndrome? A neuronal circuit approach. Brain & development. vol 25 Suppl 1. 2004-04-15. PMID:14980365. |
in the context of the discussion on the pathophysiological mechanisms that lead to the expression of tics, emphasis is placed on the pathways that lead from the ventral striatum via the dopaminergic substantia nigra to the dorsal striatum. |
2004-04-15 |
2023-08-12 |
Not clear |
| Holger Fuchs, Wolfgang Haube. Dopaminergic innervation of the rat globus pallidus characterized by microdialysis and immunohistochemistry. Experimental brain research. vol 154. issue 1. 2004-04-07. PMID:14508630. |
unilateral infusion of 6-hydroxydopamine into the substantia nigra produced a loss of dopaminergic fiber density in the globus pallidus which was correlated with the nigral extent of the lesion. |
2004-04-07 |
2023-08-12 |
rat |
| Gail Chapman, Blaine L Beaman, David A Loeffler, Dianne M Camp, Edward F Domino, Dennis W Dickson, William G Ellis, Ibsen Chen, Susan E Bachus, Peter A LeWit. In situ hybridization for detection of nocardial 16S rRNA: reactivity within intracellular inclusions in experimentally infected cynomolgus monkeys--and in Lewy body-containing human brain specimens. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769363. |
our previous studies found that experimental infection of balb/c mice with the gram-positive bacterium nocardia asteroides induced a parkinsonian-type syndrome with levodopa-responsive movement abnormalities, loss of nigrostriatal dopaminergic neurons, depletion of striatal dopamine, and intraneuronal inclusions in the substantia nigra (sn) with an appearance similar to lewy bodies. |
2004-04-02 |
2023-08-12 |
mouse |
| Diana Casper, Eric Finkelstein, Ira M Goldstein, David Palencia, Yaacov Yunger, Ann Pide. Dopaminergic neurons associate with blood vessels in neural transplants. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769371. |
neural transplantation is an attractive strategy for diseases that result in focal neurodegeneration such as parkinson's disease, where there is a selective loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2004-04-02 |
2023-08-12 |
Not clear |
| Alfredo Brancucci, Nicola Berretta, Nicola B Mercuri, Walter Francescon. Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra. Brain research. vol 997. issue 1. 2004-03-29. PMID:14715150. |
gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra. |
2004-03-29 |
2023-08-12 |
rat |
| I G Sil'ki. [The influence of neuromodulators on the synaptic plasticity in dopaminergic structures of the midbrain (hypothetical mechanism)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 53. issue 4. 2004-03-26. PMID:14598554. |
a mechanism underlying the effects of neuromodulators on long-term changes in the efficacy of excitatory and inhibitory inputs to dopaminergic and inhibitory cells of the substantia nigra and ventral tegmental area is suggested. |
2004-03-26 |
2023-08-12 |
Not clear |
| Sushil K Sharma, Manuchair Ebad. Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxidants & redox signaling. vol 5. issue 3. 2004-03-24. PMID:12880480. |
parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra zona compacta, and in other subcortical nuclei associated with a widespread occurrence of lewy bodies. |
2004-03-24 |
2023-08-12 |
Not clear |
| Shin-ichi Iwata, Masahiro Nomoto, Hirofumi Morioka, Atsuro Miyat. Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse (New York, N.Y.). vol 51. issue 4. 2004-03-24. PMID:14696015. |
in this model, mice are intrastriatally injected with 6-hydroxydopamine (6-ohda) and dopaminergic neurons in the substantia nigra (sn) gradually die by retrograde degeneration. |
2004-03-24 |
2023-08-12 |
mouse |
| Tae Eun Kim, Mi Jung Park, Eun Jung Choi, Hack Sup Lee, Sung-Ho Lee, Soo Han Yoon, Chang-Kwon Oh, Byung Ju Lee, Seung U Kim, Young Seek Lee, Myung Ae Le. Cloning and cell type-specific regulation of the human tyrosine hydroxylase gene promoter. Biochemical and biophysical research communications. vol 312. issue 4. 2004-03-18. PMID:14651989. |
tyrosine hydroxylase (th), the rate-limiting enzyme of catecholamine biosynthesis, is predominantly expressed in several cell groups within the brain, including the dopaminergic (da) neurons of the substantia nigra and ventral tegmental area, and the noradrenergic neurons of the locus coeruleus. |
2004-03-18 |
2023-08-12 |
mouse |
| Ok-Lye Son, Hyun-Taek Kim, Mi-Hyun Ji, Kyeong-Won Yoo, Myungchull Rhee, Cheol-Hee Ki. Cloning and expression analysis of a Parkinson's disease gene, uch-L1, and its promoter in zebrafish. Biochemical and biophysical research communications. vol 312. issue 3. 2004-03-12. PMID:14680807. |
the expression domain of uch-l1 overlaps with that of tyrosine hydroxylase, a molecular marker for dopaminergic neurons, in the ventral diencephalon, an equivalent structure to the substantia nigra where pd progresses in human. |
2004-03-12 |
2023-08-12 |
human |
| Abigail Snyder-Kelle. Pattern of corticostriatal innervation in organotypic cocultures is dependent on the age of the cortical tissue. Experimental neurology. vol 185. issue 2. 2004-03-02. PMID:14736507. |
dopaminergic innervation present when the substantia nigra was included in the cocultures also distributed preferentially to the developing patch compartment, but it did not substantially alter the pattern of corticostriatal innervation. |
2004-03-02 |
2023-08-12 |
rat |
| Claire Soudais, Nadia Skander, Eric J Kreme. Long-term in vivo transduction of neurons throughout the rat CNS using novel helper-dependent CAV-2 vectors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 2. 2004-02-24. PMID:14688208. |
one year after striatal injections in the rat brain, we found stable, high-level expression in striatal neurons, ~50% of the dopaminergic neurons of the substantia nigra, and the cholinergic neurons in the basal nuclei of meynert. |
2004-02-24 |
2023-08-12 |
rat |
| George J Yohrling, George C-T Jiang, Molly M DeJohn, David W Miller, Anne B Young, Kent E Vrana, Jang-Ho J Ch. Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology. Brain research. Molecular brain research. vol 119. issue 1. 2004-02-19. PMID:14597227. |
in situ hybridization revealed extensive loss of th mrna and decreased dopaminergic cell size in human hd substantia nigra. |
2004-02-19 |
2023-08-12 |
mouse |
| Declan J Quigney, Adrienne M Gorman, Afshin Samal. Heat shock protects PC12 cells against MPP+ toxicity. Brain research. vol 993. issue 1-2. 2004-02-12. PMID:14642838. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) is a neurotoxin that selectively targets dopaminergic cells of the substantia nigra and, as such, it is often used to induce neuronal cell death in models of parkinson's disease. |
2004-02-12 |
2023-08-12 |
Not clear |
| Liya Qin, Yuxin Liu, Tongguang Wang, Sung-Jen Wei, Michelle L Block, Belinda Wilson, Bin Liu, Jau-Shyong Hon. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. The Journal of biological chemistry. vol 279. issue 2. 2004-02-10. PMID:14578353. |
parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2004-02-10 |
2023-08-12 |
mouse |
| J Chen, X Cao, Y Xu, S Su. Experimental study of serum substantia nigra neuron autoantibody and its effect in Parkinson disease patients. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao. vol 21. issue 4. 2004-02-04. PMID:12539547. |
the sera from pd patients positive for substantia nigra neuron autoantibody could decrease the number of the dopaminergic neurons more seriously than those from mg and the healthy once respectively (both p < 0.01). |
2004-02-04 |
2023-08-12 |
rat |