| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Izurieta-Sánchez, S Sarre, G Ebinger, Y Michott. Muscarinic antagonists in substantia nigra influence the decarboxylation of L-dopa in striatum. European journal of pharmacology. vol 399. issue 2-3. 2000-09-22. PMID:10884514. |
this in vivo study demonstrates that anticholinergic drugs perfused at the level of the substantia nigra can modulate dopamine and gaba levels and attenuate the l-dopa decarboxylation in the striatum, possibly via modulation of the nigrostriatal dopaminergic system. |
2000-09-22 |
2023-08-12 |
rat |
| A Mehta, K Thermos, M F Chessele. Increased behavioral response to dopaminergic stimulation of the subthalamic nucleus after nigrostriatal lesions. Synapse (New York, N.Y.). vol 37. issue 4. 2000-09-14. PMID:10891867. |
the increased behavioral response observed after unilateral dopamine denervation suggests that the subthalamic nucleus is tonically regulated by dopaminergic projections from the substantia nigra. |
2000-09-14 |
2023-08-12 |
rat |
| A Plaitakis, P Shashidhara. Glutamate transport and metabolism in dopaminergic neurons of substantia nigra: implications for the pathogenesis of Parkinson's disease. Journal of neurology. vol 247 Suppl 2. 2000-09-14. PMID:10991662. |
glutamate transport and metabolism in dopaminergic neurons of substantia nigra: implications for the pathogenesis of parkinson's disease. |
2000-09-14 |
2023-08-12 |
human |
| E C Hirsc. Glial cells and Parkinson's disease. Journal of neurology. vol 247 Suppl 2. 2000-09-14. PMID:10991667. |
parkinson's disease is a neurodegenerative disease characterised by a massive loss of dopaminergic neurons in the substantia nigra. |
2000-09-14 |
2023-08-12 |
Not clear |
| E Grünblatt, S Mandel, M B Youdi. MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies. Journal of neurology. vol 247 Suppl 2. 2000-09-14. PMID:10991672. |
nevertheless, a significant body of biochemical data from human brain autopsy studies and from animal models points to an ongoing process of oxidative stress in the substantia nigra, which could initiate dopaminergic neurodegeneration. |
2000-09-14 |
2023-08-12 |
human |
| V Jackson-Lewis, M Vila, R Djaldetti, C Guegan, G Liberatore, J Liu, K L O'Malley, R E Burke, S Przedborsk. Developmental cell death in dopaminergic neurons of the substantia nigra of mice. The Journal of comparative neurology. vol 424. issue 3. 2000-09-07. PMID:10906714. |
developmental cell death in dopaminergic neurons of the substantia nigra of mice. |
2000-09-07 |
2023-08-12 |
mouse |
| R T Scheife, G T Schumock, A Burstein, M D Gottwald, M S Lue. Impact of Parkinson's disease and its pharmacologic treatment on quality of life and economic outcomes. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 57. issue 10. 2000-08-31. PMID:10832495. |
pd is a chronic and progressive neurologic disorder characterized by specific motor deficits resulting from the degeneration of dopaminergic neurons in the substantia nigra. |
2000-08-31 |
2023-08-12 |
Not clear |
| K S McNaught, P Jenne. Dysfunction of rat forebrain astrocytes in culture alters cytokine and neurotrophic factor release. Neuroscience letters. vol 285. issue 1. 2000-08-22. PMID:10788708. |
altered glial cell function occurring in substantia nigra in parkinson' disease may lead to the release of cytokines and impairment of neurotrophic factor production, which in turn, may cause dopaminergic apoptosis. |
2000-08-22 |
2023-08-12 |
rat |
| M Quik, S Police, L He, D A Di Monte, J W Langsto. Expression of D(3) receptor messenger RNA and binding sites in monkey striatum and substantia nigra after nigrostriatal degeneration: effect of levodopa treatment. Neuroscience. vol 98. issue 2. 2000-08-18. PMID:10854757. |
autoradiographic analysis showed that after mptp treatment there was a significant decline in d(3) receptors in the caudate, but not putamen, globus pallidus, substantia nigra or other dopaminergic regions. |
2000-08-18 |
