| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony S Basile, Irina Fedorova, Agustin Zapata, Xiaoguang Liu, Toni Shippenberg, Alokesh Duttaroy, Masahisa Yamada, Jurgen Wes. Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 17. 2002-09-27. PMID:12154229. |
in the brain, the m5 receptor subtype is preferentially expressed by dopaminergic neurons of the substantia nigra and the ventral tegmental area. |
2002-09-27 |
2023-08-12 |
mouse |
| Virginia M Pickel, Miguel Garzón, Elisa Mengua. Electron microscopic immunolabeling of transporters and receptors identifies transmitter-specific functional sites envisioned in Cajal's neuron. Progress in brain research. vol 136. 2002-09-19. PMID:12143378. |
dopamine terminals in the striatum and ventral pallidum, as well as dendrites of midbrain dopaminergic neurons in the ventral tegmental area and substantia nigra express the plasmalemmal dopamine transporter (dat) and the vesicular monoamine transporter (vmat2). |
2002-09-19 |
2023-08-12 |
Not clear |
| Michelle Smeyne, Richard J Smeyn. Method for culturing postnatal substantia nigra as an in vitro model of experimental Parkinson's disease. Brain research. Brain research protocols. vol 9. issue 2. 2002-09-10. PMID:12034329. |
by specifically culturing ventrolateral midbrain containing the substantia nigra, one can more directly target the effects of dopaminergic toxins. |
2002-09-10 |
2023-08-12 |
Not clear |
| M Quik, Y Polonskaya, J M McIntosh, J M Kula. Differential nicotinic receptor expression in monkey basal ganglia: effects of nigrostriatal damage. Neuroscience. vol 112. issue 3. 2002-09-06. PMID:12074903. |
treatment with mptp, a neurotoxin that selectively destroys dopaminergic nigrostriatal neurons, led to a relatively uniform decrease in nicotinic receptor sites in the striatum, but a differential effect in the substantia nigra with significantly greater declines in the ventrolateral portion. |
2002-09-06 |
2023-08-12 |
monkey |
| M Quik, Y Polonskaya, J M McIntosh, J M Kula. Differential nicotinic receptor expression in monkey basal ganglia: effects of nigrostriatal damage. Neuroscience. vol 112. issue 3. 2002-09-06. PMID:12074903. |
from these data we suggest that in the striatum alpha3/alpha6 nicotinic receptors are primarily localized on dopaminergic nerve terminals, while multiple nicotinic receptor subtypes are present on dopaminergic cell bodies in the substantia nigra. |
2002-09-06 |
2023-08-12 |
monkey |
| Alison L McCormack, Mona Thiruchelvam, Amy B Manning-Bog, Christine Thiffault, J William Langston, Deborah A Cory-Slechta, Donato A Di Mont. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiology of disease. vol 10. issue 2. 2002-09-06. PMID:12127150. |
repeated intraperitoneal paraquat injections killed dopaminergic neurons in the substantia nigra (sn) pars compacta, as assessed by stereological counting of tyrosine hydroxylase (th)-immunoreactive and nissl-stained neurons. |
2002-09-06 |
2023-08-12 |
mouse |
| Tomas T Ding, Seung-Jae Lee, Jean-Christophe Rochet, Peter T Lansbur. Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry. vol 41. issue 32. 2002-09-03. PMID:12162735. |
the parkinson's disease substantia nigra is characterized by the loss of dopaminergic neurons and the presence of cytoplasmic fibrillar lewy bodies in surviving neurons. |
2002-09-03 |
2023-08-12 |
Not clear |
| Vladimir N Uversky, Anthony L Fin. Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle. FEBS letters. vol 522. issue 1-3. 2002-08-14. PMID:12095610. |
parkinson's disease is the second most common neurodegenerative disease, and results from loss of dopaminergic neurons in the substantia nigra. |
2002-08-14 |
2023-08-12 |
mouse |
| Guangyu Gu, Patricio E Reyes, Gregory T Golden, Randall L Woltjer, Christine Hulette, Thomas J Montine, Jing Zhan. Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders. Journal of neuropathology and experimental neurology. vol 61. issue 7. 2002-08-07. PMID:12125742. |
inhibition of mitochondrial respiratory chain function may contribute to dopaminergic neurodegeneration in the substantia nigra (sn) of patients with parkinson disease (pd). |
2002-08-07 |
2023-08-12 |
Not clear |
| C Heim, L Sova, T Kurz, W Kolasiewicz, H Schwegler, K-H Sonta. Partial loss of dopaminergic neurons in the substantia nigra, ventrotegmental area and the retrorubral area -- model of the early beginning of Parkinson's symptomatology? Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111461. |
partial loss of dopaminergic neurons in the substantia nigra, ventrotegmental area and the retrorubral area -- model of the early beginning of parkinson's symptomatology? |
