| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Dagnino-Subiabre, K Marcelain, C Arriagada, I Paris, P Caviedes, R Caviedes, J Segura-Aguila. Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome. Molecular and cellular biochemistry. vol 212. issue 1-2. 2001-05-31. PMID:11108144. |
angiotensin receptor ii mrna was found to be expressed in dopaminergic neuronal cell line rcsn3 of rat substantia nigra using rt-pcr reaction. |
2001-05-31 |
2023-08-12 |
rat |
| G P Demyanenko, Y Shibata, P F Manes. Altered distribution of dopaminergic neurons in the brain of L1 null mice. Brain research. Developmental brain research. vol 126. issue 1. 2001-05-17. PMID:11172883. |
dopaminergic neurons of the mouse mesencephalon originate in the ventricular zone and migrate radially along radial glia then tangentially along nerve fibers that express the neural cell adhesion molecule l1 to form the substantia nigra (a9 group) and ventral tegmental area (vta) (a10 group). |
2001-05-17 |
2023-08-12 |
mouse |
| G P Demyanenko, Y Shibata, P F Manes. Altered distribution of dopaminergic neurons in the brain of L1 null mice. Brain research. Developmental brain research. vol 126. issue 1. 2001-05-17. PMID:11172883. |
an altered rostrocaudal distribution of dopaminergic neurons was observed within the substantia nigra and vta of l1-minus mice. |
2001-05-17 |
2023-08-12 |
mouse |
| I Paris, A Dagnino-Subiabre, K Marcelain, L B Bennett, P Caviedes, R Caviedes, C O Azar, J Segura-Aguila. Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299314. |
the mechanism of copper (cu) neurotoxicity was studied in the rcsn-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. |
2001-05-17 |
2023-08-12 |
rat |
| M Yamada, A Natsume, M Mata, T Oligino, J Goss, J Glorioso, D J Fin. Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259110. |
we have previously demonstrated that a genomic herpes simplex virus (hsv)-based vector expressing the anti-apoptotic peptide bcl-2 protects dopaminergic neurons of the substantia nigra from neurotoxin-induced apoptotic cell death and preserves the neurotransmitter phenotype of those cells. |
2001-05-10 |
2023-08-12 |
rat |
| M M Iravani, S Costa, M J Jackson, B C Tel, C Cannizzaro, R K Pearce, P Jenne. GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets. The European journal of neuroscience. vol 13. issue 3. 2001-04-26. PMID:11168568. |
parkinson's disease (pd) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. |
2001-04-26 |
2023-08-12 |
Not clear |
| H H Liou, R C Chen, T H Chen, Y F Tsai, M C Tsa. Attenuation of paraquat-induced dopaminergic toxicity on the substantia nigra by (-)-deprenyl in vivo. Toxicology and applied pharmacology. vol 172. issue 1. 2001-04-26. PMID:11264021. |
attenuation of paraquat-induced dopaminergic toxicity on the substantia nigra by (-)-deprenyl in vivo. |
2001-04-26 |
2023-08-12 |
rat |
| S Genc, F Kuralay, K Genc, M Akhisaroglu, S Fadiloglu, K Yorukoglu, M Fadiloğlu, A Gur. Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production. Neuroscience letters. vol 298. issue 2. 2001-04-19. PMID:11163297. |
since epo has neuroprotective effects in vitro and in vivo against brain injury, we investigated the effect of epo treatment on locomotor activities of animals, survival of nigral dopaminergic neurons and nitrate levels in substantia nigra and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced animal model of parkinsonism in c57/bl mice. |
2001-04-19 |
2023-08-12 |
mouse |
| J Booij, P Bergmans, A Winogrodzka, J D Speelman, E C Wolter. Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180497. |
with natural aging there is loss of dopaminergic cells in the substantia nigra and, consequently, loss of dopamine transporters in the striatum. |
2001-04-19 |
2023-08-12 |
Not clear |
| J Y Lin, J Lipsk. Dopaminergic substantia nigra neurons express functional nmda receptors in postnatal rats. Journal of neurophysiology. vol 85. issue 3. 2001-04-19. PMID:11248004. |
dopaminergic substantia nigra neurons express functional nmda receptors in postnatal rats. |
2001-04-19 |
2023-08-12 |
rat |
| A Barzilai, R Zilkha-Falb, D Daily, N Stern, D Offen, I Ziv, E Melamed, A Shirva. The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205158. |
