| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangyu Gu, Ariel Y Deutch, Jeff Franklin, Shawn Levy, Douglas C Wallace, Jing Zhan. Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochemical and biophysical research communications. vol 308. issue 1. 2003-09-03. PMID:12890501. |
since mitochondrial dysfunction plays an important role in the pathogenesis of dopaminergic neurodegeneration in parkinson's disease, we determined the expression of genes related to mitochondrial function in the substantia nigra of mice treated with n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) using a cdna array. |
2003-09-03 |
2023-08-12 |
mouse |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
agonist-induced decrease of firing rate of dopaminergic neurons in the substantia nigra. |
2003-09-02 |
2023-08-12 |
human |
| Hyun Jin Choi, Seong Who Kim, So Yeon Lee, Onyou Hwan. Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807434. |
parkinson's disease is a neurodegenerative disorder associated with selective loss of dopaminergic neurons in the substantia nigra. |
2003-08-26 |
2023-08-12 |
Not clear |
| Amy B Harkins, Aaron P Fo. Cell death in weaver mouse cerebellum. Cerebellum (London, England). vol 1. issue 3. 2003-08-22. PMID:12879981. |
cerebellar granule cell neurons die soon after birth and dopaminergic neurons are severely depleted in the substantia nigra. |
2003-08-22 |
2023-08-12 |
mouse |
| D Stanic, C L Parish, W M Zhu, E V Krstew, A J Lawrence, J Drago, D I Finkelstein, M K Horn. Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc. Journal of neurochemistry. vol 86. issue 2. 2003-08-21. PMID:12871574. |
following partial substantia nigra lesions, remaining dopaminergic neurones sprout, returning terminal density in the dorsal striatum to normal by 16 weeks. |
2003-08-21 |
2023-08-12 |
Not clear |
| Bryan Mackenzie, Martin K-H Schäfer, Jeffrey D Erickson, Matthias A Hediger, Eberhard Weihe, Hélène Varoqu. Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. The Journal of biological chemistry. vol 278. issue 26. 2003-08-20. PMID:12684517. |
localization of snat1 to certain dopaminergic neurons of the substantia nigra and cholinergic motoneurons suggests that snat1 may play additional specialized roles, providing metabolic fuel (via alpha-ketoglutarate) or precursors (cysteine, glycine) for glutathione synthesis. |
2003-08-20 |
2023-08-12 |
rat |
| Julie L Webb, Brinda Ravikumar, Jane Atkins, Jeremy N Skepper, David C Rubinsztei. Alpha-Synuclein is degraded by both autophagy and the proteasome. The Journal of biological chemistry. vol 278. issue 27. 2003-08-18. PMID:12719433. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of aggregates (lewy bodies) in neurons. |
2003-08-18 |
2023-08-12 |
human |
| Rebecca Graumann, Irmgard Paris, Pedro Martinez-Alvarado, Pamela Rumanque, Carolina Perez-Pastene, Sergio P Cardenas, Pablo Marin, Fernando Diaz-Grez, Raul Caviedes, Pablo Caviedes, Juan Segura-Aguila. Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866711. |
we suggest that dt-diaphorase plays a neuroprotective role in dopaminergic neurons, which is supported by the following observations: (i) cu-toxicity is dependent on dt-diaphorase inhibition with dicoumarol in rcsn-3 cells derived from the rat substantia nigra; (ii) the cytotoxic effect of monoamine oxidase-a inhibitor amiflamine in rcsn-3 cells is increased by 2.4-fold (p < 0.001) in the presence of the inhibitor of dt-diaphorase, dicoumarol; (iii) concomitant intracerebral administration of manganese (mn3+) together with the dt-diaphorase inhibitor dicoumarol into the left medial forebrain bundle produced a behavioral pattern characterized by contralateral rotational behavior when the rats were stimulated with apomorphine, in a manner similar to that observed in animals injected unilaterally with 6-hydroxydopamine; (iv) incubation of rcsn-3 cells with salsolinol in the presence of dt-diaphorase inhibitor significantly decreased cell survival by 2.5-fold (p < 0.001). |
2003-08-15 |
2023-08-12 |
rat |
| Sang-H Choi, Eun H Joe, Seung U Kim, Byung K Ji. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843292. |
the present study examined whether thrombin-induced microglial activation could contribute to death of dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2003-08-14 |
2023-08-12 |
rat |
