| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Nomoto, S Kaseda, S Iwata, T Shimizu, T Fukuda, S Nakagaw. The metabolic rate and vulnerability of dopaminergic neurons, and adenosine dynamics in the cerebral cortex, nucleus accumbens, caudate nucleus, and putamen of the common marmoset. Journal of neurology. vol 247 Suppl 5. 2001-02-15. PMID:11081800. |
immunohistochemical staining for tyrosine hydroxylase in the midbrains of mptp-treated marmosets showed almost complete disappearance of dopaminergic cells from the substantia nigra and good preservation of cells in the ventrotegmental area. |
2001-02-15 |
2023-08-12 |
marmoset |
| M Nomoto, S Kaseda, S Iwata, T Shimizu, T Fukuda, S Nakagaw. The metabolic rate and vulnerability of dopaminergic neurons, and adenosine dynamics in the cerebral cortex, nucleus accumbens, caudate nucleus, and putamen of the common marmoset. Journal of neurology. vol 247 Suppl 5. 2001-02-15. PMID:11081800. |
dopaminergic input from the substantia nigra acting on cholinergic neurons was decreased following mptp treatment. |
2001-02-15 |
2023-08-12 |
marmoset |
| K S McNaught, P Jenne. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neuroscience letters. vol 297. issue 3. 2001-02-15. PMID:11137760. |
the accumulation of alpha-synuclein, ubiquitin and other proteins in lewy bodies in degenerating dopaminergic neurones in substantia nigra in idiopathic parkinson's disease (pd) suggest that inhibition of normal/abnormal protein degradation may contribute to neuronal death. |
2001-02-15 |
2023-08-12 |
Not clear |
| F Dabbeni-Sala, Di Santo S, D Franceschini, S D Skaper, P Giust. Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 1. 2001-02-15. PMID:11149904. |
unilateral injection into the right substantia nigra of the catecholaminergic neurotoxin 6-hydroxydopamine (6-ohda) produces extensive loss of dopaminergic cells ('hemi-parkinsonian rat'). |
2001-02-15 |
2023-08-12 |
human |
| M Melis, G L Gessa, M Dian. Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 6. 2001-02-08. PMID:11041539. |
the intravenous administration of cumulative doses (1-4 mg/kg) of morphine, dose-dependently increased the firing rate of dopaminergic neurons projecting to the nucleus accumbens and neostriatum, while the same doses inhibited the activity of pars reticulata neurons of the substantia nigra. |
2001-02-08 |
2023-08-12 |
rat |
| R Heumann, C Goemans, D Bartsch, K Lingenhöhl, P C Waldmeier, B Hengerer, P R Allegrini, K Schellander, E F Wagner, T Arendt, R H Kamdem, K Obst-Pernberg, F Narz, P Wahle, H Bern. Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration. The Journal of cell biology. vol 151. issue 7. 2001-02-08. PMID:11134081. |
furthermore, neurotoxin-induced degeneration of dopaminergic substantia nigra neurons and their striatal projections was greatly attenuated. |
2001-02-08 |
2023-08-12 |
mouse |
| N Yanagisaw. [A prospect of treatment for Parkinson's disease in the 21st century]. Nihon rinsho. Japanese journal of clinical medicine. vol 58. issue 10. 2001-02-01. PMID:11068433. |
as exploration of neuroprotective therapies for pd has not been successful yet, continuous progress in neuronal cell death in the substantia nigra result in loss of efficacy of medication, motor fluctuations and cns side effects such as dyskinesia and psychosis in the long course of dopaminergic supplementation therapies. |
2001-02-01 |
2023-08-12 |
Not clear |
| L Besret, M A Caldwell, E M Torres, S B Dunnet. Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats. European journal of pharmacology. vol 408. issue 1. 2001-01-26. PMID:11070181. |
in order to determine whether the level of tyrosine hydroxylase could be affected by subchronic administration of haloperidol, we examined tyrosine hydroxylase-positive immunoreactive cells in the substantia nigra after blockade of dopaminergic receptors with this antipsychotic. |
2001-01-26 |
2023-08-12 |
rat |
| B S Mandavilli, S F Ali, B Van Houte. DNA damage in brain mitochondria caused by aging and MPTP treatment. Brain research. vol 885. issue 1. 2001-01-25. PMID:11121528. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treatment leads to marked depletion of dopamine (da) levels in the nigrostriatal pathway and dopaminergic neuronal degeneration in caudate-putamen and substantia nigra. |
2001-01-25 |
2023-08-12 |
mouse |
