| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Ming Gao, Janwei Jiang, Belinda Wilson, Wanqin Zhang, Jau-Shyong Hong, Bin Li. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. Journal of neurochemistry. vol 81. issue 6. 2002-07-12. PMID:12068076. |
however, it has not been clearly demonstrated whether microglial activation, the most integral part of the brain inflammatory process, will result in a delayed and progressive degeneration of dopaminergic neurons in substantia nigra, a hallmark of pd. |
2002-07-12 |
2023-08-12 |
rat |
| Ronald L Klein, Michael A King, Mary E Hamby, Edwin M Meye. Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Human gene therapy. vol 13. issue 5. 2002-06-25. PMID:11916484. |
dopaminergic cell loss induced by human a30p alpha-synuclein gene transfer to the rat substantia nigra. |
2002-06-25 |
2023-08-12 |
human |
| H Elkon, E Melamed, D Offe. 6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease. Cellular and molecular neurobiology. vol 21. issue 6. 2002-06-25. PMID:12043847. |
one of the hallmarks of parkinson's disease (pd) is pathological structure, termed lewy body, containing inclusions of ubiquitinated proteins in the dopaminergic neurons in the substantia nigra. |
2002-06-25 |
2023-08-12 |
Not clear |
| Martina Ballmaier, Michele Zoli, Giuseppina Leo, Luigi Francesco Agnati, PierFranco Span. Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia. The European journal of neuroscience. vol 15. issue 7. 2002-06-21. PMID:11982630. |
on the contrary, the nigrostriatal pathway did not show any significant alteration in heterozygous reeler mice with regards to the dopaminergic markers examined in substantia nigra cell bodies and dorsal striatum dopamine terminal fields. |
2002-06-21 |
2023-08-12 |
mouse |
| Christian Lavedan, Stephanie Buchholtz, Robert L Nussbaum, Roger L Albin, Mihael H Polymeropoulo. A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration. Neuroscience letters. vol 322. issue 1. 2002-05-30. PMID:11958843. |
parkinson's disease (pd) is a common neurodegenerative movement disorder characterized by the destruction of dopaminergic neurons of the substantia nigra. |
2002-05-30 |
2023-08-12 |
human |
| M M Iravani, K Kashefi, P Mander, S Rose, P Jenne. Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience. vol 110. issue 1. 2002-05-23. PMID:11882372. |
the loss of dopaminergic neurones in the substantia nigra with parkinson's disease may result from inflammation-induced proliferation of microglia and reactive macrophages expressing inducible nitric oxide synthase (inos). |
2002-05-23 |
2023-08-12 |
rat |
| M M Iravani, K Kashefi, P Mander, S Rose, P Jenne. Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience. vol 110. issue 1. 2002-05-23. PMID:11882372. |
similar reduction of tyrosine hydroxylase-immunoreactivity and fluorogold-labelled neurones in the substantia nigra following lipopolysaccharide administration suggests dopaminergic cell death rather than down-regulation of tyrosine hydroxylase. |
2002-05-23 |
2023-08-12 |
rat |
| A Członkowska, I Kurkowska-Jastrzebsk. [Treatment of neurodegenerative diseases: new perspectives]. Neurologia i neurochirurgia polska. vol 35. issue 4 Suppl. 2002-05-22. PMID:11873614. |
mptp causes degeneration of dopaminergic cells bodies in the substantia nigra and of their endings in striatum. |
2002-05-22 |
2023-08-12 |
mouse |
| Tatiana M Korotkova, Krister S Eriksson, Helmut L Haas, Ritchie E Brow. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regulatory peptides. vol 104. issue 1-3. 2002-05-21. PMID:11830281. |
here we have investigated the effect of orexins on the firing of dopaminergic and gabaergic neurons of the substantia nigra (sn) in brain slices. |
2002-05-21 |
2023-08-12 |
rat |
| Galit Pelled, Hagai Bergman, Gadi Goelma. Bilateral overactivation of the sensorimotor cortex in the unilateral rodent model of Parkinson's disease - a functional magnetic resonance imaging study. The European journal of neuroscience. vol 15. issue 2. 2002-05-20. PMID:11849305. |
the model involves a unilateral destruction of the right substantia nigra by intranigral injection of the dopaminergic neurotoxin 6-hydroxydopamine. |
2002-05-20 |
2023-08-12 |
rat |
| Vladimir N Uversky, Jie Li, Pierre Souillac, Ian S Millett, Sebastian Doniach, Ross Jakes, Michel Goedert, Anthony L Fin. Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11812782. |