parkinson's disease (pd) is a progressive neurological disorder caused by rather selective degeneration of the dopaminergic (da) neurons in the substantia nigra. |
2001-04-12 |
2023-08-12 |
human |
| R Klink, A de Kerchove d'Exaerde, M Zoli, J P Changeu. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 5. 2001-04-05. PMID:11222635. |
nicotinic acetylcholine receptors (nachrs) on dopaminergic (da) and gabaergic (gaba) projection neurons of the substantia nigra (sn) and ventral tegmental area (vta) are characterized by single-cell rt-pcr and patch-clamp recordings in slices of rat and wild-type, beta2-/-, alpha4-/-, and alpha7-/- mice. |
2001-04-05 |
2023-08-12 |
mouse |
| R A Barke. Prospects for the treatment of Parkinson's disease using neural grafts. Expert opinion on pharmacotherapy. vol 1. issue 5. 2001-04-05. PMID:11249498. |
it is a disease that can only be diagnosed with certainty at postmortem when the pathological hallmark is loss of the dopaminergic nigrostriatal pathway and presence of lewy bodies in the substantia nigra. |
2001-04-05 |
2023-08-12 |
Not clear |
| B T Chatha, V Bernard, P Streit, J P Bola. Synaptic localization of ionotropic glutamate receptors in the rat substantia nigra. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113353. |
a major glutamatergic input to the substantia nigra originates in the subthalamic nucleus, and the long-lasting stimulation of the dopaminergic cells of the substantia nigra pars compacta by the subthalamic neurons has been implicated in the pathophysiology of parkinson's disease. |
2001-03-01 |
2023-08-12 |
rat |
| D C German, C L Liang, K F Manaye, K Lane, P K Sonsall. Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113355. |
since the amount of vesicular monoamine transporter in locus coeruleus neurons is more than in substantia nigra neurons, and because 1-methyl-4-phenylpyridinium is sequestered within locus coeruleus neurons to a far greater extent than within substantia nigra neurons, it may be that a greater amount of vesicular monoamine transporter inhibition is required for 1-methyl-4-phenylpyridinium to be toxic to locus coeruleus neurons than to substantia nigra dopaminergic neurons. |
2001-03-01 |
2023-08-12 |
mouse |
| P M Kid. Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 6. 2001-03-01. PMID:11134975. |
parkinson's disease (pd) is the most common movement pathology, severely afflicting dopaminergic neurons within the substantia nigra (sn) along with non-dopaminergic, extra-nigral projection bundles that control circuits for sensory, associative, premotor, and motor pathways. |
2001-03-01 |
2023-08-12 |
Not clear |
| E Vaudano, C Rosenblad, A Björklun. Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor. The European journal of neuroscience. vol 13. issue 1. 2001-03-01. PMID:11134999. |
a single injection of 10 microg of glial-cell-line-derived-neurotrophic factor given at day 3 after the intrastriatal 6-hydroxydopamine lesion reduced the number of c-jun- and phosphorylated c-jun-immunoreactive nuclei in the substantia nigra and protected the dopaminergic neurons from the ensuing cell death. |
2001-03-01 |
2023-08-12 |
rat |
| K Ozawa, D S Fan, Y Shen, S Muramatsu, K Fujimoto, K Ikeguchi, M Ogawa, M Urabe, A Kume, I Nakan. Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128607. |
parkinson's disease (pd) is characterized by the progressive loss of the dopaminergic neurons in the substantia nigra and a severe decrease in dopamine in the striatum. |
2001-02-22 |
2023-08-12 |
rat |
| K Ozawa, D S Fan, Y Shen, S Muramatsu, K Fujimoto, K Ikeguchi, M Ogawa, M Urabe, A Kume, I Nakan. Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128607. |
another strategy for gene therapy of pd is the protection of dopaminergic neurons in the substantia nigra using an aav vector containing a glial cell line-derived neurotrophic factor (gdnf) gene. |
2001-02-22 |
2023-08-12 |
rat |
| T J Montine, V Amarnath, M J Picklo, K R Sidell, J Zhang, D G Graha. Dopamine mercapturate can augment dopaminergic neurodegeneration. Drug metabolism reviews. vol 32. issue 3-4. 2001-02-22. PMID:11139134. |
these data indicate that the mercapturate conjugate of dopamine may augment dopaminergic neurodegeneration and that the mercapturate pathway exists in human substantia nigra. |
2001-02-22 |
2023-08-12 |
human |