| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Maral Mouradia. Recent advances in the genetics and pathogenesis of Parkinson disease. Neurology. vol 58. issue 2. 2002-04-02. PMID:11805242. |
yet, analyses of the structure and function of these gene products point to the critical role of protein aggregation in dopaminergic neurons of the substantia nigra as the common mechanism leading to neurodegeneration in all known forms of this disease. |
2002-04-02 |
2023-08-12 |
Not clear |
| Xiujun Pi, James L Voogt, David R Gratta. Detection of prolactin receptor mRNA in the corpus striatum and substantia nigra of the rat. Journal of neuroscience research. vol 67. issue 4. 2002-03-20. PMID:11835322. |
the observation of prolactin modulation of the nigrostriatal dopaminergic system suggests the expression of prolactin receptor in the corpus striatum or substantia nigra. |
2002-03-20 |
2023-08-12 |
rat |
| L Lyras, B-Y Zeng, G McKenzie, R K B Pearce, B Halliwell, P Jenne. Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 1. 2002-03-14. PMID:11793162. |
parkinson's disease (pd) is characterised by a loss of pigmented dopaminergic neurones in the zona compacta of substantia nigra. |
2002-03-14 |
2023-08-12 |
monkey |
| D Włodarek, W Pakszys, M Barli. [Helicobacter pylori--does it only cause gastroduodenal disease?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 11. issue 65. 2002-03-14. PMID:11852823. |
the direct influence of h. pylori infection on parkinson disease is not known but the following relations are suggested: h. pylori may produce toxins that damage substantia nigra in brain; possible cross reaction of h. pylori antibodies with dopaminergic neurons; indirect influence of antacids containing aluminium used to alleviate the symptoms of ulcers. |
2002-03-14 |
2023-08-12 |
human |
| Richard B Parsons, Marie-Louise Smith, Adrian C Williams, Rosemary H Waring, David B Ramsde. Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain. Journal of neuropathology and experimental neurology. vol 61. issue 2. 2002-03-07. PMID:11853016. |
using 2 nnmt antibodies, the protein was shown to be expressed in multipolar neurons in the temporal lobe, caudate nucleus, and spinal cord, granular neurons of the cerebellum, dopaminergic neurons in the substantia nigra, and in the axons of the third nerve. |
2002-03-07 |
2023-08-12 |
Not clear |
| A Lessenich, S Lindemann, A Richter, H J Hedrich, D Wedekind, A Kaiser, W Lösche. A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions. Neuroscience. vol 107. issue 4. 2002-03-05. PMID:11720785. |
consistent with this finding, immunohistological examination of dopaminergic neurons in substantia nigra and ventral tegmental area yielded a significant laterality in the medial part of substantia nigra pars compacta with a lower density of tyrosine hydroxylase-positive neurons in the contralateral hemisphere of mutant circling rats, while no laterality was seen in unaffected rats of the background strain [bh.7a(lew)/won].thus, the novel mutant ci3 rat exhibits several features which clearly differ from previously described circling rat or mouse mutants. |
2002-03-05 |
2023-08-12 |
mouse |
| E Lorenc-Koci, M Sokolowska, L Wlode. Effect of acute administration of 1,2,3,4-tetrahydroisoquinoline on the levels of glutathione and reactive oxygen species, and on the enzymatic activity of gamma-glutamyl transpeptidase in dopaminergic structures of rat brain. Neuroscience. vol 108. issue 3. 2002-03-05. PMID:11738255. |
moreover, in 1,2,3,4-tetrahydroisoquinoline-treated rats, the production of reactive oxygen species was significantly reduced in the substantia nigra, whereas it was markedly enhanced in the striatum.our results suggest that the increase in tissue glutathione level in the dopaminergic structures studied results from inhibition of gamma-glutamyl transpeptidase and refers to the extracellular pool of this peptide. |
2002-03-05 |
2023-08-12 |
rat |
| B Drukarch, F L van Muiswinke. Neuroprotection for Parkinson's disease: a new approach for a new millennium. Expert opinion on investigational drugs. vol 10. issue 10. 2002-02-28. PMID:11772291. |
however, the medium to long-term efficacy of this pharmacotherapy, mainly consisting of dopaminomimetics like l -dopa and dopamine receptor agonists, suffers greatly from the unrelenting progression of the disease process underlying pd, i.e., the degeneration of neuromelanin-containing, dopaminergic neurones in the substantia nigra. |
2002-02-28 |
2023-08-12 |
Not clear |
| D Offen, B Shtaif, D Hadad, A Weizman, E Melamed, I Gil-A. Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson's disease. Neuroscience letters. vol 316. issue 3. 2002-02-27. PMID:11744219. |
