| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K P Datla, M Christidou, W W Widmer, H K Rooprai, D T Dexte. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport. vol 12. issue 17. 2002-01-11. PMID:11726811. |
unilateral infusion of the dopaminergic neurotoxin, 6-hydroxydopamine (6-ohda; 8 microg), onto medial forebrain bundle significantly reduced the number of tyrosine hydroxylase positive (th+) cells in the substantia nigra and decreased striatal dopamine content in the vehicle treated rats. |
2002-01-11 |
2023-08-12 |
rat |
| C R Bjarkam, J C Sørensen, N A Sunde, F A Geneser, K Ostergaar. New strategies for the treatment of Parkinson's disease hold considerable promise for the future management of neurodegenerative disorders. Biogerontology. vol 2. issue 3. 2002-01-04. PMID:11708721. |
parkinson's disease is characterized by a massive loss of dopaminergic neurons in the substantia nigra, leading to severe functional disturbance of the neuronal circuitry in the basal ganglia. |
2002-01-04 |
2023-08-12 |
Not clear |
| R C Dodel, K Berger, W H Oerte. Health-related quality of life and healthcare utilisation in patients with Parkinson's disease: impact of motor fluctuations and dyskinesias. PharmacoEconomics. vol 19. issue 10. 2002-01-03. PMID:11735671. |
idiopathic parkinson's disease (pd) is a common chronic progressive neuro-degenerative disorder associated with the progressive loss of dopaminergic neurons in the substantia nigra. |
2002-01-03 |
2023-08-12 |
Not clear |
| V N Uversky, J Li, A L Fin. Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11553618. |
parkinson's disease involves the aggregation of alpha-synuclein to form fibrils, which are the major constituent of intracellular protein inclusions (lewy bodies and lewy neurites) in dopaminergic neurons of the substantia nigra. |
2001-12-20 |
2023-08-12 |
human |
| K A Conway, J C Rochet, R M Bieganski, P T Lansbur. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science (New York, N.Y.). vol 294. issue 5545. 2001-12-07. PMID:11701929. |
the substantia nigra in parkinson's disease (pd) is depleted of dopaminergic neurons and contains fibrillar lewy bodies comprising primarily alpha-synuclein. |
2001-12-07 |
2023-08-12 |
Not clear |
| B Liss, O Franz, S Sewing, R Bruns, H Neuhoff, J Roepe. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. The EMBO journal. vol 20. issue 20. 2001-12-05. PMID:11598014. |
the activity of dopaminergic (da) substantia nigra (sn) neurons is essential for voluntary movement control. |
2001-12-05 |
2023-08-12 |
Not clear |
| P Akerud, J M Canals, E Y Snyder, E Arena. Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 20. 2001-11-01. PMID:11588183. |
we found that gdnf-nscs prevented the degeneration of dopaminergic neurons in the substantia nigra and reduced behavioral impairment in these animals. |
2001-11-01 |
2023-08-12 |
mouse |
| J Li, V N Uversky, A L Fin. Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry. vol 40. issue 38. 2001-10-25. PMID:11560511. |
parkinson's disease involves the loss of dopaminergic neurons in the substantia nigra, leading to movement disorders. |
2001-10-25 |
2023-08-12 |
human |
| Y He, S Appel, W L. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain research. vol 909. issue 1-2. 2001-10-11. PMID:11478935. |
to determine the role of immune/inflammatory factors in dopaminergic cell degeneration in parkinsonian substantia nigra, we assayed tyrosine hydroxylase (th)-positive immunoreactive neuronal numbers with stereologic techniques and cd11b-positive immunoreactive microglial profiles following 6-hydroxydopamine (6-ohda) injection into ipsilateral striatum of mice. |
2001-10-11 |
2023-08-12 |
mouse |
| C Labarca, J Schwarz, P Deshpande, S Schwarz, M W Nowak, C Fonck, R Nashmi, P Kofuji, H Dang, W Shi, M Fidan, B S Khakh, Z Chen, B J Bowers, J Boulter, J M Wehner, H A Leste. Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 5. 2001-09-13. PMID:11226318. |
these mice have a severe deficit of dopaminergic neurons in the substantia nigra, possibly because the hypersensitive receptors are continuously activated by normal extracellular choline concentrations. |