2002-08-06 |
2023-08-12 |
rat |
| C Heim, L Sova, T Kurz, W Kolasiewicz, H Schwegler, K-H Sonta. Partial loss of dopaminergic neurons in the substantia nigra, ventrotegmental area and the retrorubral area -- model of the early beginning of Parkinson's symptomatology? Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111461. |
the application of tyrosine-hydroxylase-staining showed a loss of ipsilateral neurones of the substantia nigra compacta as well as of dendrites in the pars reticulata, neurones in the ventral tegmental area and in the retrorubral area ipsilaterally as well as a loss of dopaminergic fibres both ipsilaterally and contralaterally in the striatum which should belong to the contralateral acting substantia nigra afferents. |
2002-08-06 |
2023-08-12 |
rat |
| G Richter, A Sonnenschein, T Grünewald, H Reichmann, B Janetzk. Novel mitochondrial DNA mutations in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111463. |
since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) action on dopaminergic neuronal cells and the specific decrease of mitochondrial complex i activity in substantia nigra of pd patients mitochondrial biochemistry and genetics emerged to become pandora's box in the pathogenesis of pd. |
2002-08-06 |
2023-08-12 |
Not clear |
| Kevin M Biglan, Robert G Hollowa. A review of pramipexole and its clinical utility in Parkinson's disease. Expert opinion on pharmacotherapy. vol 3. issue 2. 2002-07-24. PMID:11829733. |
parkinson's disease (pd) is a common neurodegenerative disorder characterised by selective loss of dopaminergic neurones in the substantia nigra and resulting in progressive disability. |
2002-07-24 |
2023-08-12 |
Not clear |
| H Grötzsch, G-P Pizzolato, J Ghika, D Schorderet, F J Vingerhoets, T Landis, P R Burkhar. Neuropathology of a case of dopa-responsive dystonia associated with a new genetic locus, DYT14. Neurology. vol 58. issue 12. 2002-07-23. PMID:12084887. |
substantia nigra and locus ceruleus showed a normal abundance of severely hypomelanized dopaminergic neurons and no lewy body. |
2002-07-23 |
2023-08-12 |
Not clear |
| A Czyrak, A Chocy. Search for the presence of glucocorticoid receptors in dopaminergic neurons of rat ventral tegmental area and substantia nigra. Polish journal of pharmacology. vol 53. issue 6. 2002-07-19. PMID:11985346. |
search for the presence of glucocorticoid receptors in dopaminergic neurons of rat ventral tegmental area and substantia nigra. |
2002-07-19 |
2023-08-12 |
rat |
| A Czyrak, A Chocy. Search for the presence of glucocorticoid receptors in dopaminergic neurons of rat ventral tegmental area and substantia nigra. Polish journal of pharmacology. vol 53. issue 6. 2002-07-19. PMID:11985346. |
further, we found that dopaminergic neurons (th-positive) of the ventral tegmental area and substantia nigra were not immunopositive for gr. |
2002-07-19 |
2023-08-12 |
rat |
| b' K Wedzony, K Czepiel, K Fija\\xc5\\x8. Immunohistochemical evidence for localization of NMDAR1 receptor subunit on dopaminergic neurons of the rat substantia nigra, pars compacta. Polish journal of pharmacology. vol 53. issue 6. 2002-07-19. PMID:11985345.' |
immunohistochemical evidence for localization of nmdar1 receptor subunit on dopaminergic neurons of the rat substantia nigra, pars compacta. |
2002-07-19 |
2023-08-12 |
rat |
| Ole Isacso. Models of repair mechanisms for future treatment modalities of Parkinson's disease. Brain research bulletin. vol 57. issue 6. 2002-07-16. PMID:12031282. |
most data indicate that the selectively vulnerable dopaminergic neurons in the substantia nigra of patients that have developed parkinson's disease can be modified by protective and reparative therapies. |
2002-07-16 |
2023-08-12 |
Not clear |
| Juan José Toledo-Aral, Simón Méndez-Ferrer, Ricardo Pardal, José López-Barne. Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease. Brain research bulletin. vol 57. issue 6. 2002-07-16. PMID:12031283. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra projecting to the striatum. |
2002-07-16 |
2023-08-12 |
rat |
| Jonas Lindblom, Ants Kask, Erik Hägg, Linda Härmark, Lena Bergström, Jarl Wikber. Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain. Pharmacological research. vol 45. issue 2. 2002-07-15. PMID:11846623. |
these data suggest that chronic infusion of a melanocortin receptor agonist alters the activity of dopaminergic neurons in the ventral tegmental area and substantia nigra, and support the hypothesis that melanocortin peptides may regulate the activity of central dopamine neurons. |
2002-07-15 |
2023-08-12 |
rat |