parkinson's disease (pd) is characterized by a progressive loss of 70-80% of dopaminergic (da) neurons in the substantia nigra. |
2002-02-27 |
2023-08-12 |
human |
| Henrike Neuhoff, Axel Neu, Birgit Liss, Jochen Roepe. I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11850457. |
dopaminergic (da) midbrain neurons in the substantia nigra (sn) and ventral tegmental area (vta) are involved in various brain functions such as voluntary movement and reward and are targets in disorders such as parkinson's disease and schizophrenia. |
2002-02-26 |
2023-08-12 |
mouse |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
previous in vivo experiments using rats anesthetized with chloral hydrate have revealed that nicotine applied iontophoretically increased firing of striatal neurons receiving excitatory dopaminergic input from the substantia nigra, and nicotine-induced firing was inhibited by domperidone, a dopamine d2 antagonist. |
2002-02-22 |
2023-08-12 |
rat |
| Tania Vitalis, Coralie Fouquet, Chantal Alvarez, Isabelle Seif, David Price, Patricia Gaspar, Olivier Case. Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse. The Journal of comparative neurology. vol 442. issue 4. 2002-02-21. PMID:11793338. |
maoa is expressed in all noradrenergic and adrenergic neurons early on, and in several dopaminergic cell groups such as the substantia nigra. |
2002-02-21 |
2023-08-12 |
mouse |
| A Barzilai, E Melamed, A Shirva. Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease? Cellular and molecular neurobiology. vol 21. issue 3. 2002-02-19. PMID:11569535. |
parkinson's disease is a progressive neurological disease caused by rather selective degeneration of the dopaminergic neurons in the substantia nigra. |
2002-02-19 |
2023-08-12 |
human |
| Jeffrey A Cohlberg, Jie Li, Vladimir N Uversky, Anthony L Fin. Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry. vol 41. issue 5. 2002-02-19. PMID:11814343. |
parkinson's disease is the second most common neurodegenerative disease and results from loss of dopaminergic neurons in the substantia nigra. |
2002-02-19 |
2023-08-12 |
Not clear |
| C Fillebeen, M M Ruchoux, V Mitchell, S Vincent, M Benaïssa, A Pierc. Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment. Brain research. Molecular brain research. vol 96. issue 1-2. 2002-02-14. PMID:11731015. |
the presence of the iron-binding protein lactoferrin (lf) in some specific areas of the central nervous system and particularly in the normal human substantia nigra, where it is found in dopaminergic (da) neurons and some glial cells, led us to investigate lf synthesis in this area. |
2002-02-14 |
2023-08-12 |
human |
| R E Yee, I Irwin, C Milonas, D B Stout, S C Huang, K Shoghi-Jadid, N Satyamurthy, L E Delanney, D M Togasaki, K F Farahani, K Delfani, A M Janson, M E Phelps, J W Langston, J R Barri. Novel observations with FDOPA-PET imaging after early nigrostriatal damage. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 5. 2002-02-13. PMID:11746613. |
after scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (da) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. |
2002-02-13 |
2023-08-12 |
monkey |
| R E Yee, I Irwin, C Milonas, D B Stout, S C Huang, K Shoghi-Jadid, N Satyamurthy, L E Delanney, D M Togasaki, K F Farahani, K Delfani, A M Janson, M E Phelps, J W Langston, J R Barri. Novel observations with FDOPA-PET imaging after early nigrostriatal damage. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 5. 2002-02-13. PMID:11746613. |
reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of mptp. |
2002-02-13 |
2023-08-12 |
monkey |
| E C Cooper, E Harrington, Y N Jan, L Y Ja. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739564. |
in the basal ganglia, we find kcnq2n immunoreactivity on somata of dopaminergic and parvalbumin (pv)-positive (presumed gabaergic) cells of the substantia nigra, cholinergic large aspiny neurons of the striatum, and gabaergic and cholinergic neurons of the globus pallidus. |
2002-01-23 |
2023-08-12 |
mouse |
| A Sarabi, B J Hoffer, L Olson, M Morale. GFRalpha-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area. The Journal of comparative neurology. vol 441. issue 2. 2002-01-22. PMID:11745638. |
gfralpha-1 mrna in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area. |
2002-01-22 |
2023-08-12 |
rat |
| K Tanaka, T Suzuki, T Chiba, H Shimura, N Hattori, Y Mizun. Parkin is linked to the ubiquitin pathway. Journal of molecular medicine (Berlin, Germany). vol 79. issue 9. 2002-01-14. PMID:11692161. |
ar-jp is characterized by selective and massive loss of dopaminergic neurons in the substantia nigra of the midbrain and absence of lewy bodies, the pathological hallmark of idiopathic parkinson's disease. |
2002-01-14 |
2023-08-12 |
Not clear |