| Seong Who Kim, Yeon Joo Jang, Jin Woo Chang, Onyou Hwan. Degeneration of the nigrostriatal pathway and induction of motor deficit by tetrahydrobiopterin: an in vivo model relevant to Parkinson's disease. Neurobiology of disease. vol 13. issue 2. 2003-08-08. PMID:12828940. |
direct injection of bh4 into the substantia nigra caused a loss of tyrosine hydroxylase immunoreactivity, but injection into the dorsal raphe was without effect on the gtp cyclohydrolase-immunoreactive serotonergic neurons, demonstrating selectivity for the dopaminergic system. |
2003-08-08 |
2023-08-12 |
Not clear |
| Kazuyuki Uchida, Nana Kihara, Kana Hashimoto, Hiroyuki Nakayama, Ryoji Yamaguchi, Susumu Tateyam. Age-related histological changes in the canine substantia nigra. The Journal of veterinary medical science. vol 65. issue 2. 2003-08-07. PMID:12655111. |
these results indicate that in the substantia nigra of aged dogs the dopaminergic neurons are well preserved, but intracytoplasmic inclusions and ubiquitin-positive degenerative neurites are commonly found. |
2003-08-07 |
2023-08-12 |
Not clear |
| Hyun Jin Choi, Seong Who Kim, So Yeon Lee, Young Wha Moon, Onyou Hwan. Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death. Experimental neurology. vol 181. issue 2. 2003-08-05. PMID:12782000. |
parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. |
2003-08-05 |
2023-08-12 |
Not clear |
| Tinmarla Frances Oo, Nikolai Kholodilov, Robert E Burk. Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832538. |
regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo. |
2003-08-05 |
2023-08-12 |
Not clear |
| Ryosuke Takahashi, Yuzuru Imai, Nobutaka Hattori, Yoshikuni Mizun. Parkin and endoplasmic reticulum stress. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846978. |
this protein is highly expressed in the dopaminergic neurons in the substantia nigra, which is specifically affected in parkinson's disease; although it is also widely expressed in oligodendroglias in the fiber tract. |
2003-08-04 |
2023-08-12 |
Not clear |
| E C Hirsch, T Breidert, E Rousselet, S Hunot, A Hartmann, P P Miche. The role of glial reaction and inflammation in Parkinson's disease. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846989. |
in parkinson's disease, postmortem examination reveals a loss of dopaminergic neurons in the substantia nigra associated with a massive astrogliosis and the presence of activated microglial cells. |
2003-08-04 |
2023-08-12 |
Not clear |
| Ming Zhao, Stefan Momma, Kioumars Delfani, Marie Carlen, Robert M Cassidy, Clas B Johansson, Hjalmar Brismar, Oleg Shupliakov, Jonas Frisen, Ann Marie Janso. Evidence for neurogenesis in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 13. 2003-07-31. PMID:12792021. |
however, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. |
2003-07-31 |
2023-08-12 |
mouse |
| M D Julian, A B Martin, B Cuellar, F Rodriguez De Fonseca, M Navarro, R Moratalla, L M Garcia-Segur. Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763090. |
in turn, afferent dopaminergic fibers from the substantia nigra innervate cb1 receptor-expressing striatal neurons that are known to also express dopamine receptors. |
2003-07-28 |
2023-08-12 |
rat |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
furthermore, our findings demonstrate that mptp can selectively injure the dopaminergic neurons which dat proteins are predominantly distributed on the striatum and substantia nigra. |
2003-07-24 |
2023-08-12 |
mouse |
| Ryu Otsuka, Naoto Adachi, Gen Hamami, Keyue Liu, Toshihiro Yorozuya, Tatsuru Ara. Blockade of central histaminergic H2 receptors facilitates catecholaminergic metabolism and aggravates ischemic brain damage in the rat telencephalon. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742629. |
the relationship between dopaminergic activity and the histologic outcome was estimated by lesioning the substantia nigra 2 days before mca occlusion. |
2003-07-22 |
2023-08-12 |
rat |
| Shigeyuki Nishikawa, Satoshi Goto, Kazumichi Yamada, Tadashi Hamasaki, Yukitaka Ushi. Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. The Journal of comparative neurology. vol 461. issue 2. 2003-07-16. PMID:12724835. |
in reeler mutant mice lacking reelin, dopaminergic neurons destined for the substantia nigra fail to migrate laterally and become anomalously clustered just lateral to the ventral tegmental area. |
2003-07-16 |
2023-08-12 |
mouse |