| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Lu, G Bing, T Hag. Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799760. |
here, we tested in adult rats whether injection of bacterial lipopolysaccharide (which causes inflammation and microglial activation) just above the substantia nigra, results in the death of dopaminergic substantia nigra pars compacta neurons. |
2000-07-27 |
2023-08-12 |
rat |
| X Lu, G Bing, T Hag. Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799760. |
alternatively, microglia might not cause the neuronal loss, or naloxone might act by blocking opioid receptors on (dopaminergic or gabaergic) neurons.thus, local inflammation induces and the opioid antagonist naloxone prevents the death of dopaminergic substantia nigra neurons in adult rats. |
2000-07-27 |
2023-08-12 |
rat |
| J Rohrbacher, N Ichinohe, S T Kita. Electrophysiological characteristics of substantia nigra neurons in organotypic cultures: spontaneous and evoked activities. Neuroscience. vol 97. issue 4. 2000-07-24. PMID:10842015. |
morphological and electrophysiological characteristics of dopaminergic and non-dopaminergic neurons in the substantia nigra and their postsynaptic responses to stimulation of the tegmental pedunculopontine nucleus were studied in rat organotypic triple cultures. |
2000-07-24 |
2023-08-12 |
rat |
| E H Pettus, R Betarbet, B Cottrell, D C Wallace, V Madyastha, J T Greenamyr. Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH : ubiquinone oxidoreductase) in rat brain. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854284. |
in substantia nigra, many dopaminergic neurons had little nd1 immunoreactivity, which may help to explain their sensitivity to complex i inhibitors. |
2000-07-17 |
2023-08-12 |
mouse |
| K A Reardon, F A Mendelsohn, S Y Chai, M K Horn. The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease. Australian and New Zealand journal of medicine. vol 30. issue 1. 2000-07-14. PMID:10800878. |
in humans, angiotensin type 1 receptors have been found on dopaminergic neurons in the substantia nigra and striatum. |
2000-07-14 |
2023-08-12 |
rat |
| E Grünblatt, S Mandel, M B Youdi. Neuroprotective strategies in Parkinson's disease using the models of 6-hydroxydopamine and MPTP. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863545. |
nevertheless a significant body of biochemical data from human brain autopsy studies and those from animal models point to an on going process of oxidative stress in the substantia nigra which could initiate dopaminergic neurodegeneration. |
2000-07-13 |
2023-08-12 |
human |
| J Chung, S Chang, Y Kim, H Shi. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neuroscience letters. vol 286. issue 3. 2000-07-12. PMID:10832015. |
zinc increases the excitability of dopaminergic neurons in rat substantia nigra. |
2000-07-12 |
2023-08-12 |
rat |
| G Yadid, N Fitoussi, N Kinor, R Geffen, I Gispa. Astrocyte line SVG-TH grafted in a rat model of Parkinson's disease. Progress in neurobiology. vol 59. issue 6. 2000-06-30. PMID:10845756. |
the striatum in pd that lacks the dopaminergic projection from the substantia nigra metabolizes and releases dopamine differently from normal tissue and may react to different factors released by the grafted cells. |
2000-06-30 |
2023-08-12 |
human |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
compartmental organization and chemical profile of dopaminergic and gabaergic neurons in the substantia nigra of the rat. |
2000-06-23 |
2023-08-12 |
rat |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
the substantia nigra (sn) is a midbrain center composed of dopaminergic (da-) and gamma aminobutyric acid (gaba)ergic (gaba-) neurons. |
2000-06-23 |
2023-08-12 |
rat |
| H Kim, W Jhoo, E Shin, G Bin. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799693. |
the present study was designed to understand the role of an antioxidant, selenium (se) on methamphetamine (ma)-induced dopaminergic cell damage in the substantia nigra (sn). |
2000-06-21 |
2023-08-12 |
mouse |
| C J Wilson, J C Callawa. Coupled oscillator model of the dopaminergic neuron of the substantia nigra. Journal of neurophysiology. vol 83. issue 5. 2000-06-14. PMID:10805703. |
calcium imaging using fura-2 and whole cell recording revealed the effective location of the oscillator mechanism on dopaminergic neurons of the substantia nigra, pars compacta, in slices from rats aged 15-20 days. |
2000-06-14 |
2023-08-12 |
rat |
| P Lingor, K Unsicker, K Krieglstei. GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785444. |
free radical formation is considered to be a major cause of dopaminergic (daergic) cell death in the substantia nigra leading to parkinson's disease (pd). |
2000-06-13 |
2023-08-12 |
rat |
| M S Szczypka, M A Rainey, R D Palmite. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nature genetics. vol 25. issue 1. 2000-06-12. PMID:10802666. |
dopaminergic neurons in the substantia nigra and ventral tegmental area project to the caudate putamen and nucleus accumbens, where they modulate movement and reward. |
2000-06-12 |
2023-08-12 |
mouse |
| A Pisani, P Bonsi, D Centonze, P Calabresi, G Bernard. Activation of D2-like dopamine receptors reduces synaptic inputs to striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 7. 2000-06-02. PMID:10729358. |
striatal cholinergic interneurons represent an important synaptic target of dopaminergic fibers arising from the substantia nigra and cortical glutamatergic inputs. |
2000-06-02 |
2023-08-12 |
Not clear |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
this article summarizes results obtained from studies on the differentiation of dopaminergic neurons in animal hypothalamus and human substantia nigra in situ, in vitro, and in transplants, as well as the role of the microenvironment in regulating this process. |
2000-06-02 |
2023-08-12 |
human |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
as regards the dopaminergic neurons of the substantia nigra, expression of their specific phenotype in human fetuses started with the synthesis of tyrosine hydroxylase and co-maturation of the specific dopamine reuptake mechanism during the sixth week of development. |
2000-06-02 |
2023-08-12 |
human |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
suspensions of fetal substantia nigra cells enriched with dopaminergic neurons were introduced stereotaxically into a patient's striatum through a cannula. |
2000-06-02 |
2023-08-12 |
human |
| K Nakamura, D A Wright, T Wiatr, D Kowlessur, S Milstien, X G Lei, U J Kan. Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820190. |
depletion of glutathione in the substantia nigra is one of the earliest changes observed in parkinson's disease (pd) and could initiate dopaminergic neuronal degeneration. |
2000-06-02 |
2023-08-12 |
mouse |
| G Forloni, I Bertani, A M Calella, F Thaler, R Invernizz. Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Annals of neurology. vol 47. issue 5. 2000-05-31. PMID:10805334. |
in vivo application of aggregated nac in the substantia nigra induced loss of dopaminergic neurons. |
2000-05-31 |
2023-08-12 |
rat |