| A Nicotra, S H Parve. Cell death induced by MPTP, a substrate for monoamine oxidase B. Toxicology. vol 153. issue 1-3. 2001-01-03. PMID:11090954. |
mpp(+) is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. |
2001-01-03 |
2023-08-12 |
Not clear |
| A Nicotra, S H Parve. Cell death induced by MPTP, a substrate for monoamine oxidase B. Toxicology. vol 153. issue 1-3. 2001-01-03. PMID:11090954. |
similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of pd patients. |
2001-01-03 |
2023-08-12 |
Not clear |
| D C Harvey, G Laćan, W P Melega. Regional heterogeneity of dopaminergic deficits in vervet monkey striatum and substantia nigra after methamphetamine exposure. Experimental brain research. vol 133. issue 3. 2000-12-28. PMID:10958525. |
regional heterogeneity of dopaminergic deficits in vervet monkey striatum and substantia nigra after methamphetamine exposure. |
2000-12-28 |
2023-08-12 |
monkey |
| R Usha, D Muralikrishnan, B Thomas, S Ghosh, C Mandal, K P Mohanakuma. Region-specific attenuation of a trypsin-like protease in substantia nigra following dopaminergic neurotoxicity by 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056198. |
region-specific attenuation of a trypsin-like protease in substantia nigra following dopaminergic neurotoxicity by 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine. |
2000-12-28 |
2023-08-12 |
mouse |
| K L Double, L Zecca, P Costi, M Mauer, C Griesinger, S Ito, D Ben-Shachar, G Bringmann, R G Fariello, P Riederer, M Gerlac. Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins. Journal of neurochemistry. vol 75. issue 6. 2000-12-28. PMID:11080212. |
neuromelanin (nm) is a complex polymer pigment found primarily in the dopaminergic neurons of the human substantia nigra. |
2000-12-28 |
2023-08-12 |
human |
| K A Jellinge. Morphological substrates of mental dysfunction in Lewy body disease: an update. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961431. |
dysfunction of subcorticocortical networks with neuron losses in a) the dopaminergic nigrostriatal loop, causing striato-(pre)frontal deafferentation and mesocortico-limbic system (medial substantia nigra, ventral tegmentum); b) noradrenergic (locus coeruleus), and serotonergic systems (dorsal raphe nuclei), c) cholinergic forebrain system (nucleus basalis of meynert, etc), and d) specific nuclei of amygdala and limbic system (thalamic nuclei, hippocampus); 2. |
2000-12-22 |
2023-08-12 |
Not clear |
| A Friedma. [Treatment of Parkinson's disease--from theory to practice]. Neurologia i neurochirurgia polska. vol 32 Suppl 6. 2000-12-22. PMID:11107568. |
the symptomatic treatment of parkinson's disease is based on assumption that its symptoms are a consequence of damage to the dopaminergic system at the level of substantia nigra. |
2000-12-22 |
2023-08-12 |
Not clear |
| G D Stanwood, R P Artymyshyn, M P Kung, H F Kung, I Lucki, P McGonigl. Quantitative autoradiographic mapping of rat brain dopamine D3 binding with [(125)I]7-OH-PIPAT: evidence for the presence of D3 receptors on dopaminergic and nondopaminergic cell bodies and terminals. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082459. |
lesion of dopaminergic neurons with 6-hydroxydopamine produced 50% decreases in [(125)i]7-oh-pipat binding in the nucleus accumbens and substantia nigra. |
2000-12-20 |
2023-08-12 |
rat |
| H Inou. Effects of naltrexone on the accumulation of L-3, 4-dihydroxyphenylalanine and 5-hydroxy-L-tryptophan and on the firing rate induced by acute ethanol administration. European journal of pharmacology. vol 406. issue 3. 2000-12-11. PMID:11040344. |
in addition, the firing rates of dopaminergic neurons were recorded in the substantia nigra and ventral tegmental area. |
2000-12-11 |
2023-08-12 |
rat |
| D A Kozlowski, B Connor, J L Tillerson, T Schallert, M C Boh. Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031079. |
the effects of delivering gdnf via an adenoviral vector (adgdnf) 1 week after lesioning dopaminergic neurons in the rat substantia nigra (sn) with 6-hydroxydopamine (6-ohda) were examined. |
2000-12-07 |
2023-08-12 |
rat |
| J Sevcík, K Mase. Potential role of cannabinoids in Parkinson's disease. Drugs & aging. vol 16. issue 6. 2000-11-30. PMID:10939305. |
parkinson's disease (pd) is a neurodegenerative disorder caused by a progressive loss of dopaminergic neurons of the substantia nigra, resulting from an oxidative stress. |
2000-11-30 |
2023-08-12 |
Not clear |