| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B L Beaman, D Canfield, J Anderson, B Pate, D Caln. Site-specific invasion of the basal ganglia by Nocardia asteroides GUH-2. Medical microbiology and immunology. vol 188. issue 4. 2000-11-28. PMID:10917152. |
selective dopaminergic neuronal dropout in the substantia nigra results in parkinsonian changes characterized by movement disorders responsive to l-dopa [15]. |
2000-11-28 |
2023-08-12 |
mouse |
| M A Honrubia, M T Vilaró, J M Palacios, G Mengo. Distribution of the histamine H(2) receptor in monkey brain and its mRNA localization in monkey and human brain. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020238. |
the presence of mrna in caudate and putamen nuclei, together with its absence from substantia nigra, suggests that the h(2) receptors found in the striatum are synthesized by intrinsic cells and not by nigral dopaminergic cells. |
2000-11-28 |
2023-08-12 |
human |
| N Ichinohe, B Teng, S T Kita. Morphological study of the tegmental pedunculopontine nucleus, substantia nigra and subthalamic nucleus, and their interconnections in rat organotypic culture. Anatomy and embryology. vol 201. issue 6. 2000-11-17. PMID:10909898. |
in the substantia nigra, as in the in vivo, tyrosine hydroxylase immunoreactive (putative dopaminergic) neurons were identified predominantly in the substantia nigra pars compacta, and parvalbumin immunoreactive neurons (putative gabaergic) mainly in the substantia nigra pars reticulata. |
2000-11-17 |
2023-08-12 |
rat |
| T Moos, D Trinder, E H Morga. Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter 1 (DMT1) in substantia nigra and basal ganglia of normal and beta2-microglobulin deficient mouse brain. Cellular and molecular biology (Noisy-le-Grand, France). vol 46. issue 3. 2000-11-07. PMID:10872742. |
in particular, we focussed on the substantia nigra and basal ganglia as several papers have indicated that iron may accumulate here and cause death of dopaminergic neurons. |
2000-11-07 |
2023-08-12 |
mouse |
| M Park, K Kitahama, M Geffard, T Maed. Postnatal development of the dopaminergic neurons in the rat mesencephalon. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984659. |
the number of the dopaminergic neurons in the substantia nigra and the ventral tegmentum area did not change significantly during the postnatal development. |
2000-11-07 |
2023-08-12 |
rat |
| D A Charytoniuk, E Traiffort, E Pinard, O Issertial, J Seylaz, M Rua. Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia. Neuroscience. vol 100. issue 1. 2000-11-06. PMID:10996456. |
whereas bone morphogenetic protein receptor type i expression was low in rat brain, in situ hybridization studies performed with specific digoxigenin-labelled riboprobes revealed the presence of bone morphogenetic protein receptor type ii-positive cells throughout the brain, with a notable localization in dopaminergic cells of the substantia nigra. |
2000-11-06 |
2023-08-12 |
rat |
| G Hédou, S Chasserot-Golaz, V Kemmel, S Gobaille, G Roussel, J C Artault, C Andriamampandry, D Aunis, M Maitr. Immunohistochemical studies of the localization of neurons containing the enzyme that synthesizes dopamine, GABA, or gamma-hydroxybutyrate in the rat substantia nigra and striatum. The Journal of comparative neurology. vol 426. issue 4. 2000-11-01. PMID:11027398. |
to investigate the distribution of ghb neurons in this pathway and the anatomic relationships between dopaminergic and ghb neurons, immunocytochemical identification of dopamine, gaba, and ghb neurons was carried out in the substantia nigra and striatum of the rat. |
2000-11-01 |
2023-08-12 |
rat |
| I García Cabeza, M Gutiérrez Rodríguez, M M Epifanio Gutiérre. [Psychosis with topiramate]. Actas espanolas de psiquiatria. vol 28. issue 3. 2000-10-24. PMID:11000703. |
the gabaergic action of topiramate is proposed as the principal reason for the psychotic crisis, in relation to an inhibition in the substantia nigra which could produce an overactivity in ascending dopaminergic systems. |
2000-10-24 |
2023-08-12 |
Not clear |
| J N Reynolds, J R Wicken. Substantia nigra dopamine regulates synaptic plasticity and membrane potential fluctuations in the rat neostriatum, in vivo. Neuroscience. vol 99. issue 2. 2000-10-19. PMID:10938425. |
in agreement with previous in vitro studies, our in vivo findings show that long-term depression occurs in the corticostriatal pathway, and in addition show that it is regulated by dopaminergic inputs from the substantia nigra. |
2000-10-19 |
2023-08-12 |
rat |
| K S McNaught, P Jenne. Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation. Biochemical pharmacology. vol 60. issue 7. 2000-10-19. PMID:10974207. |