the pathological hallmark of parkinson's disease is the presence of intracellular inclusions, lewy bodies, and lewy neurites, in the dopaminergic neurons of the substantia nigra and several other brain regions. |
2002-05-13 |
2023-08-12 |
Not clear |
| Jae K Ryu, Won H Shin, Jean Kim, Eun H Joe, Yong B Lee, Kyung G Cho, Young J Oh, Seung U Kim, Byung K Ji. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. vol 38. issue 1. 2002-05-10. PMID:11921200. |
the present study examines the in vivo neurotoxic effects of gt1b on dopaminergic neurons in the substantia nigra (sn) of sprague-dawley rats. |
2002-05-10 |
2023-08-12 |
rat |
| Vladimir N Uversky, Elisa M Cooper, Kiowa S Bower, Jie Li, Anthony L Fin. Accelerated alpha-synuclein fibrillation in crowded milieu. FEBS letters. vol 515. issue 1-3. 2002-05-10. PMID:11943202. |
parkinson's disease is the second most common age-related neurodegenerative disease, resulting from loss of dopaminergic neurons in the substantia nigra. |
2002-05-10 |
2023-08-12 |
Not clear |
| Craig Denis Hardman, Jasmine Monica Henderson, David Isaac Finkelstein, Malcolm Kenneth Horne, George Paxinos, Glenda Margaret Hallida. Comparison of the basal ganglia in rats, marmosets, macaques, baboons, and humans: volume and neuronal number for the output, internal relay, and striatal modulating nuclei. The Journal of comparative neurology. vol 445. issue 3. 2002-05-03. PMID:11920704. |
it uses established protocols to estimate the volume and number of neurons within the output nuclei (internal globus pallidus, igp; and nondopaminergic substantia nigra, snnd), two internal relay and modulating nuclei (subthalamic nucleus, sth; and external globus pallidus, egp), and a modulator of the striatum (dopaminergic substantia nigra, snd). |
2002-05-03 |
2023-08-12 |
rat |
| A Kupsch, J Sautter, M E Götz, W Breithaupt, J Schwarz, M B Youdim, P Riederer, M Gerlach, W H Oerte. Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 8-9. 2002-04-29. PMID:11716151. |
40%) of dopaminergic (tyrosine-hydroxylase-positive) cells in the substantia nigra, pars compacta; and 3. putaminal dopamine depletion of 98% and its metabolites dopac (88%) and hva (96%). |
2002-04-29 |
2023-08-12 |
mouse |
| A Kupsch, J Sautter, M E Götz, W Breithaupt, J Schwarz, M B Youdim, P Riederer, M Gerlach, W H Oerte. Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 8-9. 2002-04-29. PMID:11716151. |
there were no significant differences between rasagiline/mptp and selegiline/mptp-treated animals in respect to signs of motor impairment, the number of dopaminergic cells in the substantia nigra, and striatal dopamine levels. |
2002-04-29 |
2023-08-12 |
mouse |
| Tatiana M Korotkova, Helmut L Haas, Ritchie E Brow. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro. Neuroscience letters. vol 320. issue 3. 2002-04-25. PMID:11852180. |
we have investigated the effect of histamine (ha) on spontaneous firing of dopaminergic (da) and gabaergic neurons in the substantia nigra (sn) and the ventral tegmental area (vta) of the rat in vitro. |
2002-04-25 |
2023-08-12 |
rat |
| Akinori Akaike, Hiroshi Katsuki, Toshiaki Kum. [Role of nitric oxide in survival and death of neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 1. 2002-04-23. PMID:11862752. |
the prominent pathological feature of the brain in parkinson's disease is selective degeneration of dopaminergic neurons in the substantia nigra of the midbrain. |
2002-04-23 |
2023-08-12 |
Not clear |
| Michael S Turner, Laurence Mignon, T Celeste Napie. Alterations in responses of ventral pallidal neurons to excitatory amino acids after long-term dopamine depletion. The Journal of pharmacology and experimental therapeutics. vol 301. issue 1. 2002-04-18. PMID:11907195. |
electrophysiological experiments were conducted in chloral hydrate-anesthetized rats 21 to 28 days after they received unilateral substantia nigra injections of the dopaminergic toxin 6-hydroxydopamine (6-ohda). |
2002-04-18 |
2023-08-12 |
rat |
| I Date, T Shingo, H Yoshida, K Fujiwara, K Kobayashi, A Takeuchi, T Ohmot. Grafting of encapsulated genetically modified cells secreting GDNF into the striatum of parkinsonian model rats. Cell transplantation. vol 10. issue 4-5. 2002-04-09. PMID:11549061. |
the density of nigrostriatal dopaminergic fibers in the striatum as well as the number of dopaminergic cell bodies in the substantia nigra recovered significantly after gdnf-producing cell grafting. |
2002-04-09 |
2023-08-12 |
rat |