| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Iseki, M Kato, W Marui, K Uéda, K Kosak. A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies. Journal of the neurological sciences. vol 185. issue 2. 2001-08-02. PMID:11311294. |
the disturbance of the dopaminergic connections from the substantia nigra to the central nucleus may be responsible for psychotic symptoms in dlb patients. |
2001-08-02 |
2023-08-12 |
Not clear |
| S L Castro, M J Zigmon. Stress-induced increase in extracellular dopamine in striatum: role of glutamatergic action via N-methyl-D-aspartate receptors in substantia nigra. Brain research. vol 901. issue 1-2. 2001-08-02. PMID:11368949. |
we have therefore examined the influence of endogenous excitatory amino acids in substantia nigra on stress-induced dopaminergic activity in neostriatum. |
2001-08-02 |
2023-08-12 |
Not clear |
| M R D'Andrea, S Ilyin, C R Plata-Salama. Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues. Neuroscience letters. vol 306. issue 3. 2001-08-02. PMID:11406314. |
parkinson's disease (pd) is a neurodegenerative disorder associated with the appearance of cytoplasmic lewy bodies (lbs) in dopaminergic neurons of the substantia nigra and the progressive loss of these neurons. |
2001-08-02 |
2023-08-12 |
Not clear |
| M Ebadi, P Govitrapong, S Sharma, D Muralikrishnan, S Shavali, L Pellett, R Schafer, C Albano, J Eke. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease. Biological signals and receptors. vol 10. issue 3-4. 2001-07-26. PMID:11351130. |
a definitive neuropathological diagnosis of parkinson's disease requires loss of dopaminergic neurons in the substantia nigra and related brain stem nuclei, and the presence of lewy bodies in remaining nerve cells. |
2001-07-26 |
2023-08-12 |
human |
| M Ebadi, P Govitrapong, S Sharma, D Muralikrishnan, S Shavali, L Pellett, R Schafer, C Albano, J Eke. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease. Biological signals and receptors. vol 10. issue 3-4. 2001-07-26. PMID:11351130. |
this view is supported by the fact that mptp generating 1-methyl-4-phenylpyridine (mpp(+)) destroys dopaminergic neurons in the substantia nigra. |
2001-07-26 |
2023-08-12 |
human |
| J D Adams, M L Chang, L Klaidma. Parkinson's disease--redox mechanisms. Current medicinal chemistry. vol 8. issue 7. 2001-07-26. PMID:11375751. |
parkinson's disease occurs in 1% of people over the age of 65 when about 60% of the dopaminergic neurons in the substantia nigra of the midbrain are lost. |
2001-07-26 |
2023-08-12 |
Not clear |
| T Poyot, F Condé, M C Grégoire, V Frouin, C Coulon, C Fuseau, F Hinnen, F Dollé, P Hantraye, M Bottlaende. Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 7. 2001-07-26. PMID:11435790. |
11c-pe2i b'max values obtained with this approach were compared with 18f-dopa input rate constant values (ki), in vitro bmax binding of 125i-pe2i, and the number of dopaminergic neurons in the substantia nigra estimated postmortem by stereology. |
2001-07-26 |
2023-08-12 |
Not clear |
| J K Anderse. Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? Novartis Foundation symposium. vol 235. 2001-07-19. PMID:11280021. |
we will discuss the use of genetically engineered cell and mouse lines generated in our laboratory as models to examine the role that alterations in iron and glutathione levels may play in neurodegeneration of dopaminergic neurons of the substantia nigra associated with parkinson's disease, and how these two parameters may interact with one another to bring this about. |
2001-07-19 |
2023-08-12 |
mouse |
| A Natsume, M Mata, J Goss, S Huang, D Wolfe, T Oligino, J Glorioso, D J Fin. Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration. Experimental neurology. vol 169. issue 2. 2001-07-05. PMID:11358438. |
previous studies have demonstrated that either the neurotrophin glial-derived neurotrophic factor (gdnf) or the antiapoptotic peptide bcl-2 delivered into striatum by a viral vector protects dopaminergic neurons of the substantia nigra in vivo from degeneration induced by the administration of the neurotoxin 6-hydroxydopamine (6-ohda). |
2001-07-05 |
2023-08-12 |
rat |
| M T Hu, S J White, A H Herlihy, K R Chaudhuri, J V Hajnal, D J Brook. A comparison of (18)F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson's disease. Neurology. vol 56. issue 9. 2001-06-28. PMID:11342685. |
