| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Véronique Coizet, Eliane Comoli, G W Max Westby, Peter Redgrav. Phasic activation of substantia nigra and the ventral tegmental area by chemical stimulation of the superior colliculus: an electrophysiological investigation in the rat. The European journal of neuroscience. vol 17. issue 1. 2003-04-28. PMID:12534966. |
the source of short-latency visual input to midbrain dopaminergic (da) neurons is not currently known; however, the superior colliculus (sc) is a subcortical visual structure which has response latencies consistently shorter than those recorded for da neurons in substantia nigra and the ventral tegmental area. |
2003-04-28 |
2023-08-12 |
rat |
| Hiroyuki Kato, Tsutomu Araki, Yutaka Imai, Akira Takahashi, Yasuto Itoyam. Protection of dopaminergic neurons with a novel astrocyte modulating agent (R)-(-)-2-propyloctanoic acid (ONO-2506) in an MPTP-mouse model of Parkinson's disease. Journal of the neurological sciences. vol 208. issue 1-2. 2003-04-28. PMID:12639719. |
the mptp injection resulted in a loss of th-positive dopaminergic neurons (42% of control, p<0.01) in the substantia nigra after 7 days, but ono-2506 treatment prevented this neuronal loss (70% of control, p<0.01). |
2003-04-28 |
2023-08-12 |
mouse |
| Krishna P Datla, Hilary E Murray, Arani V Pillai, Glenda E Gillies, David T Dexte. Differences in dopaminergic neuroprotective effects of estrogen during estrous cycle. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544829. |
here we show that the loss of dopaminergic neurons in the substantia nigra was greater in animals lesioned at diestrus (low estrogen) using 6-hydroxydopamine or buffered iron chloride, when compared with animals lesioned at proestrus (high estrogen). |
2003-04-25 |
2023-08-12 |
Not clear |
| S Kügler, E Kilic, M Bäh. Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area. Gene therapy. vol 10. issue 4. 2003-04-14. PMID:12595892. |
as an important feature of adenoviral-mediated gene transfer to the brain, we demonstrate that dopaminergic neurons of the substantia nigra do not allow for long-term expression from adenoviral vectors. |
2003-04-14 |
2023-08-12 |
human |
| Scott A Lyness, Chris Zarow, Helena C Chu. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493547. |
cell counts in the cholinergic nucleus basalis (nb), noradrenergic locus coeruleus (lc), dopaminergic substantia nigra (sn), and the serotonergic dorsal raphe nucleus (drn) were assessed from primary-level reports in patients with alzheimer disease (ad) and in controls. |
2003-03-26 |
2023-08-12 |
Not clear |
| L Cathala, A Guyon, D Eugene, D Paupardin-Tritsc. Alpha2-adrenoceptor activation increases a cationic conductance and spontaneous GABAergic synaptic activity in dopaminergic neurones of the rat substantia nigra. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453479. |
alpha2-adrenoceptor activation increases a cationic conductance and spontaneous gabaergic synaptic activity in dopaminergic neurones of the rat substantia nigra. |
2003-03-12 |
2023-08-12 |
rat |
| L Cathala, A Guyon, D Eugene, D Paupardin-Tritsc. Alpha2-adrenoceptor activation increases a cationic conductance and spontaneous GABAergic synaptic activity in dopaminergic neurones of the rat substantia nigra. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453479. |
noradrenaline (na) plays an important role in compensating for the loss in dopaminergic (da) function following lesions of the da neurones of the substantia nigra (sn). |
2003-03-12 |
2023-08-12 |
rat |
| R J Grant, P B S Clark. Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453497. |
overall, da cell bodies in the vta were substantially less susceptible than those in the substantia nigra to depletion of dopaminergic markers. |
2003-03-12 |
2023-08-12 |
rat |
| R J Grant, P B S Clark. Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453497. |
this was associated with a 200-300% increase in residual dopaminergic markers in the mesolimbic and nigrostriatal terminal fields; no significant protection occurred in the cell body regions.collectively, these findings show that (1) the dopaminergic somata in the substantia nigra are more susceptible than those in the vta to 6-ohda-induced denervation, and (2) hypothermia can provide anatomically selective neuroprotection within the substantia nigra-vta cell population. |