2023-08-12 |
monkey |
| M L Vizuete, M Merino, J L Venero, M Santiago, J Cano, A Machad. Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899929. |
histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. |
2000-08-17 |
2023-08-12 |
rat |
| M L Vizuete, M Merino, J L Venero, M Santiago, J Cano, A Machad. Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899929. |
injection of 100 and 250 nmol of histamine in substantia nigra produced a selective damage in dopaminergic neurons evidenced by the loss of tyrosine hydroxylase mrna-expressing cells, tyrosine hydroxylase-immunolabeled-positive cell bodies, and dopamine and 3,4-dihydroxyphenylacetic acid levels. |
2000-08-17 |
2023-08-12 |
rat |
| M L Vizuete, M Merino, J L Venero, M Santiago, J Cano, A Machad. Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899929. |
the selective neurotoxicity of histamine for dopaminergic cells was demonstrated by the unaltered transcription of glutamic acid decarboxylase mrna in substantia nigra. |
2000-08-17 |
2023-08-12 |
rat |
| M L Vizuete, M Merino, J L Venero, M Santiago, J Cano, A Machad. Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899929. |
we conclude that the substantia nigra is highly sensitive to histamine-derived neurotoxicity, where inflammatory processes mediated by histamine could be important in the pathological changes that lead to dopaminergic neuronal damage after histamine infusion. |
2000-08-17 |
2023-08-12 |
rat |
| V Jackson-Lewis, G Liberator. Effects of a unilateral stereotaxic injection of Tinuvin 123 into the substantia nigra on the nigrostriatal dopaminergic pathway in the rat. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825495. |
effects of a unilateral stereotaxic injection of tinuvin 123 into the substantia nigra on the nigrostriatal dopaminergic pathway in the rat. |
2000-08-07 |
2023-08-12 |
rat |
| V Jackson-Lewis, G Liberator. Effects of a unilateral stereotaxic injection of Tinuvin 123 into the substantia nigra on the nigrostriatal dopaminergic pathway in the rat. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825495. |
herein, we revisited this issue by assessing the effect of tinuvin 123 on dopaminergic neurons of the substantia nigra following its stereotaxic injection in the rat. |
2000-08-07 |
2023-08-12 |
rat |
| J M Henderson, K Carpenter, H Cartwright, G M Hallida. Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications. Brain : a journal of neurology. vol 123 ( Pt 7). 2000-08-07. PMID:10869053. |
these sites are the dopaminergic substantia nigra, the cholinergic pedunculopontine tegmental nucleus and, from our results, the glutamatergic caudal intralaminar thalamus. |
2000-08-07 |
2023-08-12 |
Not clear |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
experimental and clinical studies of neural transplantation in parkinson's disease have focused on the placement of fetal dopaminergic grafts not in their ontogenic site (substantia nigra) but in the main nigral target area (striatum). |
2000-08-02 |
2023-08-12 |
rat |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
16 (1996) 7216-7227] using a new transplantation strategy aimed at restoring dopaminergic innervation of the nigra and striatum by simultaneous dopaminergic transplants placed in the substantia nigra and ipsilateral striatum (double grafts) in the 6-hydroxydopamine lesioned adult rat brain. |
2000-08-02 |
2023-08-12 |
rat |
| A M Lin, L T H. Melatonin suppresses iron-induced neurodegeneration in rat brain. Free radical biology & medicine. vol 28. issue 6. 2000-08-02. PMID:10802221. |
an increase in lipid peroxidation in the infused substantia nigra and reductions in dopamine levels and dopaminergic terminals in the ipsilateral striatum were observed 7 d after iron infusion. |
2000-08-02 |
2023-08-12 |
rat |
| X Lu, G Bing, T Hag. Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799760. |
naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats. |
2000-07-27 |
2023-08-12 |
rat |