dopaminergic neuronal death in substantia nigra in parkinson's disease is accompanied by depletion of reduced glutathione levels and inhibition of complex i activity which occur partially in normal or activated cells. |
2000-10-19 |
2023-08-12 |
rat |
| K A Baker, D Sadi, M Hong, I Mende. Simultaneous intrastriatal and intranigral dopaminergic grafts in the parkinsonian rat model: role of the intranigral graft. The Journal of comparative neurology. vol 426. issue 1. 2000-10-16. PMID:10980486. |
the current transplantation strategy in experimental and clinical parkinson's disease (pd) has been to place nigral dopaminergic grafts not in their ontogenic site (substantia nigra) but in their target area (striatum). |
2000-10-16 |
2023-08-12 |
rat |
| A M Canudas, B Friguls, A M Planas, C Gabriel, E Escubedo, J Camarasa, A Camins, M Pallà. MPP(+) injection into rat substantia nigra causes secondary glial activation but not cell death in the ipsilateral striatum. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964606. |
injection of mpp(+) into the substantia nigra causes extensive necrosis and anterograde degeneration of pars compacta dopaminergic neurons. |
2000-10-11 |
2023-08-12 |
rat |
| A M Canudas, B Friguls, A M Planas, C Gabriel, E Escubedo, J Camarasa, A Camins, M Pallà. MPP(+) injection into rat substantia nigra causes secondary glial activation but not cell death in the ipsilateral striatum. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964606. |
we studied secondary effects in the ipsilateral striatum by examining dopaminergic terminals, signs of neuronal damage, and glial reactivity at 1, 2, 3, and 7 days after injection of mpp(+) into the substantia nigra. |
2000-10-11 |
2023-08-12 |
rat |
| I Suárez, G Bodega, J A Ramos, J J Fernández-Ruiz, B Fernánde. Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra. Developmental neuroscience. vol 22. issue 4. 2000-10-11. PMID:10965147. |
the responses of neurons and astroglial cells to pre- and perinatal exposure to delta(9)-tetrahydrocannabinol (delta(9)-thc) were evaluated in the substantia nigra (sn) of male and female rats, at three postnatal ages (pd21, pd30 and pd70), by immunohistochemical detection of tyrosine hydroxylase (th) in dopaminergic neurons and of glial fibrillary acidic protein (gfap) in astrocytes. |
2000-10-11 |
2023-08-12 |
rat |
| D C Harvey, G Lacan, S P Tanious, W P Meleg. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain research. vol 871. issue 2. 2000-10-04. PMID:10899292. |
recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. |
2000-10-04 |
2023-08-12 |
human |
| G Mateu, A Privat, J Thibault, J Vigno. Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 6. 2000-09-28. PMID:10884605. |
glutamate toxicity was compared in substantia nigra (sn)/striatum (str) and sn/cerebellum (crb) co-cultures on both the entire neuronal population (neuron specific enolase (nse) immunopositive cells) and dopaminergic neurons (tyrosine hydroxylase (th) immunopositive cells). |
2000-09-28 |
2023-08-12 |
Not clear |
| K Nakamura, L Won, A Heller, U J Kan. Preferential resistance of dopaminergic neurons to glutathione depletion in a reconstituted nigrostriatal system. Brain research. vol 873. issue 2. 2000-09-28. PMID:10930545. |
depletion of glutathione in the substantia nigra is one of the earliest changes observed in parkinson's disease (pd), and could initiate dopaminergic neuronal degeneration. |
2000-09-28 |
2023-08-12 |
Not clear |
| J C Rochet, K A Conway, P T Lansbur. Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry. vol 39. issue 35. 2000-09-28. PMID:10978144. |
parkinson's disease (pd) is a neurodegenerative disorder attributed to the loss of dopaminergic neurons from the substantia nigra. |
2000-09-28 |
2023-08-12 |
mouse |
| J T Greenamyre, G MacKenzie, T I Peng, S E Stephan. Mitochondrial dysfunction in Parkinson's disease. Biochemical Society symposium. vol 66. 2000-09-26. PMID:10989660. |
we developed a novel model of pd in which chronic, systemic infusion of rotenone, a complex-i inhibitor, selectively kills dopaminergic nerve terminals and causes retrograde degeneration of substantia nigra neurons over a period of months. |
2000-09-26 |
2023-08-12 |
Not clear |
| N Jha, O Jurma, G Lalli, Y Liu, E H Pettus, J T Greenamyre, R M Liu, H J Forman, J K Anderse. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10846169. |
oxidative stress appears to play an important role in degeneration of dopaminergic neurons of the substantia nigra (sn) associated with parkinson's disease (pd). |
2000-09-25 |
2023-08-12 |
Not clear |