2003-03-12 |
2023-08-12 |
rat |
| D A Grimes, D E Bulma. Parkinson's genetics--creating exciting new insights. Parkinsonism & related disorders. vol 8. issue 6. 2003-03-05. PMID:12217636. |
the underlying cause for the degeneration of dopaminergic substantia nigra neurons and the formation of lewy bodies in parkinson's disease is unknown. |
2003-03-05 |
2023-08-12 |
Not clear |
| John McGrath, Elishia Lintz, Barry J Hoffer, Greg A Gerhardt, E Matthew Quintero, Ann-Charlotte Granhol. Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion. Cell transplantation. vol 11. issue 3. 2003-02-25. PMID:12075987. |
within 4 weeks of a single intrastriatal injection of raav-gdnf, unilaterally lesioned animals exhibited significant behavioral recovery, which correlated with increased expression of dopaminergic markers in the substantia nigra, the medial forebrain bundle, and the striatum. |
2003-02-25 |
2023-08-12 |
rat |
| William S Cobb, Elizabeth D Abercrombi. Differential regulation of somatodendritic and nerve terminal dopamine release by serotonergic innervation of substantia nigra. Journal of neurochemistry. vol 84. issue 3. 2003-02-14. PMID:12558977. |
nigrostriatal dopaminergic neurons release dopamine from dendrites in substantia nigra and axon terminals in striatum. |
2003-02-14 |
2023-08-12 |
Not clear |
| J M Mangin, A Guyon, D Eugène, D Paupardin-Tritsch, P Legendr. Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra. The Journal of physiology. vol 542. issue Pt 3. 2003-02-13. PMID:12154171. |
functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra. |
2003-02-13 |
2023-08-12 |
rat |
| Michael S Saporito, Robert L Hudkins, Anna C Marone. Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Progress in medicinal chemistry. vol 40. 2003-02-05. PMID:12516522. |
in parkinson's disease, dopaminergic neurons in the substantia nigra are hypothesized to undergo cell death by apoptotic processes. |
2003-02-05 |
2023-08-12 |
Not clear |
| Eunsung Junn, Sang Seop Lee, Unsun T Suhr, M Maral Mouradia. Parkin accumulation in aggresomes due to proteasome impairment. The Journal of biological chemistry. vol 277. issue 49. 2003-02-04. PMID:12364339. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra and by the presence of ubiquitinated cytoplasmic inclusions known as lewy bodies. |
2003-02-04 |
2023-08-12 |
Not clear |
| Elhadi Absi, Juan Parrado, Antonio Ayala, Alberto Machad. Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419532. |
the results show that the activity is spread throughout the brain, the highest activity being in the dopaminergic areas (striatum and substantia nigra) and in the cortex. |
2003-01-31 |
2023-08-12 |
rat |
| X Lu, D Maysinger, T Hag. Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats. Experimental neurology. vol 178. issue 2. 2003-01-21. PMID:12504884. |
for instance, brain-derived neurotrophic factor (bdnf) can prevent the death of dopaminergic substantia nigra neurons in rats. |
2003-01-21 |
2023-08-12 |
rat |
| Renata H Hasue, Sara J Shammah-Lagnad. Origin of the dopaminergic innervation of the central extended amygdala and accumbens shell: a combined retrograde tracing and immunohistochemical study in the rat. The Journal of comparative neurology. vol 454. issue 1. 2003-01-17. PMID:12410615. |
our results suggest that dopaminergic inputs to the eac and acsh arise from the ventral tegmental area-a10, substantia nigra, pars compacta-a9, and retrorubral nucleus-a8 groups as well as from the dorsal raphe nucleus and periaqueductal gray substance, housing the dorsocaudal part of a10 group (a10dc). |
2003-01-17 |
2023-08-12 |
rat |
| Joseph O'Neill, Norbert Schuff, William J Marks, Robert Feiwell, Michael J Aminoff, Michael W Weine. Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 5. 2003-01-08. PMID:12360540. |
this relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and pd subjects. |
2003-01-08 |
2023-08-12 |
human |
| Jonathan O Dostrovsky, William D Hutchison, Andres M Lozan. The globus pallidus, deep brain stimulation, and Parkinson's disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 8. issue 3. 2002-12-27. PMID:12061508. |
parkinson's disease (pd) is caused by the degeneration of the dopaminergic neurons in the substantia nigra. |
2002-12-27 |
2023-08-12 |
Not clear |