to quantify structural changes in the substantia nigra of patients with pd with inversion recovery mri and to compare these with striatal dopaminergic function measured with (18)f-dopa pet. |
2001-06-28 |
2023-08-12 |
Not clear |
| P Martinez-Alvarado, A Dagnino-Subiabre, I Paris, D Metodiewa, C J Welch, C Olea-Azar, P Caviedes, R Caviedes, J Segura-Aguila. Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival. Biochemical and biophysical research communications. vol 283. issue 5. 2001-06-28. PMID:11355881. |
the endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line rcsn-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 microm salsolinol induced a 50% survival decrease). |
2001-06-28 |
2023-08-12 |
rat |
| N Tümer, H A Demirel, L Serova, E L Sabban, C S Broxson, S K Power. Gene expression of catecholamine biosynthetic enzymes following exercise: modulation by age. Neuroscience. vol 103. issue 3. 2001-06-21. PMID:11274789. |
the responses for exercise training of aged animals differed from the young in brain noradrenergic and dopaminergic nuclei, especially in the substantia nigra, and to some extent in the locus coeruleus and the ventral tegmental area. |
2001-06-21 |
2023-08-12 |
rat |
| A Ravary, A Muzerelle, M Darmon, D L Murphy, R Moessner, K P Lesch, P Gaspa. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298795. |
conversely, low-affinity serotonin uptake was detected in vitro, and in dopaminergic neurons of the substantia nigra in vivo. |
2001-06-21 |
2023-08-12 |
mouse |
| M Mogi, A Togari, T Kondo, Y Mizuno, O Kogure, S Kuno, H Ichinose, T Nagats. Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains. Neuroscience letters. vol 300. issue 3. 2001-06-14. PMID:11226640. |
in both groups, the levels of gdnf in the various brain regions were lower (pg/mg protein) than those of brain-derived growth factor (ng/mg order), and were significantly higher in the nigro-striatal dopaminergic regions (substantia nigra, caudate nucleus, putamen) than in the cerebellum and frontal cortex (p < 0.05). |
2001-06-14 |
2023-08-12 |
Not clear |
| K Parain, V Marchand, B Dumery, E Hirsc. Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice. Brain research. vol 890. issue 2. 2001-06-07. PMID:11164803. |
mptp intoxication induced a 50% loss of dopaminergic neurons in the substantia nigra and a 45% reduction in dopaminergic fibers in the striatum. |
2001-06-07 |
2023-08-12 |
mouse |
| H H Simon, H Saueressig, W Wurst, M D Goulding, D D O'Lear. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312297. |
deficiencies in neurotransmitter-specific cell groups in the midbrain result in prominent neural disorders, including parkinson's disease, which is caused by the loss of dopaminergic neurons of the substantia nigra. |
2001-06-07 |
2023-08-12 |
mouse |
| H H Simon, H Saueressig, W Wurst, M D Goulding, D D O'Lear. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312297. |
en-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum, whereas en-2 is highly expressed by a subset of them. |
2001-06-07 |
2023-08-12 |
mouse |
| H H Simon, H Saueressig, W Wurst, M D Goulding, D D O'Lear. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312297. |
a single allele of en-1 on an en-2 null background is sufficient to produce a wild type-like substantia nigra and ventral tegmentum, whereas in contrast a single allele of en-2 on an en-1 null background results in the survival of only a small proportion of these dopaminergic neurons, a finding that relates to the differential expression of en-1 and en-2. |
2001-06-07 |
2023-08-12 |
mouse |
| B Connor, D A Kozlowski, J R Unnerstall, J D Elsworth, J L Tillerson, T Schallert, M C Boh. Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration. Experimental neurology. vol 169. issue 1. 2001-06-07. PMID:11312561. |
previously, we observed that injection of an adenoviral (ad) vector expressing glial cell line-derived neurotrophic factor (gdnf) into the striatum, but not the substantia nigra (sn), prior to a partial 6-ohda lesion protects dopaminergic (da) neuronal function and prevents the development of behavioral impairment in the aged rat. |
2001-06-07 |
2023-08-12 |
rat |
| A Dagnino-Subiabre, K Marcelain, C Arriagada, I Paris, P Caviedes, R Caviedes, J Segura-Aguila. Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome. Molecular and cellular biochemistry. vol 212. issue 1-2. 2001-05-31. PMID:11108144. |
angiotensin receptor ii is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome. |
2001-05-31 |
2023-08-12 |
rat |