2001-09-13 |
2023-08-12 |
mouse |
| K Zhang, F I Tarazi, R J Baldessarin. Nigrostriatal dopaminergic denervation enhances dopamine D(4) receptor binding in rat caudate-putamen. Pharmacology, biochemistry, and behavior. vol 69. issue 1-2. 2001-09-06. PMID:11420075. |
radioligand binding to dopamine (da) d(4) receptors was examined in adult rat forebrain 5 weeks after unilateral 6-hydroxydopamine (6-ohda) lesioning of substantia nigra to remove ascending nigrostriatal dopaminergic projections. |
2001-09-06 |
2023-08-12 |
rat |
| J R Vaughan, M B Davis, N W Woo. Genetics of Parkinsonism: a review. Annals of human genetics. vol 65. issue Pt 2. 2001-09-06. PMID:11427172. |
the pathological hallmarks are the presence of lewy bodies and massive loss of dopaminergic neurons in the pars compacta of the substantia nigra. |
2001-09-06 |
2023-08-12 |
Not clear |
| C Gutknech. [Parkinson therapy 2001, especially apomorphine in idiopathic Parkinson syndrome]. Praxis. vol 90. issue 23. 2001-09-06. PMID:11447722. |
there exists no possibility to inhibit the degeneration of dopaminergic neurons in the substantia nigra. |
2001-09-06 |
2023-08-12 |
Not clear |
| N Drandarevski, A Marburger, D Walther, T Reum, G Uh, R Morgenster. Dopaminergic mRNA expression in the intact substantia nigra of unilaterally 6-OHDA-lesioned and grafted rats: an in situ hybridization study. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 2. 2001-08-30. PMID:11314769. |
dopaminergic mrna expression in the intact substantia nigra of unilaterally 6-ohda-lesioned and grafted rats: an in situ hybridization study. |
2001-08-30 |
2023-08-12 |
rat |
| L P Lovejoy, P D Shepard, C C Canavie. Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic. Neuroscience. vol 104. issue 3. 2001-08-30. PMID:11440813. |
the method was then applied to experimental records of apamin-induced irregular firing of rat dopaminergic neurons of the substantia nigra in vitro and in vivo. |
2001-08-30 |
2023-08-12 |
rat |
| M P Muriel, Y Agid, E Hirsc. Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 3. 2001-08-16. PMID:11391736. |
the loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in parkinson's disease (pd). |
2001-08-16 |
2023-08-12 |
human |
| Y Matsuoka, M Vila, S Lincoln, A McCormack, M Picciano, J LaFrancois, X Yu, D Dickson, W J Langston, E McGowan, M Farrer, J Hardy, K Duff, S Przedborski, D A Di Mont. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of disease. vol 8. issue 3. 2001-08-16. PMID:11442360. |
to test whether overexpression of human alpha-synuclein leads to inclusion formation and neuronal loss of dopaminergic cells in the substantia nigra, we made transgenic mice in which the expression of wild-type or mutant (a30p and a53t) human alpha-synuclein protein was driven by the promoter from the tyrosine hydroxylase gene. |
2001-08-16 |
2023-08-12 |
mouse |
| Y Tanaka, S Engelender, S Igarashi, R K Rao, T Wanner, R E Tanzi, A Sawa, V L Dawson, T M Dawson, C A Ros. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human molecular genetics. vol 10. issue 9. 2001-08-02. PMID:11309365. |
parkinson's disease (pd) is a common progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. |
2001-08-02 |
2023-08-12 |
Not clear |
| E Iseki, M Kato, W Marui, K Uéda, K Kosak. A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies. Journal of the neurological sciences. vol 185. issue 2. 2001-08-02. PMID:11311294. |
the central nucleus receives dense dopaminergic fibers from the substantia nigra. |
2001-08-02 |
2023-08-12 |
Not clear |
| E Iseki, M Kato, W Marui, K Uéda, K Kosak. A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies. Journal of the neurological sciences. vol 185. issue 2. 2001-08-02. PMID:11311294. |
many ubiquitin-positive spheroids were also positive to alpha-synuclein and tyrosine-hydroxylase, suggesting that they derive from the degeneration of terminal or distal axons of lewy body-bearing dopaminergic neurons in the substantia nigra. |
2001-08-02 |
2023-08-12 |
Not clear |